Skip to main content
SpringerLink
Log in

Affektive Störungen — Neurobiologie

  • Chapter
Neurobiologie psychischer Störungen

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Angst J (1986) Verlauf und Ausgang affektiver und schizoaffektiver Erkrankungen. In: Huber G (Hrsg) Zyklothymie. Tropon (Band 41), Köln

    Google Scholar 

  • Arregui A, Mackay AV, Spokes EG, Iversen LL (1980) Reduced activity of angiotensin-converting enzyme in basal ganglia in early onset schizophrenia. Psychol Med 10: 307–313

    Article  CAS  PubMed  Google Scholar 

  • Ariyo AA, Haan M, Tangen CM, Rutledge JC, Cushman M, Dobs A, Furberg CD (2000) Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Circulation 102: 1773–1779

    Article  CAS  PubMed  Google Scholar 

  • Baghai, TC, Schule C, Zwanzger P et al (2001) Possible in uence of the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene on therapeutic outcome in affective disorders. Mol Psychiatry 6: 258–259

    Article  CAS  PubMed  Google Scholar 

  • Bardelay C, Mach E, Worcel M, Hunt P (1989) Angiotensin-converting enzyme in rat brain and extraneural tissues visualized by quantitative autoradiography using 3H trandolaprilate. J Cardiovasc Pharmacol 14: 511–518

    Article  CAS  PubMed  Google Scholar 

  • Bardeleben U von, Stalla GK, Müller OA, Holsboer F (1988) Blunting of corticotropin response to corticotropin-releasing hormone in depressed patients is avoided by metyrapone pretreatment. Biol Psychiatry 24: 782–786

    Article  Google Scholar 

  • Baulieu EE (1996) Dehydroepiandrosterone (DHEA): a fountain of youth? J Clin Endocrinol Metab 81: 3147–3151

    Article  CAS  PubMed  Google Scholar 

  • Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN (1994): Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry 51: 687–697

    Article  CAS  PubMed  Google Scholar 

  • Berghöfer A, Kossmann B, Müller-Oerlinghausen B (1996) Course of illness and pattern of recurrence in patients with affective disorders during longterm lithium prophylaxis. A retrospective analysis over 15 years. Acta Psychiatr Scand 93: 349–354

    Article  PubMed  Google Scholar 

  • Berman RM, Sanacora G, Anand A et al (2002) Monoamine depletion in unmedicated depressed subjects. Biol Psychiatry 51: 469–473

    Article  CAS  PubMed  Google Scholar 

  • Berman RM, Narasimhan M, Miller HL et al (1999) Transient depressive relapse induced by catecholamine depletion: potential phenotypic vulnerability marker? Arch Gen Psychiatry 56: 395–403

    Article  CAS  PubMed  Google Scholar 

  • Berridge KC, Robinson TE (2003) Parsing reward. Trends Neurosci 26: 507–513

    Article  CAS  PubMed  Google Scholar 

  • Blier P, Montigny C (1994): Current advances and trends in the treatment of depression. Trends Pharmacol 15: 220–225

    Article  CAS  Google Scholar 

  • Boland RJ, Keller MB (2002) Course and outcome of depression. In: Gotlib IH, Hammen CL (eds) Handbook of depression. Guilford, New York, pp 43–60

    Google Scholar 

  • Bondy B, Baghai TC, Zill P et al (2002) Combined action of the ACE D-and the G-protein β-3 T-allele in major depression: a possible link to cardiovascular disease? Mol Psychiatry 7: 1120–1126

    Article  CAS  PubMed  Google Scholar 

  • Bondy B, Baghai TC, Minov C et al (2003) Substance P serum levels are increased in major depression: preliminary results. Biol Psychiatry 53: 538–542

    Article  CAS  PubMed  Google Scholar 

  • Brodin E, Ogren SO, Theodorsson-Norheim E (1987) Effects of subchronic treatment with imipramine, zimelidine and alaproclate on regional tissue levels of substance P-and neurokinin A/neurokinin B-like immunoreactivity in the brain and spinal cord of the rat. Neuropharmacology 26: 581–590

    Article  CAS  PubMed  Google Scholar 

  • Bronisch T (2003) Suizidalität. In: Möller HJ, Laux G, Kapfhammer HP (Hrsg) Psychiatrie und Psychotherapie, 2 Aufl. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Bronisch T, Felber W, Wolfersdorf M (Hrsg) (2001) Neurobiologie suizidalen Verhaltens. Roderer, Regensburg

    Google Scholar 

  • Cuijpers P, Smit F (2004) Subthreshold depression as a risk indicator for major depressive disorder: A systematic review of prospective studies. Acta Psychiatr Scand 109: 325–331

    Article  CAS  PubMed  Google Scholar 

  • de Jong-Meyer R, Hautzinger M, Kühner C, Schramm E (2005) Psychotherapie der Depression. Behandlungsleitlinien erstellt im Auftrag der Fachgruppe Klinische Psychologie und Psychotherapie in der Deutschen Gesellschaft für Psychologie. www.klinische-psychologie-psychotherapie.de

    Google Scholar 

  • Demling J (1996) Neurobiochemie suizidalen Verhaltens. In: Wolfersdorf M, Kaschka P (Hrsg) Suizidalität — Die biologische Dimension. Springer, Berlin Heidelberg New York, S 47–72

    Chapter  Google Scholar 

  • Duman RS, Heninger GR, Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54: 597–606

    Article  CAS  PubMed  Google Scholar 

  • Duman RS, Malberg J, Nakagawa S, D’Sa C (2000) Neuronal plasticity and survival in mood disorder. Biol Psychiatry 48: 732–739

    Article  CAS  PubMed  Google Scholar 

  • Dunn AJ, Berridge CW (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Rev 15: 71–100

    Article  CAS  PubMed  Google Scholar 

  • Earle BV (1970) Thyroid hormone and tricyclic antidepressants in resistant depressions. Am J Psychiatry 126: 143–145

    Article  Google Scholar 

  • Ebert D, Lammers CH (1997) Das zentrale dopaminerge System und die Depression. Nervenarzt 68: 545–555

    Article  CAS  PubMed  Google Scholar 

  • Eisensamer B, Rammes G, Gimpl G et al (2003) Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Mol Psychiatry 8: 994–1007

    Article  CAS  PubMed  Google Scholar 

  • Ellenbogen MA, Young SN, Dean P, Palmour RM, Benkelfat C (1996) Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology 15: 465–474

    Article  CAS  PubMed  Google Scholar 

  • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889–895

    Article  CAS  PubMed  Google Scholar 

  • Förstl H, Burns A, Luthert P, Cairns N, Lantos P, Levy R (1992) Clinical and neuropathological correlates of depression in Alzheimer’s disease. Psychol Med 22(4): 877–884

    Article  PubMed  Google Scholar 

  • Frodl T, Meisenzahl EM, Zetzsche T et al (2002) Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry 159: 1112–1118

    Article  PubMed  Google Scholar 

  • Frodl T, Meisenzahl E, Zill P et al (2004a) Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression. Arch Gen Psychiatry 61: 177–183

    Article  CAS  PubMed  Google Scholar 

  • Frodl T, Meisenzahl EM, Zetzsche T et al (2004b) Hippocampal and amygdale changes in patients with major depression and healthy controls during a one-year follow-up. J Clin Psychiatry 65:492–499

    Article  PubMed  Google Scholar 

  • Gallinat J, Bottlender R, Juckel G et al (2000) The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression. Psychopharmacology 148: 404–411

    Article  CAS  PubMed  Google Scholar 

  • Garber J, Horowitz JL (2002) Depression in Children. In: Gotlib IH, Hammen CL (eds) Handbook of depression. Guilford, New York, pp 510–540

    Google Scholar 

  • Garlow SJ, Musselman DL, Nemeroff CB (1999) The neurochemistry of mood disorders: clinical studies. In: Charney DS, Nestler EJ, Bunney BS (eds) Neurobiology of mental illness. Oxford University Press, Oxford, pp 348–364

    Google Scholar 

  • Gold PW, Loriaux DL, Roy A et al (1986) Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease. N Engl J Med 314: 1329–1335

    Article  CAS  PubMed  Google Scholar 

  • Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E (1998) Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 95: 3168–3171

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Gregoire AJ, Kumar R, Everitt B, Henderson AF, Studd JW (1996) Transdermal estrogen for treatment of severe postnatal depression. Lancet 347(9006): 930–933

    Article  CAS  PubMed  Google Scholar 

  • Griffin LD, Mellon SH (1999) Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci USA 96(23): 13512–1357

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hautzinger M (1998) Depression. Fortschritte der Psychotherapie Bd 4. Hogrefe, Göttingen

    Google Scholar 

  • Hegerl U, Juckel G (1993) Intensity dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission — A new hypothesis. Biol Psychiatry 33: 173–187

    Article  CAS  PubMed  Google Scholar 

  • Hegerl U, Gallinat J, Juckel G (2001) Event-related potentials: do they reflect central serotonergic neurotransmission and do they predict clinical response to serotonin agonists? J Affect Disord 62: 93–100

    Article  CAS  PubMed  Google Scholar 

  • Heinz A, Schmidt LG, Reischies FM (1994) Anhedonia in schizophrenic, depressed, or alcohol-dependent patients — neurobiological correlates. Pharmacopsychiatry Suppl 1: 7–10

    Article  Google Scholar 

  • Henkel V, Bussfeld P, Möller HJ, Hegerl U (2002) Cognitive-behavioural theories of helplessness/hopelessness: valid models of depression? Eur Arch Psychiatry Clin Neurosci 252: 240–249

    Article  CAS  PubMed  Google Scholar 

  • Henn FA, Vollmayr B (2004) Basic pathophysiological mechanisms in depression: what are they and how might they affect the course of the illness? Pharmacopsychiatry 37: S152–S156

    Article  CAS  PubMed  Google Scholar 

  • Hollon SD, DeRubeis RJ, Shelton RC et al (2005) Prevention of relapse following cognitive therapy versus medications in moderate to severe depression. Arch Gen Psychiatry 62: 417–426

    Article  PubMed  Google Scholar 

  • Holoubek G, Nöldner M, Treiber K, Müller WE (2004) Effect of chronic antidepressant treatment on β-receptor coupled signal transduction cascade. Which effect matters most? Pharmacopsychiatry 37: S113–S119

    Article  CAS  PubMed  Google Scholar 

  • Holsboer F, Barden N (1996) Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 17: 187–205

    Article  CAS  PubMed  Google Scholar 

  • Hudson JI, Hudson MS (1984) Endocrine dysfunction in anorexia nervosa and bulima: comparison with abnormalities in other psychiatric disorders and disturbances due to metabolic factors. Psychiatry Dev 2: 237–272

    CAS  Google Scholar 

  • Hudson CJ, Young LT, Li PP, Warsh JJ (1993) CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia. Synapse 13: 278–293

    Article  CAS  PubMed  Google Scholar 

  • Jacobi F, Wittchen HU, Hölting C, Höfler M, Pfister H, Müller N et al. (2004) Prevalence, co-morbidity and correlates of mental disorders in the general population: Results from the German Health Interview and Examination Survey. Psychol Med 34: 597–611

    Article  CAS  PubMed  Google Scholar 

  • Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72: 165–229

    CAS  PubMed  Google Scholar 

  • Jacobs BL, Tanapat P, Reeves AJ, Gould E (1998) Serotonin stimulates the production of new hippocampal granule neurons via the 5HT1A receptor in the adult rat. Soc Neurosci Abs 24: 1992

    Google Scholar 

  • Janowsky DS, Overstreet DH (1995) The role of acetylcholine mechanisms in mood disorders. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: The fourth generation of progress. Raven Press, New York, pp 945–956

    Google Scholar 

  • Jeunemaitre X (1998) Genetic polymorphisms in the renin-angiotensin system. Therapie 53: 271–277

    CAS  PubMed  Google Scholar 

  • Johnson SL, Kizer A (2002) Bipolar and unipolar depression. Comparisons of course, symptoms, and psychosocial predictors. In: Gotlib IH, Hammen CL (eds) Handbook of Depression. Guilford, New York, pp141–166

    Google Scholar 

  • Juckel G, Molnár M, Hegerl U, Csepe V, Karmos G (1997) Auditoryevoked potentials as indicator of brain serotonergic activity — first evidence in behaving cats. Biol Psychiatry 41: 1181–1195

    Article  CAS  PubMed  Google Scholar 

  • Juckel G, Hegerl U, Molnár M, Csepe V, Karmos G (1999) Auditory evoked potentials reflect serotonergic neural activity — a study in behaving cats administered drugs acting on 5-HT1a autoreceptors in the dorsal raphe nucleus. Neuropsychopharmacology 21: 710–716

    Article  CAS  PubMed  Google Scholar 

  • Juckel G, Hegerl U, Mavrogiorgou P et al (2000) Clinical and biological findings in a case with 48-hour bipolar ultra-rapid cycling before and under valproate treatment. J Clin Psychiatry 61: 585–593

    Article  CAS  PubMed  Google Scholar 

  • Juckel G, Mavrogiorgou P, Bredemeier S et al (2004) Auditory evoked dipole source as predictors of outcome to prophylactic lithium treatment. Pharmacopsychiatry 37: 46–51

    CAS  PubMed  Google Scholar 

  • Judd LL, Akiskal HS, Schettler PJ et al (2003) A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar disorder. Arch Gen Psychiatry 60: 261–269

    Article  PubMed  Google Scholar 

  • Keller MB, Boland RJ (1998) Implications of failing to achieve successful long-term maintenance treatment of recurrent unipolar major depression. Biol Psychiatry 44(5):348–360

    Article  CAS  PubMed  Google Scholar 

  • Keller MB, Lavori PW, Mueller TI et al (1992) Time to recovery, chronicity, and levels of psychopathology in major depression. A 5-year prospective follow-up of 431 subjects. Arch Gen Psychiatry 49(10):809–816

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS, Kessler RC, Walters EE, MacLean C, Neale MC, Heath AC, Eaves LJ (1995) Stressful life events, genetic liability and onset of an episode of major depression in women. Am J Psychiatry 152: 833–842

    Article  CAS  PubMed  Google Scholar 

  • Kessler RC (2002) Epidemiology of Depression. In: Gotlib IH, Hammen CL (eds) Handbook of depression. Guilford, New York, pp 23–42

    Google Scholar 

  • Kessler RC, Berglund P, Demler O, Jin R, Walters EE, Wang PS (2003) The epidemiology of major depressive disorder. Results form the NCSR. J Am Med Ass 289: 3095–3105

    Article  Google Scholar 

  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSMIV disorders in the NCS-R. Arch Gen Psychiatry 62: 593–602

    Article  PubMed  Google Scholar 

  • Kinder LS, Carnethon MR, Palaniappan LP, King AC, Fortman SP (2004) Depression and the metabolic syndrome in young adults. Findings from the 3rd national health and nutrition examination survey. Psychosom Med 66: 316–322

    Article  PubMed  Google Scholar 

  • Kramer MS (2002) Clinical update: substance P antagonists in patients with major depression. Eur Psychiatry 17: 10

    Article  Google Scholar 

  • Kramer MS, Cutler N, Feighner J et al (1998) Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281: 1640–1645

    Article  CAS  PubMed  Google Scholar 

  • Krieg JC, Lauer CJ, Hermle L, von Bardeleben U, Pollmacher T, Holsboer F (1990) Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results. Neuropsychobiology 23(2): 57–67

    Article  CAS  PubMed  Google Scholar 

  • Krieg JC, Lauer CJ, Schreiber W, Modell S, Holsboer F (2001) Neuroendrocine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the „Munich vulnerability study“ J Affect Disord 62: 33–37

    Article  CAS  PubMed  Google Scholar 

  • Kupfer, DJ, Frank E, Perel JM et al (1992) Five year outcome for maintenance therapies in recurrent depression. Arch Gen Psychiatry 49: 769–774

    Article  CAS  PubMed  Google Scholar 

  • Lesch KP, Rupprecht R (1989) Psychoneuroendocrine research in depression: II. Hormonal responses to releasing hormones as a probe for hypothalamic-pituitary-endorgan dysfunction. J Neural Transm 75: 179–194

    Article  CAS  PubMed  Google Scholar 

  • Lewinsohn PM, Essau CA (2002) Depression in Adolescents. In: Gotlib IH, Hammen CL (eds) Handbook of depression. Guilford, New York, pp 541–559

    Google Scholar 

  • Linka T, Müller BW, Bender S, Sartory G (2004) The intensity dependence of the auditory evoked N1 component as a predictor of response to Citalopram treatment in patients with major depression. Neurosci Lett 367: 375–378

    Article  CAS  PubMed  Google Scholar 

  • Linkowski P, Mendlewicz J, Kerkhofs M et al (1987) 24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment. J Clin Endocrinol Metab 65: 141–152

    Article  CAS  PubMed  Google Scholar 

  • Linnoila M, Cowdry R, Bror-Axel L, Makinen T, Rubinow D (1983) CSF triiodothyronine (rT3) levels in patients with affective disorders. Biol Psychiatry 18: 1489–1492

    CAS  PubMed  Google Scholar 

  • Loosen PT, Prange Jr AJ (1982) Serum thyreotropin response to thyreotropin-releasing hormone in psychiatric patients: a review. Am J Psychiatry 139: 405–415

    Article  CAS  PubMed  Google Scholar 

  • Magarinos AM, McEwen BS, Flugge G, Fuchs E (1996) Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 16: 3534–3540

    CAS  PubMed  Google Scholar 

  • Maubach KA, Rupniak NM, Kramer MS, Hill RG (1999) Novel strategies for pharmacotherapy of depression. Curr Opin Chem Biol 3: 481–488

    Article  CAS  PubMed  Google Scholar 

  • Meyer TD Hautzinger M (2004) Manisch-depressive Störungen. Kognitiv-verhaltenstherapeutisches Behandlungsmanual. Beltz/PVU, Weinheim

    Google Scholar 

  • Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS (1996) Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Arch Gen Psychiatry 53: 117–128

    Article  CAS  PubMed  Google Scholar 

  • Murphy DL (1990): Peripheral indices of central serotonin function in humans. Ann NY Acad Sci 600: 282–296

    Article  CAS  PubMed  Google Scholar 

  • Nemeroff CB, Widerlöv E, Bisette G et al (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226: 1342–1343

    Article  CAS  PubMed  Google Scholar 

  • Nutt D (1998) Substance-P antagonists: a new treatment for depression? Lancet 352: 1644–1646

    Article  CAS  PubMed  Google Scholar 

  • Pariante CM, Thomas SA, Lovestone S, Makoff A, Kerwin RW (2004) Do antidepressants regulate how cortisol affects the brain? Psychoneuroendocrinology 29(4): 423–427

    Article  CAS  PubMed  Google Scholar 

  • Penninx BWJH, Geerlings SW, Deeg DJH, van Eijk JTM, van Tilburg W, Beekman ATF (1999) Minor and major depression and the risk of death in older persons. Arch Gen Psychiatry 56:889–898

    Article  CAS  PubMed  Google Scholar 

  • Pitchot W (2001) Reduced dopaminergic activity in depressed suicides. Psychoneuroendocrinology 26: 331–335

    Article  CAS  PubMed  Google Scholar 

  • Pitchot W Ansseau M, Gonzales Moreno A, Hansenne M, von Frenckell R (1992) Dopaminergic function in panic disorder: comparison with major and minor depression Biol Psychiatry 32: 1004–1011

    Article  CAS  PubMed  Google Scholar 

  • Pogarell O, Tatsch K, Juckel G et al (2004) Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder. Neuropsychopharmacology 29: 1910–1917

    Article  CAS  PubMed  Google Scholar 

  • Rasenick MM, Chaney KA, Chen J (1996) G protein-mediated signal transduction as a target of antidepressant and antibipolar drug action: evidence from model systems. J Clin Psychiatry 57: 49–55

    CAS  PubMed  Google Scholar 

  • Reilly JG, McTavish SFB, Young AH (1997) Rapid depletion of plasma tryptophan: a review of studies and experimental methodology. J Psychopharmacol 11: 381–392

    Article  CAS  PubMed  Google Scholar 

  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion/deletion polymorphism in the angiotensin-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86: 1343–1346

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rupniak NM, Kramer MS (1999) Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists. Trends Pharmacol Sci 20: 485–490

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R (2003) Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 28: 139–168

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Holsboer F (1999) Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22: 410–416

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Lesch KP (1989) Psychoneuroendocrine research in depression: I. Hormone levels of different neuroendocrine axes and the dexamethasone suppression test. J Neural Transm 75: 167–178

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Rupprecht C, Rupprecht M, Noder M, Mahlstedt J (1989) Triiodothyronine, thyroxine and TSH response to dexamethasone in depressed patients and normal controls. Biol Psychiatry 25: 22–32

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Kornhuber J, Wodarz N et al (1991a) Disturbed glucocorticoid receptor autoregulation and corticotropin release to dexamethasone in depressives pretreated with metyrapone. Biol Psychiatry 29: 1099–1109

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Wodarz N, Kornhuber J et al (1991b) In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression. Eur Arch Psychiatry Clin Neurosci 214: 35–40

    Article  Google Scholar 

  • Sapolsky RM (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57: 925–935

    Article  CAS  PubMed  Google Scholar 

  • Schatzberg AF (2002) Major depression: causes or effects? Am J Psychiatry 159: 1078–1079

    Google Scholar 

  • Shah PJ, Ebmeier KP, Glabus MF, Goodwin GM (1998) Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression. Controlled magnetic resonance imaging study. Br J Psychiatry 172: 527–532

    Article  CAS  PubMed  Google Scholar 

  • Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996) Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 93: 3908–3913

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sheline YI, Sanghani M, Mintan MA, Gado MH (1999) Depression duration but not age predicts hippocampal volume loss in medically healthy woman with recurrent major depression. J Neurosci 19: 5034–5043

    CAS  PubMed  Google Scholar 

  • Shink E, Morissette J, Villeneuve A et al (2002) Support for the presence of bipolar disorder susceptibility loci on chromosome 5: heterogeneity in a homogeneous population in Quebec. Prog Neuropsychopharmacol Biol Psychiatry 26: 1273–1277

    Article  CAS  PubMed  Google Scholar 

  • Shirayama Y, Mitsushio H, Takashima M, Ichikawa H, Takahashi K (1996) Reduction of substance P after chronic antidepressant treatment in the striatum, substantia nigra and amygdala of the rat. Brain Res 739: 70–78

    Article  PubMed  Google Scholar 

  • Siffert W (2001) Molecular genetics of G-proteins and atherosclerosis risk. Basic Res Cardiol 96: 606–611

    Article  CAS  PubMed  Google Scholar 

  • Siffert W, Rosskopf D, Siffert G et al (1998) Association of a human Gprotein β3 subunit variant with hypertension. Nature Genet 18: 45–48

    Article  CAS  PubMed  Google Scholar 

  • Silberg J, Pickles A, Rutter M et al (1999) The influence of genetic factors and life stress on depression among adolescent girls. Arch Gen Psychiatry 56: 225–232

    Article  CAS  PubMed  Google Scholar 

  • Smith KA, Fairburn GG, Cowen PJ (1997) Relapse of depression after rapid depletion of tryptophan. Lancet 349: 915–919

    Article  CAS  PubMed  Google Scholar 

  • Solomon DA, Keller MB, Leon AC (1997) Recovery from major depression. A 10-year prospective follow-up across multiple episodes. Arch Gen Psychiatry 54: 1001–1006

    Article  CAS  PubMed  Google Scholar 

  • Starkmann MM, Schteingart DE (1981) Neuropsychiatric manifestations of patients with Cushing’s syndrome. Relationship to cortisol and adrenocorticotropic hormone levels. Arch Internat Med 141: 215–219

    Article  Google Scholar 

  • Sullivan PF, Wilson DA, Mulder RT, Joya VR (1997) The hypothalamus-pituitary-thyroid axis in major depression. Acta Psychiatr Scand 95: 370–378

    Article  CAS  PubMed  Google Scholar 

  • Thome J, Duman RS, Henn FA (2002) Molekulare Aspekte antidepressiver Therapie. Nervenarzt 73: 595–599

    Article  CAS  PubMed  Google Scholar 

  • Tsukada K, Ishimitsu T, Tsuchiya N, Horinaka S, Matsuoka H (1997) Angiotensin converting enzyme gene polymorphism and cardiovascular endocrine system in coronary angiography patients. Jpn Heart J 38: 799–810

    Article  CAS  PubMed  Google Scholar 

  • Uhr M, Grauer MT, Holsboer F (2003) Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry 54: 840–846

    Article  CAS  PubMed  Google Scholar 

  • Vaillant GE (1998) Natural history of male psychological health. Relationship of mood disorder vulnerability to physical health. Am J Psychiatry 155: 184–191

    CAS  PubMed  Google Scholar 

  • Wallace AE, Kofoed LL, West AN (1995) Double-blind placebo-controlled trial of methylphenidate in older, depressed, medically ill patients. Am J Psychiatry 152: 929–931

    Article  CAS  PubMed  Google Scholar 

  • WHO (2004) Prevalence, severity, and unmet need for treatment of mental disorders in the world health organization. World mental health surveys. J Am Med Ass 291:2581–2590

    Article  Google Scholar 

  • Wittchen HU, Jacobi F (2005) Size and burden of mental disorders in Europe. A critical review and appraisal of 27 studies. Eur Neuropsychopharmacol 15:357–376

    Article  CAS  PubMed  Google Scholar 

  • Wittchen H-U, Winter S, Höfler M et al (2000) Häufigkeiten und Erkennungsrate von Depressionen in der hausärztlichen Praxis. Fortschr Med 118 (Sonderheft 1/2000): 22–30

    Google Scholar 

  • Wooley CS, Gould E, McEwen BS (1990) Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res 531: 225–231

    Article  Google Scholar 

  • Wulsin LW, Vaillant GE, Wells VE (1999) A systematic review of the mortality of depression. Psychosom Med 61: 6–17

    Article  CAS  PubMed  Google Scholar 

  • Zill P, Baghai TC, Zwanzger P et al (2000) Evidence for an association between a G-protein β3-gene variant with depression and response to antidepressant treatment. Neuroreport 11: 1893–1897

    Article  CAS  PubMed  Google Scholar 

  • Zobel AW, Yassouridis A, Frieboes RM, Holsboer F (1999) Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am J Psychiatry 156: 949–951

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Klinische Neurophysiologie Psychiatrische Klinik und Poliklinik, Klinikum der Universität München, Nußbaumstraße 7, 80336, München

    Ulrich Hegerl (Prof. Dr. med.) & Rainer Rupprecht (Prof. Dr. med.)

Authors
  1. Ulrich Hegerl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rainer Rupprecht
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Hans Förstl

  2. Abteilung für Klinische Psychologie und Entwicklungspsychologie, Universität Tübingen, Christophstraße 2, 72072, Tübingen, Germany

    Martin Hautzinger

  3. Institut für Hirnforschung, Universität Bremen, Postfach 33 04 40, 28334, Bremen, Germany

    Gerhard Roth

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Hegerl, U., Rupprecht, R. (2006). Affektive Störungen — Neurobiologie. In: Förstl, H., Hautzinger, M., Roth, G. (eds) Neurobiologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30887-3_9

Download citation

  • DOI: https://doi.org/10.1007/3-540-30887-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25694-6

  • Online ISBN: 978-3-540-30887-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation