Abstract
Hypoxic ischemic encephalopathy (HIE) in newborn infants is one of the causes of later serious brain damage. In recent years, hypothermia therapy has attracted attention as an effective means of for preventing HIE-induced brain damage and has been used clinically 1, 2,3. However, the problem of which newborn infants should be selected for hypothermia therapy remains unsolved. Currently, selection is based on results of various tests such as neurological tests, blood biochemical tests and electroencephalography (EEG) 4. However, there is no definitive evaluation method.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
MR. Battin, JA. Dezoete, TR. Gunn, PD. Gluckman, M. Gunn, Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia, Pediatrics. 107, 480–484 (2001).
JS. Wyatt, M. Thoresen, Hypothermia treatment and the newborn, Pediatrics. 100, 1028–1030 (1997).
M. Thoresen, Cooling the asphyxiated brain — ready for clinical trials? Eur.J.Pediatr. 158: 5–8 (1999).
D. Azzopardi, N J. obertson, FM. Cowan, MA. Rutherford, M. Rampling, AD. Edwards, Pilot study of treatment with whole body hypothermia for neonatal encephalopathy, Pediatrics. 106, 684–694 (2000).
I. Oda, Y. Wada, S. Takeuchi, Y. Oikawa, N. Sakauchi, Y. Ito, I. Konishi, Y. Tsunazawa, T. Kusaka, K. Isobe, S. Itoh, S. Onishi, Near infrared optical imager for cerebral blood flow and oxygenation detection, Proc. SPIE 4250, 371–379 (2001).
I. Roberts, P. Fallon, FJ. Kirkham, A. Lloyd-Thomas, C. Cooper, R. Maynard, M. Eliot, AD. Edwards, Estimation of cerebral blood flow with near infrared spectroscopy and Indocyanine green, Lancet. 342, 1425 (1993).
J. Peter, K. Marks, I. Roberts, D. Azzopardi, AD. Edwards, Measurement of cerebral blood flow in newborn infants using near infrared spectroscopy with Indocyanine green, Pediatr, Res. 43, 34–39 (1998).
T. Kusaka, K. Isobe, K. Nagano, K. Okubo, S. Yasuda, K. Kawada, S. Itoh, S. Onishi, I. Oda, Y. Wada, I. Konishi, T. Tsunazawa, Estimation of regional cerebral blood flow distribution in infants by multichannel near-infrared spectroscopy with indocyanine green, Proc. SPIE 4250, 301–305 (2001).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this paper
Cite this paper
Okubo, K. et al. (2003). Estimation of Cerebral Blood Flow in a Newborn Piglet Model of Neonatal Asphyxia. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_2
Download citation
DOI: https://doi.org/10.1007/978-1-4757-6125-2_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3428-4
Online ISBN: 978-1-4757-6125-2
eBook Packages: Springer Book Archive