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Schmerztherapie von Skelettmetastasen mittels ionisierender Strahlung

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Praktische Schmerztherapie
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Literatur

Literatur zu Kap. 16.1

  • Adamietz IA, Diel IJ (2003) Bisphosphonate. Onkologe 9:495–509

    Article  Google Scholar 

  • Adamietz IA, Schneider O et al. (2002) Results of a nationwide survey on radiotherapy of bone metastases in Germany. Strahlenther Onkol 178,10:531–536

    Article  PubMed  Google Scholar 

  • Arcangeli G, Giovinazzo G et al. (1998) Radiation therapy in the management of symptomatic bone metastases: the effect of total dose and histology on pain relief and response duration. Int J Radiat Oncol Biol Phys 425:1119–1126

    Article  PubMed  CAS  Google Scholar 

  • Blitzer PH (1985) Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer 55,7:1468–1472

    Article  PubMed  CAS  Google Scholar 

  • Bone-Trial-Working-Party (1999) 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Bone Pain Trial Working Party. Radiother Oncol 52,2:111–121

    Google Scholar 

  • Böttcher HD, Adamietz IA (1997) Klinik der Skelettmetastasen. Zuck-schwerdt, München Bern Wien New York

    Google Scholar 

  • Hoskin PJ, Price P et al. (1992) A prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiother Oncol 23,2: 74–78

    Article  PubMed  CAS  Google Scholar 

  • Kagan AR, Rose CM et al. (2000) Bone metastases. American College of Radiology. ACR Appropriateness Criteria. Radiology 215Suppl: 1077–10104

    PubMed  Google Scholar 

  • Koswig S, Buchali A et al. (1999) Palliative Strahlentherapie von Knochenmetastasen. Eine retrospektive Analyse von 176 Patienten. Strahlenther Onkol 175,10:509–14

    Article  PubMed  CAS  Google Scholar 

  • Koswig S, Budach V (1999) Remineralisation und Schmerzlinderung von Knochenmetastasen nach unterschiedlich fraktionierter Strahlentherapie (10mal 3 Gy vs. 1mal 8 Gy). Strahlenther Onkol 175: 500–508

    Article  PubMed  CAS  Google Scholar 

  • Ratanatharathorn V, Powers WE et al. (1999) Bone metastasis: review and critical analysis of random allocation trials of local field treatment. Int J Radiat Oncol Biol Phys 441:1–18

    Article  PubMed  CAS  Google Scholar 

  • Rieden K, Adolph J et al. (1989) Strahlentherapeutischer Effekt bei knochenmetastasen in Abhängigkeit von der Metastasenhäufig, Metastasenlokalisation und der Histologie des Primärtumors. Strahlenther Onkol 165,5:380–385

    PubMed  CAS  Google Scholar 

  • Rieden K, Mende U et al. (1989) Akzelerierte Bestrahlung von Knochenmetastasen. Strahlenther Onkol 165,1:23–27

    PubMed  CAS  Google Scholar 

  • Salazar OM, DaMotta NW et al. (1996) Fractionated half-body irradiation for pain palliation in widely metastatic cancers: comparison with single dose. Int J Radiat Oncol Biol Phys 36,1:49–60

    Article  PubMed  CAS  Google Scholar 

  • Salazar OM, Sandhu T et al. (2001) Fractionated half-body irradiation HBI) for the rapid palliation of widespread, symptomatic, metastatic bone disease: a randomized Phase III trial of the International Atomic Energy Agency IAEA). Int J Radiat Oncol Biol Phys 50,3: 765–775

    Article  PubMed  CAS  Google Scholar 

  • Tong D, Gillick L et al. (1982) The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology Group. Cancer 50,5:893–899

    Article  PubMed  CAS  Google Scholar 

Literatur zu Kap. 16.2

  1. Atkins HL, Mausner LF Srivastava SC, Meinken GE et al. (1995) Tin-117m(4+)-DTPA for palliation of pain from osseous metstases: a pilotstudy. J Nucl Med 36: 725–729

    PubMed  CAS  Google Scholar 

  2. Averbuch SD (1993) New bisphosphonates in the treatment of bone metastases. Cancer Suppl 72:3443–3451

    CAS  Google Scholar 

  3. Baziotis N, Yakoumakis E, Zissimopoulos et al. (1998) Strontium-89 chloride in the treatment of bone metatases from breast cancer. Oncology 55:377–381

    Article  PubMed  CAS  Google Scholar 

  4. Blake GM, Zivanovic MA, McEwan AJB, Ackery DM (1986) Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate. Eur J Nucl Med 12:447–454

    PubMed  CAS  Google Scholar 

  5. Bolger JJ, Dearnaley DP, Kirk D, Lewington VJ et al. (1993) Strontium-89 (Metastron) versus external beam radiotherapy in patients with painful bone metatases secondary to prostate cancer: preliminary report of a multicente trial. Sem Oncol 20,Suppl 2:32–33

    CAS  Google Scholar 

  6. Bouchet LG, Bolch WE, Goddu SM et al. (2000) Considerations in the selection of radiopharmaceuticals for palliation of bone pain from metastatic osseous lesions. J Nucl Med 41:682–687

    PubMed  CAS  Google Scholar 

  7. Brenner W, Kampen WU, Kampen AM, Henze E (2001) Skeletal uptake and soft tissue retention of 186-Re-HEDP and 153-Sm-EDTMP in patients with metastatic bone disease. J Nucl Med 42:231–236

    Google Scholar 

  8. Brucer M (1990) A chronology of nuclear medicine. Heritage Publications, St. Louis

    Google Scholar 

  9. Coleman RE (1997) Skeletal complications of malignancy. Cancer 80: 1588–1594

    Article  PubMed  CAS  Google Scholar 

  10. Coleman RE, Smith P, Rubens RD (1998) Clinical course and prognostic factors following bone recurrence from breast cancer. Br J Cancer 77:336–340

    PubMed  CAS  Google Scholar 

  11. Deguchi T, Yang M, Ehara H et al. (1997). Detection of micrometastatic prostate cancer cells in the bone marrow of patients with prostate cancer. Br J Cancer 75:634–638

    PubMed  CAS  Google Scholar 

  12. deKlerk JMH (1995) Re-186-HEDP in treatment of metatatic bone disease: pharmakokinetics and toxocity. Ponson & Looigen, Wagenningen

    Google Scholar 

  13. Ducy P, Schinke T, Karsenty G (2000) The osteoblast: a sophisticated fibroblast under central surveillance. Science 289:1501–1504

    Article  PubMed  CAS  Google Scholar 

  14. Elgazzar AH, Maxon HR (1993) Radioisotope therapy of cancer related bone pain. In: Limouris GS, Shukla SK (eds) Radionuclides for therapy. Mediterra, Athen, pp 111–116

    Google Scholar 

  15. Fischer M (1999) Leitlinie für die Radionuklidtherapie bei schmerzhaften Knochenmetastasen. Nuklearmedizin 38:270–272

    PubMed  CAS  Google Scholar 

  16. Fischer M, Böhme K (1996) Nuklearmedizinsche Schmerztherapie bei metastasiertem Prostatakarzinom. Nuklearmediziner 5:339–344

    Google Scholar 

  17. Fuster D, Herranz R, Vidal-Sicart S et al. (2000) Usefulness of strontium-89 for bone pain palliation in metastatic breast cancer patients. Nucl Med Commun 21:623–626

    Article  PubMed  CAS  Google Scholar 

  18. Galasko CSB (1982) Mechanisms of lytic and blastic metastatic disease of bone. Clin Orthop 169:20–27

    PubMed  Google Scholar 

  19. Geldof AA, de Rooij L, Versteegh RT et al. (1999) Combination 186-Re-HEDP and cisplatin supraadditive treatment effects in prostate cancer cells. J Nucl Med 40:667–671

    PubMed  CAS  Google Scholar 

  20. Goddu SM, Bbishayee A, Bouchet LG et al. (2000) Marrow toxicity of 33-P versus 32-P-orthophosphate: implication for therapy of bone pain and bone metastases. J Nucl Med 41:941–951

    PubMed  CAS  Google Scholar 

  21. Henriksen G, Breistøl K, Bruland ØS, Fodstad Ø, Larsen RH (2002) Significant antitumor effect from bone-seeking, α-particle-emitting 223-Ra demonstrated in an experimental skeletal metastases model. Cancer Res 62:3120–3125

    PubMed  CAS  Google Scholar 

  22. Kalesnikov-Gauthier H, Carpenier P, Depreux P et al. (2000) Evaluation of toxicity and efficacy of 186-Re-hydroxyethylidene diphosphonate in patients with painful bone metastases of prostate or breast cancer. J Nucl Med 41:1689–1694

    Google Scholar 

  23. Kasalický J, Kraská V (1998) The effect of repeated strontium-89 chloride therapy in bone pain palliation in patients with skeletal cancer metastases. Eur J Nucl Med 25:1362–1367

    Article  PubMed  Google Scholar 

  24. Krasnow AZ, Hellman RS, Timins ME, Collier BD, Anderson T, Isitman AT (1997) Diagnostic bone scanning in oncology. Semin Nucl Med 27:107–141

    Article  PubMed  CAS  Google Scholar 

  25. Krishnamurthy GT, Krishnamurthy S (2000) Invited commentary: Radionuclides for metastatic bone pain palliation: a need for rational re-evaluation in the new millenium. J Nucl Med 41:688–691

    PubMed  CAS  Google Scholar 

  26. Lau WF, Hicks R, Binns D (2001) Differential effects of bisphosphonate on Paget’s disease and metastatic prostatic carcinoma bone scan findings. Clin Nucl Med 26:347–348

    Article  PubMed  CAS  Google Scholar 

  27. Liepe K, Franke W-G, Koch R et al. (2000) Comparison of Rhenium-188, Rhenium-186 and Strontium in palliation of painful bone metastases. Nuklearmedizin 39:146–151

    PubMed  CAS  Google Scholar 

  28. Malmberg I, Persson U, Ask A et al. (1997) Painful bone metastases in hormon-refractory prostate cancer: economic cost of strontium-89 and/or external radiotherapy. Urology 50: 747–753

    Article  PubMed  CAS  Google Scholar 

  29. Marcus CS, Saeed S, Mlikotic A, Mishkin F, Pham HL, Javellana T, Diestelhorst S, Minami C (2002) Lack of effect of a bisphosphonate (pamidronate disodium) infusion on subsequent skeletal uptake of Sm-153-EDTMP. Clin Nucl Med 27:427–430

    Article  PubMed  Google Scholar 

  30. Maxon HR, Deutsch EA, Thomas SR, Libson K (1988) Re-186 (Sn) HEDP for treatment of multiple metastatic foci in bone: human biodistribution and dosimetric studies. Radiology 166:501–507

    PubMed  CAS  Google Scholar 

  31. McCready VR, O’Sullivan J, Dearnaly D, Cook G (2002) Prediction of response of skeletal metastases from cancer of the prostate to high activity 186-Re HEDP therapy. J Nucl Med 43Suppl 316 (abstr.)

    Google Scholar 

  32. McEwan AJB (1994) Palliation of bone pain. In: Murray IPC, Ell PJ (Hrsg) Nuclear medicine in clinical diagnosis and treatment. Churchill Livingston, Edinburgh, pp 877–892

    Google Scholar 

  33. McEwan AJB et al. (1994) A retrospective analysis of the cost effectiveness of treatment with Metastron in patients with prostate cancer metastatic to bone. Eur J Urol 26,Suppl 1:26–31

    Google Scholar 

  34. Nilsson S, Larsen RH, Fossa SD et al. (2005). First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases. Clin Cancer Res 11:4451–4459

    Article  PubMed  CAS  Google Scholar 

  35. Palmedo H, Manka-Waluch A, Albers P et al. (2003). Repeated bontargeted therapy for hormone-refractory prostate carcinoma: randomized phase II trial with the new, high-energy radiopharmaceutical rhenium-188 hydroxyethylidenediphosphonate. J Clin Oncol 21: 2869–2875

    Article  PubMed  CAS  Google Scholar 

  36. Paulus P (1995) Re-186-HEDP in routine use: correlation between dose rate measurements and clinical efficacy. Update 1:17–20

    Google Scholar 

  37. Pecher C (1942) Biological investigations with radioactive calcium and strontium: preliminary report on the use of radioactive strontium in the treatment of metastatic bone cancer. Univ California Publ Pharmacol 2:117–149

    CAS  Google Scholar 

  38. Pons F, Herranz R, Garcia A, Vidal-Sicart S, Conill C, Grau JJ, Alcover J, Fuster D, Setoain J (1997) Strontium-89 for palliation of pain from bone metastases in patients with prostate and breast cancer. Eur J Nucl Med 24:1210–1214

    Article  PubMed  CAS  Google Scholar 

  39. Porter AT, McEwan AJB, Powe JE, Reid R et al. (1993) Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local external beam irradiation in the managemant of endocrine resistant metastatic prostate cancer. Int J Rad Oncol Biol Phys 25:805–813

    CAS  Google Scholar 

  40. Roodman GD (1997) Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer 80:1557–1514

    Article  PubMed  CAS  Google Scholar 

  41. Sciuto R, Tofani A, Festa A et al. (2000) Short-and long-term effects of 186-Re-1,-hydroxyethylidene diphosphonate in the treatment of painful bone metastases. J Nucl Med 41:647–654

    PubMed  CAS  Google Scholar 

  42. Sciuto R, Festa A, Rea S et al. (2002) Effects of low-dose Cisplatin on 89-Sr therapy for painful bone metastases from prostate cancer: a randomized clinical trial. J Nucl Med 43: 79–86

    PubMed  CAS  Google Scholar 

  43. Serafini AN (2000) Samarium Sm-153 Lexidronam for the palliation of bone pain associated with metastases. Cancer 88(Suppl) 2034–2039

    Google Scholar 

  44. Serafini AN (2001) Therapy of metstatic bone pain. J Nucl Med 42: 895–906

    PubMed  CAS  Google Scholar 

  45. Singh A, Holmes RA, Farhangi M, Volkert WA (1989) Human pharmacokinetics of Samarium-153 EDTMP in metastatic cancer. J Nucl Med 30:1814–1818

    PubMed  CAS  Google Scholar 

  46. Soerdjbalie-Maikoe V, Pelger RCM, Lycklama á Nijeholt GAB et al. (2002) Strontium-89 (Metastron) and the bisphosphonate olpadronate reduce the incidence of spinal cord compression in patients with hormone-refractory prostate cancer metastatic to the skeleton. Eur J Nucl Med 29:494–498

    Article  CAS  Google Scholar 

  47. Tannock I, Gospodarowicz M, Meakin W, Panzarella T, Stewart L, Rider W (1989) Treatment of metastatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. J Clin Oncol 7:590–597

    PubMed  CAS  Google Scholar 

  48. Tu SM, Delpass ES, Jones D et al. (1997) Strontium-89 combined with doxorubicin in the treatment of patients with androgen independent prostate cancer. Urol Oncol 2:191–197

    Google Scholar 

  49. Tu SM, Millikan RE, Mengistu B et al. (2001). Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: a randomised phase II trial. Lancet 357:336–341

    Article  PubMed  CAS  Google Scholar 

  50. Wagner G (1984) Frequency of pain in patients with cancer. Recent Results Cancer Res 89:64–71

    PubMed  CAS  Google Scholar 

  51. World Health Organisation (1990) Cancer pain relief and palliative care. WHO Tech Rep Ser 804:7–73

    Google Scholar 

  52. Zyskowski A, Lamb D, Morum P et al. (2001) Strontium-89 treatment for prostate cancer bone metastases: does a protate specific antigen response predict for improved survival? Aust Radiol 45:39–42

    Article  CAS  Google Scholar 

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(2007). Schmerztherapie von Skelettmetastasen mittels ionisierender Strahlung. In: Baron, R., Strumpf, M. (eds) Praktische Schmerztherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49663-2_16

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  • DOI: https://doi.org/10.1007/978-3-540-49663-2_16

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