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Social Cognition

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Cognitive Enhancement

Abstract

Social cognition is a major problem underlying deficiencies in interpersonal relationships in several psychiatric populations. And yet there is currently no gold standard for pharmacological treatment of psychiatric illness that directly targets these social cognitive areas. This chapter serves to illustrate some of the most innovative attempts at pharmacological modulation of social cognition in psychiatric illnesses including schizophrenia, borderline personality disorder, autism spectrum disorders, antisocial personality disorder and psychopathy, social anxiety disorder, and posttraumatic stress disorder. Pharmacological modulation includes studies administering oxytocin, ecstasy (MDMA), modafinil, methylphenidate, and D-cycloserine. Furthermore, some background on social cognition research in healthy individuals, which could be helpful in developing future treatments, is provided as well as the potential for each drug as a long-term treatment option.

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References

  • Adolphs R (2003) Cognitive neuroscience of human social behaviour. Nat Rev Neurosci 4(3):165–178

    CAS  PubMed  Google Scholar 

  • Altemus M, Fong J, Yang R, Damast S, Luine V, Ferguson D (2004) Changes in cerebrospinal fluid neurochemistry during pregnancy. Biol Psychiatry 56(6):386–392

    CAS  PubMed  Google Scholar 

  • American Psychiatric Association (2013) The diagnostic and statistical manual of mental disorders: DSM 5. American Psychiatric Association, Washington, DC

    Google Scholar 

  • American Psychiatric Association (2014) Autism spectrum disorders. Retrieved 24 June 2014, from http://www.psychiatry.org/autism

  • Anagnostou E, Soorya L, Chaplin W, Bartz J, Halpern D, Wasserman S et al (2012) Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial. Mol Autism 3(1):16. doi:10.1186/2040-2392-3-16

    PubMed Central  CAS  PubMed  Google Scholar 

  • Anagnostou E, Soorya L, Brian J, Dupuis A, Mankad D, Smile S, Jacob S (2014) Intranasal oxytocin in the treatment of autism spectrum disorders: a review of literature and early safety and efficacy data in youth. Brain Res 1580:188–198, http://dx.doi.org/10.1016/j.brainres.2014.01.049

    CAS  PubMed  Google Scholar 

  • Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A (2010) Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U S A 107(9):4389–4394. doi:10.1073/pnas.0910249107

    PubMed Central  CAS  PubMed  Google Scholar 

  • Auranen M, Vanhala R, Varilo T, Ayers K, Kempas E, Ylisaukko-Oja T et al (2002) A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27. Am J Hum Genet 71(4):777–790. doi:10.1086/342720

    PubMed Central  PubMed  Google Scholar 

  • Averbeck BB, Bobin T, Evans S, Shergill SS (2012) Emotion recognition and oxytocin in patients with schizophrenia. Psychol Med 42(2):259–266. doi:10.1017/s0033291711001413

    PubMed Central  CAS  PubMed  Google Scholar 

  • Bakermans-Kranenburg MJ, van IJzendoorn MH (2013) Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy. Transl Psychiatry 3:e258. doi:10.1038/tp.2013.34

    PubMed Central  CAS  PubMed  Google Scholar 

  • Banks WA, Kastin AJ (1985) Permeability of the blood-brain barrier to neuropeptides: the case for penetration. Psychoneuroendocrinology 10(4):385–399, http://dx.doi.org/10.1016/0306-4530(85)90079-4

    CAS  PubMed  Google Scholar 

  • Baron-Cohen S, Leslie AM, Frith U (1985) Does the autistic child have a “theory of mind”? Cognition 21(1):37–46, http://dx.doi.org/10.1016/0010-0277(85)90022-8

    CAS  PubMed  Google Scholar 

  • Baron-Cohen S, Ring HA, Wheelwright S, Bullmore ET, Brammer MJ, Simmons A, Williams SCR (1999) Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci 11(6):1891–1898. doi:10.1046/j.1460-9568.1999.00621.x

    CAS  PubMed  Google Scholar 

  • Baron-Cohen S, Ring HA, Bullmore ET, Wheelwright S, Ashwin C, Williams SCR (2000) The amygdala theory of autism. Neurosci Biobehav Rev 24(3):355–364, http://dx.doi.org/10.1016/S0149-7634(00)00011-7

    CAS  PubMed  Google Scholar 

  • Bartz JA, Simeon D, Hamilton H, Kim S, Crystal S, Braun A et al (2011a) Oxytocin can hinder trust and cooperation in borderline personality disorder. Soc Cogn Affect Neurosci 6(5):556–563. doi:10.1093/scan/nsq085

    PubMed Central  PubMed  Google Scholar 

  • Bartz JA, Zaki J, Bolger N, Ochsner KN (2011b) Social effects of oxytocin in humans: context and person matter. Trends Cogn Sci 15(7):301–309. doi:10.1016/j.tics.2011.05.002

    CAS  PubMed  Google Scholar 

  • Bassett DS, Bullmore E, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A (2008) Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci 28(37):9239–9248

    PubMed Central  CAS  PubMed  Google Scholar 

  • Baumgartner T, Heinrichs M, Vonlanthen A, Fischbacher U, Fehr E (2008) Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 58(4):639–650

    CAS  PubMed  Google Scholar 

  • Bear MF, Malenka RC (1994) Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol 4(3):389–399

    CAS  PubMed  Google Scholar 

  • Bechi M, Riccaboni R, Ali S, Fresi F, Buonocore M, Bosia M et al (2012) Theory of mind and emotion processing training for patients with schizophrenia: preliminary findings. Psychiatry Res 198(3):371–377. doi:10.1016/j.psychres.2012.02.004

    PubMed  Google Scholar 

  • Bechi M, Spangaro M, Bosia M, Zanoletti A, Fresi F, Buonocore M et al (2013) Theory of Mind intervention for outpatients with schizophrenia. Neuropsychol Rehabil 23(3):383–400. doi:10.1080/09602011.2012.762751

    PubMed  Google Scholar 

  • Bedi G, Phan KL, Angstadt M, de Wit H (2009) Effects of MDMA on sociability and neural response to social threat and social reward. Psychopharmacology (Berl) 207(1):73–83. doi:10.1007/s00213-009-1635-z

    CAS  Google Scholar 

  • Bedi G, Hyman D, de Wit H (2010) Is ecstasy an “empathogen”? Effects of +/-3,4-methylenedioxymethamphetamine on prosocial feelings and identification of emotional states in others. Biol Psychiatry 68(12):1134–1140. doi:10.1016/j.biopsych.2010.08.003

    PubMed Central  CAS  PubMed  Google Scholar 

  • Benkert O, Hippius H, Gründer G, Heiser P, Hiemke C, Himmerich H et al (2013) Kompendium der psychiatrischen Pharmakotherapie. Springer, Berlin

    Google Scholar 

  • Bertrand MC, Sutton H, Achim AM, Malla AK, Lepage M (2007) Social cognitive impairments in first episode psychosis. Schizophr Res 95(1–3):124–133. doi:10.1016/j.schres.2007.05.033

    PubMed  Google Scholar 

  • Bertsch K, Gamer M, Schmidt B, Schmidinger I, Walther S, Kästel T et al (2013) Oxytocin and reduction of social threat hypersensitivity in women with borderline personality disorder. Am J Psychiatry 170(10):1169–1177

    PubMed  Google Scholar 

  • Biederman J, Pliszka SR (2008) Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents. J Pediatr 152(3):394–399.e392, http://dx.doi.org/10.1016/j.jpeds.2007.07.052

    CAS  PubMed  Google Scholar 

  • Birbaumer N, Veit R, Lotze M, Erb M, Hermann C, Grodd W, Flor H (2005) Deficient fear conditioning in psychopathy: a functional magnetic resonance imaging study. Arch Gen Psychiatry 62(7):799–805. doi:10.1001/archpsyc.62.7.799

    PubMed  Google Scholar 

  • Blair RJ (2001) Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. J Neurol Neurosurg Psychiatry 71(6):727–731

    PubMed Central  CAS  PubMed  Google Scholar 

  • Blair RJ (2008) The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy. Philos Trans R Soc Lond B Biol Sci 363(1503):2557–2565. doi:10.1098/rstb.2008.0027

    PubMed Central  CAS  PubMed  Google Scholar 

  • Blair RJ, Jones L, Clark F, Smith M (1997) The psychopathic individual: a lack of responsiveness to distress cues? Psychophysiology 34(2):192–198

    CAS  PubMed  Google Scholar 

  • Blair HT, Schafe GE, Bauer EP, Rodrigues SM, LeDoux JE (2001) Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learn Mem 8(5):229–242

    CAS  PubMed  Google Scholar 

  • Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407):31–39

    CAS  PubMed  Google Scholar 

  • Boccia M, Petrusz P, Suzuki K, Marson L, Pedersen C (2013) Immunohistochemical localization of oxytocin receptors in human brain. Neuroscience 253:155–164

    CAS  PubMed  Google Scholar 

  • Bradley B, Davis TA, Wingo AP, Mercer KB, Ressler KJ (2013) Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene. Eur J Psychotraumatol 4, http://www.ejpt.net/index.php/ejpt/rt/captureCite/21659/0/ApaCitationPlugin, http://www.ncbi.nlm.nih.gov/pubmed/?term=bradley+wingo+mercer+family

  • Brodsky BS, Groves SA, Oquendo MA, Mann JJ, Stanley B (2006) Interpersonal precipitants and suicide attempts in borderline personality disorder. Suicide Life Threat Behav 36(3):313–322

    PubMed  Google Scholar 

  • Brownstein MJ, Russell JT, Gainer H (1980) Synthesis, transport, and release of posterior pituitary hormones. Science 207(4429):373–378. doi:10.1126/science.6153132

    CAS  PubMed  Google Scholar 

  • Brüne M, Ebert A, Kolb M, Tas C, Edel MA, Roser P (2013) Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder. Hum Psychopharmacol 28(6):552–561

    PubMed  Google Scholar 

  • Cain CK, McCue M, Bello I, Creedon T, Tang D, Laska E, Goff DC (2014) d-Cycloserine augmentation of cognitive remediation in schizophrenia. Schizophr Res 153(1–3):177–183, http://dx.doi.org/10.1016/j.schres.2014.01.016

    PubMed  Google Scholar 

  • Calabrese JR, Ketter TA, Youakim JM, Tiller JM, Yang R, Frye MA (2010) Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study. J Clin Psychiatry 71(10):1363–1370

    CAS  PubMed  Google Scholar 

  • Calcagnoli F, de Boer SF, Althaus M, den Boer JA, Koolhaas JM (2013) Antiaggressive activity of central oxytocin in male rats. Psychopharmacology (Berl) 229(4):639–651. doi:10.1007/s00213-013-3124-7

    CAS  Google Scholar 

  • Carton JS, Kessler EA, Pape CL (1999) Nonverbal decoding skills and relationship well-being in adults. J Nonverbal Behav 23(1):91–100

    Google Scholar 

  • Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein RP, Heinrichs M (2011) Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proc Natl Acad Sci U S A 108(50):19937–19942. doi:10.1073/pnas.1113079108

    PubMed Central  CAS  PubMed  Google Scholar 

  • Constans JI, Penn DL, Ihen GH, Hope DA (1999) Interpretive biases for ambiguous stimuli in social anxiety. Behav Res Ther 37(7):643–651

    CAS  PubMed  Google Scholar 

  • Cullen KR, Kumra S, Westerman M, Schulz SC (2008) Atypical antipsychotics for treatment of schizophrenia spectrum disorders. Psychiatric Times: Schizophrenia. Retrieved 25 June 2014

    Google Scholar 

  • Dackis CA, Kampman KM, Lynch KG, Pettinati HM, O’Brien CP (2004) A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology 30(1):205–211

    Google Scholar 

  • Dadds MR, Moul C, Cauchi A, Dobson-Stone C, Hawes DJ, Brennan J, Ebstein RE (2014a) Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy. Dev Psychopathol 26(01):33–40. doi:10.1017/S0954579413000497

    PubMed  Google Scholar 

  • Dadds MR, Moul C, Cauchi A, Dobson-Stone C, Hawes DJ, Brennan J et al (2014b) Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy. Dev Psychopathol 26(01):21–31. doi:10.1017/S0954579413000485

    PubMed  Google Scholar 

  • Davis MC, Lee J, Horan WP, Clarke AD, McGee MR, Green MF, Marder SR (2013) Effects of single dose intranasal oxytocin on social cognition in schizophrenia. Schizophr Res 147(2):393–397

    PubMed  Google Scholar 

  • Davis MC, Green MF, Lee J, Horan WP, Senturk D, Clarke AD, Marder SR (2014) Oxytocin-augmented social cognitive skills training in schizophrenia [original article]. Neuropsychopharmacology. doi:10.1038/npp.2014.68

    PubMed Central  Google Scholar 

  • de Kleine RA, Hendriks G-J, Kusters WJ, Broekman TG, van Minnen A (2012) A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry 71(11):962–968

    PubMed  Google Scholar 

  • de Kleine RA, Hendriks G-J, Smits JA, Broekman TG, van Minnen A (2014) Prescriptive variables for D-cycloserine augmentation of exposure therapy for posttraumatic stress disorder. J Psychiatr Res 48(1):40–46

    PubMed  Google Scholar 

  • de la Torre R, Farré M, Roset PN, Pizarro N, Abanades S, Segura M et al (2004) Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit 26(2):137–144

    PubMed  Google Scholar 

  • Deutsch SI, Burket JA, Jacome LF, Cannon WR, Herndon AL (2011) d-Cycloserine improves the impaired sociability of the Balb/c mouse. Brain Res Bull 84(1):8–11

    CAS  PubMed  Google Scholar 

  • Deutsch SI, Pepe GJ, Burket JA, Winebarger EE, Herndon AL, Benson AD (2012) d-cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old mice. Brain Res 1439:96–107, http://dx.doi.org/10.1016/j.brainres.2011.12.040

    CAS  PubMed  Google Scholar 

  • Dodhia S, Hosanagar A, Fitzgerald DA, Labuschagne I, Wood AG, Nathan PJ, Phan KL (2014) Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder [original article]. Neuropsychopharmacology. doi:10.1038/npp.2014.53

    PubMed  Google Scholar 

  • Domes G, Heinrichs M, Michel A, Berger C, Herpertz SC (2007) Oxytocin improves “mind-reading” in humans. Biol Psychiatry 61(6):731–733. doi:10.1016/j.biopsych.2006.07.015

    CAS  PubMed  Google Scholar 

  • Domes G, Schulze L, Herpertz SC (2009) Emotion recognition in borderline personality disorder—a review of the literature. J Pers Disord 23(1):6–19. doi:10.1521/pedi.2009.23.1.6

    PubMed  Google Scholar 

  • Domes G, Lischke A, Berger C, Grossmann A, Hauenstein K, Heinrichs M (2010) Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology 35(1):83–93. doi:10.1016/j.psyneuen.2009.06.016

    CAS  PubMed  Google Scholar 

  • Domes G, Heinrichs M, Kumbier E, Grossmann A, Hauenstein K, Herpertz SC (2013) Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder. Biol Psychiatry 74(3):164–171. doi:10.1016/j.biopsych.2013.02.007

    CAS  PubMed  Google Scholar 

  • du Vigneaud V, Ressler C, Swan CJM, Roberts CW, Katsoyannis PG, Gordon S (1953) The synthesis of an octapeptide amide with the hormonal activity of oxytocin. J Am Chem Soc 75(19):4879–4880. doi:10.1021/ja01115a553

    Google Scholar 

  • du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG (1954) The synthesis of oxytocin1. J Am Chem Soc 76(12):3115–3121. doi:10.1021/ja01641a004

    Google Scholar 

  • Dumont GJ, Sweep FC, van der Steen R, Hermsen R, Donders AR, Touw DJ et al (2009) Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Soc Neurosci 4(4):359–366. doi:10.1080/17470910802649470

    CAS  PubMed  Google Scholar 

  • Eack SM (2013) Cognitive enhancement therapy. In: Roberts DL, Penn DL (eds) Social cognition in schizophrenia. Oxford University Press, New York

    Google Scholar 

  • Ebert A, Kolb M, Heller J, Edel M-A, Roser P, Brüne M (2013) Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma. Soc Neurosci 8(4):305–313

    PubMed  Google Scholar 

  • Eckstein M, Hurlemann R (2013) Oxytocin: evidence for a therapeutic potential of the social neuromodulator. Nervenarzt 84(11):1321–1328. doi:10.1007/s00115-013-3832-6

    CAS  PubMed  Google Scholar 

  • Elfenbein HA, Ambady N (2002) On the universality and cultural specificity of emotion recognition: a meta-analysis. Psychol Bull 128(2):203

    PubMed  Google Scholar 

  • Ermisch A, Barth T, Rühle H, Skopkova J, Hrbas P, Landgraf R (1985a) On the blood-brain barrier to peptides: accumulation of labelled vasopressin, DesGlyNH2-vasopressin and oxytocin by brain regions. Endocrinologia Experimentalis 19(1):29–37

    CAS  PubMed  Google Scholar 

  • Ermisch A, Ruhle HJ, Landgraf R, Hess J (1985b) Blood-brain barrier and peptides. J Cereb Blood Flow Metab 5(3):350–357

    CAS  PubMed  Google Scholar 

  • Fan X, Jin WY, Wang YT (2014) The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse [Review]. Front Cell Neurosci 8:160. doi:10.3389/fncel.2014.00160

    PubMed Central  PubMed  Google Scholar 

  • Fanselow MS, LeDoux JE (1999) Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron 23(2):229–232

    CAS  PubMed  Google Scholar 

  • Farre M, De La Torre R, Mathúna BÓ, Roset P, Peiro A, Torrens M et al (2004) Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics. Psychopharmacology (Berl) 173(3–4):364–375

    CAS  Google Scholar 

  • Fava M, Thase ME, DeBattista C, Doghramji K, Arora S, Hughes RJ (2007) Modafinil augmentation of selective serotonin reuptake inhibitor therapy in MDD partial responders with persistent fatigue and sleepiness. Ann Clin Psychiatry 19(3):153–159

    PubMed  Google Scholar 

  • Fioravanti M, Carlone O, Vitale B, Cinti ME, Clare L (2005) A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia. Neuropsychol Rev 15(2):73–95

    PubMed  Google Scholar 

  • Fischer-Shofty M, Shamay-Tsoory SG, Levkovitz Y (2013) Characterization of the effects of oxytocin on fear recognition in patients with schizophrenia and in healthy controls. Front Neurosci 7:127

    PubMed Central  CAS  PubMed  Google Scholar 

  • Frye M, Grunze H, Suppes T, McElroy S, Keck P, Walden J et al (2007) A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression. Am J Psychiatry 164(8):1242–1249

    PubMed  Google Scholar 

  • Gibson CM, Penn DL, Smedley KL, Leserman J, Elliott T, Pedersen CA (2014) A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia. Schizophr Res 156(2–3):261–265, http://dx.doi.org/10.1016/j.schres.2014.04.009

    PubMed  Google Scholar 

  • Gimpl G, Fahrenholz F (2001) The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81(2):629–683

    CAS  PubMed  Google Scholar 

  • Goldman M, Marlow-O’Connor M, Torres I, Carter CS (2008) Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits. Schizophr Res 98(1–3):247–255. doi:10.1016/j.schres.2007.09.019

    PubMed Central  PubMed  Google Scholar 

  • Goldman MB, Gomes AM, Carter CS, Lee R (2011) Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia. Psychopharmacology (Berl) 216(1):101–110. doi:10.1007/s00213-011-2193-8

    CAS  Google Scholar 

  • Golubchik P, Sever J, Weizman A (2014) Methylphenidate treatment in children with attention deficit hyperactivity disorder and comorbid social phobia. Int Clin Psychopharmacol 29(4):212–215. doi:10.1097/YIC.0000000000000029

    PubMed Central  PubMed  Google Scholar 

  • Gordon I, Vander Wyk BC, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA et al (2013) Oxytocin enhances brain function in children with autism. Proc Natl Acad Sci U S A 110(52):20953–20958. doi:10.1073/pnas.1312857110

    PubMed Central  CAS  PubMed  Google Scholar 

  • Gorka SM, Fitzgerald DA, Labuschagne I, Hosanagar A, Wood AG, Nathan PJ, Phan KL (2014) Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology. doi:10.1038/npp.2014.168

    PubMed  Google Scholar 

  • Green L, Fein D, Modahl C, Feinstein C, Waterhouse L, Morris M (2001) Oxytocin and autistic disorder: alterations in peptide forms. Biol Psychiatry 50(8):609–613

    CAS  PubMed  Google Scholar 

  • Gross TF (2004) The perception of four basic emotions in human and nonhuman faces by children with autism and other developmental disabilities. J Abnorm Child Psychol 32(5):469–480

    PubMed  Google Scholar 

  • Guastella AJ, Richardson R, Lovibond PF, Rapee RM, Gaston JE, Mitchell P, Dadds MR (2008) A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder. Biol Psychiatry 63(6):544–549, http://dx.doi.org/10.1016/j.biopsych.2007.11.011

    CAS  PubMed  Google Scholar 

  • Guastella AJ, Howard AL, Dadds MR, Mitchell P, Carson DS (2009) A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 34(6):917–923, http://dx.doi.org/10.1016/j.psyneuen.2009.01.005

    CAS  PubMed  Google Scholar 

  • Guastella AJ, Einfeld SL, Gray KM, Rinehart NJ, Tonge BJ, Lambert TJ, Hickie IB (2010) Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol Psychiatry 67(7):692–694. doi:10.1016/j.biopsych.2009.09.020

    CAS  PubMed  Google Scholar 

  • Guastella AJ, Hickie IB, McGuinness MM, Otis M, Woods EA, Disinger HM et al (2013) Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology 38(5):612–625

    CAS  PubMed  Google Scholar 

  • Gunderson JG, Lyons-Ruth K (2008) BPD’s interpersonal hypersensitivity phenotype: a gene-environment-developmental model. J Pers Disord 22(1):22

    PubMed Central  PubMed  Google Scholar 

  • Hare RD, Neumann CS (2006) The PCL-R assessment of psychopathy. In: Patrick CJ (ed) Handbook of psychopathy. Guilford, New York, pp 58–88

    Google Scholar 

  • Haxby JV, Hoffman EA, Gobbini MI (2000) The distributed human neural system for face perception. Trends Cogn Sci 4(6):223–233

    PubMed  Google Scholar 

  • Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U (2003) Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54(12):1389–1398

    CAS  PubMed  Google Scholar 

  • Herpertz SC, Bertsch K (2014) The social-cognitive basis of personality disorders. Curr Opin Psychiatry 27(1):73–77

    PubMed  Google Scholar 

  • Hezel DM, McNally RJ (2014) Theory of mind impairments in social anxiety disorder. Behav Ther 45(4):530–540, http://dx.doi.org/10.1016/j.beth.2014.02.010c

    PubMed  Google Scholar 

  • Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T et al (2010) Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice. J Neuroendocrinol 22(5):373–379. doi:10.1111/j.1365-2826.2010.01976.x

    CAS  PubMed  Google Scholar 

  • Higashida H, Yokoyama S, Munesue T, Kikuchi M, Minabe Y, Lopatina O (2011) CD38 gene knockout juvenile mice: a model of oxytocin signal defects in autism. Biol Pharm Bull 34(9):1369–1372

    CAS  PubMed  Google Scholar 

  • Hill EL, Frith U (2003) Understanding autism: insights from mind and brain. Philos Trans R Soc Lond B Biol Sci 358(1430):281–289. doi:10.1098/rstb.2002.1209

    PubMed Central  PubMed  Google Scholar 

  • Hinshaw SP, Henker B, Whalen CK (1984a) Cognitive-behavioral and pharmacologic interventions for hyperactive boys: comparative and combined effects. J Consult Clin Psychol 52(5):739

    CAS  PubMed  Google Scholar 

  • Hinshaw SP, Henker B, Whalen CK (1984b) Self-control in hyperactive boys in anger-inducing situations: effects of cognitive-behavioral training and of methylphenidate. J Abnorm Child Psychol 12(1):55–77

    CAS  PubMed  Google Scholar 

  • Hirsch CR, Clark DM (2004) Information-processing bias in social phobia. Clin Psychol Rev 24(7):799–825

    PubMed  Google Scholar 

  • Hofmann SG, Pollack MH, Otto MW (2006) Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine. CNS Drug Rev 12(3–4):208–217. doi:10.1111/j.1527-3458.2006.00208.x

    PubMed Central  CAS  PubMed  Google Scholar 

  • Hofmann SG, Smits JA, Rosenfield D, Simon N, Otto MW, Meuret AE et al (2013) D-Cycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder. Am J Psychiatry 170(7):751–758. doi:10.1176/appi.ajp.2013.12070974

    PubMed Central  PubMed  Google Scholar 

  • Hoge EA, Pollack MH, Kaufman RE, Zak PJ, Simon NM (2008) Oxytocin levels in social anxiety disorder. CNS Neurosci Ther 14(3):165–170

    CAS  PubMed  Google Scholar 

  • Holdiness MR (1985) Cerebrospinal fluid pharmacokinetics of the antituberculosis drugs. Clin Pharmacokinet 10:532–534

    CAS  PubMed  Google Scholar 

  • Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L et al (2007) Oxytocin increases retention of social cognition in autism. Biol Psychiatry 61(4):498–503. doi:10.1016/j.biopsych.2006.05.030

    CAS  PubMed  Google Scholar 

  • Huber D, Veinante P, Stoop R (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308(5719):245–248

    CAS  PubMed  Google Scholar 

  • Hurlemann R, Patin A, Onur OA, Cohen MX, Baumgartner T, Metzler S et al (2010) Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. J Neurosci 30(14):4999–5007. doi:10.1523/jneurosci.5538-09.2010

    CAS  PubMed  Google Scholar 

  • Hysek CM, Domes G, Liechti ME (2012) MDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions. Psychopharmacology (Berl) 222(2):293–302. doi:10.1007/s00213-012-2645-9

    CAS  Google Scholar 

  • Jansen LM, Gispen-de Wied CC, Wiegant VM, Westenberg HG, Lahuis BE, Van Engeland H (2006) Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder. J Autism Dev Disord 36(7):891–899

    PubMed  Google Scholar 

  • Johnson J, Ascher P (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325(6104):529–531

    CAS  PubMed  Google Scholar 

  • Jones P, Robinson I (1982) Differential clearance of neurophysin and neurohypophysial peptides from the cerebrospinal fluid in conscious guinea pigs. Neuroendocrinology 34(4):297–302

    CAS  PubMed  Google Scholar 

  • Kagerbauer S, Martin J, Schuster T, Blobner M, Kochs E, Landgraf R (2013) Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid. J Neuroendocrinol 25(7):668–673

    CAS  PubMed  Google Scholar 

  • Kelley AM, Webb CM, Athy JR, Ley S, Gaydos S (2012) Cognition enhancement by modafinil: a meta-analysis. Aviat Space Environ Med 83(7):685–690

    CAS  PubMed  Google Scholar 

  • Kendrick KM (2004) The neurobiology of social bonds. J Neuroendocrinol 16(12):1007–1008

    CAS  PubMed  Google Scholar 

  • Kendrick K, Keverne E, Hinton M, Goode J (1991) Cerebrospinal fluid and plasma concentrations of oxytocin and vasopressin during parturition and vaginocervical stimulation in the sheep. Brain Res Bull 26(5):803–807

    CAS  PubMed  Google Scholar 

  • Kendrick KM, Da Costa AP, Broad KD, Ohkura S, Guevara R, Lévy F, Keverne EB (1997) Neural control of maternal behaviour and olfactory recognition of offspring. Brain Res Bull 44(4):383–395

    CAS  PubMed  Google Scholar 

  • Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995) Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52(12):1048–1060

    CAS  PubMed  Google Scholar 

  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62(6):593–602

    PubMed  Google Scholar 

  • Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, Liddle PF (2001) Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 50(9):677–684

    CAS  PubMed  Google Scholar 

  • Kirkpatrick MG, Francis SM, Lee R, de Wit H, Jacob S (2014) Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology 46:23–31, http://dx.doi.org/10.1016/j.psyneuen.2014.04.006

    CAS  PubMed  Google Scholar 

  • Kleckner NW, Dingledine R (1988) Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 241(4867):835–837

    CAS  PubMed  Google Scholar 

  • Knobloch HS, Charlet A, Hoffmann LC, Eliava M, Khrulev S, Cetin AH et al (2012) Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73(3):553–566, http://dx.doi.org/10.1016/j.neuron.2011.11.030

    CAS  PubMed  Google Scholar 

  • Korzekwa MI, Dell PF, Links PS, Thabane L, Webb SP (2008) Estimating the prevalence of borderline personality disorder in psychiatric outpatients using a two-phase procedure. Compr Psychiatry 49(4):380–386

    PubMed  Google Scholar 

  • Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435(7042):673–676. doi:10.1038/nature03701

    CAS  PubMed  Google Scholar 

  • Kraepelin E (1971) Dementia praecox and paraphrenia. Krieger, Huntington, NY

    Google Scholar 

  • Kuypers KP, de la Torre R, Farre M, Yubero-Lahoz S, Dziobek I, Van den Bos W, Ramaekers JG (2014) No evidence that MDMA-induced enhancement of emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation. PLoS One 9(6):e100719

    PubMed Central  PubMed  Google Scholar 

  • Labuschagne I, Phan KL, Wood A, Angstadt M, Chua P, Heinrichs M et al (2010) Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 35(12):2403–2413

    PubMed Central  CAS  PubMed  Google Scholar 

  • Labuschagne I, Phan KL, Wood A, Angstadt M, Chua P, Heinrichs M et al (2012) Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. Int J Neuropsychopharmacol 15(07):883–896. doi:10.1017/S1461145711001489

    CAS  Google Scholar 

  • Lapierre D, Braun CM, Hodgins S (1995) Ventral frontal deficits in psychopathy: neuropsychological test findings. Neuropsychologia 33(2):139–151

    CAS  PubMed  Google Scholar 

  • Leake RD, Weitzman RE, Fisher DA (1980) Pharmacokinetics of oxytocin in the human subject. Obstet Gynecol 56(6):701–704

    CAS  PubMed  Google Scholar 

  • Lee Y-S, Silva AJ (2009) The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci 10(2):126–140

    PubMed Central  CAS  PubMed  Google Scholar 

  • Lee HJ, Choi J-S, Brown TH, Kim JJ (2001) Amygdalar NMDA receptors are critical for the expression of multiple conditioned fear responses. J Neurosci 21(11):4116–4124

    CAS  PubMed  Google Scholar 

  • Lee R, Garcia F, van de Kar LD, Hauger RD, Coccaro EF (2003) Plasma oxytocin in response to pharmaco-challenge to D-fenfluramine and placebo in healthy men. Psychiatry Res 118(2):129–136

    CAS  PubMed  Google Scholar 

  • Lerner H, St. Peter S (1984) The Roschach H response and object relations. J Pers Assess 48(4):345–350

    CAS  PubMed  Google Scholar 

  • Li F, Tsien JZ (2009) Memory and the NMDA receptors. N Engl J Med 361(3):302

    PubMed Central  CAS  PubMed  Google Scholar 

  • Li XF, Phillips R, LeDoux JE (1995) NMDA and non-NMDA receptors contribute to synaptic transmission between the medial geniculate body and the lateral nucleus of the amygdala. Exp Brain Res 105(1):87–100

    CAS  PubMed  Google Scholar 

  • Liechti ME, Vollenweider FX (2001) Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies. Hum Psychopharmacol 16(8):589–598. doi:10.1002/hup.348

    CAS  PubMed  Google Scholar 

  • Lim MM, Young LJ (2006) Neuropeptidergic regulation of affiliative behavior and social bonding in animals. Horm Behav 50(4):506–517

    CAS  PubMed  Google Scholar 

  • Lim MM, Murphy AZ, Young LJ (2004) Ventral striatopallidal oxytocin and vasopressin V1a receptors in the monogamous prairie vole (Microtus ochrogaster). J Comp Neurol 468(4):555–570

    CAS  PubMed  Google Scholar 

  • Lin I-F, Kashino M, Ohta H, Yamada T, Tani M, Watanabe H et al (2014) The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study. Mol Autism 5(1):20

    PubMed Central  PubMed  Google Scholar 

  • Linehan M (1995) Understanding borderline personality disorder. Guildford, New York

    Google Scholar 

  • Litz BT, Salters-Pedneault K, Steenkamp MM, Hermos JA, Bryant RA, Otto MW, Hofmann SG (2012) A randomized placebo-controlled trial of D-cycloserine and exposure therapy for posttraumatic stress disorder. J Psychiatr Res 46(9):1184–1190

    PubMed  Google Scholar 

  • Losh M, Adolphs R, Poe MD, Couture S, Penn D, Baranek GT, Piven J (2009) Neuropsychological profile of autism and the broad autism phenotype. Arch Gen Psychiatry 66(5):518–526

    PubMed Central  PubMed  Google Scholar 

  • Loup F, Tribollet E, Dubois-Dauphin M, Dreifuss J (1991) Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res 555(2):220–232

    CAS  PubMed  Google Scholar 

  • Lucas-Thompson RG, Holman EA (2013) Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress. Horm Behav 63(4):615–624, http://dx.doi.org/10.1016/j.yhbeh.2013.02.015

    CAS  PubMed  Google Scholar 

  • Ludwig M, Leng G (2006) Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci 7(2):126–136

    CAS  PubMed  Google Scholar 

  • Lynam DR, Caspi A, Moffitt TE, Loeber R, Stouthamer-Loeber M (2007) Longitudinal evidence that psychopathy scores in early adolescence predict adult psychopathy. J Abnorm Psychol 116(1):155–165. doi:10.1037/0021-843x.116.1.155

    PubMed Central  PubMed  Google Scholar 

  • Maoz H, Tsviban L, Gvirts HZ, Shamay-Tsoory SG, Levkovitz Y, Watemberg N, Bloch Y (2014) Stimulants improve theory of mind in children with attention deficit/hyperactivity disorder. J Psychopharmacol 28(3):212–219. doi:10.1177/0269881113492030

    PubMed  Google Scholar 

  • Marsh AA, Blair RJ (2008) Deficits in facial affect recognition among antisocial populations: a meta-analysis. Neurosci Biobehav Rev 32(3):454–465. doi:10.1016/j.neubiorev.2007.08.003

    PubMed Central  PubMed  Google Scholar 

  • Marsh AA, Kozak MN, Ambady N (2007) Accurate identification of fear facial expressions predicts prosocial behavior. Emotion 7(2):239

    PubMed Central  PubMed  Google Scholar 

  • Martin J, Kagerbauer SM, Schuster T, Blobner M, Kochs EF, Landgraf R (2014) Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage. Neuropeptides 48(2):91–96

    CAS  PubMed  Google Scholar 

  • Mas M, Farré M, de la Torre R, Roset PN, Ortuño J, Segura J, Camí J (1999) Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans. J Pharmacol Exp Ther 290(1):136–145

    CAS  PubMed  Google Scholar 

  • McAllister K (1994) D-cycloserine enhances social behaviour in individually-housed mice in the resident-intruder test. Psychopharmacology (Berl) 116(3):317–325

    CAS  Google Scholar 

  • McClure EB, Nowicki S Jr (2001) Associations between social anxiety and nonverbal processing skill in preadolescent boys and girls. J Nonverbal Behav 25(1):3–19

    Google Scholar 

  • Meffert H, Gazzola V, den Boer JA, Bartels AAJ, Keysers C (2013) Reduced spontaneous but relatively normal deliberate vicarious representations in psychopathy. Brain 136(8):2550–2562. doi:10.1093/brain/awt190

    PubMed Central  PubMed  Google Scholar 

  • Meisenberg G, Simmons WH (1983) Peptides and the blood-brain barrier. Life Sci 32(23):2611–2623, http://dx.doi.org/10.1016/0024-3205(83)90352-1

    CAS  PubMed  Google Scholar 

  • Mens WB, Witter A, Van Wimersma Greidanus TB (1983) Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Res 262(1):143–149

    CAS  PubMed  Google Scholar 

  • Meyer C, Freund-Mercier M, Guerne Y, Richard P (1987) Relationship between oxytocin release and amplitude of oxytocin cell neurosecretory bursts during suckling in the rat. J Endocrinol 114(2):263–270

    CAS  PubMed  Google Scholar 

  • Meyer-Lindenberg A (2008) Impact of prosocial neuropeptides on human brain function. In: Inga DN, Rainer L (eds) Progress in brain research, vol 170. Elsevier, New York, pp 463–470

    Google Scholar 

  • Miller GM (2011) The emerging role of trace amine‐associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J Neurochem 116(2):164–176

    PubMed Central  CAS  PubMed  Google Scholar 

  • Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Doblin R (2011) The safety and efficacy of ±3, 4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. J Psychopharmacol 25(4):439–452

    PubMed Central  CAS  PubMed  Google Scholar 

  • Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Martin SF, Yazar-Klosinski B et al (2013) Durability of improvement in posttraumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3, 4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. J Psychopharmacol 27(1):28–39. doi:10.1177/0269881112456611

    PubMed Central  CAS  PubMed  Google Scholar 

  • Modahl C, Green LA, Fein D, Morris M, Waterhouse L, Feinstein C, Levin H (1998) Plasma oxytocin levels in autistic children. Biol Psychiatry 43(4):270–277

    CAS  PubMed  Google Scholar 

  • Mogg K, Philippot P, Bradley BP (2004) Selective attention to angry faces in clinical social phobia. J Abnorm Psychol 113(1):160

    PubMed  Google Scholar 

  • Mottolese R, Redouté J, Costes N, Le Bars D, Sirigu A (2014) Switching brain serotonin with oxytocin. Proc Natl Acad Sci U S A 111(23):8637–8642. doi:10.1073/pnas.1319810111

    PubMed Central  CAS  PubMed  Google Scholar 

  • Moul C, Killcross S, Dadds MR (2012) A model of differential amygdala activation in psychopathy. Psychol Rev 119(4):789–806. doi:10.1037/a0029342

    PubMed  Google Scholar 

  • Mueser KT, Yarnold P, Bellack A (1992) Diagnostic and demographic correlates of substance abuse in schizophrenia and major affective disorder. Acta Psychiatrica Scandinavica 85(1):48–55

    CAS  PubMed  Google Scholar 

  • Murphy DA, Pelham WE, Lang AR (1992) Aggression in boys with attention deficit-hyperactivity disorder: methylphenidate effects on naturalistically observed aggression, response to provocation, and social information processing. J Abnorm Child Psychol 20(5):451–466

    CAS  PubMed  Google Scholar 

  • Nair KGS, Epstein IG, Baron H, Mulinos MG (1956) Absorption, distribution and excretion of cycloserine in man. Antibiot Annu 3:136–140

    Google Scholar 

  • Najjar S, Pearlman DM (2015) Neuroinflammation and white matter pathology in schizophrenia: systematic review. Schizophr Res 161(1):102–112

    PubMed  Google Scholar 

  • Oehen P, Traber R, Widmer V, Schnyder U (2013) A randomized, controlled pilot study of MDMA (±3, 4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD). J Psychopharmacol 27(1):40–52

    CAS  PubMed  Google Scholar 

  • Onur OA, Schlaepfer TE, Kukolja J, Bauer A, Jeung H, Patin A et al (2010) The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans. Biol Psychiatry 67(12):1205–1211, http://dx.doi.org/10.1016/j.biopsych.2010.01.022

    CAS  PubMed  Google Scholar 

  • Parrott AC (2013) Human psychobiology of MDMA or ‘Ecstasy’: an overview of 25 years of empirical research. Hum Psychopharmacol 28(4):289–307. doi:10.1002/hup.2318

    CAS  PubMed  Google Scholar 

  • Pedersen CA, Gibson CM, Rau SW, Salimi K, Smedley KL, Casey RL et al (2011) Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia. Schizophr Res 132(1):50–53

    PubMed  Google Scholar 

  • Pelham WE, Sturges J, Hoza J, Schmidt C, Bijlsma JJ, Milich R, Moorer S (1987) Sustained release and standard methylphenidate effects on cognitive and social behavior in children with attention deficit disorder. Pediatrics 80(4):491–501

    PubMed  Google Scholar 

  • Perälä J, Suvisaari J, Saarni SI, Kuoppasalmi K, Isometsä E, Pirkola S et al (2007) Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry 64(1):19–28

    PubMed  Google Scholar 

  • Pierce K, Redcay E (2008) Fusiform function in children with an autism spectrum disorder is a matter of “who”. Biol Psychiatry 64(7):552–560

    PubMed Central  PubMed  Google Scholar 

  • Pierce K, Müller R-A, Ambrose J, Allen G, Courchesne E (2001) Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI. Brain 124(10):2059–2073

    CAS  PubMed  Google Scholar 

  • Pitman RK, Orr SP, Lasko NB (1993) Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res 48(2):107–117, http://dx.doi.org/10.1016/0165-1781(93)90035-F

    CAS  PubMed  Google Scholar 

  • Posey DJ, Kem DL, Swiezy NB, Sweeten TL, Wiegand RE, McDougle CJ (2004) A pilot study of D-cycloserine in subjects with autistic disorder. Am J Psychiatry 161(11):2115–2117

    PubMed  Google Scholar 

  • Preckel K, Scheele D, Kendrick KM, Maier W, Hurlemann R (2014) Oxytocin facilitates social approach behavior in women. Front Behav Neurosci 8:191. doi:10.3389/fnbeh.2014.00191

    PubMed Central  PubMed  Google Scholar 

  • Randall DC, Shneerson JM, Plaha KK, File SE (2003) Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum Psychopharmacol 18(3):163–173

    CAS  PubMed  Google Scholar 

  • Rapee RM, Abbott MJ (2006) Mental representation of observable attributes in people with social phobia. J Behav Ther Exp Psychiatry 37(2):113–126

    PubMed  Google Scholar 

  • Repantis D, Schlattmann P, Laisney O, Heuser I (2010) Modafinil and methylphenidate for neuroenhancement in healthy individuals: a systematic review. Pharmacol Res 62(3):187–206

    CAS  PubMed  Google Scholar 

  • Rodrigues H, Figueira I, Lopes A, Gonçalves R, Mendlowicz MV, Coutinho ESF, Ventura P (2014) Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS One 9(7):e93519

    PubMed Central  PubMed  Google Scholar 

  • Roepke S, Vater A, Preißler S, Heekeren HR, Dziobek I (2013) Social cognition in borderline personality disorder. Front Neurosci 6:195. doi:10.3389/fnins.2012.00195

    PubMed Central  PubMed  Google Scholar 

  • Rothbaum BO, Price M, Jovanovic T, Norrholm SD, Gerardi M, Dunlop B et al (2014) A Randomized, double-blind evaluation of d-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan war veterans. Am J Psychiatry 171(6):640–648

    PubMed  Google Scholar 

  • Roy M-A, Maziade M, Labbé A, Mérette C (2001) Male gender is associated with deficit schizophrenia: a meta-analysis. Schizophr Res 47(2):141–147

    CAS  PubMed  Google Scholar 

  • Rubin LH, Carter CS, Drogos L, Pournajafi-Nazarloo H, Sweeney JA, Maki PM (2010) Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophr Res 124(1–3):13–21. doi:10.1016/j.schres.2010.09.014

    PubMed Central  PubMed  Google Scholar 

  • Rydén G, Sjöholm I (1969) Half-life of oxytocin in blood of pregnant and non-pregnant women. Acta Endocrinologica 61(3):425–431. doi:10.1530/acta.0.0610425

    PubMed  Google Scholar 

  • Saavedra-Velez C, Yusim A, Anbarasan D, Lindenmayer J-P (2009) Modafinil as an adjunctive treatment of sedation, negative symptoms, and cognition in schizophrenia: a critical review. J Clin Psychiatry 70(1):104–112

    CAS  PubMed  Google Scholar 

  • Šagud M, Mihaljević-Peleš A, Mück-Šeler D, Pivac N, Vuksan-Ćusa B, Brataljenović T, Jakovljević M (2009) Smoking and schizophrenia. Psychiatria Danubina 21(3):371–375

    PubMed  Google Scholar 

  • Saha S, Chant D, McGrath J (2007) A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 64(10):1123–1131

    PubMed  Google Scholar 

  • Scheele D, Striepens N, Gunturkun O, Deutschlander S, Maier W, Kendrick KM, Hurlemann R (2012) Oxytocin modulates social distance between males and females. J Neurosci 32(46):16074–16079. doi:10.1523/jneurosci. 2755-12.2012

    CAS  PubMed  Google Scholar 

  • Scheele D, Wille A, Kendrick KM, Stoffel-Wagner B, Becker B, Güntürkün O et al (2013) Oxytocin enhances brain reward system responses in men viewing the face of their female partner. Proc Natl Acad Sci U S A 110(50):20308–20313

    PubMed Central  CAS  PubMed  Google Scholar 

  • Scoriels L, Barnett JH, Murray GK, Cherukuru S, Fielding M, Cheng F et al (2011) Effects of modafinil on emotional processing in first episode psychosis. Biol Psychiatry 69(5):457–464

    CAS  PubMed  Google Scholar 

  • Shahrestani S, Kemp AH, Guastella AJ (2013) The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis. Neuropsychopharmacology 38(10):1929–1936. doi:10.1038/npp.2013.86

    PubMed Central  CAS  PubMed  Google Scholar 

  • Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (2009) Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biol Psychiatry 66(9):864–870. doi:10.1016/j.biopsych.2009.06.009

    CAS  PubMed  Google Scholar 

  • Shao Y, Wolpert CM, Raiford KL, Menold MM, Donnelly SL, Ravan SA et al (2002) Genomic screen and follow-up analysis for autistic disorder. Am J Med Genet 114(1):99–105

    PubMed  Google Scholar 

  • Siegal M, Varley R (2002) Neural systems involved in ‘theory of mind’. Nat Rev Neurosci 3(6):463–471

    CAS  PubMed  Google Scholar 

  • Simeon D, Bartz J, Hamilton H, Crystal S, Braun A, Ketay S, Hollander E (2011) Oxytocin administration attenuates stress reactivity in borderline personality disorder: a pilot study. Psychoneuroendocrinology 36(9):1418–1421. doi:10.1016/j.psyneuen.2011.03.013

    CAS  PubMed  Google Scholar 

  • Simmons CF Jr, Clancy TE, Quan R, Knoll JH (1995) The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. Genomics 26(3):623–625

    CAS  PubMed  Google Scholar 

  • Smits JA, Hofmann SG, Rosenfield D, DeBoer LB, Costa PT, Simon NM et al (2013a) D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: prognostic and prescriptive variables. J Consult Clin Psychol 81(6):1100–1112. doi:10.1037/a0034120

    PubMed Central  PubMed  Google Scholar 

  • Smits JA, Rosenfield D, Otto MW, Marques L, Davis ML, Meuret AE et al (2013b) d-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions. J Psychiatr Res 47(10):1455–1461, http://dx.doi.org/10.1016/j.jpsychires.2013.06.020

    PubMed Central  PubMed  Google Scholar 

  • Staebler K, Renneberg B, Stopsack M, Fiedler P, Weiler M, Roepke S (2011) Facial emotional expression in reaction to social exclusion in borderline personality disorder. Psychol Med 41(09):1929–1938

    CAS  PubMed  Google Scholar 

  • Sterzer P, Stadler C, Krebs A, Kleinschmidt A, Poustka F (2005) Abnormal neural responses to emotional visual stimuli in adolescents with conduct disorder. Biol Psychiatry 57(1):7–15. doi:10.1016/j.biopsych.2004.10.008

    PubMed  Google Scholar 

  • Stiglmayr C, Grathwol T, Linehan M, Ihorst G, Fahrenberg J, Bohus M (2005) Aversive tension in patients with borderline personality disorder: a computer‐based controlled field study. Acta Psychiatr Scand 111(5):372–379

    CAS  PubMed  Google Scholar 

  • Stone VE, Baron-Cohen S, Calder A, Keane J, Young A (2003) Acquired theory of mind impairments in individuals with bilateral amygdala lesions. Neuropsychologia 41(2):209–220

    PubMed  Google Scholar 

  • Stopa L, Clark DM (2000) Social phobia and interpretation of social events. Behav Res Ther 38(3):273–283

    CAS  PubMed  Google Scholar 

  • Striepens D, Scheele D, Kendrick KM, Becker B, Schäfer L, Schwalba K et al. (2012) Oxytocin facilitates protective responses to aversive social stimuli in males. Proc Natl Acad Sci U S A 109(44):18144–18149.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Striepens N, Kendrick KM, Hanking V, Landgraf R, Wüllner U, Maier W, Hurlemann R (2013) Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Sci Rep 3:3440

    PubMed Central  PubMed  Google Scholar 

  • Stuart J, Western D, Lohr N, Benjamin J, Becker S, Vorus N, Silk K (1990) Object relations in borderlines, depressives, and normals: an examination of human responses on the Rorschach. J Pers Assess 55(1–2):296–318

    CAS  PubMed  Google Scholar 

  • Tancer M, Johanson C-E (2003) Reinforcing, subjective, and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP. Drug Alcohol Depend 72(1):33–44, http://dx.doi.org/10.1016/S0376-8716(03)00172-8

    CAS  PubMed  Google Scholar 

  • Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS (2007) A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (“ecstasy”). Neuroscience 146(2):509–514. doi:10.1016/j.neuroscience.2007.02.032

    CAS  PubMed  Google Scholar 

  • Trull TJ, Jahng S, Tomko RL, Wood PK, Sher KJ (2010) Revised NESARC personality disorder diagnoses: gender, prevalence, and comorbidity with substance dependence disorders. J Pers Disord 24(4):412

    PubMed Central  PubMed  Google Scholar 

  • Tudusciuc O, Adolphs R (2013) Social cognitive neuroscience: clinical foundations. In: Roberts DL, Penn DL (eds) Social cognition in schizophrenia. Oxford University Press, New York

    Google Scholar 

  • Turner DC, Clark L, Pomarol-Clotet E, McKenna P, Robbins TW, Sahakian BJ (2004) Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 29(7):1363–1373

    CAS  PubMed  Google Scholar 

  • Van IJzendoorn MH, Bakermans-Kranenburg MJ (2012) A sniff of trust: meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group. Psychoneuroendocrinology 37(3):438–443. doi:10.1016/j.psyneuen.2011.07.008

    PubMed  Google Scholar 

  • van Os J, Kapur S (2009) Schizophrenia. Lancet 374(9690):635–645, http://dx.doi.org/10.1016/S0140-6736(09)60995-8

    CAS  PubMed  Google Scholar 

  • Veit R, Konicar L, Klinzing JG, Barth B, Yilmaz O, Birbaumer N (2013) Deficient fear conditioning in psychopathy as a function of interpersonal and affective disturbances. Front Hum Neurosci 7:706. doi:10.3389/fnhum.2013.00706

    PubMed Central  PubMed  Google Scholar 

  • Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F et al (2009) Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301(11):1148–1154

    PubMed Central  CAS  PubMed  Google Scholar 

  • Voncken MJ, Bögels SM, de Vries K (2003) Interpretation and judgmental biases in social phobia. Behav Res Ther 41(12):1481–1488

    PubMed  Google Scholar 

  • Walker DL, Davis M (2002) The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacol Biochem Behav 71(3):379–392

    CAS  PubMed  Google Scholar 

  • Walss-Bass C, Fernandes JM, Roberts DL, Service H, Velligan D (2013) Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia. Schizophr Res 147(2-3):387–392. doi:10.1016/j.schres.2013.04.003

    PubMed  Google Scholar 

  • Watanabe T, Abe O, Kuwabara H et al (2014) Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial. JAMA Psychiatry 71(2):166–175. doi:10.1001/jamapsychiatry.2013.3181

    PubMed  Google Scholar 

  • Wermter A-K, Kamp-Becker I, Hesse P, Schulte-Körne G, Strauch K, Remschmidt H (2010) Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am J Med Genet B Neuropsychiatr Genet 153B(2):629–639. doi:10.1002/ajmg.b.31032

    CAS  PubMed  Google Scholar 

  • Williams LM, Hermens DF, Palmer D, Kohn M, Clarke S, Keage H et al (2008) Misinterpreting emotional expressions in attention-deficit/hyperactivity disorder: evidence for a neural marker and stimulant effects. Biol Psychiatry 63(10):917–926, http://dx.doi.org/10.1016/j.biopsych.2007.11.022

    PubMed  Google Scholar 

  • Wittkampf LC, Arends J, Timmerman L, Lancel M (2012) A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia. Ther Adv Psychopharmacol 2(3):115–125

    PubMed Central  CAS  PubMed  Google Scholar 

  • Woolley J, Chuang B, Lam O, Lai W, O’Donovan A, Rankin K, Mathalon D (2014) Oxytocin administration enhances controlled social cognition in patients with schizophrenia. Psychoneuroendocrinology 47:116–125

    PubMed Central  CAS  PubMed  Google Scholar 

  • Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M et al (2005) Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry 58(1):74–77. doi:10.1016/j.biopsych.2005.03.013

    CAS  PubMed  Google Scholar 

  • Zhang Y, Lin L, Lin C-P, Zhou Y, Chou K-H, Lo C-Y et al (2012) Abnormal topological organization of structural brain networks in schizophrenia. Schizophr Res 141(2):109–118

    PubMed  Google Scholar 

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Patin, A., Hurlemann, R. (2015). Social Cognition. In: Kantak, K., Wettstein, J. (eds) Cognitive Enhancement. Handbook of Experimental Pharmacology, vol 228. Springer, Cham. https://doi.org/10.1007/978-3-319-16522-6_10

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