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EBV Diseases

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DNA Tumor Viruses

Abstract

Epstein-Barr Virus, the first human tumor virus, also causes infectious mononucleosis and hairy leukoplakia. How the same virus can cause both malignant and benign conditions is best understood through the pathogenesis of EBV infection. The virus was discovered in 1962 in African Burkitt s lymphoma; however, the basic molecular lesions in all BL, EBV-negative or positive are chromosomal translocations that activate c-myc. EBV causes immunoblastic B-cell lymphomas and is associated with Hodgkin s lymphomas. Monoclonal EBV episomes are universally present in the distinctive epithelial malignancy, nasopharyngeal carcinoma, and in parotid tumors, but only a subset of gastric tumors. Other associations, NK/T-cell lymphomas, some breast cancers, and leiomyosarcoma, are inconsistent and obscure pathobiologically. Vaccines to prevent infection and regimens to treat IM remain under development. However, exploiting virus-specific features of the EBV malignancies therapeutically is showing progress while at the same time illuminating the biology of cancer cells and their genesis.

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  1. Lineberger Comprehensive Cancer Center, University of the North Carolina, Chapel Hill, NC 27599, USA

    Joseph S. Pagano

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  1. Joseph S. Pagano
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Correspondence to Joseph S. Pagano .

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  1. University of North Carolina Chapel Hill, NC, USA

    Blossom Damania

  2. University of Pittsburgh Pittsburgh, PA, USA

    James M. Pipas

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© 2009 Springer Science + Business Media, LLC

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Pagano, J.S. (2009). EBV Diseases. In: Damania, B., Pipas, J.M. (eds) DNA Tumor Viruses. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68945-6_10

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