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Herpes genitalis

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Infektionserkrankungen der Schwangeren und des Neugeborenen

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Zusammenfassung

Die Infektion mit dem Herpes-simplex-Virus (HSV) ist weltweit eine der am häufigsten auftretenden, durch Geschlechtsverkehr übertragenen Viruserkrankungen. Der Herpes-simplex-Virus Typ 2 (HSV-2) ist die Hauptursache eines genitalen Herpes, wobei Infektionen des Genitaltrakts auch bei HSV-1 mittlerweile vermehrt beobachtet werden. Da fast 75 % aller weiblichen Patienten mit genitaler Herpesinfektion – unabhängig davon, ob es sich um eine Primärinfektion oder ein Rezidiv handelt – keine oder sogar atypische Symptome aufweisen, gestaltet sich eine korrekte Diagnose recht schwierig. Die wesentliche Gefahr in der Schwangerschaft besteht in der Übertragung des Virus auf den Feten bzw. das Neugeborene mit teils schweren klinischen Verläufen.

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Literatur

  • Friese K, Schäfer A, Hof H (2003) Infektionskrankheiten in Gynäkologie und Geburtshilfe. Springer, Berlin

    Google Scholar 

  • Mylonas I, Friese K (2009) Infektionen in Gynäkologie und Geburtshilfe. Elsevier, Urban, München

    Google Scholar 

Weiterführende Literatur: Geburtshilfe

  • ACOG practice bulletin (2000) Management of herpes in pregnancy. Number 8 October 1999. Clinical management guidelines for obstetrician-gynecologists. Int J Gynaecol Obstet 68:165–173

    Article  Google Scholar 

  • Andrews WW, Kimberlin DF, Whitley R, Cliver S, Ramsey PS, Deeter R (2006) Valacyclovir therapy to reduce recurrent genital herpes in pregnant women. Am J Obstet Gynecol 194:774–781

    Article  PubMed  CAS  Google Scholar 

  • Baker DA (2007) Consequences of herpes simplex virus in pregnancy and their prevention. Curr Opin Infect Dis 20:73–76

    Article  PubMed  Google Scholar 

  • Braig S, Luton D, Sibony O, Edlinger C, Boissinot C, Blot P, Oury JF (2001) Acyclovir prophylaxis in late pregnancy prevents recurrent genital herpes and viral shedding. Eur J Obstet Gynecol Reprod Biol 96:55–58

    Article  PubMed  CAS  Google Scholar 

  • Brown Z (2004) Preventing herpes simplex virus transmission to the neonate. Herpes 11(Suppl 3):175 A–186 A

    Google Scholar 

  • Brown ZA, Wald A, Morrow RA, Selke S, Zeh J, Corey L (2003) Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA 289:203–209

    Article  PubMed  Google Scholar 

  • Brown ZA, Gardella C, Wald A, Morrow RA, Corey L (2005) Genital herpes complicating pregnancy. Obstet Gynecol 106:845–856

    Article  PubMed  Google Scholar 

  • Cherpes TL, Meyn LA, Krohn MA, Lurie JG, Hillier SL (2003) Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis. Clin Infect Dis 37:319–325

    Article  PubMed  Google Scholar 

  • Cunningham AL, Lee FK, Ho DW, Field PR, Law CL, Packham DR, McCrossin ID, Sjogren-Jansson E, Jeansson S, Nahmias AJ (1993) Herpes simplex virus type 2 antibody in patients attending antenatal or STD clinics. Med J Aust 158:525–528

    PubMed  CAS  Google Scholar 

  • Cusini M, Cusan M, Parolin C, Scioccati L, Decleva I, Mengoli C, Suligoi B, Palu G (2000) Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy. Italian Herpes Forum. Sex Transm Dis 27:292–295

    Article  PubMed  CAS  Google Scholar 

  • Desselberger U (1998) Herpes simplex virus infection in pregnancy: diagnosis and significance. Intervirology 41:185–190

    Article  PubMed  CAS  Google Scholar 

  • DiCenso A, Guyatt G, Willan A, Griffith L (2002) Interventions to reduce unintended pregnancies among adolescents: systematic review of randomised controlled trials. BMJ 324:1426

    Article  PubMed  Google Scholar 

  • Dickson N, van Roode T, Herbison P, Taylor J, Cunningham A, Paul C (2007) Risk of herpes simplex virus type 2 acquisition increases over early adulthood: evidence from a cohort study. Sex Transm Infect 83:87–90

    Article  PubMed  CAS  Google Scholar 

  • Enders G, Risse B, Zauke M, Bolley I, Knotek F (1998) Seroprevalence study of herpes simplex virus type 2 among pregnant women in Germany using a type-specific enzyme immunoassay. Eur J Clin Microbiol Infect Dis 17:870–872

    Article  PubMed  CAS  Google Scholar 

  • Fleming DT, McQuillan GM, Johnson RE, Nahmias AJ, Aral SO, Lee FK, St Louis ME (1997) Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med 337:1105–1111

    Article  PubMed  CAS  Google Scholar 

  • Gardella C, Brown Z, Wald A, Selke S, Zeh J, Morrow RA, Corey L (2005) Risk factors for herpes simplex virus transmission to pregnant women: a couples study. Am J Obstet Gynecol 193:1891–1899

    Article  PubMed  Google Scholar 

  • Gottlieb SL, Douglas Jr JM, Schmid DS, Bolan G, Iatesta M, Malotte CK, Zenilman J, Foster M, Baron AE, Steiner JF, Peterman TA, Kamb ML (2002) Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics. J Infect Dis 186:1381–1389

    Article  PubMed  Google Scholar 

  • Gupta R, Warren T, Wald A (2007) Genital herpes. Lancet 370:2127–2137

    Article  PubMed  Google Scholar 

  • Hensleigh PA, Andrews WW, Brown Z, Greenspoon J, Yasukawa L, Prober CG (1997) Genital herpes during pregnancy: inability to distinguish primary and recurrent infections clinically. Obstet Gynecol 89:891–895

    Article  PubMed  CAS  Google Scholar 

  • Hollier LM, Wendel GD (2008) Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Cochrane Database Syst Rev: CD004946

    Google Scholar 

  • Kaye EM, Dooling EC (1981) Neonatal herpes simplex meningoencephalitis associated with fetal monitor scalp electrodes. Neurology 31:1045–1047

    Article  PubMed  CAS  Google Scholar 

  • Kriebs JM (2008) Understanding herpes simplex virus: transmission, diagnosis, and considerations in pregnancy management. J Midwifery Womens Health 53:202–208

    Article  PubMed  Google Scholar 

  • Kulhanjian JA, Soroush V, Au DS, Bronzan RN, Yasukawa LL, Weylman LE, Arvin AM, Prober CG (1992) Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy. N Engl J Med 326:916–920

    Article  PubMed  CAS  Google Scholar 

  • Mahnert N, Roberts SW, Laibl VR, Sheffield JS, Wendel Jr GD (2007) The incidence of neonatal herpes infection. Obstet Gynecol 196:e55–56

    Article  Google Scholar 

  • Major CA, Towers CV, Lewis DF, Garite TJ (2003) Expectant management of preterm premature rupture of membranes complicated by active recurrent genital herpes. Am J Obstet Gynecol 188:1551–1554 (discussion 1554–1555)

    Article  PubMed  Google Scholar 

  • Marques AR, Straus SE (2000) Herpes simplex type 2 infections – an update. Dis Mon 46:325–359

    Article  PubMed  CAS  Google Scholar 

  • Morris SR, Bauer HM, Samuel MC, Gallagher D, Bolan G (2008) Neonatal herpes morbidity and mortality in California. Sex Transm Dis 35:14–18

    PubMed  Google Scholar 

  • Mylonas I (2011) Herpes genitalis in der Schwangerschaft. Der Gynäkologe 44:623–629

    Article  Google Scholar 

  • Mylonas I, Friese K (2006) Infektionserkrankungen in der Geburtshilfe. In: Schneider H, Husslein P, Scheider KTM (Hrsg) Die Geburtshilfe, 3. Aufl. Springer, Heidelberg, S 349–395

    Chapter  Google Scholar 

  • Patel R, Barton SE, Brown D, Cowan FM, Kinghorn GR, Munday PE, Scoular A, Timmins D, Whittaker M, Woolley P (2001) Herpes Simplex Virus Special Interest Group of the Medical Society for the Study of Venereal Diseases UK, European Branch of the International Union against Sexually Transmitted I, the European Office of the World Health O. European guideline for the management of genital herpes. Int J STD AIDS 12(Suppl 3):34–39

    Article  PubMed  Google Scholar 

  • Reiff-Eldridge R, Heffner CR, Ephross SA, Tennis PS, White AD, Andrews EB (2000) Monitoring pregnancy outcomes after prenatal drug exposure through prospective pregnancy registries: a pharmaceutical company commitment. Am J Obstet Gynecol 182:159–163

    Article  PubMed  CAS  Google Scholar 

  • Roizman B (1999) HSV gene functions: what have we learned that could be generally applicable to its near and distant cousins? Acta Virol 43:75–80

    PubMed  CAS  Google Scholar 

  • Rudnick CM, Hoekzema GS (2002) Neonatal herpes simplex virus infections. Am Fam Physician 65:1138–1142

    PubMed  Google Scholar 

  • Sauerbrei A, Wutzler P (2007) Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infections. Med Microbiol Immunol 196:89–94

    Article  PubMed  CAS  Google Scholar 

  • Schleiss MR (2003) Vertically transmitted herpesvirus infections. Herpes 10:4–11

    PubMed  Google Scholar 

  • Scott LL, Hollier LM, McIntire D, Sanchez PJ, Jackson GL, Wendel Jr GD (2001) Acyclovir suppression to prevent clinical recurrences at delivery after first episode genital herpes in pregnancy: an open-label trial. Infect Dis Obstet Gynecol 9:75–80

    Article  PubMed  CAS  Google Scholar 

  • Sheffield JS, Hollier LM, Hill JB, Stuart GS, Wendel GD (2003) Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review. Obstet Gynecol 102:1396–1403

    Article  PubMed  CAS  Google Scholar 

  • Sheffield JS, Hill JB, Hollier LM, Laibl VR, Roberts SW, Sanchez PJ, Wendel Jr GD (2006) Valacyclovir prophylaxis to prevent recurrent herpes at delivery: a randomized clinical trial. Obstet Gynecol 108:141–147

    Article  PubMed  Google Scholar 

  • Smith PD, Roberts CM (2009) American College Health Association annual Pap test and sexually transmitted infection survey: 2006. J Am Coll Health 57:389–394

    Article  PubMed  Google Scholar 

  • Swiss Herpes Management F (2004) Swiss recommendations for the management of genital herpes and herpes simplex virus infection of the neonate. Swiss Med Wkly 134:205–214

    Google Scholar 

  • Underhill K, Montgomery P, Operario D (2007) Sexual abstinence only programmes to prevent HIV infection in high income countries: systematic review. BMJ 335:248

    Article  PubMed  Google Scholar 

  • Wald A, Huang ML, Carrell D, Selke S, Corey L (2003) Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. J Infect Dis 188:1345–1351

    Article  PubMed  CAS  Google Scholar 

  • Wald A, Langenberg AG, Krantz E, Douglas Jr JM, Handsfield HH, DiCarlo RP, Adimora AA, Izu AE, Morrow RA, Corey L (2005) The relationship between condom use and herpes simplex virus acquisition. Ann Intern Med 143:707–713

    Article  PubMed  Google Scholar 

  • Watts DH, Brown ZA, Money D, Selke S, Huang ML, Sacks SL, Corey L (2003) A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and cesarean delivery. Am J Obstet Gynecol 188:836–843

    Article  PubMed  CAS  Google Scholar 

  • Weiss H (2004) Epidemiology of herpes simplex virus type 2 infection in the developing world. Herpes 11(Suppl 1):24 A–35 A

    Google Scholar 

  • Whitley R (2004) Neonatal herpes simplex virus infection. Curr Opin Infect Dis 17:243–246

    Article  PubMed  Google Scholar 

  • Whitley R, Davis EA, Suppapanya N (2007) Incidence of neonatal herpes simplex virus infections in a managed-care population. Sex Transm Dis 34:704–708

    Article  PubMed  Google Scholar 

  • Xu F, Sternberg MR, Kottiri BJ, McQuillan GM, Lee FK, Nahmias AJ, Berman SM, Markowitz LE (2006) Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA 296:964–973

    Article  PubMed  CAS  Google Scholar 

Weiterführende Literatur: Neonatologie

  • Bonkowsky JL, Filloux FM, Byington CL (2006) Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropin. Pediatrics 117:e1045–e1048

    Article  PubMed  Google Scholar 

  • Braig S, Chanzy B (2004) Management of genital herppes during pregnancy: the french experience. Herpes 11:45–47

    PubMed  Google Scholar 

  • Fonseca-Aten M, Messina AF, Jafri HS, Sánchez PJ (2005) Herpes simplex virus encephalitis durino suppressive therapy with acyclovir in an premature infant. Pediatrics 115:804–805

    Article  PubMed  Google Scholar 

  • Frenkel LM (2005) Challenges in the diagnosis and management of neonatal herpes simplex virus encephalitis. Pediatrics 115:795–797

    Article  PubMed  Google Scholar 

  • Ito Y, Kimura H, Yabuta Y et al (2000) Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Clin Infect Dis 30:185–187

    Article  PubMed  CAS  Google Scholar 

  • Kimberlin DW, Lin CY, Jacobs RF et al (2001) Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics 108:223–229

    Article  PubMed  CAS  Google Scholar 

  • Kimberlin DW, Lin CY, Jacobs RF et al (2001) Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics 108:230–238

    Article  PubMed  CAS  Google Scholar 

  • Nahmias AJ (2004) Neonatal HSV infection part I: Continuing Challenges. Herpes: 11:33–37

    Google Scholar 

  • O’Riordan DP, Golden C, Aucott SW et al (2006) Herpes simplex virus infections in preterm infants. Pediatrics 118:1612–1620

    Article  Google Scholar 

  • Whitley R, Arvin A, Prober C et al (1991) A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex infection. Infectious Diseases Collaborative Antiviral Study Group. New Eng J Med 324:444–449

    Article  PubMed  CAS  Google Scholar 

  • Whitley R, Arvin A, Prober C et al (1991) Predictors of morbidity and mortality in neonates with herpes simplex virus infections. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. New Eng J Med 324:450–454

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik u. Poliklinik f. Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Ludwig-Maximilians-Universität München, Maistraße 11, 80337, München, Deutschland

    Klaus Friese Prof. Dr. med.

  2. Klinik u. Poliklinik f. Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Ludwig-Maximilians-Universität München, Maistraße 11, 80337, München, Deutschland

    Ioannis Mylonas

  3. Kinderklinik, ehemals Städtisches Krankenhaus München-Harlaching, Sanatoriumsplatz 2, 81545, München, Deutschland

    Reinhard Roos Prof. Dr. med.

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  1. Klaus Friese Prof. Dr. med.
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  2. Ioannis Mylonas
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  3. Reinhard Roos Prof. Dr. med.
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  1. Klinik u. Poliklinik f. Frauenheilkunde, und Geburtshilfe, Ludwig-Maximilians-Universität München, Maistraße 11, München, 80337, Germany

    Klaus Friese

  2. Klinikum Innenstadt, Klinik für Geburtshilfe, Ludwig-Maximilians-Universität München, Maistr. 11, München, 80337, Germany

    Ioannis Mylonas

  3. Neonato. im Perinatalzen. Großhadern, Dr. von Haunerschen Kinderspital, Universitätsklinikum München, Marchioninistr. 15, München, 81377, Germany

    Andreas Schulze

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Friese, K., Mylonas, I., Roos, R. (2013). Herpes genitalis. In: Friese, K., Mylonas, I., Schulze, A. (eds) Infektionserkrankungen der Schwangeren und des Neugeborenen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78325-1_13

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  • DOI: https://doi.org/10.1007/978-3-540-78325-1_13

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