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Estimation of Cerebral Blood Flow in a Newborn Piglet Model of Neonatal Asphyxia

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Oxygen Transport to Tissue XXV

Abstract

Hypoxic ischemic encephalopathy (HIE) in newborn infants is one of the causes of later serious brain damage. In recent years, hypothermia therapy has attracted attention as an effective means of for preventing HIE-induced brain damage and has been used clinically 1, 2,3. However, the problem of which newborn infants should be selected for hypothermia therapy remains unsolved. Currently, selection is based on results of various tests such as neurological tests, blood biochemical tests and electroencephalography (EEG) 4. However, there is no definitive evaluation method.

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References

  1. MR. Battin, JA. Dezoete, TR. Gunn, PD. Gluckman, M. Gunn, Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia, Pediatrics. 107, 480–484 (2001).

    Article  PubMed  CAS  Google Scholar 

  2. JS. Wyatt, M. Thoresen, Hypothermia treatment and the newborn, Pediatrics. 100, 1028–1030 (1997).

    Article  PubMed  CAS  Google Scholar 

  3. M. Thoresen, Cooling the asphyxiated brain — ready for clinical trials? Eur.J.Pediatr. 158: 5–8 (1999).

    Article  Google Scholar 

  4. D. Azzopardi, N J. obertson, FM. Cowan, MA. Rutherford, M. Rampling, AD. Edwards, Pilot study of treatment with whole body hypothermia for neonatal encephalopathy, Pediatrics. 106, 684–694 (2000).

    Article  PubMed  CAS  Google Scholar 

  5. I. Oda, Y. Wada, S. Takeuchi, Y. Oikawa, N. Sakauchi, Y. Ito, I. Konishi, Y. Tsunazawa, T. Kusaka, K. Isobe, S. Itoh, S. Onishi, Near infrared optical imager for cerebral blood flow and oxygenation detection, Proc. SPIE 4250, 371–379 (2001).

    Article  Google Scholar 

  6. I. Roberts, P. Fallon, FJ. Kirkham, A. Lloyd-Thomas, C. Cooper, R. Maynard, M. Eliot, AD. Edwards, Estimation of cerebral blood flow with near infrared spectroscopy and Indocyanine green, Lancet. 342, 1425 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. J. Peter, K. Marks, I. Roberts, D. Azzopardi, AD. Edwards, Measurement of cerebral blood flow in newborn infants using near infrared spectroscopy with Indocyanine green, Pediatr, Res. 43, 34–39 (1998).

    Google Scholar 

  8. T. Kusaka, K. Isobe, K. Nagano, K. Okubo, S. Yasuda, K. Kawada, S. Itoh, S. Onishi, I. Oda, Y. Wada, I. Konishi, T. Tsunazawa, Estimation of regional cerebral blood flow distribution in infants by multichannel near-infrared spectroscopy with indocyanine green, Proc. SPIE 4250, 301–305 (2001).

    Article  Google Scholar 

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© 2003 Springer Science+Business Media New York

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Okubo, K. et al. (2003). Estimation of Cerebral Blood Flow in a Newborn Piglet Model of Neonatal Asphyxia. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_2

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  • DOI: https://doi.org/10.1007/978-1-4757-6125-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3428-4

  • Online ISBN: 978-1-4757-6125-2

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