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Altered Biosynthesis

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Handbook of Teratology

Abstract

Biosynthesis is essential to life. All living organisms require the synthesis of such macromolecules as DNA, the RNAs, and various structural and enzyme proteins. The synthesis of macromolecules is in turn dependent upon the synthesis or availability of precursors—the building blocks—and of ATP, the energy needed to put them together, as well as that required for the organism to function.

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References

  • Adamson, R. H., and Fabro, S., 1968, Embryotoxic effect of L-asparaginase, Nature 218:1164–1165.

    Article  Google Scholar 

  • Alexander, C. S., Swingle, K. F., and Nagasawa, H. T., 1966, Teratogenic effect of puromycin aminonucleoside on rat kidney, Nephron 3:344–351.

    Article  Google Scholar 

  • Alleyne, G. A. O., Flores, H., Picou, D. I. M., and Waterlow, J. C., 1972, Metabolic changes in children with protein-calorie manutrition, in: Nutrition and Development (M. Winick, ed.), pp. 201–238, Wiley, New York.

    Google Scholar 

  • Armentrout, S. A., and Weisberger, A. S., 1967, Inhibition of directed protein synthesis by chloramphenicol. Effect of magnesium concentration, Biochem. Biophys. Res. Commun. 26:712–716.

    Article  Google Scholar 

  • Balis, M. E., 1968, Antagonists and Nucleic Acids, Wiley, New York.

    Google Scholar 

  • Beaudoin, A. R., 1974, Teratogenicity of sodium arsenate in rats, Teratology 10:153–158.

    Article  Google Scholar 

  • Becker, F. F., and Broome, J. D., 1967, L-Asparaginase: Inhibition of early mitosis in regenerating rat liver, Science 156:1602–1603.

    Article  Google Scholar 

  • Bernstein, J., Meyer, R., and Pickman, D. S., 1962, Failure of amino-nucleoside to produce abnormalities in the fetus of the rat, Nature 195:1209.

    Article  Google Scholar 

  • Bevelander, G., and Cohlan, S. Q., 1962, The effect on the rat fetus of transplacentally acquired tetracycline, Biol. Neonate 4:365–370.

    Article  Google Scholar 

  • Billet, F. S., Collini, R., and Hamilton, L., 1965, The effects of D-and L-threochloramphenicol in the early development of the chick embryo, J. Embryol. Exp. Morphol. 13:341–356.

    Google Scholar 

  • Blackwood, U. B., 1962, The changing inhibition of early differentiaton and general development in the chick embryo by 2-ethyl-5-methylbenzimidazole and chloramphenicol, J. Embryol. Exp. Morphol. 10:315–336.

    Google Scholar 

  • Boucher, D., and Delost, P., 1964, Dévelopment post-natal des descendants issus de mères traitées par la streptomycine au cours de la gestation chez la souris, C.R. Soc. Biol 158:2065–2069.

    Google Scholar 

  • Broome, J. D., 1961, Evidence that the L-asparaginase activity of guinea pig serum is responsible for its antilymphoma effects, Nature 191:1114–1115.

    Article  Google Scholar 

  • Brown, D. M., Harper, K. H., Palmer, A. K., and Tesh, S. A., 1968, Effect of antibiotics upon the rabbit, Toxicol. Appl. Pharmacol. 12:295.

    Google Scholar 

  • Brown, R. F., Umeda, T., Takai, S. I., and Lieberman, I., 1970, Effect of inhibitors of protein synthesis on DNA formation in liver, Biochim. Biophys. Acta 209:49–53.

    Article  Google Scholar 

  • Butcher, R. E., Scott, W. J., Kazmaier, K., and Ritter, E. J., 1973, Postnatal effects in rats of prenatal treatment with hydroxyurea, Teratology 7:161–166.

    Article  Google Scholar 

  • Caplan, A. I., 1972, Effects of a nicotinamide-sensitive teratogen 6-aminonicotinamide on chick limb cells in culture, Exp. Cell Res. 70:185–195.

    Article  Google Scholar 

  • Carter, W., and McCarty, K. S., 1966, Molecular mechanisms of antibiotic action, Ann. Intern. Med. 64:1087–1113.

    Google Scholar 

  • Chamberlain, J. G., 1967, Effects of acute vitamin replacement therapy on 6-aminonicotinamide induced cleft palate late in rat pregnancy, Proc. Soc. Exp. Biol. Med. 124:888–890.

    Google Scholar 

  • Chamberlain, J. G., 1970, Early neurovascular abnormalities underlying 6-aminonicotinamide (6-AN)-induced congenital hydrocephalus in rats, Teratology 3:377–388.

    Article  Google Scholar 

  • Chamberlain, J. G., and Goldyne, M. E., 1970, Intra-amniotic injection of pyridine nucleotides or adenosine triphosphate as counter therapy for 6-aminonicotinamide (6-AN) teratogenesis, Teratology 3:11–16.

    Article  Google Scholar 

  • Chang, F. N., Sih, C. U., and Weisblum, B., 1966, Lincomycin, an inhibitor of aminoacyl sRNA binding to ribosomes, Proc. Natl. Acad. Sci. U.S.A. 55:435–438.

    Google Scholar 

  • Chase, H. P., Dorsey, J., and McKhann, G. M., 1967, The effect of malnutrition on the synthesis of a myelin lipid, Pediatrics 40:551–559.

    Google Scholar 

  • Courtney, K. D., and Valerio, D. A., 1968, Teratology in the Macaca mulatta, Teratology 1:163–172.

    Article  Google Scholar 

  • Cox, S. J., and Gunberg, D. L., 1972, Metabolite utilization by isolated embryonic rat hearts in vitro, J. Embryol. Exp. Morphol. 28:235–245.

    Google Scholar 

  • Curley, F. J., Ingalls, T. H., and Zappasodi, P., 1968, 6-Aminonicotinamide induced skeletal malformations in mice, Arch. Environ. Health 16:309–315.

    Google Scholar 

  • Davies, J., Gilbert, W., and Gorini, L., 1964, Streptomycin, suppression, and the code, Proc. Natl. Acad. Sci. U.S.A. 51:883–890.

    Article  Google Scholar 

  • Dietrich, L. S., Friedland, I. M., and Kaplan, L. A., 1958, Pyridine nucleotide metabolism: Mechanism of action of the niacin antagonist, 6-aminonicotinamide, J. Biol. Chem. 233:964–968.

    Google Scholar 

  • Ericson-Strandvik, B., and Gyllensten, L., 1963, The central nervous system of fetal mice after administration of streptomycin, Acta Pathol. Microbiol. Scand. 59:292–300.

    Article  Google Scholar 

  • Fillipi, B., 1967, Antibiotics and congenital malformations. Evaluation of the teratogenicity of antibiotics, Adv. Teratol. 2:239–256.

    Google Scholar 

  • Fritz, H., and Hess, R. I., 1971, The effect of chloramphenicol on the prenatal development of rats, mice and rabbits, Toxicol. Appl. Pharmacol. 19:667–674.

    Article  Google Scholar 

  • Grabowski, C. T., 1961, Lactic acid accumulation as a cause of hypoxia-induced malformations in the chick embryo, Science 134:1359–1360.

    Article  Google Scholar 

  • Grabowski, C. T., 1970, Embryonic oxygen deficiency—a physiological approach to analysis of teratological mechanisms, Adv. Teratol. 4:123–167.

    Google Scholar 

  • Hallman, N., Hjelt, L., and Kouvalainen, K., 1960, Attempts to produce experimental congenital nephrosis, Ann. Paediatr. Fenn. 6:289–298.

    Google Scholar 

  • Harvey, J. E., and Srebnik, H. H., 1968, Fetal death and malformations produced by single injections of actinomycin D at midpregnancy and amelioration with thyroxine, Anat. Rec. 160:362.

    Google Scholar 

  • Hicks, S. P., Brown, B. L., and D’Amato, C. J., 1957, Regeneration and malformation in the nervous system, eye, and mesenchyme of the mammalian embryo after radiation injury, Am. J. Pathol. 33:459–481.

    Google Scholar 

  • Hurley, L. S., and Tuchmann-Duplessis, H., 1963, Influence de la tetracycline sur la développement pré-et post-natal du rat, C.R. Acad. Sci. 257:302–304.

    Google Scholar 

  • Ingall, D., and Sherman, J. D., 1970, Chloramphenicol, in: Antimicrobial Therapy (B. M. Kagan, ed.), pp. 61–77, W. B. Saunders, Philadelphia.

    Google Scholar 

  • Johnson, W. J., and McColl, J. D., 1955, 6-Aminonicotinamide—a potent nicotinamide antagonist, Science 122:834.

    Article  Google Scholar 

  • Jordan, R. L., 1969, Studies on the uptake and incorporation of tritiated uridine in the rat embryo and associated structures after treatment with actinomycin D, Thesis, University of Cincinnati.

    Google Scholar 

  • Jordan, R. L., and Wilson, J. G., 1970, Radioautographic study of RNA synthesis in normal and actinomycin D treated rat embryos, Anat. Rec. 168:549–564.

    Article  Google Scholar 

  • Kidd, J. G., 1953, Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum, J. Exp. Med. 98:565–582.

    Article  Google Scholar 

  • Köhler, E., and Merker, H.-J., 1972, Studies of the teratogenic phase specificity of actinomycin D in the rat, Naunyn Schmiedebergs Arch. Pharmakol. 275:31–44.

    Article  Google Scholar 

  • Kunin, C. M., 1970, The tetracyclines, in: Antimicrobial Therapy (B. M. Kagan, ed.), p. 47, W. B. Saunders, Philadelphia.

    Google Scholar 

  • Landauer, W., 1957, Niacin antagonists and chick development, J. Exp. Zool. 136:509–530.

    Article  Google Scholar 

  • Landauer, W., and Wakasugi, N., 1968, Teratological studies with sulfonamides and their implications, J. Embryol. Exp. Morphol. 20:261–284.

    Google Scholar 

  • Lash, J. W., Glick, M. C., and Madden, J. W., 1964, Cartilage induction in vitro and sulfateactivating enzymes, Natl. Cancer Inst. Monogr. 13:39–49.

    Google Scholar 

  • Mackler, B., Grace, R., and Duncan, H. M., 1971, Studies of mitochondrial development during embryogenesis in the rat, Arch. Biochem. Biophys. 144:603–610.

    Article  Google Scholar 

  • McColl, J. D., Globus, M., and Robinson, S., 1965, Effect of some therapeutic agents on the developing rat fetus, Toxicol. Appl. Pharmacol. 7:409–417.

    Article  Google Scholar 

  • Murphy, M. L., Dagg, C. P., and Karnofsky, D. A., 1957, Comparison of teratogenic chemicals in the rat and chick embryos, Pediatrics 19:701–714.

    Google Scholar 

  • Nelson, M. M., Baird, C. D. C., Wright, H. V., and Evans, H. M., 1956, Multiple congenital abnormalities in the rat resulting from riboflavin deficiency induced by the antimetabolite galactoflavin, J. Nutr. 58:125–134.

    Google Scholar 

  • Neubert, D., Merker, H.-J., Köhler, E., Krowke, R., and Barrach, H. J., 1970, Biochemical aspects of teratology, in: Advances in the Biosciences (G. Raspe, ed.), pp. 575–622, Pergamon Press, Oxford.

    Google Scholar 

  • Pinsky, L., and Fraser, F. C., 1960, Congenital malformations after a two-hour inactivation of nicotinamide in pregnant mice, Br. Med. J. 2:195–197.

    Article  Google Scholar 

  • Proctor, N. H., and Casida, J. E., 1975, Organophosphorus and methyl carbamate insecticide teratogenesis: Diminished NAD in chicken embryos, Science 190:580–582.

    Article  Google Scholar 

  • Ritter, E. J., Scott, W. J., and Wilson, J. G., 1971, Teratogenesis and inhibition of DNA synthesis induced in rat embryos by cytosine arabinoside, Teratology 4:7–14.

    Article  Google Scholar 

  • Ritter, E. J., Scott, W. J., and Wilson, J. G., 1973, Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis, Teratology 7:219–226.

    Article  Google Scholar 

  • Ritter, E. J., Scott, W. J., and Wilson, J. G., 1975a, Inhibition of ATP synthesis associated with 6-aminonicotinamide (6-AN) teratogenesis in rat embryos, Teratology 12:233–238.

    Article  Google Scholar 

  • Ritter, E. J., Scott, W. J., and Wilson, J. G., 1975b, Factors involved in differential teratogenic sensitivity to hydroxyurea in rats on days 10 and 12 of gestation, Teratology 11:30A.

    Google Scholar 

  • Roux, C., and Taillemite, J. L., 1969, Action tératogène de la rubidomycine chez le rat, C.R. Soc. Biol. 163:1299–1302.

    Google Scholar 

  • Roux, C., Emerit, I., and Taillemite, J. L., 1971, Chromosomal breakage and teratogenesis, Teratology 4:303–316.

    Article  Google Scholar 

  • Rusconi, A., and Calendi, E., 1966, Action of daunomycin on nucleic acid metabolism in Hela cells, Biochim. Biophys. Acta 119:413–415.

    Article  Google Scholar 

  • Sanders, E., and Cluff, L. E., 1970, Antimicrobial drugs: mechanisms and factors influencing their action, in: Antimicrobial Therapy (B. M. Kagan, ed.), p. 5, W. B. Saunders, Philadelphia.

    Google Scholar 

  • Scott, W. J., Ritter, E. J., and Wilson, J. G., 1971, DNA synthesis inhibition and cell death associated with hydroxyurea teratogenesis in rat embryos, Dev. Biol. 26:306–315.

    Article  Google Scholar 

  • Seegmiller, R. E., and Runner, M. N., 1974, Normal incorporation rates for precursors of collagen and mucopolysaccharide during expression of micromelia induced by 6-aminonicotinamide J. EmbryoL Exp. Morphol. 31:305–312.

    Google Scholar 

  • Seegmiller, R. E., Overman, D. O., and Runner, M. N., 1972, Histological and fine structural changes during chondrogenesis in micromelia induced by 6-aminonicotinamide, Dev. Biol. 28:555–572.

    Article  Google Scholar 

  • Shepard, T. H., 1973, Catalog of Teratogenic Agents, The Johns Hopkins University Press, Baltimore.

    Google Scholar 

  • Shepard, T. H., Lemire, R. J., Aksu, O., and Mackler, B., 1968, Studies of the development of congenital anomalies in embryos of riboflavin-deficient, galactoflavin fed rats. I. Growth and embryologic pathology, Teratology 1:75–92.

    Article  Google Scholar 

  • Sobin, L. H., and Kidd, J. G., 1966, Alterations in protein and nucleic acid metabolism of lymphoma 6C3HED-OG cells in mice given guinea pig serum, J. Exp. Med. 123:55–73.

    Article  Google Scholar 

  • Tanimura, T., and Shephard, T. H., 1970, Glucose metabolism by rat embryos in vitro, Proc. Soc. Exp. Biol. Med. 135:51–54.

    Google Scholar 

  • Tuchmann-Duplessis, H., and Mercier-Parot, L., 1958, Sur l’active tératogène chez le rat de l’actinomycine D, C.R. Acad. Sci. 247:2200–2203.

    Google Scholar 

  • Tuchmann-Duplessis, H., and Mercier-Parot, L., 1960, The teratogenic action of the antibiotic actinomycin D, in: Ciba Foundation Symposium on Congenital Malformations (G. E. W. Wolsten-holme and C. M. O’Connor, eds.), pp. 115–128, Little, Brown, Boston.

    Google Scholar 

  • Varpela, E., Hietalahti, J., and Aro, M. J. T., 1969, Streptomycin and dihydrostreptomycin medication during pregnancy and their effect on the childs inner ear, Scand. J. Respir. Dis. 50:101–109.

    Google Scholar 

  • Warkany, J., and Schraffenberger, E., 1943, Congenital malformations induced in rats by maternal nutritional deficiency. V. Effect of a purified diet lacking riboflavin, Proc. Soc. Exp. Biol. Med. 54:92–94.

    Google Scholar 

  • Warkany, J., and Schraffenberger, E., 1944, Congenital malformations induced in rats by maternal nutritional deficiency. VI. The preventive factor, J. Nutr. 27:477–484.

    Google Scholar 

  • Wilson, J. G., 1966, Effects of acute and chronic treatment with actinomycin D on pregnancy and the fetus in the rat, Harper Hosp. Bull. 24:109–118.

    Google Scholar 

  • Winfield, J. B., and Bennett, D., 1971, Gene-teratogen interaction: Potentiation of actinomycin D teratogenesis in the house mouse by the lethal gene brachyury, Teratology 4:157–170.

    Article  Google Scholar 

  • Yoshida, J., Metcoff, J., and Frenk, S., 1968, Reduced pyruvic kinase activity, altered growth patterns of ATP in leukocytes, and protein-calorie malnutrition, Am. J. Clin. Nutr. 21:162–166.

    Google Scholar 

  • Zimmerman, E. F., Andrew, F., and Kalter, H., 1970, Glucocorticoid inhibition of RNA synthesis responsible for cleft palate in mice: A model, Proc. Natl. Acad. Sci. U.S.A. 67:779–785.

    Article  Google Scholar 

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© 1977 Plenum Press, New York

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Ritter, E.J. (1977). Altered Biosynthesis. In: Wilson, J.G., Fraser, F.C. (eds) Handbook of Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8933-4_5

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  • DOI: https://doi.org/10.1007/978-1-4615-8933-4_5

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