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Developmental Genetics

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Handbook of Teratology

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Abstract

The concept of “developmental genetics” has undergone significant changes in recent years, particularly since molecular biology and genetics began to focus attention on mechanisms of gene transcription and translation within the context of problems of cell differentiation. As a consequence, the field has broadened and at present covers a wide area ranging from the molecular level of transcription to that of organogenesis and its genetic control. The present chapter will not attempt to cover the entire field but will be restricted to aspects of developmental genetics closest to problems of teratology, in particular those dealing with developmental mechanisms and their genetic control in the normal as well as the abnormal organism.

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References

  • Apte, B. N., and Zipser, D., 1973, In vivo splicing of protein: One continuous polypeptide from two independently functioning operons (β-galactosidase/lactose Operon), Proc. Natl. Acad. Sci. U.S.A. 70:2969.

    Article  Google Scholar 

  • Auerbach, R., 1954, Analysis of the developmental effects of a lethal mutation in the house mouse, J. Exp. Zool. 127:305.

    Article  Google Scholar 

  • Beatty, R. A., and Gluecksohn-Waelsch, S., eds., 1972, Edinburgh Symposium on the Genetics of the Spermatozoon (R. A. Beatty and S. Gluecksohn-Waelsch, eds. and publishers), Edinburgh, U.K.

    Google Scholar 

  • Bennett, D., 1956, Developmental analysis of a mutation with pleiotropic effects in the mouse, J. Morphol. 98:199.

    Article  Google Scholar 

  • Bennett, D., 1975, The T-locus of the mouse, Cell 6:441.

    Article  Google Scholar 

  • Bennett, D., and Dunn, L. C., 1960, A lethal mutant (t 18) in the house mouse showing partial duplications, J. Exp. Zool. 143:203.

    Article  Google Scholar 

  • Bennett, D., Artzt, K., Spiegelman, M., and Magnusen, T., 1977, Experimental teratomas as a way of analyzing the development of the T/t locus mutations, Proc. VI Sigrid Suselius Symposium, Cell Interactions in Differentiation, Academic Press (in press).

    Google Scholar 

  • Boveri, T., 1902, On multipolar mitosis as a means of analysis of the cell nucleus, in: Foundations of Experimental Embryology (B. H. Willier and J. M. Oppenheimer, eds.), Prentice-Hall, Engle-wood Cliffs, N.J.

    Google Scholar 

  • Braden, A. W. H., Erickson, R. P., Gluecksohn-Waelsch, S., Hard, D. L., Peacock, W. J., and Sandler, L., 1972, Comparison of effects and properties of segregation distorting alleles in the mouse (t) and in Drosophila (SD), in: Edinburgh Symposium on the Genetics of the Spermatozoon (R. A. Beatty and S. Gluecksohn-Waelsch, eds. and publishers), Edinburgh, U.K.

    Google Scholar 

  • Calarco, P G., and Brown, E. H., 1968, Cytological and ultrastructural comparisons of t 12/t 12 and normal mouse morulae, J. Exp. Zool. 168:169.

    Article  Google Scholar 

  • Chui, D., and Russell, E. S., 1974, Fetal erythropoiesis in Steel mutant mice: I. A. Morphological study of erythroid cell development in fetal livers, Dev. Biol. 40:256.

    Article  Google Scholar 

  • Deol, M. S., 1970, The relationship between abnormalities of pigmentation and of the inner ear, Proc. R. Soc. London 175:201.

    Article  Google Scholar 

  • Deol, M. S., and Whitten, W. K., 1972a, X-chromosome inactivation: Does it occur at the same time in all cells of the embryo? Nature (London) New Biol. 240:277.

    Google Scholar 

  • Deol, M. S., and Whitten, W. K., 1972b, Time of X-chromosome inactivation in retinal melanocytes of the mouse. Nature (London), New Biol. 238:159.

    Google Scholar 

  • Dewey, M. J., Gearhart, J. D., and Mintz, B., 1977, Cell surface antigens of totipotent mouse teratoma cells grown in vivo: Their relation to embryo, adult and tumor antigens, Dev. Biol. (Feb., 1977; in press).

    Google Scholar 

  • Dickinson, W. J., 1975, A genetic locus affecting the developmental expression of an enzyme in Drosophila melanogaster, Dev. Biol. 42:131.

    Article  Google Scholar 

  • Dunn, L. C., 1940, Heredity and development of early abnormalities in vertebrates, Harvey Lect. 35:135.

    Google Scholar 

  • Epstein, C. J., 1969, Mammalian oocytes: X-chromosome activity, Science 163:1078.

    Article  Google Scholar 

  • Felton, J., Meisler, M, and Paigen, K., 1974, A locus determining β-galactosidase activity in the mouse, J. Biol Chem. 249:3267.

    Google Scholar 

  • Gardner, R. L., 1968, Mouse chimaeras obtained by the injection of cells into the blastocyst, Nature 220:596.

    Article  Google Scholar 

  • Gardner, R. L., and Lyon, M. F., 1971, X chromosome inactivation studied by injection of a single cell into the mouse blastocyst, Nature (London) 231:385.

    Article  Google Scholar 

  • Garder, S. M., Andina, R., and Gant, N., 1975, Ontogeny of X-chromosome inactivation in the female germ line, Exp. Cell. Res. 91:454.

    Article  Google Scholar 

  • Gehring, W. J., 1969, Problems of cell determination and differentiation in Drosophila, in: Problems in Biology: RNA in Development (E. W. Hanly, ed.), Univ. of Utah Press, Salt Lake City, Utah.

    Google Scholar 

  • Gluecksohn-Schoenheimer, S., 1940, The effect of an early lethal (t 0) in the house mouse, Genetics 25:391.

    Google Scholar 

  • Gluecksohn-Schoenheimer, S., 1949, The effects of a lethal mutation responsible for duplications and twinning in mouse embryos, J. Exp. Zool. 110:47.

    Article  Google Scholar 

  • Gluecksohn-Waelsch, S., and Cori, C. F., 1970, Glucose-6-phosphate deficiency: Mechanisms of genetic control and biochemistry, Biochem. Genet. 4:195.

    Article  Google Scholar 

  • Gluecksohn-Waelsch, S., and Erickson, R. P., 1970, The T-locus of the mouse: Implications for mechanisms of development, Curr. Top. Dev. Biol. 5:281.

    Article  Google Scholar 

  • Gluecksohn-Waelsch, S., and Erickson, R. P., 1971, Cellular membranes, a possible link between H-2 and T-locus effects, in: Proc. Symp. Immunogenetics of the H-2 System (A. Lengerova and M. Vojtiskova, eds.), Liblice-Prague, Karger, Basel.

    Google Scholar 

  • Gluecksohn-Waelsch, S., Schiffman, M. B., Thorndike, J., and Cori, C. F., 1974, Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase, Proc. Natl. Acad. Sci. U.S.A. 71:825.

    Article  Google Scholar 

  • Green, M. C., 1967, A defect of the splanchnic mesoderm caused by the mutant gene dominant hemimelia in the mouse, Dev. Biol. 15:62.

    Article  Google Scholar 

  • Grobstein, C., 1955, Inductive interaction in the development of the mouse metanephros, J. Exp. Zool. 130:319.

    Article  Google Scholar 

  • Grüneberg, H., 1943, Congenital hydrocephalus in the mouse, a case of spurious pleiotropism, J. Genet. 45:1.

    Article  Google Scholar 

  • Gurdon, J. B., 1970, Nuclear transplantation and the control of gene activity in animal development, Proc. R. Soc. London, Ser. B 176:303.

    Article  Google Scholar 

  • Hadorn, E., 1945, Zur Pleiotropie der Genwirkung, Arch. Julius Klaus-Stift., Suppl. 20:82.

    Google Scholar 

  • Hadorn, E., 1966, Dynamics of determination, in: Major Problems in Developmental Biology (M. Locke, ed.), Academic Press, New York.

    Google Scholar 

  • Hadorn, E., 1974, Experimental Studies of Amphibian Development, Springer-Verlag, Berlin.

    Book  Google Scholar 

  • Hillman, N., Hillman, R., and Wileman, G., 1970, Ultrastructural studies of cleavage stage t 12 /t 12 mouse embryos, Am. J. Anat. 128:311.

    Article  Google Scholar 

  • Illmensee, K., and Mintz, B., 1976, Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts, Proc. Natl. Acad. Sci. 73:549.

    Article  Google Scholar 

  • Jacob, F., 1977, Mouse teratocarcinoma and embryonic antigens, Transpl. Rev. (in press).

    Google Scholar 

  • Kemler, R., Babinet, C., Condamine, H., Gachelin, G., Guenet, J. L., and Jacob, F., 1976, Embryonal carcinoma antigens and the Tit locus of the mouse, Proc. Natl. Acad. Sci. 73:4080.

    Article  Google Scholar 

  • Lifschytz, E., 1972, X-chromosome inactivation. An essential feature of normal spermiogenesis in male heteragametic organisms, in: Genetics of the Spermatozoon (R. A. Beatty and S. Gluecksohn-Waelsch, eds. and publishers), Edinburgh, U.K.

    Google Scholar 

  • Lyon, M., 1961, Gene action in X-chromosome of the mouse (Mus musculus L.), Nature (London) 190:373.

    Article  Google Scholar 

  • Martin, G. R., 1975, Teratocarcinomas as a model system for the study of embryogenesis and neoplasia. Cell 5:229.

    Article  Google Scholar 

  • McLaren, A., 1972, Germ cell differentiation in artificial chimaeras of mice, in: Genetics of the Spermatozoon (R. A. Beatty and S. Gluecksohn-Waelsch, eds. and publishers), Edinburgh, U.K.

    Google Scholar 

  • Miller, D. A., and Miller O. J., 1972, Chromosome mapping in the mouse, Science 178:949.

    Article  Google Scholar 

  • Miller, D. A., Dev. V. G., Tantravahi, R., Miller, O. J., Schiffman, M. B., Yates, R. A., and Gluecksohn-Waelsch, S., 1974, Cytological detection of the c 25H deletion involving the albino (c) locus on chromosome 7 in the mouse, Genetics 78:905.

    Google Scholar 

  • Mintz, B., 1974, Gene control of mammalian differentiation, Annu. Rev. Genet. 8:411.

    Article  Google Scholar 

  • Moser, G. C., and Gluecksohn-Waelsch, S., 1967, Developmental genetics of a recessive allele at the complex T-locus in the mouse, Dev. Biol. 16:564.

    Article  Google Scholar 

  • Ohno, S., 1963, Life history of female germ cells in mammals, in: Congenital Malformations (M. Fishbein, ed.), International Medical Congress Ltd., New York.

    Google Scholar 

  • Oppenheimer, J. M., 1968, Some historical relationships between teratology and experimental embryology, Bull. Hist. Med. 42:145.

    Google Scholar 

  • Pai, A. C., 1964a, Developmental genetics of a lethal mutation, muscular dysgenesis (mdg), in the mouse. I. Genetic analysis and gross morphology, Dev. Biol. 11:82.

    Article  Google Scholar 

  • Pai, A. C., 1964b, Developmental genetics of a lethal mutation, muscular dysgenesis (mdg), in the mouse. II. Developmental analysis, Dev. Biol. 11:93.

    Article  Google Scholar 

  • Paigen, K., 1971, The genetics of enzyme realization, in: Enzyme Synthesis and Degradation in Mammalian Systems (M. Rechcigl., Jr., ed.), Karger, Basel.

    Google Scholar 

  • Papaioannou, V., McBurney, M., Gardner, R., and Evans, M., 1975, Fate of teratocarcinoma cells injected into early mouse embryos, Nature 258:70.

    Article  Google Scholar 

  • Platzer, A. C., and Gluecksohn-Waelsch, S., 1972, Fine structure of mutant (muscular dysgenesis) embryonic mouse muscle, Dev. Biol. 28:242.

    Article  Google Scholar 

  • Race, R. R., and Sanger, R., 1968, Blood Groups in Man, F. A. Davis, Philadelphia, Pa.

    Google Scholar 

  • Rota, T. R., and Gluecksohn-Waelsch, S., 1963, Development in organ tissue culture of kidney rudiments from mutant mouse embryos, Dev. Biol. 7:432.

    Article  Google Scholar 

  • Rotmann, E., 1931, Die Rolle des Ektoderms und Mesoderms bei der Formbildung der Kiemen und Extremitäten von Triton, Arch. Entwicklungsmeck Org. 124:747.

    Article  Google Scholar 

  • Russell, E. S., and McFarland, E. C., 1966, Analysis of pleiotropic effects of W and F genic substitutions in the mouse, Genetics 53:949.

    Google Scholar 

  • Russell, E. S., Thompson, M. W., and McFarland, E. C., 1968, Analysis of effects of W and f genetic substitutions on fetal mouse hematology, Genetics 58:259.

    Google Scholar 

  • Sherman, M. I., and Solter, D. (eds.), 1975, Teratomas and Differentiation, Academic Press, New York.

    Google Scholar 

  • Sisken, B. F., and Gluecksohn-Waelsch, S., 1959, A developmental study of the mutation “phocomelia” in the mouse, J. Exp. Zool. 142:623.

    Article  Google Scholar 

  • Smith, L. J., 1956, A morphological and histochemical investigation of a preimplantation lethal (t 12) in the house mouse, J. Exp. Zool. 132:51.

    Article  Google Scholar 

  • Spemann, H., and Schotté, O., 1932, Über xenoplastische Transplantation als Mittel zur Analyse der embryonalen Induktion, Naturwissenschaften 20:463.

    Article  Google Scholar 

  • Stern, P. L., Martin, G. R., and Evans, M. J., 1975, Cell surface antigens of clonal teratocarcinoma cells at various stages of differentiation, Cell 6:455.

    Article  Google Scholar 

  • Tarkowski, A. P., 1961, Mouse chimaeras developed from fused eggs, Nature (London) 190:857.

    Article  Google Scholar 

  • Theiler, K., and Gluecksohn-Waelsch, S., 1956, The morphological effects and the development of the fused mutation in the mouse, Anat. Rec. 125:83.

    Article  Google Scholar 

  • Thorndike, J., Trigg, M. J., Stocken, R., Gluecksohn-Waelsch, S., and Cori, C. F., 1973, Multiple biochemical effects of a series of X-ray induced mutations at the albino locus in the mouse, Biochem. Genet. 9:25.

    Article  Google Scholar 

  • Trigg, M. J., and Gluecksohn-Waelsch, S., 1973, Ultrastructural basis of biochemical effects in a series of lethal alleles in the mouse, J. Cell Biol. 58:549.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

    Salome Gluecksohn-Waelsch

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  1. Salome Gluecksohn-Waelsch
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Editors and Affiliations

  1. The Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA

    James G. Wilson

  2. Departments of Biology and Paediatrics, McGill University and The Montreal Children’s Hospital, Montreal, Canada

    F. Clarke Fraser

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© 1977 Plenum Press, New York

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Gluecksohn-Waelsch, S. (1977). Developmental Genetics. In: Wilson, J.G., Fraser, F.C. (eds) Handbook of Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8933-4_2

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  • DOI: https://doi.org/10.1007/978-1-4615-8933-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8935-8

  • Online ISBN: 978-1-4615-8933-4

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