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Effect of Taurine and Guanidinoethane Sulfonate on Glutathione Metabolism in the Rat

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Taurine 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 442))

Abstract

Taurine is synthesized via the oxidation and decarboxylation of cysteine (Cys), a precursor for glutathione (GSH) biosynthesis. GSH is the major intracellular nonprotein sulfhydryl compound and is important in various biochemical processes, including detoxification of reactive oxygen species and electrophilic metabolites formed from xenobiotics. It is known that dietary sulfur amino acids, such as Cys or methionine, significantly influence the synthesis of taurine9,27 and GSH9,29. However, the effect of dietary taurine on Cys or GSH metabolism has long been ignored.

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Authors and Affiliations

  1. Department of Pharmacology, University of Arizona, College of Medicine, Tucson, AZ, 85724, USA

    Chong Chao Yan & Ryan J. Huxtable

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  1. Chong Chao Yan
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  2. Ryan J. Huxtable
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Editor information

Editors and Affiliations

  1. University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen Schaffer

  2. Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    John B. Lombardini

  3. University of Arizona College of Medicine, Tucson, Arizona, USA

    Ryan J. Huxtable

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© 1998 Springer Science+Business Media New York

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Yan, C.C., Huxtable, R.J. (1998). Effect of Taurine and Guanidinoethane Sulfonate on Glutathione Metabolism in the Rat. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_5

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  • DOI: https://doi.org/10.1007/978-1-4899-0117-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0119-4

  • Online ISBN: 978-1-4899-0117-0

  • eBook Packages: Springer Book Archive

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