Abstract
Pyrrolizidine alkaloids (PA) comprise a major group of toxins derived from plants. They are botanically and geographically widespread and cause many public health and economic problems5. PAs cause hepatomegaly, veno-occlusive disease of the liver, and cirrhosis7. The toxicity of PAs can also be expressed in other organ systems, including the heart, lung, and central nervous system.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Cooper, R.A. and Huxtable, R.J., 1996, A simple procedure for determining the aqueous half-lives of pyrrolic metabolites of pyrrolizidine alkaloids, Toxicon, 34:604–607.
Ellman, G.L., 1958, A colorimetric method for determining low concentrations of mercaptans, Arch. Biochem. Biophys., 74:443–450.
Fisher, R.L., Hasal, S.J., Sanuik, J.T., Gandolfi, A.J., and Brendel, K., 1995, Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices: Optimization of tissue slice culture, II, Toxicology Methods, 5:115–130.
Gordon, R.E., Shaker, A.A., and Solano, D.F., 1986, Taurine protects hamster bronchioles from acute NO2-induced alterations, Am. J. Pathol., 125:585–600.
Huxtable, R. J., 1989, Human health implications of pyrrolizidine alkaloids and herbs containing them, in: “Toxicants of Plant Origin, Vol I: Alkaloids”,. Cheeke, P.R., ed., CRC Press, Boca Raton, Florida, pp. 41–86.
Lake, N., 1993, Loss of cardiac myofibrils: Mechanism of contractile deficits induced by taurine deficiency, Am. J. Physiol. Heart Circ. Physiol., 264:H1323–H1326.
McLean, E.K., 1970, The toxic actions of pyrrolizidine (Senecio) alkaloids, Pharm. Rev., 22:429–483.
Watanabe, A., Hobara, N., Kobayashi, M., and Nagashima, H., 1985, Effect of taurine on blood acetaldehyde elevation following alcohol ingestion, Res. Comm. Sub. Abuse, 6:247–250.
Yan, C.C. and Huxtable, R.J., 1996, Effects of taurine and guanidinoethane sulfonate on right ventricular hypertrophy induced by the pyrrolizidine alkaloid, monocrotaline, Biochem. Pharmacol., 51:321–329.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hasal, S.J., Sun, Y., Yan, C.C., Brendel, K., Huxtable, R.J. (1998). Effects of Taurine in Precision-Cut Liver Slices Exposed to the Pyrrolizidine Alkaloid, Retrorsine. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_10
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0117-0_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0119-4
Online ISBN: 978-1-4899-0117-0
eBook Packages: Springer Book Archive