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High-Flow Oxygen Therapy

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Practical Trends in Anesthesia and Intensive Care 2017

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Abstract

Oxygen (O2) therapy is essential for treating hypoxemic patients. First records about oxygen therapy date back to the eighteenth century, but only during the First World War, specific nasal cannula systems for oxygen supplementation were developed to treat gas-poisoned patients [1]. Since then oxygen delivery systems progressed to meet individual patient’s need with higher gas flow and fraction of inspired oxygen (FiO2). Ventilatory support may be required in patients with acute respiratory failure (ARF), going from continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV) to endotracheal intubation and mechanical ventilation depending on patient’s characteristics.

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References

  1. Leigh JM. The evolution of oxygen therapy apparatus. Anaesthesia. 1974;29:462–85.

    Article  CAS  PubMed  Google Scholar 

  2. Hutchings FA, Hilliard TN, Davis PJ. Heated humidified high-flow nasal cannula therapy in children. Arch Dis Child. 2015;100:571–5.

    Article  CAS  PubMed  Google Scholar 

  3. Ricard J-D. High flow nasal oxygen in acute respiratory failure. Minerva Anestesiol. 2012;78:836–41.

    PubMed  Google Scholar 

  4. O’Driscoll BR, Howard LS, Davison AG. BTS guideline for emergency oxygen use in adult patients. Thorax. 2008;63(Suppl 6):vi1–68.

    PubMed  Google Scholar 

  5. Malinowski T, Lamberti J. Oxygen concentrations via nasal cannula at high flow rates. Respir Care. 2002;47:1039.

    Google Scholar 

  6. L’Her E, Deye N, Lellouche F, Taille S, Demoule A, Fraticelli A, et al. Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir Crit Care Med. 2005;172:1112–8.

    Article  PubMed  Google Scholar 

  7. Wettstein RB, Peters JI, Shelledy DS. Pharyngeal oxygen concentration in normal subjects wearing high flow nasal cannula. Respir Care. 2004;49:1444.

    Google Scholar 

  8. Tiep B, Barnett M. High flow nasal vs high flow mask oxygen delivery: tracheal gas concentrations through a head extension airway model. Respir Care. 2002;47:1079.

    Google Scholar 

  9. Spence KL, Murphy D, Kilian C, McGonigle R, Kilani RA. High-flow nasal cannula as a device to provide continuous positive airway pressure in infants. J Perinatol. 2007;27:772–5.

    Article  CAS  PubMed  Google Scholar 

  10. Miller TL, Blackson TJ, Shaffer TH, Touch SM. Tracheal gas insufflation-augmented continuous positive airway pressure in a spontaneously breathing model of neonatal respiratory distress. Pediatr Pulmonol. 2004;38:386–95.

    Article  PubMed  Google Scholar 

  11. Dewan NA, Bell CW. Effect of low flow and high flow oxygen delivery on exercise tolerance and sensation of dyspnea. A study comparing the transtracheal catheter and nasal prongs. Chest. 1994;105:1061–5.

    Article  CAS  PubMed  Google Scholar 

  12. Chatila W, Nugent T, Vance G, Gaughan J, Criner GJ. The effects of high-flow vs low-flow oxygen on exercise in advanced obstructive airways disease. Chest. 2004;126:1108–15.

    Article  PubMed  Google Scholar 

  13. Itagaki T, Okuda N, Tsunano Y, Kohata H, Nakataki E, Onodera M, et al. Effect of high-flow nasal cannula on thoraco-abdominal synchrony in adult critically ill patients. Respir Care. 2014;59:70–4.

    Article  PubMed  Google Scholar 

  14. Groves N, Tobin A. High flow nasal oxygen generates positive airway pressure in adult volunteers. Aust Crit Care. 2007;20:126–31.

    Article  PubMed  Google Scholar 

  15. Miller MJ, DiFiore JM, Strohl KP, Martin RJ. Effects of nasal CPAP on supraglottic and total pulmonary resistance in preterm infants. J Appl Physiol (1985). 1990;68:141–6.

    CAS  Google Scholar 

  16. Parke R, McGuinness S, Eccleston M. Nasal high-flow therapy delivers low level positive airway pressure. Br J Anaesth. 2009;103:886–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Ritchie JE, Williams AB, Gerard C, Hockey H. Evaluation of a humidified nasal high-flow oxygen system, using oxygraphy, capnography and measurement of upper airway pressures. Anaesth Intensive Care. 2011;39:1103–10.

    CAS  PubMed  Google Scholar 

  18. Parke RL, McGuinness SP. Pressures delivered by nasal high flow oxygen during all phases of the respiratory cycle. Respir Care. 2013;58:1621–4.

    Article  PubMed  Google Scholar 

  19. Corley A, Caruana LR, Barnett AG, Tronstad O, Fraser JF. Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients. Br J Anaesth. 2011;107:998–1004.

    Article  CAS  PubMed  Google Scholar 

  20. Fontanari P, Burnet H, Zattara-Hartmann MC, Jammes Y. Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals. J Appl Physiol (1985). 1996;81:1739–43.

    CAS  Google Scholar 

  21. Greenspan JS, Wolfson MR, Shaffer TH. Airway responsiveness to low inspired gas temperature in preterm neonates. J Pediatr. 1991;118:443–5.

    Article  CAS  PubMed  Google Scholar 

  22. Roca O, Riera J, Torres F, Masclans JR. High-flow oxygen therapy in acute respiratory failure. Respir Care. 2010;55:408–13.

    PubMed  Google Scholar 

  23. Boyer A, Vargas F, Delacre M, Saint-Leger M, Clouzeau B, Hilbert G, et al. Prognostic impact of high-flow nasal cannula oxygen supply in an ICU patient with pulmonary fibrosis complicated by acute respiratory failure. Intensive Care Med. 2011;37:558–9.

    Article  PubMed  Google Scholar 

  24. Chikata Y, Izawa M, Okuda N, Itagaki T, Nakataki E, Onodera M, et al. Humidification performance of two high-flow nasal cannula devices: a bench study. Respir Care. 2014;59:1186–90.

    Article  PubMed  Google Scholar 

  25. Mayfield S, Jauncey-Cooke J, Hough JL, Schibler A, Gibbons K, Bogossian F. High-flow nasal cannula therapy for respiratory support in children. Cochrane Database Syst Rev. 2014;3:CD009850.

    Google Scholar 

  26. Sztrymf B, Messika J, Mayot T, Lenglet H, Dreyfuss D, Ricard J-D. Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study. J Crit Care. 2012;27:324.e9–13.

    Article  Google Scholar 

  27. Sztrymf B, Messika J, Bertrand F, Hurel D, Leon R, Dreyfuss D, et al. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med. 2011;37:1780–6.

    Article  CAS  PubMed  Google Scholar 

  28. Rello J, Perez M, Roca O, Poulakou G, Souto J, Laborda C, et al. High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza a/H1N1v. J Crit Care. 2012;27:434–9.

    Article  PubMed  Google Scholar 

  29. Frat J-P, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015;372:2185–96.

    Article  CAS  PubMed  Google Scholar 

  30. Messika J, Ben Ahmed K, Gaudry S, Miguel-Montanes R, Rafat C, Sztrymf B, et al. Use of high-flow nasal cannula oxygen therapy in subjects with ARDS: a 1-year observational study. Respir Care. 2015;60:162–9.

    Article  PubMed  Google Scholar 

  31. Ou X, Hua Y, Liu J, Gong C, Zhao W. Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure: a meta-analysis of randomized controlled trials. CMAJ. 2017;189:E260–7.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Tiruvoipati R, Lewis D, Haji K, Botha J. High-flow nasal oxygen vs high-flow face mask: a randomized crossover trial in extubated patients. J Crit Care. 2010;25:463–8.

    Article  PubMed  Google Scholar 

  33. Rittayamai N, Tscheikuna J, Rujiwit P. High-flow nasal cannula versus conventional oxygen therapy after endotracheal extubation: a randomized crossover physiologic study. Respir Care. 2014;59:485–90.

    Article  PubMed  Google Scholar 

  34. Brotfain E, Zlotnik A, Schwartz A, Frenkel A, Koyfman L, Gruenbaum SE, et al. Comparison of the effectiveness of high flow nasal oxygen cannula vs. standard non-rebreather oxygen face mask in post-extubation intensive care unit patients. Isr Med Assoc J. 2014;16:718–22.

    PubMed  Google Scholar 

  35. Maggiore SM, Idone FA, Vaschetto R, Festa R, Cataldo A, Antonicelli F, et al. Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med. 2014;190:282–8.

    Article  PubMed  Google Scholar 

  36. Corley A, Bull T, Spooner AJ, Barnett AG, Fraser JF. Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI >/=30: a randomised controlled trial. Intensive Care Med. 2015;41:887–94.

    Article  PubMed  Google Scholar 

  37. Hernández G, Vaquero C, González P, Subira C, Frutos-Vivar F, Rialp G, et al. Effect of postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients. A randomized clinical trial. JAMA. 2016;315:1354–61.

    Article  PubMed  Google Scholar 

  38. Hernández G, Vaquero C, Colinas L, Cuena R, González P, Canabal A, et al. Effect of postextubation high-flow nasal cannula vs noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients. A randomized clinical trial. JAMA. 2016;316:1565–74.

    Article  PubMed  Google Scholar 

  39. Stephan F, Barrucand B, Petit P, Rezaiguia-Delclaux S, Medard A, Delannoy B, et al. High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: a randomized clinical trial. JAMA. 2015;313:2331–9.

    Article  CAS  PubMed  Google Scholar 

  40. Esteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguía C, González M, et al. Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med. 2004;350:2452–60.

    Article  CAS  PubMed  Google Scholar 

  41. Kang BJ, Koh Y, Lim CM, Huh JW, Baek S, Han M, et al. Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med. 2015;41:623–32.

    Article  PubMed  Google Scholar 

  42. Futier E, Paugam-Burtz C, Godet T, Khoy-Ear L, Rozencwajg S, Delay JM, et al. OPERA study investigators. Effect of early postextubation high-flow nasal cannula vs conventional oxygen therapy on hypoxaemia in patients after major abdominal surgery: a French multicentre randomised controlled trial (OPERA). Intensive Care Med. 2016;42:1888–98.

    Article  CAS  PubMed  Google Scholar 

  43. Ni YN, Luo J, Yu H, Liu D, Ni Z, Cheng J, et al. Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation? A systematic review and meta-analysis. Chest. 2017;151:764–75.

    Article  PubMed  Google Scholar 

  44. Peters SG, Holets SR, Gay PC. High-flow nasal cannula therapy in do-not-intubate patients with hypoxemic respiratory distress. Respir Care. 2013;58:597–600.

    PubMed  Google Scholar 

  45. Roca O, de Acilu MG, Caralt B, Sacanell J, Masclans JR. Humidified high flow nasal cannula supportive therapy improves outcomes in lung transplant recipients readmitted to the intensive care unit because of acute respiratory failure. Transplantation. 2015;99:1092–8.

    Article  PubMed  Google Scholar 

  46. Lee HY, Rhee CK, Lee JW. Feasibility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematologic malignancies: a retrospective single-center study. J Crit Care. 2015;30:773–7.

    Article  PubMed  Google Scholar 

  47. Mokart D, Geay C, Chow-Chine L, Brun J-P, Faucher M, Blache J-L, et al. High-flow oxygen therapy in cancer patients with acute respiratory failure. Intensive Care Med. 2015;41:2008–10.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesia and Critical Care, ASST Ovest Milanese Ospedale di Legnano, Legnano, Italy

    Cristina Mietto

  2. Department of Anesthesia and Critical Care, ASST Santi Paolo e Carlo, Università Degli Studi di Milano, Milano, Italy

    Davide Chiumello

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  1. Cristina Mietto
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  2. Davide Chiumello
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Correspondence to Cristina Mietto .

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  1. Department of “Scienze della Salute”, University of Milan, Milan, Italy

    Davide Chiumello

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Mietto, C., Chiumello, D. (2018). High-Flow Oxygen Therapy. In: Chiumello, D. (eds) Practical Trends in Anesthesia and Intensive Care 2017. Springer, Cham. https://doi.org/10.1007/978-3-319-61325-3_11

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  • DOI: https://doi.org/10.1007/978-3-319-61325-3_11

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  • Publisher Name: Springer, Cham

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