Auszug
Das Geburtsgewicht ist die wichtigste Determinante für die perinatale Morbidität und Mortalität. Bei gleichem Gestationsalter sind niedrige Fetalgewichte mit einer 4- bis 8fach höheren perinatalen Mortalität korreliert (Schneider 1993). Die»Intrauterine-Growth-Restriction«(IUGR) macht mehr als 20% der intrauterinen Fruchttode aus (Haram et al. 2006). Die Tatsache, dass unter Frühgeburten ein höherer Anteil an IUGR-Feten zu finden ist (20% bei Einlingen, 30% bei Gemini) als unter Reifgeborenen weist darauf hin, dass durch die plazentare Insuffizienz Frühgeburtlichkeit induziert wird. Darüber hinaus ist das relative Risiko dieser Feten bezüglich Asphyxie, Mekoniumaspiration, Hypoglykämie und Hyperviskosität als Zeichen chronischer Hypoxämie um ein Vielfaches erhöht. Wachstumsretardierte Kinder zeigen zudem vermehrt Störungen in ihrer neurologischen Langzeitentwicklung (Clark 1992; Wienerrhoiter 2001; Haram et al. 2006). Das Risiko einer Chromosomenstörung bei Verdacht auf IUGR wird mit 2–8% angegeben. Da Fehlbildungen nahezu jedes fetalen Organs mit einer intrauterinen Wachstumsretardierung assoziiert sein können, sollte neben einer genetischen Abklärung intensiv nach derartigen Fehlbildungen gefahndet werden (Khoury et al. 1988; Harkness u. Mari 2004). All diese Faktoren machen deutlich, dass der Diagnostik und der Fürsorge für SGAbzw. IUGR-Feten eine zentrale Bedeutung in der Schwangerenbetreuung zukommt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Anyaegbunam A, Brustman L, Langer O (1991) A longitudinal evaluation of the efficacy of umbilical Doppler velocimetry in the diagnosis of intrauterine growth retardation. Int JGynecol Obstet 34:121–125
Arabin B, Mohnhaupt A, Vollert W, Weitzel HK (1994) Prediction of fetal distress and poor outcome in prolonged pregnancy using Doppler ultrasound and fetal heart rate monitoring combined with stress tests (II). Fetal Diagn Ther 9:1–6
Arbeille P (1991) Cerebral Doppler in the assessment of IUGR and the fetal hypoxia. J Matern Fetal Invest 1:51–56
Arduini D (1991) Fetal renal artery velocity waveforms and amniotic fluid volume in growth-retarded and post-term fetuses. Obstet Gynecol 77:370–373
Arduini D, Romanini C, Mancuso S (1987) Fetal blood flow velocity wave forms as predictors of growth retardation. Obstet Gynecol 70:7–10
Baschat AA (2005) Arterial and venous Doppler in the diagnosis and management of early onset fetal growth restriction. Early Hum Dev. 81(11): 877–887.
Bates JA, Evans JA, Mason G (1996) Differentiation of growth retarded from normally grown fetuses and prediction of intrauterine growth retardation using Doppler ultrasound. Br J Obstet Gynecol 103:670–675
Bats AS, Lejeune V, Cynober E, Safar E, Gonzales M, Milliez J, Carbonne B (2004) Antiphospholipid syndrome and second or third-tri-mester fetal death: follow-up in the next pregnancy. Eur J Obstet Gynecol Reprod Biol. 15;114(2):125–129
Beattie RB, Dornan JC (1989) Antenatal screening for intrauterine growth retardation with umbilical artery Doppler ultrasonography. Br Med J 298:631–635
Beley S, Chard, Grudzinskas G, Cooper D, Campbell S (1992) Early prediction of uteroplacental complications of pregnancy using Doppler ultrasound, placental function tests and combinating testing. Ultrasound Obstet Gynecol 2:333–337
Bilardo CM, Nicolaides KH, Campbell S (1990) Doppler measurements of fetal and uteroplacental circulations: relationship with umbilical venous blood gases measured at cordocentesis. Am J Obstet Gynecol 162:115–120
Burke G, Stuart B, Crowley P, Scanaill S, Drumm J (1990) Is intrauterine growth retardation with normal umbilical artery blood flow a benign condition? Br Med J 300:1044–1045
Campbell S, Pearce JM, Hackett G, Cohen-Overbeck T, Hernandez C (1986) Qualitative assessment of uteroplacental blood flow: early screening test for high-risk pregnancies. Obstet Gynecol 68:649–653
Carlson DE (1988) Maternal diseases associated with intrauterine growth retardation. Semin Perinatal 12:17–22
Chang TC, Boys RJ, Spencer JA (1992) Prediction of the small for gestational age infant: which ultrasonic measurement is best? Obstet Gynecol 80:1030–1038
Clark SL (1992) Patterns of intrauterine growth retardation: case examples. Clin Obstet Gynecol 35:194–201
Divon MY (1992) Maternal and fetal blood flow velocity waveforms in intrauterine growth retardation. Am J Obstet Gynecol 35:156–171
Divon MY, Guidetti DA, Braverman JJ (1988) Intrauterine growth retardation: a prospective study of the diagnostic value of real-time sonography combined with umbilical artery flow velocimetry. Obstet Gynecol 72:611–614
Divon MY, Hsu HW, Katz NT, Henderson CE (1992) A Meta-Analysis of umbilical artery Doppler velocimetry for the diagnosis of IUGR in high risk pregnancies. Soc Gynecol Invest 131
Ferrazzi E, Bozzo M, Rigano S, Bellotti M, Morabito A, Pardi G, Battaglia FC, Galan HL (2002) Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth-restricted fetus. Ultrasound Obstet Gynecol. 2002 19(2):140–146.
Flynn AM, Kelly J, Matthews K, O’Conor M, Viegas O (1982) Predictive value of, and observer variablity in, several ways of reporting antepartum cardiotocographs. Br J Obstet Gynaecol 89:434–440
Gagnon R, Van den Hof M; Diagnostic Imaging Committee, Executive and Council of the Society of Obstetricians and Gynaecologists of Canada (2003) The use of fetal Doppler in obstetrics J Obstet Gynaecol Can. 25(7):601–614
Galan HL, Ferrazzi E, Hobbins JC (2002) Intrauterine growth restriction (IUGR): biometric and Doppler assessment. Prenat Diagn. 22(4):331–337.
Gardosi J, Chang A, Kalyan B, Sahota D, Symonds EM (1992) Customised antenatal growth charts. Lancet 339:283–287
Gaudoin MR (1992) Cardiotocography and Doppler velocimetry for surveillance of small-for-gestational-age fetuses. Lancet 340:1348–1349
Gnirs J (1995) Kineto-Kardiotokographie — automatische Detektion der fetalen Bewegungsaktivität als integraler Bestandteil antepartualer CTG Registrierungen und ihre Bedeutung für die fetale Zustandsdiagnostik. Habilitationsschrift,TU München
Gudmundsson S, Marsal K (1991) Blood velocity waveforms in the fetal aorta and umbilical artery as predictors of fetal outcome: a comparison. Am J Perinatol 8:1–6
Haram K, Softeland E, Bukowski R (2006) Intrauterine growth restriction. Int J Gynaecol Obstet. 93(1)5–12
Harkness UF, Mari G (2004) Diagnosis and management of intrauterine growth restriction. Clin Perinatol. 31(4):743–764
Jacobson SL, Imhof R, Manning N, Mannion V, Little D, Rey E, Redman C (1990) The value of Doppler assessment of the uteroplacental circulation in predicting preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 162:110–114
Karsdorp VHM, van Geijn HP, Kostense PJ, Arduini D, Montenegro N, Todros T (1994) Clinical significance of absent or reversed end diastolic velocity waveforms (ARED flow) in the umbilical artery: results of a multicenter European study. Lancet 344:1664–1667
Kay HH, Dahmus M, Killam AP (1991). Sonographic measurements with umbilical and uterine artery Doppler analysis in suspected intrauterine growth retardation. J Reprod Med 36:65–68
Khoury MJ, Errickson JD, Cordero JF, McCarthy BJ (1988) Congenital malformations and intrauterine growth retardation: a population study. Pediatrics 82:83–90
Kurjak A (1992) Antepartum and intrapartum management of the growth-retarded fetus. Clin Obstet Gynecol 35:185–193
Kutschera J, Tomaselli J, Urlesberger B et al (2002) Absent or reversed enddiastolic blood flow in the umbilical artery and abnormal Doppler cerebroplacental ratio-cognitive, neurological and somatic development at 3 to 6 years. Early Hum Dev. 69(1–2):47–56.
Kwon JY, Kwon HS, Kim YH, Park YW (2006) Abnormal Doppler velocimetry is related to adverse perinatal outcome for borderline amniotic fluid index during third trimester. J Obstet Gynaecol Res. 32(6)545–549
Larsen T, Petersen S, Greisen G (1992) Detection of small-for-gestatio-nal-age fetuses by ultrasound screening in a high risk population: a randomized controlled study. Br J Obstet Gynaecol 99:469–474
Laurin J, Marsal K, Persson PH, Lingman G (1987) Ultrasound measurement of fetal blood flow in predicting fetal outcome. Br J Obstet Gynecol 94:940–948
Lees C, Baumgartner H (2005) The TRUFFLE study-a collaborative publicly funded project from concept to reality: how to negotiate an ethical, administrative and funding obstacle course in the European Union. Ultrasound Obstet Gynecol 25(2):105–107
Lindhard A, Nielsen PV, Mouritsen LA, Zachariassen A, Sörensen HU, Rosenö H (1990) The implications of introducing the symphyseal-fundal height-measurement. A prospective randomized controlled trial. Br J Obstet Gynaecol 97:675–680
Meizner I, Glezerman M (1992) Cordocentesis in the evaluation of the growth-retarded fetus. Clin Obstet Gynecol 35:126–137
Mutterschaftsrichtlinien (1995) Ultraschall-Doppler. Deutsches Ärzteblatt 92:233–235
Nicolaides KH, Vyas S, Rabinowitz R, Rosen DJD, Campbell S (1990) Relation of rate of urine production to oxygen tension in smallfor-gestational-age fetuses. Am J Obstet Gynecol 162:387–391
Nicolaides KH, Economides DL, Soothill PW (1989) Blood gases, pH, and lactate in appropriate-and small-for-gestational-age fetuses. Am J Obstet Gynecol 161:996–1001
Nienhuis SJ, Vles JS, Gerver WJ, Hoogland HJ (1997) Doppler ultrasonography in suspected intrauterine growth retardation: a randomized clinical trial. Ultrasound Obstet Gynecol 9:6–13
Pfeiffer KH (1990) Die Erfassung der fetalen Wachstumsretardierung durch apparative und biochemische Überwachungsmethoden. Z Geburtshilfe Perinatal 194:99–103
Piazze J, Padula F, Cerekja A, Cosmi EV, Anceschi MM (2005) Prognostic value of umbilical-middle cerebral artery pulsatility index ratio in fetuses with growth restriction. Int J Gynaecol Obstet 91(3):233–237
Sarmandal P (1990) Effectiveness of ultrasound determination of fetal abdominal circumference and fetal ponderal index in the diagnosis of asymmetrical growth retardation. Br J Obstet Gynaecol 97:118–123
Schneider KTM (1993) lUGR-Probleme der Diagnostik. In: Schmidt W (Hrsg) Jahrbuch der Gynäkologie und Geburtshilfe 1992/93. Biermann, Zülpich, S. 113–123
Schneider KTM (2003) Standards in der Perinatalmedizin-Dopplersonographie in der Schwangerschaft. Geburtshilfe Frauenheilkd 63:21–25
Schneider KTM, Amberg-Wendland D, Renz S, Fürstenau U (1991) Prospektiv randomisierte Untersuchung zum klinischen Wert der Dopplersonographie als Screeningverfahren. Gynakol Geburtshilfliche Rundsch 31:139–140
Secher NJ, Lundbye-Christensen S, Qvist I, Bagger P (1991) An evaluation of clinical estimation of fetal weight and symphysis fundal distance for detection of SGA infants. Eur J Obstet Gynecol Reprod Biol 38:91–96
Soothill PW, Campbell S (1993) Predicition of morbidity in small and normally grown fetuses by fetal heart rate variability, biophysical profile score and umbilical artery Doppler studies. Br J Obstet Gynaecol 100:742–745
Steiner H, Schaffer H, Spitzer D, Staudach A (1994) Umbilical artery Doppler velocimetry classes and fetal outcome. J Matern Fetal Invest 4:163–166
Steiner H, Staudach A, Spitzer D, Schaffer H, Gregg A, Weiner CP (1995) Growth deficient fetuses with absent or reversed umbilical artery end-diastolic flow are metabolically compromised. Early Hum Dev 41:1–9
Thacker SB, Berkelman RL (1986) Assessing the diagnostic accuracy and efficacy of selected fetal surveillance techniques. Obstet Gynecol Surv 41:121–141
Thorpe-Beeston JG (1992) Serum prolactin concentration in normal and small for gestational age fetuses. Br J Obstet Gynaecol 99:981–984
Thornton JG, Hornbuckle J, Vail A, Spiegelhalter DJ, Levene M; GRIT study group (2004) Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial. Lancet. 364(9433)513–520.
Todros T, Ferrazzi E, Arduini D et al (1995) Performance of Doppler ultrasonography as a screening test in low risk pregnancies: Results of a multicenter study. J Ultrasound Med 14:343–348
Van Vugt JMG (1991) Validity of umbilical artery blood velocimetry in the prediction of intrauterine growth retardation and fetal compromise. J Perinat Med 19:15–20
Vintzileos AM, Rodis JF, McLean DA, Fleming AD, Scorza WE (1991) The relationship between fetal biophysical assessment, umbilical artery velocimetry, and fetal acidosis. Obstet Gynecol 77:622–626
Villar J, Belizan JM (1986) The evaluation of methods used in the diagnosis of intrauterine growth retardation. Obstet. Gynecol Surv 41:187–199
Voigt M, Schneider KTM, Jährig K (1996) Analyse des Geburtengutes des Jahrgangs 1992 der Bundesrepublik Deutschland.Teil 1:Neue Perzentilmaße für die Körpergewichte Neugeborener. Geburtshilfe Frauenheilkd 56:550–258
Voigt M, Schneider KTM, Jährig K (1997) Analyse des Geburtengutes des Jahrgangs 1992 der Bundesrepublik Deutschland. Teil 2: Mehrdimensionale Zusammenhänge zwischen Alter, Körpergewicht und Körperhöhe der Mutter und dem Geburtsgewicht. Geburtshilfe Frauenheilkd 57:246–255
Wienerroither H, Steiner H, Tomaselli J, Lobendanz M, Thun-Hohen-stein L (2001) Intrauterine blood flow and long-term intellectual, neurologic, and social development. Obstet Gynecol 97(3):449–453
Weiner CP, Williamson RA (1989) Evaluation of severe growth retardation using cordocentesis: hematologic and metabolic alterations by etiology. Obstet Gynecol 73:225–229
Wladimiroff JW (1991) A review of the etiology, diagnostic techniques and management of IUGR, and the clinical application of Doppler in the assessment of placental blood flow. J Perinat Med 19:11–13
Zimmer EZ, Divon MY (1992) Sonographic diagnosis of IUGR-Macrosomia. Clin Obstet Gynecol 35:172–184
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Schneider, K.T.M., Steiner, H. (2008). Der SGA-Fetus — die intrauterine Wachstumsrestriktion. In: Steiner, H., Schneider, KT.M. (eds) Dopplersonographie in Geburtshilfe und Gynäkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72371-4_8
Download citation
DOI: https://doi.org/10.1007/978-3-540-72371-4_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72370-7
Online ISBN: 978-3-540-72371-4
eBook Packages: Medicine (German Language)