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Abnormal Cellular and Tissue Interactions

  • Chapter
Handbook of Teratology

Abstract

Morphogenesis in multicellular embryos involves proliferation, aggregation, migration, and organization of differentiating cells in a manner that is strictly controlled temporally and spatially. Most tissues comprise several cell types or tissue components with differing developmental histories. Consequently, such synchronism requires a precise morphogenetic building plan, which can be implemented only if cells are “aware” of each other and can communicate in a developmentally meaningful way. This morphogenetic communication, first demonstrated between the optic vesicle and the presumptive lens ectoderm by Spemann (1901), has long been known as embryonic induction. The classic term has more recently been replaced by the somewhat more defined expression “morphogenetic tissue interactions,” defined by its proposer Grobstein (1956a) as follows: “Inductive or morphogenetic tissue interactions take place whenever in development two or more tissues of different history and properties become intimately associated and the alteration of the developmental course of the interactants results.” In addition to such heterotypic tissue interactions, like cells also interact, as they must be capable of recognizing each other in order to aggregate selectively within the organism and form organ anlagen. This capacity of cells for homotypic interaction is gradually achieved during cell differentiation and constitutes another major prerequisite for normal development (Moscona, 1961; Moscona and Garber, 1968).

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  1. Third Department of Pathology, University of Helsinki, 00290, Helsinki 29, Finland

    Lauri Saxén

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  1. Lauri Saxén
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  1. The Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA

    James G. Wilson

  2. Departments of Biology and Paediatrics, McGill University and The Montreal Children’s Hospital, Montreal, Canada

    F. Clarke Fraser

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© 1977 Plenum Press, New York

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Saxén, L. (1977). Abnormal Cellular and Tissue Interactions. In: Wilson, J.G., Fraser, F.C. (eds) Handbook of Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8933-4_8

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  • DOI: https://doi.org/10.1007/978-1-4615-8933-4_8

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