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Roles for SUMO Modification during Senescence

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Protein Metabolism and Homeostasis in Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 694))

Abstract

SUMOylation is a reversible post-translational modification, where a small peptide (SUMO) is covalently attached to a target protein and changes its activity, subcellular localization and/or interaction with other macromolecules. SUMOylation substrates are numerous and diverse and modification by SUMO is involved in many biological functions, including the response to stress. The SUMO pathway has recently been implicated in the process of cellular senescence, the irreversible loss of cell replication potential that occurs during aging in vivo and in vitro. SUMO peptides, a SUMO E3 ligase and a SUMO-specific peptidase can induce or hinder the onset of senescence, thus supporting an association of SUMOylation with cell growth arrest and organismal aging. Preliminary results on comparative analysis of proteomics and mRNA levels between young and old human and murine tissues show elevated levels of global protein SUMOylation and a decrease in components of the SUMOylation process with age. Further connections between the SUMO pathway and the aging process remain to be elucidated.

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  1. Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), N. Plastira 100, Vassilika Vouton, PO Box 1385, Heraklion, GR 70013, Crete, Greece

    Artemisia M. Andreou & Nektarios Tavernarakis

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  1. Artemisia M. Andreou
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    Nektarios Tavernarakis PhD

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Andreou, A.M., Tavernarakis, N. (2010). Roles for SUMO Modification during Senescence. In: Tavernarakis, N. (eds) Protein Metabolism and Homeostasis in Aging. Advances in Experimental Medicine and Biology, vol 694. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7002-2_12

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