Skip to main content
SpringerLink
Log in

Introduction to Diseases Associated with Kaposi’s Sarcoma-Associated Herpesvirus

  • Chapter
  • First Online:
DNA Tumor Viruses

  • 1217 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adams, V., Kempf, W., Schmid, M., Müller, B., Briner, J. and Burg, G. (1995) Absence of herpesvirus-like DNA sequences in skin cancers of non-immunosuppressed patients. Lancet. 346, 1715.

    PubMed  CAS  Google Scholar 

  • Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J. (1990) Basic local alignment search tool. J Mol Biol. 215, 403–410.

    PubMed  CAS  Google Scholar 

  • Ambinder, R. F., Newman, C., Hayward, G. S., Biggar, R., Melbye, M., Kestens, L., Van Marck, E., Piot, P., Gigase, P. and Wright, P. B. (1985) Lack of association of cytomegalovirus with endemic African Kaposi's sarcoma. J Infect Dis. 156, 133.

    Google Scholar 

  • Ambroziak, J. A., Blackbourn, D. J., Herndier, B. G., Glogau, R. G., Gullett, J. H., McDonald, A. R., Lennette, E. T. and Levy, J. A. (1995) Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science. 268, 582–583.

    PubMed  CAS  Google Scholar 

  • Arvanitakis, L., Mesri, E. A., Nador, R. G., Said, J. W., Asch, A. S., Knowles, D. M. and Cesarman, E. (1996) Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood. 88, 2648–2654.

    PubMed  CAS  Google Scholar 

  • Athale, U. M., Patil, P. S., Chintu, C. and Elem, B. (1995) Influence of HIV Epidemic on the Incidence of Kaposi's Sarcoma in Zambian Children. J AIDS and Hum Retro. 8, 96–100.

    CAS  Google Scholar 

  • Barozzi, P., Luppi, M., Facchetti, F., Mecucci, C., Alu, M., Sarid, R., Rasini, V., Ravazzini, L., Rossi, E., Festa, S., Crescenzi, B., Wolf, D. G., Schulz, T. F. and Torelli, G. (2003) Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nat Med. 9, 554–561.

    PubMed  CAS  Google Scholar 

  • Bassett, M. T., Chokunonga, E., Mauchaza, B., Levy, L., Ferlay, J. and Parkin, D. M. (1995) Cancer in the African population of Harare, Zimbabwe, 1990–1992. Internatl J Cancer. 63, 29–36.

    CAS  Google Scholar 

  • Beck, J. T., Hsu, S. M., Wijdenes, J., Bataille, R., Klein, B., Vesole, D., Hayden, K., Jagannath, S. and Barlogie, B. (1994) Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. New Engl J Med. 330, 602–605.

    PubMed  CAS  Google Scholar 

  • Beral, V., Peterman, T. A., Berkelman, R. L. and Jaffe, H. W. (1990) Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet. 335, 123–128.

    PubMed  CAS  Google Scholar 

  • Biggar, R. J., Whitby, D., Marshall, V., Linhares, A. C. and Black, F. (2000) Human herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype. J Infect Dis. 181, 1562–1568.

    PubMed  CAS  Google Scholar 

  • Boshoff, C., Gao, S. J., Healy, L. E., Matthews, S., Thomas, A. J., Coignet, L., Warnke, R. A., Strauchen, J. A., Matutes, E., Kamel, O. W., Moore, P. S., Weiss, R. A. and Chang, Y. (1998) Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood. 91, 1671–1679.

    PubMed  CAS  Google Scholar 

  • Boshoff, C., Schulz, T. F., Kennedy, M. M., Graham, A. K., Fisher, C., Thomas, A., McGee, J. O., Weiss, R. A. and O'Leary, J. J. (1995) Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med. 1, 1274–1278.

    PubMed  CAS  Google Scholar 

  • Boshoff, C., Talbot, S., Kennedy, M., O'Leary, J., Schulz, T. and Chang, Y. (1996) HHV8 and skin cancers in immunosuppressed patients [letter] [published erratum appears in Lancet 1996 Jul 13; 348(9020):138]. Lancet. 347, 338–339.

    PubMed  CAS  Google Scholar 

  • Boshoff, C., Whitby, D., Hatziionnou, T., Fisher, C., van der Walt, J., Hatzakis, A., Weiss, R. and Schulz, T. (1995) Kaposi's sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet. 345, 1043–1044.

    PubMed  CAS  Google Scholar 

  • Brandt, S. J., Bodine, D. M., Dunbar, C. E. and Nienhuis, A. W. (1990) Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest. 86, 592–599.

    PubMed  CAS  Google Scholar 

  • Breimer, L. H. (1984) Did Moriz Kaposi describe AIDS in 1872?Clin Med. 19, 156–158.

    CAS  Google Scholar 

  • Casper, C., Nichols, W. G., Huang, M. L., Corey, L. and Wald, A. (2004) Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment. Blood. 103, 1632–1634.

    PubMed  CAS  Google Scholar 

  • Castleman, B., Iverson, L. and Menendez, V. P. (1956) Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer. 9, 822.

    Google Scholar 

  • Cesarman, E., Chang, Y., Moore, P. S., Said, J. W. and Knowles, D. M. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 332, 1186–1191.

    PubMed  CAS  Google Scholar 

  • Cesarman, E., Moore, P. S., Rao, P. H., Inghirami, G., Knowles, D. M. and Chang, Y. (1995) In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood. 86, 2708–2714.

    PubMed  CAS  Google Scholar 

  • Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M. and Moore, P. S. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 265, 1865–1869.

    Google Scholar 

  • Chang, Y., Ziegler, J. L., Wabinga, H., Katongole-Mbidde, E., Boshoff, C., Whitby, D., Schulz, T., Weiss, R. A., Jaffe, H. A., Group, U. K. s. S. S. and Moore, P. S. (1996) Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Archiv Int Med. 156, 202–204.

    CAS  Google Scholar 

  • Chen, K. T. (1984) Multicentric Castleman's disease and Kaposi's sarcoma. Am J Surg Pathol. 8, 287–293.

    PubMed  CAS  Google Scholar 

  • Chow, D.-c., He, X.-l., Snow, A. L., Rose-John, S. and Garcia, K. C. (2001) Structure of an extracellular gp130 cytokine receptor signaling complex. Science. 291, 2150–2155.

    PubMed  CAS  Google Scholar 

  • Collandre, H., Ferris, S., Grau, O., Montagnier, L. and Blanchard, A. (1995) Kaposi's sarcoma and new herpesvirus. Lancet. 345, 1043.

    PubMed  CAS  Google Scholar 

  • Collins, L. S., Fowler, A., Tong, C. Y. and de Ruiter, A. (2006) Multicentric Castleman's disease in HIV infection. Int J STD AIDS. 17, 19–24; quiz 25.

    PubMed  CAS  Google Scholar 

  • Cook-Mozaffari, P., Newton, R., Beral, V. and Burkitt, D. P. (1998) The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic. Br J Cancer. 78, 1521–1528.

    PubMed  CAS  Google Scholar 

  • Dagna, L., Broccolo, F., Paties, C. T., Ferrarini, M., Sarmati, L., Praderio, L., Sabbadini, M. G., Lusso, P. and Malnati, M. S. (2005) A relapsing inflammatory syndrome and active human herpesvirus 8 infection. N Engl J Med. 353, 156–163.

    PubMed  CAS  Google Scholar 

  • Davies, J. N. and Lothe, F. (1962) Kaposi's sarcoma in African children. Acta Unio Int Contra Cancrum. 18, 394–399.

    PubMed  CAS  Google Scholar 

  • De Benedetti, F., Pignatti, P., Vivarelli, M., Meazza, C., Ciliberto, G., Savino, R. and Martini, A. (2001) In vivo neutralization of human IL-6 (hIL-6) achieved by immunization of hIL-6-transgenic mice with a hIL-6 receptor antagonist. J Immunol. 166, 4334–4340.

    PubMed  Google Scholar 

  • De Lellis, L., Fabris, M., Cassai, E., Corallini, A., Giraldo, G., Feo, C. and Monini, P. (1995) Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma. J Infect Dis. 172, 1605–1607.

    PubMed  CAS  Google Scholar 

  • De Rosa, G., Barra, E., Guarino, M. and Gentile, R. (1989) Multicentric Castleman's disease in association with Kaposi's sarcoma. Appl Pathol. 7, 105–110.

    PubMed  Google Scholar 

  • Desrosiers, R. C., Sasseville, V. G., Czajak, S. C., Zhang, X., Mansfield, K. G., Kaur, A., Johnson, R. P., Lackner, A. A. and Jung, J. U. (1997) A herpesvirus of rhesus monkeys related to the human Kaposi sarcoma-associated herpesvirus. J Virol. 71, 9764–9769.

    PubMed  CAS  Google Scholar 

  • Dickson, D., Ben-Ezra, J. M., Reed, J., Flax, H. and Janis, R. (1985) Multicentric giant lymph node hyperplasia, Kaposi's sarcoma, and lymphoma. Arch Pathol Lab Med. 109, 1013–1018.

    PubMed  CAS  Google Scholar 

  • Dorfman, R. F. (1988) Kaposi's sarcoma: evidence supporting its origin from the lymphatic system. Lymphology. 21, 45–52.

    PubMed  CAS  Google Scholar 

  • Du, M. Q., Diss, T. C., Liu, H., Ye, H., Hamoudi, R. A., Cabecadas, J., Dong, H. Y., Harris, N. L., Chan, J. K., Rees, J. W., Dogan, A. and Isaacson, P. G. (2002) KSHV- and EBV-associated germinotropic lymphoproliferative disorder. Blood. 100, 3415–3418.

    PubMed  CAS  Google Scholar 

  • Du, M. Q., Liu, H., Diss, T. C., Ye, H., Hamoudi, R. A., Dupin, N., Meignin, V., Oksenhendler, E., Boshoff, C. and Isaacson, P. G. (2001) Kaposi sarcoma-associated herpesvirus infects monotypic (IgMlambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood. 97, 2130–2136.

    PubMed  CAS  Google Scholar 

  • Dupin, N., Diss, T. L., Kellam, P., Tulliez, M., Du, M. Q., Sicard, D., Weiss, R. A., Isaacson, P. G. and Boshoff, C. (2000) HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood. 95, 1406–1412.

    PubMed  CAS  Google Scholar 

  • Dupin, N., Grandadam, M., Calvez, V., Gorin, I., Aubin, J. T., Harvard, S., Lamy, F., Leibowitch, M., Huraux, J. M., Escande, J. P. and Agut, H. (1995) Herpesvirus-like DNA in patients with Mediterranean Kaposi's sarcoma. Lancet. 345, 761–762.

    PubMed  CAS  Google Scholar 

  • Eltom, M. A., Jemal, A., Mbulaiteye, S. M., Devesa, S. S. and Biggar, R. J. (2002) Trends in Kaposi's sarcoma and non-Hodgkin's lymphoma incidence in the United States from 1973 through 1998. J Natl Cancer Inst. 94, 1204–1210.

    PubMed  Google Scholar 

  • Ensoli, B., Barillari, G. and Gallo, R. C. (1992) Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma. Immunol Rev. 127, 147–155.

    PubMed  CAS  Google Scholar 

  • Ensoli, B., Barillari, G., Salahuddin, S. Z., Gallo, R. C. and Wong, S. F. (1990) Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature. 345, 84–86.

    PubMed  CAS  Google Scholar 

  • Eto, H., Kamidigo, N. O., Murakami, M. K., Nakamura, S., Toriyama, K. and Itakura, H. (1996) Short report: herpes-like DNA sequences in African-endemic and acquired immunodeficiency syndrome-associated Kaposi's sarcoma. Am J Trop Med Hyg. 55, 405–406.

    PubMed  CAS  Google Scholar 

  • Fan, W., Bubman, D., Chadburn, A., Harrington, W. J., Jr., Cesarman, E. and Knowles, D. M. (2005) Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J Virol. 79, 1244–1251.

    PubMed  CAS  Google Scholar 

  • Flamand, L., Zeman, R. A., Bryant, J. L., Lunardi, I. Y. and Gallo, R. C. (1996) Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines. J Acquir Immune Defic Syndr Hum Retrovirol. 13, 194–197.

    PubMed  CAS  Google Scholar 

  • Foreman, K. E., Friborg, J. J., Kong, W. P., Woffendin, C., Polverini, P. J., Nickoloff, B. J. and Nabel, G. J. (1997) Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. New Engl J Med. 336, 163–171.

    PubMed  CAS  Google Scholar 

  • Frizzera, G. (1988) Castleman's disease and related disorders. Semin Diagn Pathol. 5, 346–364.

    PubMed  CAS  Google Scholar 

  • Frizzera, G., Banks, P. M., Massarelli, G. and Rosai, J. (1983) A systemic lymphoproliferative disorder with morphologic features of Castleman's disease. Pathological findings in 15 patients. Am J Surg Pathol. 7, 211–231.

    CAS  Google Scholar 

  • Frizzera, G., Peterson, B. A., Bayrd, E. D. and Goldman, A. (1985) A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol. 3, 1202–1216.

    PubMed  CAS  Google Scholar 

  • Gaidano, G., Capello, D., Cilia, A. M., Gloghini, A., Perin, T., Quattrone, S., Migliazza, A., Lo Coco, F., Saglio, G., Ascoli, V. and Carbone, A. (1999) Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: implications for disease pathogenesis and histogenesis. Genes Chromosomes Cancer. 24, 16–23.

    PubMed  CAS  Google Scholar 

  • Gao, S.-J., Kingsley, L., Hoover, D. R., Spira, T. J., Rinaldo, C. R., Saah, A., Phair, J., Detels, R., Parry, P., Chang, Y. and Moore, P. S. (1996) Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. New Engl J Med. 335, 233–241.

    PubMed  CAS  Google Scholar 

  • Gao, S. J., Kingsley, L., Li, M., Zheng, W., Parravicini, C., Ziegler, J., Newton, R., Rinaldo, C. R., Saah, A., Phair, J., Detels, R., Chang, Y. and Moore, P. S. (1996) KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med. 2, 925–928.

    PubMed  CAS  Google Scholar 

  • Giraldo, G., Beth, E. and Haguenau, F. (1972) Herpes-type particles in tissue culture of Kaposi's sarcoma from different geographic regions. J Natl Cancer Inst. 49, 1509.

    PubMed  CAS  Google Scholar 

  • Giraldo, G., Kourilsky, F. M., Henle, W., Mike, V., Huraux, J. M., Andersen, H. K., Gharbi, M. R., Kyalwazi, S. K. and Puissant, A. (1975) Antibody patterns to herpesviruses in Kaposi's sarcoma: serological association of European Kaposi's sarcoma with cytomegalovirus. Int J Cancer. 15, 839–848.

    PubMed  CAS  Google Scholar 

  • Harwood, A. R., Osoba, D. and Hofstader, S. L. (1979) Kaposi's sarcoma in recipients of renal transplants. Am J Med. 67, 759–765.

    PubMed  CAS  Google Scholar 

  • Haverkos, H. W. and Curran, J. W. (1982) The current outbreak of Kaposi's sarcoma and opportunistic infections. CA Cancer J Clin. 32, 330–339.

    PubMed  CAS  Google Scholar 

  • Haverkos, H. W., Kopstein, A. N., Wilson, H. and Drotman, P. (1994) Nitrite inhalants: history, epidemiology, and possible links to AIDS. Environ Health Perspect. 102, 858–861.

    PubMed  CAS  Google Scholar 

  • Hayward, G. S. (1999) KSHV strains: the origins and global spread of the virus. Semin Cancer Biol. 9, 187–199.

    PubMed  CAS  Google Scholar 

  • Hill, A. B. (1965) Environment and disease: association or causation ? Proc R Soc Med. 58, 295–300.

    Google Scholar 

  • Hladik, W., Dollard, S. C., Mermin, J., Fowlkes, A. L., Downing, R., Amin, M. M., Banage, F., Nzaro, E., Kataaha, P., Dondero, T. J., Pellett, P. E. and Lackritz, E. M. (2006) Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med. 355, 1331–1338.

    PubMed  CAS  Google Scholar 

  • Hocqueloux, L., Agbalika, F., Oksenhendler, E. and Molina, J. M. (2001) Long-term remission of an AIDS-related primary effusion lymphoma with antiviral therapy. Aids. 15, 280–282.

    PubMed  CAS  Google Scholar 

  • Holubar, K. and Fatovic-Ferencic, S. (2001) 2002, a hundred years after Kaposi – a post-holocaust coup d'oeuil of Vienna's Jewish heritage in dermatology. J Invest Dermatol. 117, 1329–1330.

    PubMed  CAS  Google Scholar 

  • Holubar, K. and Frankl, J. (1981) Moriz (Kohn) Kaposi. Am J Dermatopathol. 3, 349–354.

    PubMed  CAS  Google Scholar 

  • IARC Working Group (1997) Proceedings of the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus/Human Herpesvirus 8. Lyon, France, 17–24 June 1997. IARC Monogr Eval Carcinog Risks Hum. 70, 1–492.

    Google Scholar 

  • International Collaboration on HIV and Cancer (2000) Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J Natl Cancer Inst. 92, 1823–1830.

    Google Scholar 

  • Jaffe, H. W., Choi, K., Thomas, P. A. and et al. (1983) National case-control study of Kaposi's sarcoma and pneumocystis carinii pneumonia in homosexual men. I. Epidemiologic results. Ann Intern Med. 99, 145–151.

    CAS  Google Scholar 

  • Janier, M., Morel, P. and Civatte, J. (1990) The Koebner phenomenon in AIDS-related Kaposi's sarcoma. J Am Acad Dermatol. 22, 125–126.

    PubMed  CAS  Google Scholar 

  • Judde, J. G., Lacoste, V., Briere, J., Kassa-Kelembho, E., Clyti, E., Couppie, P., Buchrieser, C., Tulliez, M., Morvan, J. and Gessain, A. (2000) Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases. J Natl Cancer Inst. 92, 729–736.

    PubMed  CAS  Google Scholar 

  • Jung, C. P., Horster, S., Lohse, P., Bogner, J. R., Emmerich, B. and Goebel, F. D. (2003) Uncommon hematologic malignancies. Case 1. Plasmablastic leukemia in HIV-associated multicentric Castleman's disease. J Clin Oncol. 21, 4248–4249.

    Google Scholar 

  • Kamiyama, K., Kinjo, T., Chinen, K., Iwamasa, T., Uezato, H., Miyagi, J. I., Mori, N. and Yamane, N. (2004) Human herpesvirus 8 (HHV8) sequence variations in HHV8 related tumours in Okinawa, a subtropical island in southern Japan. J Clin Pathol. 57, 529–535.

    PubMed  CAS  Google Scholar 

  • Kaposi, M. (1872) Idiopathic multiple pigmented sarcoma of the skin. English translation CA 1982; 32, 342–347. 4, 265–273 English translation in CA: A Cancer Journal for Clinicians, New York, 1982; 1, 1342–1347.

    Google Scholar 

  • Katano, H., Sato, Y., Kurata, T., Mori, S. and Sata, T. (2000) Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology. 269, 335–344.

    PubMed  CAS  Google Scholar 

  • Kedes, D. H., Lagunoff, M., Renne, R. and Ganem, D. (1997) Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest. 100, 2606–2610.

    PubMed  CAS  Google Scholar 

  • Kedes, D. H., Operskalski, E., Busch, M., Kohn, R., Flood, J. and Ganem, D. (1996) The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med. 2, 918–924.

    PubMed  CAS  Google Scholar 

  • Kellam, P., Boshoff, C., Whitby, D., Matthews, S., Weiss, R. A. and Talbot, S. J. (1997) Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome. J Hum Virol. 1, 19–29.

    PubMed  CAS  Google Scholar 

  • Keller, A. R., Hochholzer, L. and Castleman, B. (1972) Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 29, 670–683.

    PubMed  CAS  Google Scholar 

  • Kessler, E. (1985) Multicentric giant lymph node hyperplasia. A report of seven cases. Cancer. 56, 2446–2451.

    CAS  Google Scholar 

  • Klein, U., Gloghini, A., Gaidano, G., Chadburn, A., Cesarman, E., Dalla-Favera, R. and Carbone, A. (2003) Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood. 101, 4115–4121.

    PubMed  CAS  Google Scholar 

  • Knowles, D. M., Inghirami, G., Ubriaco, A. and Dalla-Favera, R. (1989) Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of Epstein-Barr virus. Blood. 73, 792–799.

    PubMed  CAS  Google Scholar 

  • Lacoste, V., Mauclere, P., Dubreuil, G., Lewis, J., Georges-Courbot, M. C. and Gessain, A. (2000) KSHV-like herpesviruses in chimps and gorillas. Nature. 407, 151–152.

    PubMed  CAS  Google Scholar 

  • Lennette, E. T., Blackbourn, D. J. and Levy, J. A. (1996) Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet. 348, 858–861.

    PubMed  CAS  Google Scholar 

  • Levy, J. A. (1995) A new human herpesvirus: KSHV or HHV8? [comment]. Lancet. 346, 8978.

    Google Scholar 

  • Levy, J. A. and Ziegler, J. L. (1983) Acquired immunodeficiency syndrome is an opportunistic infection and Kaposi's sarcoma results from secondary immune stimulation. Lancet. 2, 78–81.

    PubMed  CAS  Google Scholar 

  • Li, C. F., Ye, H., Liu, H., Du, M. Q. and Chuang, S. S. (2006) Fatal HHV-8-associated hemophagocytic syndrome in an HIV-negative immunocompetent patient with plasmablastic variant of multicentric Castleman disease (plasmablastic microlymphoma). Am J Surg Pathol. 30, 123–127.

    PubMed  Google Scholar 

  • Lisitsyn, N., Lisitsyn, N. and Wigler, M. (1993) Cloning the differences between two complex genomes. Science. 259, 946–951.

    PubMed  CAS  Google Scholar 

  • Luppi, M., Barozzi, P., Schulz, T. F., Setti, G., Staskus, K., Trovato, R., Narni, F., Donelli, A., Maiorana, A., Marasca, R., Sandrini, S. and Torelli, G. (2000) Bone marrow failure associated with human herpesvirus 8 infection after transplantation. N Engl J Med. 343, 1378–1385.

    PubMed  CAS  Google Scholar 

  • Mandel, C., Silberstein, M. and Hennessy, O. (1993) Case report: fatal pulmonary Kaposi's sarcoma and Castleman's disease in a renal transplant recipient. Br J Radiol. 66, 264–265.

    PubMed  CAS  Google Scholar 

  • Marcelin, A. G., Aaron, L., Mateus, C., Gyan, E., Gorin, I., Viard, J. P., Calvez, V. and Dupin, N. (2003) Rituximab therapy for HIV-associated Castleman disease. Blood. 102, 2786–2788.

    PubMed  CAS  Google Scholar 

  • Martin, D. F., Kuppermann, B. D., Wolitz, R. A., Palestine, A. G., Li, H. and Robinson, C. A. (1999) Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. N Engl J Med. 340, 1063–1070.

    PubMed  CAS  Google Scholar 

  • Matsushima, A. Y., Strauchen, J. A., Lee, G., Scigliano, E., Hale, E. E., Weisse, M. T., Burstein, D., Kamel, O., Moore, P. S. and Chang, Y. (1999) Posttransplantation plasmacytic proliferations related to Kaposi's sarcoma-associated herpesvirus. Am J Surg Pathol. 23, 1393–1400.

    PubMed  CAS  Google Scholar 

  • Mendez, J. C. and Paya, C. V. (2000) Kaposi's Sarcoma and Transplantation. Herpes. 7, 18–23.

    PubMed  Google Scholar 

  • Miles, S. A., Martinez, M. O., Rezai, A., Magpantay, L., Kishimoto, T., Nakamura, S., Radka, S. F. and Linsley, P. S. (1992) Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science. 255, 1432–1434.

    PubMed  CAS  Google Scholar 

  • Miller, G., Rigsby, M. O., Heston, L., Grogan, E., Sun, R., Metroka, C., Levy, J. A., Gao, S. J., Chang, Y. and Moore, P. (1996) Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. New Engl J Med. 334, 1292–1297.

    PubMed  CAS  Google Scholar 

  • Molden, J., Chang, Y., You, Y., Moore, P. S. and Goldsmith, M. A. (1997) A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J Biol Chem. 272, 19625–19631.

    PubMed  CAS  Google Scholar 

  • Moore, P. S. (2000) The emergence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). N Engl J Med. 343, 1411–1413.

    PubMed  CAS  Google Scholar 

  • Moore, P. S., Boshoff, C., Weiss, R. A. and Chang, Y. (1996) Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science. 274, 1739–1744.

    PubMed  CAS  Google Scholar 

  • Moore, P. S. and Chang, Y. (1995) Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma lesions from persons with and without HIV infection. New Engl J Med. 332, 1181–1185.

    PubMed  CAS  Google Scholar 

  • Moore, P. S. and Chang, Y. (2001) Molecular virology of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci. 356, 499–516.

    PubMed  CAS  Google Scholar 

  • Moore, P. S., Gao, S. J., Dominguez, G., Cesarman, E., Lungu, O., Knowles, D. M., Garber, R., Pellett, P. E., McGeoch, D. J. and Chang, Y. (1996) Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J Virol. 70, 549–558.

    PubMed  CAS  Google Scholar 

  • Moore, P. S., Kingsley, L. A., Holmberg, S. D., Spira, T., Gupta, P., Hoover, D. R., Parry, J. P., Conley, L. J., Jaffe, H. W. and Chang, Y. (1996) Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma. AIDS. 10, 175–180.

    PubMed  CAS  Google Scholar 

  • Murgia, C., Pritchard, J. K., Kim, S. Y., Fassati, A. and Weiss, R. A. (2006) Clonal origin and evolution of a transmissible cancer. Cell. 126, 477–487.

    PubMed  CAS  Google Scholar 

  • Nador, R. G., Cesarman, E., Chadburn, A., Dawson, D. B., Ansari, M. Q., Sald, J. and Knowles, D. M. (1996) Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood. 88, 645–656.

    PubMed  CAS  Google Scholar 

  • Nair, B. C., DeVico, A. L., Nakamura, S., Copeland, T. D., Chen, Y., Patel, A., O'Neil, T., Oroszlan, S., Gallo, R. C. and Sarngadharan, M. G. (1992) Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. Science. 255, 1430–1432.

    PubMed  CAS  Google Scholar 

  • Neipel, F., Albrecht, J. C., Ensser, A., Huang, Y. Q., Li, J. J., Friedman, K. A. and Fleckenstein, B. (1997) Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol. 71, 839–842.

    PubMed  CAS  Google Scholar 

  • Newsom-Davis, T., Bower, M., Wildfire, A., Thirlwell, C., Nelson, M., Gazzard, B. and Stebbing, J. (2004) Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels. Leuk Lymphoma. 45, 1939–1941.

    PubMed  Google Scholar 

  • Nicholas, J., Ruvolo, V. R., Burns, W. H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S. B., Guo, H. G., Hayward, G. S. and Reitz, M. S. (1997) Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat Med. 3, 287–292.

    PubMed  CAS  Google Scholar 

  • Nishimoto, N., Kanakura, Y., Aozasa, K., Johkoh, T., Nakamura, M., Nakano, S., Nakano, N., Ikeda, Y., Sasaki, T., Nishioka, K., Hara, M., Taguchi, H., Kimura, Y., Kato, Y., Asaoku, H., Kumagai, S., Kodama, F., Nakahara, H., Hagihara, K., Yoshizaki, K. and Kishimoto, T. (2005) Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood. 106, 2627–2632.

    PubMed  CAS  Google Scholar 

  • Nishimoto, N., Sasai, M., Shima, Y., Nakagawa, M., Matsumoto, T., Shirai, T., Kishimoto, T. and Yoshizaki, K. (2000) Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood. 95, 56–61.

    PubMed  CAS  Google Scholar 

  • Oksenhendler, E., Boulanger, E., Galicier, L., Du, M. Q., Dupin, N., Diss, T. C., Hamoudi, R., Daniel, M. T., Agbalika, F., Boshoff, C., Clauvel, J. P., Isaacson, P. G. and Meignin, V. (2002) High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood. 99, 2331–2336.

    PubMed  CAS  Google Scholar 

  • Oksenhendler, E., Carcelain, G., Aoki, Y., Boulanger, E., Maillard, A., Clauvel, J. P. and Agbalika, F. (2000) High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients. Blood. 96, 2069–2073.

    PubMed  CAS  Google Scholar 

  • Oksenhendler, E., Clauvel, J. P., Jouveshomme, S., Davi, F. and Mansour, G. (1998) Complete remission of a primary effusion lymphoma with antiretroviral therapy. Am J Hematol. 57, 266.

    Google Scholar 

  • Oksenhendler, E., Duarte, M., Soulier, J., Cacoub, P., Welker, Y., Cadranel, J., Cazals, H. D., Autran, B., Clauvel, J. P. and Raphael, M. (1996) Multicentric Castleman's disease in HIV infection: a clinical and pathological study of 20 patients. AIDS. 10, 61–67.

    PubMed  CAS  Google Scholar 

  • Osborne, J., Moore, P. S. and Chang, Y. (1999) KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways. Hum Immunol. 60, 921–927.

    PubMed  CAS  Google Scholar 

  • Parravicini, C., Chandran, B., Corbellino, M., Berti, E., Paulli, M., Moore, P. S. and Chang, Y. (2000) Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol. 156, 743–749.

    PubMed  CAS  Google Scholar 

  • Parravicini, C., Corbellino, M., Paulli, M., Magrini, U., Lazzarino, M., Moore, P. S. and Chang, Y. (1997) Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease. Am J Pathol. 151, 1517–1522.

    PubMed  CAS  Google Scholar 

  • Parravicini, C., Olsen, S. J., Capra, M., Poli, F., Sirchia, G., Gao, S.-J., Berti, E., Nocera, A., Rossi, E., Bestetti, G., Pizzuto, M., Galli, M., Moroni, M., Moore, P. S. and Corbellino, M. (1997) Risk of Kaposi's sarcoma-associated herpesvirus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Blood. 90, 2826–2829.

    PubMed  CAS  Google Scholar 

  • Pellett, P. E., Wright, D. J., Engels, E. A., Ablashi, D. V., Dollard, S. C., Forghani, B., Glynn, S. A., Goedert, J. J., Jenkins, F. J., Lee, T. H., Neipel, F., Todd, D. S., Whitby, D., Nemo, G. J. and Busch, M. P. (2003) Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion. 43, 1260–1268.

    PubMed  CAS  Google Scholar 

  • Penn, I. (1979) Kaposi's sarcoma in organ transplant recipients: report of 20 cases. Transplantation. 27, 8–11.

    PubMed  CAS  Google Scholar 

  • Platt, G., Carbone, A. and Mittnacht, S. (2002) p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma. Oncogene. 21, 1823–1831.

    PubMed  CAS  Google Scholar 

  • Rainbow, L., Platt, G. M., Simpson, G. R., Sarid, R., Gao, S. J., Stoiber, H., Herrington, C. S., Moore, P. S. and Schulz, T. F. (1997) The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol. 71, 5915–5921.

    PubMed  CAS  Google Scholar 

  • Renne, R., Lagunoff, M., Zhong, W. and Ganem, D. (1996) The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol. 70, 8151–8154.

    PubMed  CAS  Google Scholar 

  • Renne, R., Zhong, W., Herndier, B., McGrath, M., Abbey, N., Kedes, D. and Ganem, D. (1996) Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med. 2, 342–346.

    PubMed  CAS  Google Scholar 

  • Rose, T. M., Strand, K. B., Schultz, E. R., Schaefer, G., Rankin, G. J., Thouless, M. E., Tsai, C. C. and Bosch, M. L. (1997) Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol. 71, 4138–4144.

    PubMed  CAS  Google Scholar 

  • Russo, J. J., Bohenzky, R. A., Chien, M. C., Chen, J., Yan, M., Maddalena, D., Parry, J. P., Peruzzi, D., Edelman, I. S., Chang, Y. and Moore, P. S. (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A. 93, 14862–14867.

    Google Scholar 

  • Rywlin, A. M., Rosen, L. and Cabello, B. (1983) Coexistence of Castleman's disease and Kaposi's sarcoma. Report of a case and a speculation. Am J Dermatopathol. 5, 277–281.

    CAS  Google Scholar 

  • Sarid, R., Olsen, S. J. and Moore, P. S. (1999) Kaposi's sarcoma-associated herpesvirus: epidemiology, virology and molecular biology. Adv Virus Res. 52, 139–232.

    PubMed  CAS  Google Scholar 

  • Schalling, M., Ekman, M., Kaaya, E. E., Linde, A. and Biberfeld, P. (1995) A role for a new herpesvirus (KSHV) in different forms of Kaposi's sarcoma. Nat Med. 1, 707–708.

    PubMed  CAS  Google Scholar 

  • Seckin, D., Ozcan, G., Demirag, A., Hizel, N. and Haberal, M. (1998) The Koebner phenomenon in Kaposi's sarcoma in a renal transplant recipient [letter]. Br J Dermatol. 139, 346–348.

    PubMed  CAS  Google Scholar 

  • Simpson, G. R., Schulz, T. F., Whitby, D., Cook, P. M., Boshoff, C., Rainbow, L., Howard, M. R., Gao, S. J., Bohenzky, R. A., Simmonds, P., Lee, C., de Ruiter, A., Hatzakis, A., Tedder, R. S., Weller, I. V., Weiss, R. A. and Moore, P. S. (1996) Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet. 348, 1133–1138.

    PubMed  CAS  Google Scholar 

  • Soulier, J., Grollet, L., Oksenhendler, E., Cacoub, P., Cazals-Hatem, D., Babinet, P., d'Agay, M.-F., Clauvel, J.-P., Raphael, M., Degos, L. and Sigaux, F. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 86, 1276–1280.

    PubMed  CAS  Google Scholar 

  • Strauchen, J. A., Hauser, A. D., Burstein, D. A., Jiminez, R., Moore, P. S. and Chang, Y. (1996) Body cavity-based malignant lymphoma containing Kaposi sarcoma-associated herpesvirus in an HIV-negative man with previous Kaposi Sarcoma. Ann Intern Med. 125, 822–825.

    PubMed  CAS  Google Scholar 

  • Su, I.-J., Hsu, Y.-S., Chang, Y.-C. and Wang, I.-W. (1995) Herpesvirus-like DNA sequence in Kaposi's sarcoma from AIDS and non-AIDS patients in Taiwan. Lancet. 345, 722–723.

    PubMed  CAS  Google Scholar 

  • Wabinga, H. R., Parkin, D. M., Wabwire-Mangen, F. and Mugerwa, J. (1993) Cancer in Kampala, Uganda, in 1989–91: changes in incidence in the era of AIDS. Int J Cancer. 54, 5–22.

    Google Scholar 

  • Wabinga, H. R., Parkin, D. M., Wabwire-Mangen, F. and Mugerwa, J. W. (1993) Cancer in Kampala, Uganda, in 1989–91: changes in incidence in the era of AIDS. Int J Cancer. 54, 26–36.

    PubMed  CAS  Google Scholar 

  • Walter, P. R., Philippe, E., Nguemby-Mbina, C. and Chamlian, A. (1984) Kaposi's sarcoma: presence of herpes-type particles in a tumor specimen. Hum Pathol. 15, 1145–1146.

    PubMed  CAS  Google Scholar 

  • Whitby, D., Howard, M. R., Tenant-Flowers, M., Brink, N. S., Copas, A., Boshoff, C., Hatziouannou, T., Suggett, F. E. A., Aldam, D. M., Denton, A. S., Miller, R. F., Weller, I. V. D., Weiss, R. A., Tedder, R. S. and Schulz, T. F. (1995) Detection of Kaposi's sarcoma-associated herpesvirus (KSHV) in peripheral blood of HIV-infected individuals predicts progression to Kaposi's sarcoma. Lancet. 364, 799–802.

    Google Scholar 

  • Wilson, K. S., McKenna, R. W., Kroft, S. H., Dawson, D. B., Ansari, Q. and Schneider, N. R. (2002) Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities. Br J Haematol. 116, 113–121.

    PubMed  Google Scholar 

  • Wood, R. D., Robins, P. and Lindahl, T. (1988) Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell. 53, 97–106.

    PubMed  CAS  Google Scholar 

  • Yoshizaki, K., Matsuda, T., Nishimoto, N., Kuritani, T., Taeho, L., Aozasa, K., Nakahata, T., Kawai, H., Tagoh, H., Komori, T., Kishimoto, S., Hirano, T. and Kishimoto, T. (1989) Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood. 74, 1360–1367.

    PubMed  CAS  Google Scholar 

  • Zhong, W., Wang, H., Herndier, B. and Ganem, D. (1996) Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A. 93, 6641–6646.

    Google Scholar 

  • Ziegler, J. L. and Katongole-Mbidde, E. (1996) Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and relationship to HIV infection. Int J Cancer. 65, 200–203.

    PubMed  CAS  Google Scholar 

  • Zong, J., Ciufo, D. M., Viscidi, R., Alagiozoglou, L., Tyring, S., Rady, P., Orenstein, J., Boto, W., Kalumbuja, H., Romano, N., Melbye, M., Kang, G. H., Boshoff, C. and Hayward, G. S. (2002) Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism. J Clin Virol. 23, 119–148.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA

    Patrick S. Moore

  2. Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA

    Yuan Chang

Authors
  1. Patrick S. Moore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuan Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Patrick S. Moore .

Editor information

Editors and Affiliations

  1. University of North Carolina Chapel Hill, NC, USA

    Blossom Damania

  2. University of Pittsburgh Pittsburgh, PA, USA

    James M. Pipas

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science + Business Media, LLC

About this chapter

Cite this chapter

Moore, P.S., Chang, Y. (2009). Introduction to Diseases Associated with Kaposi’s Sarcoma-Associated Herpesvirus. In: Damania, B., Pipas, J.M. (eds) DNA Tumor Viruses. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68945-6_18

Download citation

Publish with us

Policies and ethics

Search

Navigation