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Protein Metabolism and Lifespan in Caenorhabditis elegans

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Protein Metabolism and Homeostasis in Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 694))

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Abstract

Lifespan of the versatile model system Caenorhabditis elegans can be extended by a decrease of insulin/IGF-1 signaling, TOR signaling, mitochondrial function, protein synthesis and dietary intake. The exact molecular mechanisms by which these modulations confer increased life expectancy are yet to be determined but increased stress resistance and improved protein homeostasis seem to be of major importance. In this chapter, we explore the interactions among several genetic pathways and cellular functions involved in lifespan extension and their relation to protein homeostasis in C. elegans. Several of these processes have been associated, however some relevant data are conflicting and further studies are needed to clarify these interactions. In mammals, protein homeostasis is also implicated in several neurodegenerative diseases, many of which can be modeled in C. elegans.

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Authors and Affiliations

  1. Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000, Ghent, Belgium

    Geert Depuydt, Jacques R. Vanfleteren & Bart P. Braeckman

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  1. Geert Depuydt
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  2. Jacques R. Vanfleteren
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  3. Bart P. Braeckman
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Correspondence to Bart P. Braeckman .

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  1. Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Crete, Greece

    Nektarios Tavernarakis PhD

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Depuydt, G., Vanfleteren, J.R., Braeckman, B.P. (2010). Protein Metabolism and Lifespan in Caenorhabditis elegans . In: Tavernarakis, N. (eds) Protein Metabolism and Homeostasis in Aging. Advances in Experimental Medicine and Biology, vol 694. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7002-2_8

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