Zusammenfassung
Die quantitative sensorische Testung (QST) unterscheidet sich von der klinisch neurologischen Sensibilitätsprüfung durch eine stärkere Formalisierung des Untersuchungsablaufs, die Verwendung von kalibrierten Reizstärken und die Standardisierung der Instruktionen für den Patienten. Auch wenn die Reize teilweise durch einen Computer gesteuert werden, bleibt die Methode abhängig von den subjektiven Angaben der Patienten. Die Standardisierung der QST-Methodik führt jedoch zu reproduzierbaren und vom Untersucher unabhängigen Befunden. Ähnlich wie die klinische Sensibilitätsprüfung soll QST alle Submodalitäten der Somatosensorik erfassen (Tastsinn, Propriozeption, Temperatursinn, Nozizeption). Das Muster von Funktionsverlust und Funktionssteigerung der Somatosensorik erlaubt Rückschlüsse auf die zugrunde liegenden pathophysiologischen Mechanismen: Läsion dicker Afferenzen oder des Hinterstrangsystems, Läsion dünner Afferenzen oder des Vorderseitenstrangsystems, periphere Sensibilisierung, zentrale Sensibilisierung, Defizit der endogenen Schmerzhemmung.
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Literatur
Baron R, Wasner G (1998) Quantitative Thermotestung. Untersuchung der thermosensiblen und nozizeptiven Afferenzen bei Neuropathien. Schmerz 12:209–211
Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede RD (2002) Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain 96:141–151
Beise RD, Carstens E, Kohllöffel LUE (1998) Psychophysical study of stinging pain evoked by brief freezing of superficial skin and ensuing short-lasting changes in sensations of cool and cold pain. Pain 74:275–286
Chan AW, MacFarlane IA, Bowsher D, Campbell JA (1992) Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy. J Neurol Neurosurg Psychiat 55:56–59
Cruccu G, Anand P, Attal N, Garcia-Larrea L, Haanpää M, Jørum E, Serra J, Jensen TS (2004) EFNS guidelines on neuropathic pain assessment. Eur J Neurol 11:153–162
Frost SA, Raja SN, Campbell JN, Meyer RA, Khan AA (1988) Does hyperalgesia to cooling stimuli characterize patients with sympathetically maintained pain (reflex sympathetic dystrophy)? In: Dubner R, Gebhart GF, Bond MR (Eds.) Proceedings of the Vth World Congress on Pain. Elsevier, Amsterdam, pp 151–156
Fruhstorfer H, Lindblom U, Schmidt WG (1976) Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiat 39:1071–1075
Fruhstorfer H, Gross W, Selbmann O (2001) von Frey hairs: new materials for a new design. Eur J Pain 5:341–342
Giesecke T, Williams DA, Harris RE, Cupps TR, Tian X, Tian TX, Gracely RH, Clauw DJ (2003) Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum 48:2916–2922
Gracely RH, Grant MAB, Giesecke T (2003) Evoked pain measures in fibromyalgia. Best Practice & Res Clinl Rheumatol 17:593–609
Greenspan JD, Mcgillis SLB (1991) Stimulus features relevant to the perception of sharpness and mechanically evoked cutaneous pain. Somatosens Motor Res 8:137–147
Hansson P (2002) Neuropathic pain: clinical characteristics and diagnostic workup. Eur J Pain 6Suppl A: 47–50
Jensen TS, Baron R (2003) Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102:1–8
Koltzenburg M, Lundberg LER, Torebjörk HE (1992) Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51:207–219
Merskey H, Albe-Fessard D, Bonica JJ, Carmon A, Dubner R, Kerr FWL, Lindblom U, Mumford JM, Nathan PW, Noordenbos W, Pagni CA, Renaer MJ, Sternbach RA, Sunderland S (1979) Pain terms: a list with definitions and notes on usage. Recommended by the IASP subcommittee on taxonomy. Pain 6:249–252
Ochoa JL, Yarnitsky D (1993) Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 33:465–472
Perkins BA, Bril V (2003) Diabetic neuropathy: a review emphasizing diagnostic methods. Clin Neurophysiol 114:1167–1175
Pestronk A, Florence J, Levine T, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M (2004) Sensory exam with a quantitative tuning fork. Rapid, sensitive and predictive of SNAP amplitude. Neurology 62:461–464
Rolke R, Magerl W, Andrews-Campbell K, Schalber C, Caspari S, Birklein F, Treede RD (2006a) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10:77–88
Rolke R, Baron R, Maier C, Tölle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B (2006b) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values. Pain 123:231–243
Shy ME, Frohman EM, So YT, Arezzo JC, Cornblath DR, Giuliani MJ, Kincaid JC, Ochoa JL, Parry GJ, Weimer LH (2003) Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 60: 898–904
Treede RD, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 483:747–758
Treede RD, Rolke R, Andrews K, Magerl W (2002) Pain elicited by blunt pressure: neurobiological basis and clinical relevance. Pain 98: 235–240
Treede RD, Handwerker HO, Baumgärtner U, Meyer RA, Magerl W (2004) Hyperalgesia and allodynia:taxonomy, assessment, and mechanisms. In: Brune K, Handwerker HO (eds) Hyperalgesia: molecular mechanisms and clinical implications. IASP Press, Seattle, pp 1–15
Yarnitsky D (1997) Quantitative sensory testing. Muscle Nerve 20:198–204
Yarnitsky D, Sprecher E (1994) Thermal testing: normative data and repeatability for various test algorithms. J Neurol Sci 125:39–45
Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA (1995) Heat pain thresholds: Normative data and repeatability. Pain 60:329–332
Ziegler D, Mayer P, Gries FA (1988) Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients. J Neurol Neurosurg Psychiat 51:1420–1424
Ziegler EA, Magerl W, Meyer RA, Treede RD (1999) Secondary hyperalgesia to punctate mechanical stimuli: Central sensitization to A — fibre nociceptor input. Brain 122:2245–2257
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Treede, R.D. (2007). Quantitative sensorische Testung (QST). In: Baron, R., Strumpf, M. (eds) Praktische Schmerztherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49663-2_8
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DOI: https://doi.org/10.1007/978-3-540-49663-2_8
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