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Autophagy and Longevity: Lessons from C. elegans

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Protein Metabolism and Homeostasis in Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 694))

Abstract

Aging is a process in which individuals undergo an exponential decline in vitality, leading to death. In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction and mitochondrial activity, control aging in C. elegans. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. Here, we review the current progress in understanding the role of autophagy in the regulation of C. elegans life span.

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Authors and Affiliations

  1. Florida Atlantic University, 777 Glades Rd, Boca Raton, Florida, 33431, USA

    Kailiang Jia

  2. Southwestern Medical Center, HHMI, 5323 Harry Hines Blvd, Dallas, Texas, 75390-9113, USA

    Beth Levine

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  1. Kailiang Jia
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  2. Beth Levine
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Correspondence to Kailiang Jia or Beth Levine .

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  1. Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Crete, Greece

    Nektarios Tavernarakis PhD

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Jia, K., Levine, B. (2010). Autophagy and Longevity: Lessons from C. elegans . In: Tavernarakis, N. (eds) Protein Metabolism and Homeostasis in Aging. Advances in Experimental Medicine and Biology, vol 694. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7002-2_5

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