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EBV Immunotherapy

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Abstract

Epstein–Barr virus (EBV) is associated with a range of malignancies including Burkitt’s lymphoma (BL), Hodgkin’s disease (HD), nasopharyngeal carcinoma (NPC), and lymphoproliferative disease (LPD), and EBV proteins expressed in these malignancies provide targets for cytotoxic T lymphocytes (CTL). Adoptive immunotherapy with ex vivo-generated EBV-specific CTLs has proven safe and effective as prophylaxis and treatment for EBV-driven lymphoproliferative disease after hematopoietic stem cell transplant. EBV-specific CTLs have also shown promise as therapy for other EBV-associated malignancies, but genetic manipulation of the CTL to circumvent immune evasion strategies employed by tumors may be required before CTLs can reliably eliminate tumors in immunocompetent individuals.

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  1. Departments of Pediatrics; Immunology; and Virology; Baylor College of Medicience, The Methodist Hospital and Texas Children’s Hospital, Houston, TX 77030, USA

    Cliona M. Rooney

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  1. Leslie E. Huye
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  1. University of North Carolina Chapel Hill, NC, USA

    Blossom Damania

  2. University of Pittsburgh Pittsburgh, PA, USA

    James M. Pipas

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Huye, L.E., Rooney, C.M. (2009). EBV Immunotherapy. In: Damania, B., Pipas, J.M. (eds) DNA Tumor Viruses. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68945-6_16

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