Skip to main content
SpringerLink
Log in

Neue Arzneimittel 2006

  • Chapter
Arzneiverordnungs-Report 2007

  • 578 Accesses

Auszug

Im Jahr2006 wurden 27 Arzneimittel mit neuen Wirkstoffen in Deutschland auf den Markt gebracht. Damit liegt die Zahl der Neueinführungen wieder deutlich höher als im Vorjahr (21 Wirkstoffe) und in etwa im Durchschnitt der letzten zehn Jahre. Auffällig ist die hohe Zahl von zehn Arzneimitteln für seltene Krankheiten (Orphan-Arzneimittel).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  • Arbeit RD, Maki D, Tally FP, Campanaro E, Eisenstein BI; Daptomycin 98-01 and 99-01 Investigators (2004): The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. Clin Infect Dis 38: 1673–1681.

    Article  PubMed  CAS  Google Scholar 

  • Arzneimittelkommission der deutschen Ärzteschaft (2004): Empfehlungen zur Prophylaxe und Therapie der stabilen koronaren Herzkrankheit. 1. Auflage Arzneiverordnung in der Praxis, Band 31 Sonderheft 1 (Therapieempfehlungen). Internet: www.akdae.de/35/76_KHK_2004_1 Auflage.pdf

    Google Scholar 

  • Babinchak T, Ellis-Grosse E, Dartois N, Rose GM, Loh E; Tigecycline 301 Study Group; Tigecycline 306 Study Group (2005): The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data. Clin Infect Dis 41Suppl 5: S354–S367.

    Article  PubMed  CAS  Google Scholar 

  • Barst RJ, Langleben D, Frost A, Horn EM, Oudiz R, Shapiro S, McLaughlin V, Hill N, Tapson VF, Robbins IM, Zwicke D, Duncan B, Dixon RA, Frumkin LR; STRIDE-1 Study Group (2004): Sitaxsentan therapy for pulmonary arterial hypertension. Am J Resp Crit Care Med 169: 441–447.

    Article  PubMed  Google Scholar 

  • Barst RJ, Langleben D, Badesch D, Frost A, Lawrence EC, Shapiro S, Naeije R, Galie N; STRIDE-2 Study Group (2006): Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J Am Coll Cardiol 47: 2049–2056.

    Article  PubMed  CAS  Google Scholar 

  • Benedict NJ (2007): Sitaxsentan in the management of pulmonary arterial hypertension. Am J Health Syst Pharm 64: 363–368.

    Article  PubMed  CAS  Google Scholar 

  • Berger JR, Koralnik IJ (2005): Progressive multifocal leukoencephalopathy and natalizumab — unforeseen consequences. N Engl J Med 353: 414–416.

    Article  PubMed  CAS  Google Scholar 

  • Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen EA, Creager MA, Easton JD, Fiather MD, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Mak KH, Mas JL, Montalescot G, Pearson TA, Steg PG, Steinhubl SR, Weber MA, Brennan DM, Fabry-Ribaudo L, Booth J, Topol EJ; CHARISMA Investigators (2006): Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 354: 1706–1717.

    Article  PubMed  CAS  Google Scholar 

  • Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ; PaTH Study Investigators (2003): The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349: 1207–1215.

    Article  PubMed  CAS  Google Scholar 

  • Block SL, Nolan T, Sattler C, Barr E, Giacoletti KE, Marchant CD, Castellsague X, Rusche SA, Lukac S, Bryan JT, Cavanaugh PF Jr, Reisinger KS; Protocol 016 Study Group (2006): Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women. Pediatrics 118: 2135–2145.

    Article  PubMed  Google Scholar 

  • Borer JS, Fox K, Jaillon P, Lerebours G; Ivabradine Investigators Group (2003): Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107: 817–823.

    Article  PubMed  Google Scholar 

  • Brent J (2001): Current management of ethylene glycol poisoning. Drugs. 61: 979–988.

    Article  PubMed  CAS  Google Scholar 

  • Brent J, McMartin K, Phillips S, Burkhart KK, Donovan JW, Wells M, Kulig K (1999): Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med 340: 832–838.

    Article  PubMed  CAS  Google Scholar 

  • Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, Aydinok Y, Kattamis A, Kilinc Y, Porter J, Capra M, Galanello R, Fattoum S, Drelichman G, Magnano C, Verissimo M, Athanassiou-Metaxa M, Giardina P, Kourakli-Symeonidis A, Janka-Schaub G, Coates T, Vermylen C, Olivieri N, Thuret I, Opitz H, Ressayre-Djaffer C, Marks P, Alberti D (2006): A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood 107: 3455–3462.

    Article  PubMed  CAS  Google Scholar 

  • CAPRIE Steering Committee (1996): A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348: 1329–1339.

    Article  Google Scholar 

  • Chang TT, Gish RG, de Man R, Gadano A, Sollano J, Chao YC, Lok AS, Han KH, Goodman Z, Zhu J, Cross A, DeHertogh D, Wilber R, Colonno R, Apelian D; BEHoLD AI463022 Study Group (2006): A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 354: 1001–1010.

    Article  PubMed  CAS  Google Scholar 

  • CDC (2007) Postmarketing monitoring of intussusception after RotaTeq™ vaccination — United States, February 1, 2006–February 15, 2007. MMWR Weekly, 56: 218–222. http://www.cdc.gov/mmwr/preview/ mmwrhtml/mm5610a3.htm

    Google Scholar 

  • Chow LQ, Eckhardt SG (2007): Sunitinib: From rational design to clinical efficacy. J Clin Oncol 25: 884–896.

    Article  PubMed  CAS  Google Scholar 

  • Colgrove J (2006): The ethics and politics of compulsory HPV vaccination. N Engl J Med 355: 2389–2391.

    Article  PubMed  CAS  Google Scholar 

  • Curioni C, Andre C (2006): Rimonabant for overweight or obesity. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006162.

    Google Scholar 

  • Dansereau J, Joshi AK, Helewa ME, Doran TA, Lange IR, Luther ER, Farine D, Schulz ML, Horbay GL, Griffin P, Wassenaar W (1999): Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section. Am J Obstet Gynecol 180: 670–676.

    Article  PubMed  CAS  Google Scholar 

  • Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG (2007): Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368: 1329–1338.

    Article  CAS  Google Scholar 

  • Despres JP, Golay A, Sjostrom L; Rimonabant in Obesity-Lipids Study Group (2005): Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353: 2121–2134.

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ; MATCH investigators (2004): Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, doubleblind, placebo-controlled trial. Lancet 364: 331–337.

    Article  PubMed  CAS  Google Scholar 

  • DiFrancesco D, Camm JA (2004): Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs 64: 1757–1765.

    Article  PubMed  CAS  Google Scholar 

  • Ellis-Grosse EJ, Babinchak T, Dartois N, Rose G, Loh E; Tigecycline 300 cSSSI Study Group; Tigecycline 305 cSSSI Study Group (2005): The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam. Clin Infect Dis. 2005 Sep 1;41Suppl 5:S341–S353.

    Article  PubMed  CAS  Google Scholar 

  • El-Saghir N, Otrock Z, Mufarrij A, Abou-Mourad Y, Salem Z, Shamseddine A, Abbas J (2004): Dexrazoxane for anthracycline extravasation and GM-CSF for skin ulceration and wound healing. Lancet Oncol 5: 320–321.

    Article  PubMed  CAS  Google Scholar 

  • EMEA (2006a): Naglazyme. Europäischer öffentlicher Beurteilungsbericht (EPAR). Internet: www.emea.eu.int/humandocs/PDFs/EPAR/naglazyme/ H-640-PI-de. pdf

    Google Scholar 

  • EMEA (2006b): Procoralan. Europäischer öffentlicher Beurteilungsbericht (EPAR). Internet: http://www.emea.europa.eu/humandocs/PDFs/EPAR/ procoralan/ 32044705en6.pdf

    Google Scholar 

  • EMEA (2006c): Tsyabri. Europäischer öffentlicher Beurteilungsbericht (EPAR). Internet: www.emea.eu.int/humandocs/PDFs/EPAR/tysabri/TysabriEPA Rsummary-de.pdf

    Google Scholar 

  • EMEA (2006d): Preotact. Europäischer öffentlicher Beurteilungsbericht (EPAR). Internet: http://www.emea.europa.eu/humandocs/PDFs/EPAR/ preotact/Preota ctEparScientificDen.pdf

    Google Scholar 

  • EMEA (2006e): Rotigotin. Europäischer öffentlicher Beurteilungsbericht (EPAR). Internet: www.emea.eu.int/humandocs/PDFs/EPAR/neupro/ 062606del.pdf

    Google Scholar 

  • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Freeman S, Schwartz B, Shan M, Simantov R, Bukowski RM; TARGET Study Group (2007): Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125–134.

    Article  PubMed  CAS  Google Scholar 

  • FDA Information (2006): Natalizumab (marketed as Tysabri) information. Updated June 14, 2006. Internet: www.fda.gov/cder/drug/infopage/ natalizumab/default. htm

    Google Scholar 

  • Fowler VG, Boucher HW, Corey GR, Abrutyn E, Karchmer AW, Rupp ME, Levine DP, Chambers HF, Tally FP, Vigliani GA, Cabell CH, Link AS, DeMeyer I, Filler SG, Zervos M, Cook P, Parsonnet J, Bernstein JM, Price CS, Forrest GN, Fätkenheuer G, Gareca M, Rehm SJ, Brodt HR, Tice A, Cosgrove SE, S. aureus Endocarditis and Bacteremia Study Group (2006) Daptomycin versus standard therapy for bacteremia and endocarditis caused by staphylococcus aureus. N Engl J Med 355: 653–665.

    Article  PubMed  CAS  Google Scholar 

  • Fricke U (2000): Arzneimittelinnovationen — Neue Wirkstoffe: 1978–1999. Eine Bestandsaufnahme. In: Klauber J, Schröder H, Selke GW (Hrsg): Innovation im Arzneimittelmarkt, Springer-Verlag, Berlin-Heidelberg-New York, pp. 85–97.

    Google Scholar 

  • Fricke U (2007): Im Jahr 2006 neu eingeführte Präparate und ihre Bewertung. Arzneiverordnung in der Praxis 34: 51.

    Google Scholar 

  • Gadde KM, Allison DB (2006): Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks. Circulation 114: 974–984.

    Article  PubMed  CAS  Google Scholar 

  • Gandhi V, Plunkett W (2006): Clofarabine and nelarabine: two new purine nucleoside analogs. Curr Opin Oncol 18: 584–590.

    Article  PubMed  CAS  Google Scholar 

  • Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC (2007): Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women. JAMA 297: 969–977.

    Article  PubMed  CAS  Google Scholar 

  • Garland SM, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, Tang GW, Ferris DG, Steben M, Bryan J, Taddeo FJ, Railkar R, Esser MT, Sings HL, Nelson M, Boslego J, Sattler C, Barr E, Koutsky LA; Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators (2007): Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 356: 1928–1043.

    Article  PubMed  CAS  Google Scholar 

  • Garg N, Sharmar MK, Sinha N (2006): Role of sildenafil in severe pulmonary arterial hypertension: clinical efficacy and dose response relationship. Int J Cardiol Dec 14 [Epub ahead of printing].

    Google Scholar 

  • Gemeinsamer Bundesausschuss (2006): Bekanntmachung [1095 A] eines Beschlusses des Gemeinsamen Bundesausschusses über die Änderung der Arzneimittel-Richtlinie/AMR in Anlage 8: Lifestyle Arzneimittel vom 17. Oktober 2006. BAnz. Nr. 8 (S. 400) vom 12.01.2007. Internet: www.g-ba.de/downloads/39-261-337/2006-10-17_AMR8-Rimonabant_BAnz.pdf

    Google Scholar 

  • Gesellschaft der epidemiologischen Krebsregister in Deutschland (Hrsg) (2006a): Krebs in Deutschland. Häufigkeiten und Trends. 5. Ausgabe, Saarbrücken, Seite 56. Internet: www.rki.de/cln_048/nn_196910/DE/Content/GBE/DachdokKrebs/ Broschuere/kid2006,templateld=raw,property= publicationFile.pdf/kid2006.pdf

    Google Scholar 

  • Gesellschaft der epidemiologischen Krebsregister in Deutschland (Hrsg) (2006b): Krebs in Deutschland. Häufigkeiten und Trends. 5. Ausgabe, Saarbrücken, Seite 76–79. Internet: www.rki.de/cln_048/nn_196910/DE/ Content/GBE/ DachdokKrebs/Broschuere/kid2006,templateId=raw,property =publicationFile. pdf/kid2006.pdf

    Google Scholar 

  • Glass RI, Parashar UD, Bresee JS, Turcios R, Fischer TK, Widdowson MA, Jiang B, Gentsch JR (2006): Rotavirus vaccines: current prospects and future challenges. Lancet 368: 323–332.

    Article  PubMed  CAS  Google Scholar 

  • Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR; VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group (2004): Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 351: 2805–2816.

    Article  PubMed  CAS  Google Scholar 

  • Greenspan SL, Bone HG, Ettinger MP, Hanley DA, Lindsay R, Zanchetta JR, Blosch CM, Mathisen AL, Morris SA, Marriott TB (2007): Effect of recombinant human parathyroid hormone (1–84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: A randomized trial. Ann Intern Med 146: 326–339.

    PubMed  Google Scholar 

  • Harmatz P, Giugliani R, Schwartz I, Guffon N, Teles EL, Miranda MC, Wraith JE, Beck M, Arash L, Scarpa M, Yu ZF, Wittes J, Berger KI, Newman MS, Lowe AM, Kakkis E, Swiedler SJ; MPS VI Phase 3 Study Group (2006): Enzyme replacement therapy for mucopolysaccharidosis VI: A phase 3, randomized, doubleblind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study. J Pediatr 148: 533–539.

    Article  PubMed  CAS  Google Scholar 

  • Hunter DJ, Schulz P, Wassenaar W (1992): Effect of carbetocin, a long-acting oxytocin analog on the postpartum uterus. Clin Pharmacol Ther 52: 60–67.

    PubMed  CAS  Google Scholar 

  • Hutchison AJ, Maes B, Vanwalleghem J, Asmus G, Mohamed E, Schmieder R, Backs W, Jamar R, Vosskuhler A (2005): Efficacy, tolerability, and safety of lanthanum carbonate in hyperphosphatemia: a 6-month, randomized, comparative trial versus calcium carbonate. Nephron Clin Pract 100: c8–c19.

    Article  PubMed  CAS  Google Scholar 

  • Jacobsen D (1999): New treatment for ethylene glycol poisoning. N Engl J Med 340: 879–881.

    Article  PubMed  CAS  Google Scholar 

  • Jeha S, Gaynon PS, Razzouk BI, Franklin J, Kadota R, Shen V, Luchtman-Jones L, Rytting M, Bomgaars LR, Rheingold S, Ritchey K, Albano E, Arceci RJ, Goldman S, Griffin T, Altman A, Gordon B, Steinherz L, Weitman S, Steinherz P (2006): Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. J Clin Oncol 24: 1917–1923.

    Article  PubMed  CAS  Google Scholar 

  • Jichlinski P, Guillou L, Karlsen SJ, Malmstrom PU, Jocham D, Brennhovd B, Johansson E, Gartner T, Lange N, van den Bergh H, Leisinger HJ (2003): Hexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer — a multicenter study. J Urol 170: 226–229.

    Article  PubMed  Google Scholar 

  • Jocham D, Witjes F, Wagner S, Zeylemaker B, van Moorselaar J, Grimm MO, Muschter R, Popken G, König F, Knuchel R, Kurth KH (2005): Improved detection and treatment of bladder cancer using hexaminolevulinate imaging: a prospective, phase III multicenter study. J Urol 174: 862–866.

    Article  PubMed  Google Scholar 

  • Joy MS, Finn WF; LAM-302 Study Group (2003): Randomized, double-blind, placebo-controlled, dose-titration, phase III study assessing the efficacy and tolerability of lanthanum carbonate: a new phosphate binder for the treatment of hyperphosphatemia. Am J Kidney Dis 42: 96–107.

    Article  PubMed  CAS  Google Scholar 

  • Kantarjian HM, Talpaz M, Giles F, O’Brien S, Cortes J (2006): New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance. Ann Intern Med 145: 913–923.

    PubMed  Google Scholar 

  • Kern WV (2006): Daptomycin: first in a new class of antibiotics for complicated skin and soft-tissue infections. Int J Clin Pract 60: 370–378.

    Article  PubMed  CAS  Google Scholar 

  • Kishnani PS, Corzo D, Nicolino M, Byrne B, Mandel H, Hwu WL, Leslie N, Levine J, Spencer C, McDonald M, Li J, Dumontier J, Halberthal M, Chien YH, Hopkin R, Vijayaraghavan S, Gruskin D, Bartholomew D, van der Ploeg A, Clancy JP, Parini R, Morin G, Beck M, De la Gastine GS, Jokic M, Thurberg B, Richards S, Bali D, Davison M, Worden MA, Chen YT, Wraith JE (2007): Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology 68: 99–109.

    Article  PubMed  CAS  Google Scholar 

  • Kishnani PS, Howell RR (2004): Pompe disease in infants and children. J Pediatr 144(5 Suppl): S35–S43.

    PubMed  CAS  Google Scholar 

  • Lai CL, Shouval D, Lok AS, Chang TT, Cheinquer H, Goodman Z, DeHertogh D, Wilber R, Zink RC, Cross A, Colonno R, Fernandes L; BEHoLD AI463027 Study Group (2006): Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 354: 1011–1020.

    Article  PubMed  CAS  Google Scholar 

  • Lange N, Jichlinski P, Zellweger M, Forrer M, Marti A, Guillou L, Kucera P, Wagnieres G, van den Bergh H (1999): Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study. Br J Cancer 80: 185–193.

    Article  PubMed  CAS  Google Scholar 

  • Langer SW, Sehested M, Jensen PB (2000): Treatment of anthracycline extravasation with dexrazoxane. Clin Cancer Res 6: 3680–3686.

    PubMed  CAS  Google Scholar 

  • Lauffer RB, Parmelee DJ, Dunham SU, Ouellet HS, Dolan RP, Witte S, McMurry TJ, Walovitch RC (1998): MS-325: albumin-targeted contrast agent for MR angiography. Radiology 207: 529–538.

    PubMed  CAS  Google Scholar 

  • Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman LR, Hilton L, Suttorp M, Solomon V, Shekelle PG, Morton SC (2005): Meta-analysis: pharmacologie treatment of obesity. Ann Intern Med 142: 532–546.

    PubMed  CAS  Google Scholar 

  • Lyseng-Williamson KA, Perry C (2006): Ziconotide. CNS Drugs 20: 331–338.

    Article  PubMed  CAS  Google Scholar 

  • Mehta SR, Yusuf S, Peters RJG, Bertrand ME, Lewis BL, Katarajan MK et al. for the Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators (2001): Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients underoing percutaneous coronary intervention: The PCI-CURE study. Lancet 358: 527–533.

    Article  PubMed  CAS  Google Scholar 

  • Mensink GB, Lampert T, Bergmann E (2005): Übergewicht und Adipositas in Deutschland 1984–2003. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48: 1348–1356.

    Article  PubMed  CAS  Google Scholar 

  • Miller DH, Khan OA, Sheramata WA et al (2003): A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 348: 15–23.

    Article  PubMed  CAS  Google Scholar 

  • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA (2007): Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356: 115–124.

    Article  PubMed  CAS  Google Scholar 

  • Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE, Li JZ, Bello CL, Theuer CP, George DJ, Rini BI (2006a): Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24: 16–24.

    Article  PubMed  CAS  Google Scholar 

  • Motzer RJ, Rini BI, Bukowski RM, Curti BD, George DJ, Hudes GR, Redman BG, Margolin KA, Merchan JR, Wilding G, Ginsberg MS, Bacik J, Kim ST, Baum CM, Michaelson MD (2006b): Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295: 2516–2524.

    Article  PubMed  CAS  Google Scholar 

  • Mouridsen H, Langer S, Buter J, Eidtmann H, Rosti G, de Wit M, Knoblauch P, Rasmussen A, Dahlstrom K, Jensen P, Giaccone G (2007): Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies. Ann Oncol 18: 546–550.

    Article  PubMed  CAS  Google Scholar 

  • Murray TM, Rao LG, Divieti P, Bringhurst FR (2005): Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands. Endocr Rev 26: 78–113.

    Article  PubMed  CAS  Google Scholar 

  • Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG (2000): Multiple sclerosis. N Engl J Med 343: 938952.

    Article  Google Scholar 

  • NN (2006a): Pegaptanib: new drug. In macular degeneration: too many risks for too little benefit. Prescrire Int 15: 127–129.

    Google Scholar 

  • NN (2006b): Rimonabant: new drug. Obesity: loss of a few kilos, many questions. Prescrire Int 15: 123–126.

    Google Scholar 

  • Olschewski H, Simonneau G, Galiè N, Higenbottam T, Naeije R, Rubin LJ, Nikkho S, Speich R, Hoeper MM, Behr J, Winkler J, Sitbon O, Popov W, Ghofrani HA, Manes A, Kiely DG, Ewert R, Meyer A, Corris PA, Delcroix M, Gomez-Sanchez M, Siedentop H, Seeger W, for the Aerosolized Iloprost Randomized Study Group (2002): Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 347: 322–329.

    Article  PubMed  CAS  Google Scholar 

  • Pacher P, Batkai S, Kunos G (2006): The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389–462.

    Article  PubMed  CAS  Google Scholar 

  • Perreault P, Edelman MA, Baum RA, Yucel EK, Weisskoff RM, Shamsi K, Mohler ER 3rd (2003): MR angiography with gadofosveset trisodium for peripheral vascular disease: phase II trial. Radiology 229: 811–820.

    Article  PubMed  Google Scholar 

  • Pi-Sunyer EX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J; RIO-North America Study Group (2006): Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295: 761–775.

    Article  PubMed  CAS  Google Scholar 

  • Polman CH, O’Connor PW, Havrdova E et al (2006): A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 354: 899–910.

    Article  PubMed  CAS  Google Scholar 

  • Rauck RL, Wallace MS, Leong MS, Minehart M, Webster LR, Charapata SG, Abraham JE, Buffington DE, Ellis D, Kartzinel R; Ziconotide 301 Study Group (2006): A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. J Pain Symptom Manage 31: 393–406.

    Article  PubMed  CAS  Google Scholar 

  • Ratain MJ, Eisen T, Stadler WM, Flaherty KT, Kaye SB, Rosner GL, Gore M, Desai AA, Patnaik A, Xiong HQ, Rowinsky E, Abbruzzese JL, Xia C, Simantov R, Schwartz B, O’Dwyer PJ (2006): Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 24: 2505–2512.

    Article  PubMed  CAS  Google Scholar 

  • Robinson DM, Scott LJ, Plosker GL (2006): Entecavir: a review of its use in chronic hepatitis B. Drugs 66: 1605–1622.

    Article  PubMed  CAS  Google Scholar 

  • Rudick RA, Stuart WH, Calabresi PA, Confavreux C, Galetta SL, Radue EW, Lublin FD, Weinstock-Guttman B, Wynn DR, Lynn F, Panzara MA, Sandrock AW; SENTINEL Investigators (2006): Natalizumab plus interferon beta-la for relapsing multiple sclerosis. N Engl J Med 354: 911–923.

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Palacios GM, Perez-Schael I, Velazquez FR, Abate H, Breuer T, Clemens SC, Cheuvart B, Espinoza F, Gillard P, Innis BL, Cervantes Y, Linhares AC, Lopez P, Macias-Parra M, Ortega-Barria E, Richardson V, Rivera-Medina DM, Rivera L, Salinas B, Pavia-Ruz N, Salmeron J, Ruttimann R, Tinoco JC, Rubio P, Nunez E, Guerrero ML, Yarzabal JP, Damaso S, Tornieporth N, Saez-Llorens X, Vergara RF, Vesikari T, Bouckenooghe A, Clemens R, De Vos B, O’Ryan M; Human Rotavirus Vaccine Study Group (2006): Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med 354: 11–22.

    Article  PubMed  CAS  Google Scholar 

  • Rund D, Rachmilewitz E (2005): ß-Thalassemia. N Engl J Med 353: 1135–1146.

    Article  PubMed  CAS  Google Scholar 

  • Ruzyllo W, Tendera M, Ford I Fox KM (2007): Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial. Drugs 67: 393–405.

    Article  PubMed  CAS  Google Scholar 

  • Sanofi Aventis (2007): FDA Advisory Committe did not recommend approval of riminabant (Zimulti©) für use in obese ans overweight patients with associated risks factors. Press release June 13, 2007. Internet: http://en.sanofi-aventis.com/ Images/20070613_Rimonabant_AD_Comm_EN_tcm24-16868.pdf

    Google Scholar 

  • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF; RIO-Diabetes Study Group (2006): Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 368: 1660–1672.

    Article  PubMed  CAS  Google Scholar 

  • Schmidbauer J, Witjes F, Schmeller N, Donat R, Susani M, Marberger M; Hexvix PCB301/01 Study Group (2004): Improved detection of urothelial carcinoma in situ with hexaminolevulinate fluorescence cystoscopy. J Urol 171: 135–138.

    Article  PubMed  Google Scholar 

  • Schrader WF (2006): Altersbedingte Makuladegeneration. Sozioökonomische Zeitbombe in der alternden Gesellschaft. Ophthalmologe 103: 742–748.

    Article  PubMed  CAS  Google Scholar 

  • Sherman M, Yurdaydin C, Sollano J, Silva M, Liaw YF, Cianciara J, Boron-Kaczmarska A, Martin P, Goodman Z, Colonno R, Cross A, Denisky G, Kreter B, Hindes R; AI463026 BEHoLD Study Group (2006): Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B. Gastroenterology 130:2039–2049.

    Article  PubMed  CAS  Google Scholar 

  • Siderowf A, Stern M (2003): Update on Parkinson disease. Ann Intern Med 138: 651–658.

    PubMed  Google Scholar 

  • Sjostrom L, Rissanen A, Andersen T, Boldrin M, Golay A, Koppeschaar HP, Krempf M (1998): Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group. Lancet 352: 167–172.

    Article  PubMed  CAS  Google Scholar 

  • Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M, Fisher R, Bryce DA, Mangieri EA, Luther RR, Mayo M, McGuire D, Ellis D (2004): Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS. JAMA 291: 63–70.

    Article  PubMed  CAS  Google Scholar 

  • Staehler M, Haseke N, Schoppler G, Stadler T, Adam C, Stief CG (2006): Therapiestrategien des fortgeschrittenen Nierenkarzinoms. Urologe A 45: 99–110.

    Article  PubMed  CAS  Google Scholar 

  • Ständige Impfkommission beim Robert-Koch-Institut (STIKO) (2007): Impfung gegen humane Papillomaviren (HPV) für Mädchen von 12 bis 17 Jahren-Empfehlung und Begründung. Epidemiologisches Bulletin Nr. 12, Seite 971-103. Internet: www.rki.de/cln_049/nn_205760/DE/Content/Infekt/EpidBull/Archiv/ 2007/Ausschnitte/HPV_STIKO_12_07, templateld=raw,property=publicati onFile.pdf

    Google Scholar 

  • Stein GE, Craig WA (2006): Tigecycline: a critical analysis. Clin Infect Dis 43: 518–524.

    Article  PubMed  CAS  Google Scholar 

  • Sweeney G, Holbrook AM, Levine M, Yip M, Alfredson K, Cappi S, et al (1990): Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, in nonpregnant women. Curr Ther Res 47: 528–540.

    CAS  Google Scholar 

  • Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O’Brien S, Nicaise C, Bleickardt E, Blackwood-Chirchir MA, Iyer V, Chen TT, Huang F, Decillis AP, Sawyers CL (2006): Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354: 2531–2541.

    Article  PubMed  CAS  Google Scholar 

  • Tanne J (2006): CDC recommends expensive vaccine for all girls aged 11–12. BMJ 333: 114.

    Article  PubMed  Google Scholar 

  • Tardif JC, Ford I, Tendera M, Bourassa MG, Fox K; INITIATIVE Investigators (2005): Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J 26: 2529–2536.

    Article  PubMed  CAS  Google Scholar 

  • Taylor D (2003): Fewer new drugs from the pharmaceutical industry. Brit Med J 326: 408–409.

    Article  PubMed  Google Scholar 

  • The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators (2001): Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without st-segment elevation. N Engl J Med 345: 494–502.

    Article  Google Scholar 

  • The FUTURE II Study Group (2007): Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N Engl J Med 356: 1915–1927.

    Article  Google Scholar 

  • The Parkinson Study Group (2003): A controlled trial of rotigotine monotherapy in early Parkinson’s disease. Arch Neurol 60: 1721–1728.

    Article  Google Scholar 

  • Truby H, Baic S, deLooy A, Fox KR, Livingstone MBE, Logan CM, Macdonald IA, Morgan LM, Taylor MA, Millward DJ (2006) Randomised controlled trial of four commercial weight loss programmes in the UK: initial findings from the BBC “diet trials”. BMJ 332: 1309–1315.

    Article  PubMed  Google Scholar 

  • US Food and Drug Administration (2007a): Medwatch Safety Information. 2007 Safety Alerts for Drugs, Biologics, Medical Devices, and Dietary Supplements: Exjade May 14, 2007, Dear Health Care Professional Letter. Internet: www.fda. gov/medwatch/safety/2007/Exjade_DHCPL_May2007.pdf

    Google Scholar 

  • US Food and Drug Administration — Center for Biologics Evaluation and Research (2007b): Information pertaining to labeling revision for RotaTeq. http://www. fda.gov/cber/label/rotateqLBinfo.htm

    Google Scholar 

  • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S; RIO-Europe Study Group (2005): Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365: 1389–1397.

    Article  PubMed  CAS  Google Scholar 

  • VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group (2006): Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 113: 1508–1521.

    Google Scholar 

  • Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z, Dallas MJ, Heyse JF, Goveia MG, Black SB, Shinefield HR, Christie CD, Ylitalo S, Itzler RF, Coia ML, Onorato MT, Adeyi BA, Marshall GS, Gothefors L, Campens D, Karvonen A, Watt JP, O’Brien KL, DiNubile MJ, Clark HF, Boslego JW, Offit PA, Heaton PM; Rotavirus Efficacy and Safety Trial (REST) Study Team (2006): Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med 354: 23–33.

    Article  PubMed  CAS  Google Scholar 

  • Veznik Z, Holub A, Zraly Z, Kummer V, Holcak V, Jost K, Cort JH (1979): Regulation of bovine labor with a long-acting carba-analog of oxytocin: a preliminary report. Am J Vet Res 40: 425–429.

    PubMed  CAS  Google Scholar 

  • Villa LL, Costa RL, Petta CA, Andrade RP, Ault KA, Giuliano AR, Wheeler CM, Koutsky LA, Malm C, Lehtinen M, Skjeldestad FE, Olsson SE, Steinwall M, Brown DR, Kurman RJ, Ronnett BM, Stoler MH, Ferenczy A, Harper DM, Tamms GM, Yu J, Lupinacci L, Railkar R, Taddeo FJ, Jansen KU, Esser MT, Sings HL, Saah AJ, Barr E (2005): Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol 6: 271–278.

    Article  PubMed  Google Scholar 

  • Villa LL, Costa RL, Petta CA, Andrade RP, Paavonen J, Iversen OE, Olsson SE, Hoye J, Steinwall M, Riis-Johannessen G, Andersson-Ellstrom A, Elfgren K, Krogh G, Lehtinen M, Malm C, Tamms GM, Giacoletti K, Lupinacci L, Railkar R, Taddeo FJ, Bryan J, Esser MT, Sings HL, Saah AJ, Barr E (2006): High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 viruslike particle vaccine through 5 years of follow-up. Br J Cancer 95: 1459–1466.

    Article  PubMed  CAS  Google Scholar 

  • Wadden TA, Berkowitz RI, Womble LG, Sarwer DB, Phelan S, Cato RK, Hesson LA, Osei SY, Kaplan R, Stunkard AJ (2005): Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med 353: 2111–2120.

    Article  PubMed  CAS  Google Scholar 

  • Wallace MS, Charapata SG, Fisher R, Byas-Smith M, Staats PS, Mayo M, McGuire D, Ellis D, The Ziconotide Nonmalignant Pain Study 96-002 Group (2006): Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trial. Neuromodulation 9: 75–86.

    Article  Google Scholar 

  • Watts RL, Jankovic J, Waters C, Rajput A, Boroojerdi B, Rao J (2007): Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease. Neurology 68: 272–276.

    Article  PubMed  CAS  Google Scholar 

  • WHO Collaborating Centre for Drug Statistics Methodology (2006): Anatomischtherapeutisch-chemischer (ATC) Index mit definierten Tagesdosen (DDD). Oslo. Internet: www.whocc.no/atcddd/

    Google Scholar 

  • Yousry TA, Major EO, Ryschkewitsch C, Fahle G, Fischer S, Hou J, Curfman B, Miszkiel K, Mueller-Lenke N, Sanchez E, Barkhof F, Radue EW, Jager HR, Clifford DB (2006): Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 354: 924–933.

    Article  PubMed  CAS  Google Scholar 

  • zur Hausen H (2002): Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2: 342–350.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Pharmakologie der Universität zu Köln, Gleueler Straße 24, 50924, Köln

    Prof. Dr. rer. nat. Uwe Fricke

  2. Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Prof. Dr. med. Ulrich Schwabe

Authors
  1. Prof. Dr. rer. nat. Uwe Fricke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. med. Ulrich Schwabe
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Ulrich Schwabe

  2. AOK Schleswig-Holstein Die Gesundheitskasse, Edisonstraße 70, 24145, Kiel

    Dieter Paffrath

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Fricke, U., Schwabe, U. (2008). Neue Arzneimittel 2006. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72548-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-72548-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-72547-3

  • Online ISBN: 978-3-540-72548-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation