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Schizophrenie und verwandte Störungen — Neurobiologie

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Neurobiologie psychischer Störungen

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Literatur

  • Adler CM, Malhotra AK, Elman I, Goldberg T, Egan M et al (1999) Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am J Psychiatry 156: 1646–1949

    Article  CAS  PubMed  Google Scholar 

  • Akbarian S, Smith MA, Jones EG (1995) Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer’s disease, Huntington’s disease and schizophrenia. Brain Res 699: 297–304

    Article  CAS  PubMed  Google Scholar 

  • Allen JE, Jenner A, Stevens JC (1991) Early cortical tactile-evoked potentials, laterality and schizophrenia. Br J Psychiatry 158: 529–533

    Article  CAS  PubMed  Google Scholar 

  • an der Heiden W, Hafner H (2000) The epidemiology of onset and course of schizophrenia. Eur Arch Psychiatry Clin Neurosci 250: 292–303

    Article  Google Scholar 

  • Andreasen NC (1999) A unitary model of schizophrenia: Bleuler’s »fragmented Phrene« as schizencephaly. Arch Gen Psychiatry 56: 781–787

    Article  CAS  PubMed  Google Scholar 

  • Andreasen NC, Olson S (1982) Negative versus positive schizophrenia: definition and validation. Arch Gen Psychiatry 39: 789–794

    Article  CAS  PubMed  Google Scholar 

  • Aparicio-Legarza MI, Davis B, Hutson PH, Reynolds GP (1998) Increased density of glutamate/N-methyl-D-aspartate receptors in putamen from schizophrenic patients. Neurosci Lett 241: 143–146

    Article  CAS  PubMed  Google Scholar 

  • Arndt S, Andreasen NC, Flaum M, Miller D, Nopoulos P (1995) A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change. Arch Gen Psychiatry 52: 352–360

    Article  CAS  PubMed  Google Scholar 

  • Arnold SE, Smutzer GS, Trojanowski JQ, Moberg PJ (1998) Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer’s disease and schizophrenia. Ann NY Acad Sci 855: 762–775

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Steege D, Nolte A (1993) Störungen der Augenbewegungen bei Schizophrenen — Kritische Übersicht und zukünftige Perspektiven. Fortschr Neurol Psychiatr 61: 90–105

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Lencer R, Nolte A et al (1996) Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 67: 564–579

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Weitzsch C, Wilke I, Nolte A, Pinnow M, Rothermundt M, Kirchner H (1997) Production of interferon-γ in families with multiple occurrence of schizophrenia. Psychiatry Res 66: 145–152

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Teichert HM, Steege D, Lencer R, Heide W (1998) Distinguishing schizophrenic patients from healthy controls by quantitative measurement of eye movement parameters. Biol Psychiatry 44: 448–458

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Lencer R, Purmann S, Schurmann M, Muller-Myhsok B, Krecker K, Schwinger E (1999) Testing for linkage of eye tracking dysfunction and schizophrenia to markers on chromosomes 6, 8, 9, 20, and 22 in families multiply affected with schizophrenia. Am J Med Genet 88: 603–606

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Rothermundt M, Wandinger KP, Kirchner H (2000) Decreased in vitro production of interferon-γ and interleukin-2 in whole blood of patients with schizophrenia during treatment. Mol Psychiatry 5: 150–158

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Rothermundt M, Peters M, Leonard B (2002) Immunological research in clinical psychiatry: report on the consensus debate during the 7th Expert Meeting on Psychiatry and Immunology. Mol Psychiatry 7: 822–826

    Article  CAS  PubMed  Google Scholar 

  • Azmitia EC (2001) Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56: 413–424

    Article  CAS  PubMed  Google Scholar 

  • Bailer U, Leisch F, Meszaros K et al (2000) Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology 42: 175–182

    Article  CAS  PubMed  Google Scholar 

  • Bantick RA, Deakin JF, Grasby PM (2001) The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics? J Psychopharmacol 15: 37–46

    Article  CAS  PubMed  Google Scholar 

  • Bar KJ, Gaser C, Nenadic I, Sauer H (2002) Transient activation of a somatosensory area in painful hallucinations shown by fMRI. Neuroreport 13: 805–808

    Article  PubMed  Google Scholar 

  • Barnett W, Mundt C, Richter P (1996) Primäre und sekundäre Negativsymptome: eine nützliche Differenzierung? Eine empirische Studie. Nervenarzt 67: 558–563

    CAS  PubMed  Google Scholar 

  • Bartzokis G (2002) Schizophrenia: Breakdown in the well-regulated lifelong process of brain development and maturation. Neuropsychopharmacology 27: 672–683

    Article  PubMed  Google Scholar 

  • Bartzokis G, Nuechterlein KH, Lu PH, Gitlin M, Rogers S, Mintz J (2003) Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study. Biol Psychiatry 53: 412–421

    Article  PubMed  Google Scholar 

  • Bedwell JS, Brown JM, Miller LS (2003) The magnocellular visual system and schizophrenia: what can the color red tell us? Schizophr Res 63: 273–284

    Article  PubMed  Google Scholar 

  • Benes FM (2000) Emerging principles of altered neural circuitry in schizophrenia. Brain Res Rev 31: 251–269

    Article  CAS  PubMed  Google Scholar 

  • Benson MA, Newey SE, Martin-Rendon E, Hawkes R, Blake DJ (2001) Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem 276: 24 232–24 241

    Article  CAS  Google Scholar 

  • Bilder RM, Mukherjee S, Rieder RO, Pandurangi AK (1985) Symptomatic and neuropsychological components of defect states. Schizophr Bull 11: 409–419

    Article  CAS  PubMed  Google Scholar 

  • Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ (2001) Schizophrenia and affective disorders — cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 69: 428–433

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bleich A, Brown SL, Kahn R, van Praag HM (1988) The role of serotonin in schizophrenia. Schizophr Bull 14: 297–315

    Article  CAS  PubMed  Google Scholar 

  • Bleich S, Bleich K, Wiltfang J, Maler JM, Kornhuber J (2001) Glutamaterge Neurotransmission bei Schizophrenien. Fortschr Neurol Psychiatr 69: 56–61

    Article  Google Scholar 

  • Bleuler E (1911) Dementia praecox oder die Gruppe der Schizophrenien. In: Aschaffenburg G (Hrsg) Handbuch der Psychiatrie, spezieller Teil, 4. Abteilung, 1. Hälfte. Deuticke, Leipzig

    Google Scholar 

  • Blouin JL, Dombroski BA, Nath SK et al (1998) Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nature Genet 20: 70–73

    Article  CAS  PubMed  Google Scholar 

  • Boin F, Zanardini R, Pioli R, Altamura CA, Maes M, Gennarelli M (2001) Association between G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry 6: 79–82

    Article  CAS  PubMed  Google Scholar 

  • Boks MP, Russo S, Knegtering R, van den Bosch RJ (2000) The specificity of neurological signs in schizophrenia: a review. Schizophr Res 43: 109–116

    Article  CAS  PubMed  Google Scholar 

  • Böning J, Drechsler F, Neuhauser B (1989) Somatosensory event-related potentials and selective attention impairment in young chronic schizophrenics. Neuropsychobiology 21: 146–151

    Article  PubMed  Google Scholar 

  • Bonnet-Brilhault F, Laurent C, Campion D et al (1999) No evidence for involvement of KCNN3 (hSKCa3) potassium channel gene in familial and isolated cases of schizophrenia. Eur J Hum Genet 7: 247–250

    Article  CAS  PubMed  Google Scholar 

  • Borrell J, Vela JM, Arevalo-Martin A, Molina-Holgado E, Guaza C (2002) Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology 26: 204–215

    Article  CAS  PubMed  Google Scholar 

  • Bottlender R, Strauss A, Moller HJ (2000) Impact of duration of symptoms prior to first hospitalization on acute outcome in 998 schizophrenic patients. Schizophr Res 44: 145–150

    Article  CAS  PubMed  Google Scholar 

  • Botvinick M, Cohen J (1998) Rubber hands »feel« touch that eyes see. Nature 391: 756

    Article  CAS  PubMed  Google Scholar 

  • Braff DL, Saccuzzo DP(1981) Information processing dysfunction in paranoid schizophrenia: a two-factor deficit. Am J Psychiatry 138: 1051–1056

    Article  CAS  PubMed  Google Scholar 

  • Braus DF, Weber-Fahr W, Tost H, Ruf M, Henn FA (2002) Sensory information processing in neuroleptic-naive first-episode schizophrenic patients: a functional magnetic resonance imaging study. Arch Gen Psychiatry 59: 696–701

    Article  PubMed  Google Scholar 

  • Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ, O’Donovan MC (2003) A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 73: 152–161

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Breier A, Su TP, Saunders R et al (1997) Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography methods. Proc Natl Acad Sci USA 94: 2569–2574

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bressan RA, Erlandsson K, Jones HM et al (2003) Optimising limbic selective D2/D3 receptor occupancy by risperidone — a 1231 epidepride SPECT study. J Clin Psychopharmacol 23: 5–14

    Article  CAS  PubMed  Google Scholar 

  • Brody D, Saccuzzo DP, Braff DL (1980) Information processing for masked and unmasked stimuli in schizophrenia and old age. J Abnorm Psychol 89: 617–622

    Article  CAS  PubMed  Google Scholar 

  • Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS (2000) Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21–q22. Science 288: 678–682

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Brzustowicz LM, Hayter JE, Hodgkinson KA, Chow EW, Bassett AS (2002) Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. Hum Hered 54: 199–209

    Article  CAS  PubMed  Google Scholar 

  • Buchanan RW, Heinrichs DW (1989) The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 27: 335–350

    Article  CAS  PubMed  Google Scholar 

  • Butler PD, Schechter I, Zemon V, Schwartz SG, Greenstein VC (2001) Dysfunction of early-stage visual processing in schizophrenia. Am J Psychiatry 158: 1126–1133

    Article  CAS  PubMed  Google Scholar 

  • Cadenhead KS, Serper Y, Braff DL (1998) Transient versus sustained visual channels in the visual backward masking deficits of schizophrenia patients. Biol Psychiatry 43: 132–138

    Article  CAS  PubMed  Google Scholar 

  • Cahn W, HulshoffPol HE, Lerns EB et al (2002) Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Arch Gen Psychiatry 59: 1002–1010

    Article  PubMed  Google Scholar 

  • Calkins ME, Iacono WG (2000) Eye movement dysfunction in schizophrenia: a heritable characteristic for enhancing phenotype definition. Am J Med Genet 97: 72–76

    Article  CAS  PubMed  Google Scholar 

  • Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR (2003) Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry 160: 2209–2215

    Article  PubMed  Google Scholar 

  • Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M (1998) The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry 55: 67–74

    Article  CAS  PubMed  Google Scholar 

  • Cantor-Graae E, McNeil TF, Rickler KC, Sjostrom K, Rawlings R, Higgins ES, Hyde TM (1994) Are neurological abnormalities in well discordant monozygotic co-twins of schizophrenic subjects the result of perinatal trauma? Am J Psychiatry 151: 1194–1199

    Article  CAS  PubMed  Google Scholar 

  • Cantor-Graae E, Ismail B, McNeil TF (2000) Are neurological abnormalities in schizophrenic patients and their siblings the result of perinatal trauma? Acta Psychiatr Scand 101: 142–147

    Article  CAS  PubMed  Google Scholar 

  • Carlsson A, Lindqvist M (1963) Effect of chlorpromazine or haloperidol on the formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol 20: 140–144

    Article  CAS  Google Scholar 

  • Carlsson A, Waters N, Holm-Wolters S, Tedroff J, Nilsson M, Carlsson ML (2001) Interactions between monoamines, glutamate and GABA in schizophrenia: New evidence. Annu Rev Pharmacol Tocxicol 41: 237–260

    Article  CAS  Google Scholar 

  • Cauller L (1995) Layer I of primary sensory neocortex: where top-down converges with bottom-up. Behav Brain Res 71: 163–170

    Article  CAS  PubMed  Google Scholar 

  • Chandy KG, Fantino E, Wittekindt O et al (1998) Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry 3: 32–37

    Article  CAS  PubMed  Google Scholar 

  • Chang BP, Lenzenweger MF (2001) Somatosensory processing in the biological relatives of schizophrenia patients: a signal detection analysis of two-point discrimination. J Abnorm Psychol 110: 433–442

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Levy DL, Nakayama K, Matthysse S, Palafox G, Holzman PS (1999a) Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia. Arch Gen Psychiatry 56: 155–161

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Nakayama K, Levy DL, Matthysse S, Holzman PS (1999b) Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit. Proc Natl Acad Sci USA 96: 4724–4729

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Chen EY, Kwok CL, Au JW, Chen RY, Lau BS (2000) Progressive deterioration of soft neurological signs in chronic schizophrenic patients. Acta Psychiatr Scand 102: 342–349

    Article  CAS  PubMed  Google Scholar 

  • Chen S, Rio C, Ji RR, Dikkes P, Coggeshall RE, Woolf CJ, Corfas G (2003) Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nature Neurosci 6: 1186–1193

    Article  CAS  PubMed  Google Scholar 

  • Chowdari KV, Mirnics K, Semwal P et al (2002) Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum Mol Genet 11: 1373–1380

    Article  CAS  PubMed  Google Scholar 

  • Chumakov I, Blumenfeld M, Guerassimenko O et al (2002) Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99: 13 675–13 680

    Article  CAS  Google Scholar 

  • Church SM, Cotter D, Bramon E, Murray RM (2002) Does schizophrenia result from developmental or degenerative processes? J Neural Transm Suppl 63: 129–147

    PubMed  Google Scholar 

  • Costa E, Grayson DR, Mitchell CP, Tremolizzo L, Veldic M, Guidotti A (2003) GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Crit Rev Neurobiol 15: 121–142

    Article  CAS  PubMed  Google Scholar 

  • Craig TJ, Bromet EJ, Fennig S, Tanenberg-Karant M, Lavelle J, Galambos N (2000) Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series? Am J Psychiatry 157: 60–66

    Article  CAS  PubMed  Google Scholar 

  • Crow TJ (1997) Temporolimbic or transcallosal connections: where is the primary lesion in schizophrenia and what is its nature? Schiz Bull 23(3): 521–523

    Article  CAS  Google Scholar 

  • Csernansky JG, Wang L, Jones D et al (2002) Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping. Am J Psychiatry 159: 2000–2006

    Article  PubMed  Google Scholar 

  • Cullen TJ, Walker MA, Parkinson N, Craven R, Crow TJ, Esiri MM, Harrison PJ (2003) A post mortem study of the mediodorsal nucleus of the thalamus in schizophrenia. Schizophr Res 60: 157–166

    Article  CAS  PubMed  Google Scholar 

  • Danos P, Baumann B, Kramer A et al (2003) Volumes of association thalamic nuclei in schizophrenia: a post mortem study. Schizophr Res 60: 141–155

    Article  PubMed  Google Scholar 

  • Davidson LL, Heinrichs RW (2003) Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis. Psychiatry Res 15: 69–87

    Article  Google Scholar 

  • Dazzan P, Murray RM (2002) Neurological soft signs in first-episode psychosis: a systematic review. Br J Psychiatry Suppl 43: 50–57

    Article  Google Scholar 

  • Dazzan P, Morgan KD, Orr KG et al (2004) The structural brain correlates of neurological soft signs in AESOP first-episode psychoses study. Brain 127: 143–153

    Article  PubMed  Google Scholar 

  • de Paulis T (2001) M-100907 (Aventis). Curr Opin Invest Drugs 2: 123–132

    Google Scholar 

  • Dean B (2003) The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice. J Neurochem 85: 1–13

    Article  CAS  PubMed  Google Scholar 

  • Delevoye-Turrell Y, Giersch A, Danion JM (2003) Abnormal sequencing of motor actions in patients with schizophrenia: evidence from grip force adjustments during object manipulation. Am J Psychiatry 160: 134–141

    Article  PubMed  Google Scholar 

  • DeLisi LE (1999) Defining the course of brain structual change and plasticity in schizophrenia. Psychiatry Res Neuroimaging 92: 1–9

    Article  CAS  PubMed  Google Scholar 

  • DeLisi LE, Shaw SH, Crow TJ et al (2002) A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 159: 803–812

    Article  PubMed  Google Scholar 

  • Dierks T, Linden DE, Jandl M, Formisano E, Goebel R, Lanfermann H, Singer W (1999) Activation of Heschl’s gyrus during auditory hallucinations. Neuron 22: 615–621

    Article  CAS  PubMed  Google Scholar 

  • Dreben EK, Fryer JH, McNair DM (1995) Perceptual and conceptual information processing in schizophrenia and depression. Percept Mot Skills 80: 447–465

    Article  CAS  PubMed  Google Scholar 

  • Dubertret C, Gorwood P, Ades J, Feingold J, Schwartz JC, Sokoloff P (1998) Meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians. Am J Med Genet 81: 318–322

    Article  CAS  PubMed  Google Scholar 

  • Egan MF, Goldberg TE, Kolachana BS et al (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98: 6917–6922

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ekelund J, Hovatta I, Parker A et al (2000) Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 10: 1611–1617

    Article  Google Scholar 

  • Engelien A, Stern E, Silbersweig D (2001) Functional neuroimaging of human central auditory processing in normal subjects and patients with neurological and neuropsychiatric disorders. J Clin Exp Neuropsychol 23: 94–120

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Meyer J, Matise T et al (1999) Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion. Am J Med Genet 88: 607–608

    Article  CAS  PubMed  Google Scholar 

  • Fenton WS, McGlashan TH (1991) Natural history of schizophrenia subtypes. I. Longitudinal study of paranoid, hebephrenic, and undifferentiated schizophrenia. Arch Gen Psychiatry 48: 969–977

    Article  CAS  PubMed  Google Scholar 

  • Feinberg I (1982-83) Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatry Res 17: 319–334

    Article  Google Scholar 

  • Flyckt L, Sydow O, Bjerkenstedt L, Edman G, Rydin E, Wiesel FA (1999) Neurological signs and psychomotor performance in patients with schizophrenia, their relatives and healthy controls. Psychiatry Res 86: 113–129

    Article  CAS  PubMed  Google Scholar 

  • Frankle WG, Laruelle M (2002) Neuroreceptor imaging in psychiatric disorders. Ann Nucl Med 16: 437–446

    Article  CAS  PubMed  Google Scholar 

  • Freedman R, Coon H, Myles-Worsley M et al (1997) Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA 94: 587–592

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S (2003) The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep 5: 155–161

    Article  PubMed  Google Scholar 

  • Friedman JI, Temporini H, Davis KL (1999) Pharmacologic stategies for augmenting cognitive performance in schizophrenia. Biol Psychiatry 45: 1–16

    Article  CAS  PubMed  Google Scholar 

  • Furlong P, Barczak P, Hayes G, Harding G (1990) Somatosensory evoked potentials in schizophrenia. A lateralisation study. Br J Psychiatry 157: 881–887

    Article  CAS  PubMed  Google Scholar 

  • Gao XM, Sakai K, Roberts RC et al (2000) Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am J Psychiatry 157: 1141–1149

    Article  CAS  PubMed  Google Scholar 

  • Gaser C, Volz HP, Kiebel S, Riehemann S, Sauer H (1999) Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research. Neuroimage 10: 107–113

    Article  CAS  PubMed  Google Scholar 

  • Gaser C, Nenadic I, Volz HP, Buchel C, Sauer H (2004) Neuroanatomy of »hearing voices«: a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia. Cerebr Cortex 14: 91–96

    Article  Google Scholar 

  • Gasperoni TL, Ekelund J, Huttunen M et al (2003) Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 11: 8–16

    Article  Google Scholar 

  • Gershon ES, Goldin LR (1986) Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies. Acta Psychiatr Scand 74: 113–118

    Article  CAS  PubMed  Google Scholar 

  • Goldberg TE, Egan MF, Gscheidle T et al (2003) Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60: 889–896

    Article  CAS  PubMed  Google Scholar 

  • Goldstein JM, Goodman JM, Seidman LJ et al (1999) Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch Gen Psychiatry 56: 537–547

    Article  CAS  PubMed  Google Scholar 

  • Goudsmit N, Coleman E, Seckinger RA et al (2003) A brief smell identification test discriminates between deficit and non-deficit schizophrenia. Psychiatry Res 120: 155–164

    Article  PubMed  Google Scholar 

  • Gourion D, Goldberger C, Bourdel MC, Bayle FJ, Millet B, Olie JP, Krebs MO (2003) Neurological soft signs and minor physical anomalies in schizophrenia: differential transmission within families. Schizophr Res 63: 181–187

    Article  PubMed  Google Scholar 

  • Gourion D, Goldberger C, Olie JP, Loo H, Krebs MO (2004) Neurological and morphological anomalies and the genetic liability to schizophrenia: a composite phenotype. Schizophr Res 67: 23–31

    Article  CAS  PubMed  Google Scholar 

  • Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153: 321–330

    Article  CAS  PubMed  Google Scholar 

  • Green MF, Bracha HS, Satz P, Christenson CD (1994a) Preliminary evidence for an association between minor physical anomalies and second trimester neurodevelopment in schizophrenia. Psychiatry Res 53: 119–127

    Article  CAS  PubMed  Google Scholar 

  • Green MF, Satz P, Christenson C (1994b) Minor physical anomalies in schizophrenia patients, bipolar patients, and their siblings. Schizophr Bull 20: 433–440

    Article  CAS  PubMed  Google Scholar 

  • Green MF, Nuechterlein KH, Breitmeyer B (1997) Backward masking performance in unaffected siblings of schizophrenic patients. Evidence for a vulnerability indicator. Arch Gen Psychiatry 54: 465–472

    Article  CAS  PubMed  Google Scholar 

  • Green MF, Kern RS, Braff DL, Mintz J (2000) Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the »right stuff«? Schizophr Bull 26: 119–136

    Article  CAS  PubMed  Google Scholar 

  • Grove WM, Lebow BS, Clementz BA, Cerri A, Medus C, Iacono WG (1991) Familial prevalence and coaggregation of schizotypy indicators: a multitrait family study. J Abnorm Psychol 100: 115–121

    Article  CAS  PubMed  Google Scholar 

  • Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker W, Gur RC (1998) A follow-up magnetic resonance imaging study of schizophrenia. Arch Gen Psychiatry 55: 145–152

    Article  CAS  PubMed  Google Scholar 

  • Gurling HM, Kalsi G, Brynjolfson J et al (2001) Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21–22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3–24 and 20q12.1–11.23. Am J Hum Genet 68: 661–673

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kuhn M, Schuld A, Pollmacher T (1999) Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatry Res 33: 407–418

    Article  CAS  Google Scholar 

  • Häfner H (2000) Onset and early course as determinants of the further course of schizophrenia. Acta Psychiatr Scand 407(Suppl 102): 44–48

    Article  Google Scholar 

  • Häfner H (2003) Gender differences in schizophrenia. Psychoneuroendocrinology 28: 17–54

    Article  PubMed  Google Scholar 

  • Häfner H, an der Heiden W (2003) Course and outcome of schizophrenia. In: Hirsch SR, Weinberger D (eds) Schizophrenia 2nd edn. Blackwell, Oxford, 101–141

    Chapter  Google Scholar 

  • Halbreich U, Kahn LS (2003) Hormonal aspects of schizophrenias: an overview. Psychoneuroendocrinology 28: 1–16

    CAS  Google Scholar 

  • Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122: 593–624

    Article  PubMed  Google Scholar 

  • Harrison PJ, Eastwood SL (2001) Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus 11: 508–519

    Article  CAS  PubMed  Google Scholar 

  • Harrison PJ, Owen MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361: 417–419

    Article  CAS  PubMed  Google Scholar 

  • Heckers S, Konradi, C (2002) Hippocampal neurons in schizophrenia. J Neural Transm 109: 891–905

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Highley JR, Walker MA, McDonald B, Crow TJ, Esiri MM (2003) Size of hippocampal pyramidal neurons in schizophrenia. Br J Psychiatry 183: 414–417

    Article  CAS  PubMed  Google Scholar 

  • Ho BC, Andreasen NC, Flaum M, Nopoulos P, Miller D (2000) Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia. Am J Psychiatry 157: 808–815

    Article  CAS  PubMed  Google Scholar 

  • Ho BC, Alicata D, Ward J, Moser DJ, O’Leary DS, Arndt S, Andreasen NC (2003a) Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia. Am J Psychiatry 160: 142–148

    Article  PubMed  Google Scholar 

  • Ho BC, Andreasen NC, Noploulos P, Arndt S, Magnotta V, Flaum M (2003b) Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Arch Gen Psychiatry 60: 585–594

    Article  PubMed  Google Scholar 

  • Hoff AL, Sakuma M, Razi K, Heydebrand G, Csernansky JG, DeLisi LE (2000) Lack of association between duration of untreated illness and severity of cognitive and structural brain deficits at the first episode of schizophrenia. Am J Psychiatry 157: 1824–1828

    Article  CAS  PubMed  Google Scholar 

  • Holzman PS (2000) Eye movements and the search for the essence of schizophrenia. Brain Res Brain Res Rev 31: 350–356

    Article  CAS  PubMed  Google Scholar 

  • Holzman PS, Proctor LR, Hughes DW (1973) Eyetracking patterns in schizophrenia. Science 181: 179–181

    Article  CAS  PubMed  Google Scholar 

  • Hovatta I, Varilo T, Suvisaari J et al (1999) A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet 65: 1114–1124

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hulshoff Pol HE, Schnack HG, Mandl RC, Cahn W, Collins DL, Evans AC, Kahn RS (2004) Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. Neuroimage 21: 27–35

    Article  PubMed  Google Scholar 

  • Ismail B, Cantor-Graae E, McNeil TF (1998) Neurological abnormalities in schizophrenic patients and their siblings. Am J Psychiatry 155: 84–89

    Article  CAS  PubMed  Google Scholar 

  • Ismail B, Cantor-Graae E, McNeil TF(2000) Minor physical anomalies in schizophrenia: cognitive, neurological and other clinical correlates. J Psychiatry Res 34: 45–56

    Article  CAS  Google Scholar 

  • Jahn T (1999) Diskrete motorische Störungen bei Schizophrenie. Belz PVU, Weinheim

    Google Scholar 

  • Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 2(7992): 924–926

    Article  CAS  PubMed  Google Scholar 

  • Jones PB (2002) Risk factors for schizophrenia in childhood an youth. In: Häfner H (ed) Risk and protective factors in schizophrenia: towards a conceptual model of the disease process. Steinkopff, Darmstadt, pp 141–162

    Chapter  Google Scholar 

  • Jones HM, Pilowsky (2002) Dopamine and antipsychotic drug action revisited. Br J Psychiatry 181: 271–275

    Article  CAS  PubMed  Google Scholar 

  • Kapur S, Seeman P (2001) Does fast dissocation from the dopamine D2 receptor explain the action of atypical antipsychotics? A new hypothesis. Am J Psychiatry 158: 360–369

    Article  CAS  PubMed  Google Scholar 

  • Kapur S, Zipursky R, Remington G (1999) Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone and olanzapine in schizophrenia. Am J Psychiatry 156:286–293

    CAS  PubMed  Google Scholar 

  • Karlsson H (2003) Viruses and schizophrenia, connection of coincidence? Neuroreport 14: 535–542

    Article  PubMed  Google Scholar 

  • Kasai K, Iwanami A, Yamasue H (2002) Neuroanatomy and neurophysiology in schizophrenia. Neurosci Res 43: 110

    Article  Google Scholar 

  • Kasai K, Shenton ME, Salisbury DF et al (2003) Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry 160: 156–164

    Article  PubMed Central  PubMed  Google Scholar 

  • Kaufmann CA, Suarez B, Malaspina D et al (1998) NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am J Med Genet 81: 282–289

    Article  CAS  PubMed  Google Scholar 

  • Keller A, Castellanos FX, Vaituzis AC, Jeffries NO, Giedd JN, Rapoport JL (2003) Progressive loss of cerebellar volume in childhood-onset schizophrenia. Am J Psychiatry 160: 128–133

    Article  PubMed  Google Scholar 

  • Kemether EM, Buchsbaum MS, Byne W et al (2003) Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia. Arch Gen Psychiatry 60: 983–991

    Article  PubMed  Google Scholar 

  • Kendler KS, MacLean CJ, O’Neill FA et al (1996) Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 153: 1534–1540

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS, Myers JM, O’Neill FA et al (2000) Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 157: 402–408

    Article  CAS  PubMed  Google Scholar 

  • Keri S, Antal A, Szekeres G, Benedek G, Janka Z (2000) Visual information processing in patients with schizophrenia: evidence for the impairment of central mechanisms. Neurosci Lett 293: 69–71

    Article  CAS  PubMed  Google Scholar 

  • Keshavan MS, Anderson S, Pettegrew JW (1994) Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J Psychiatry Res 28: 239–265

    Article  CAS  Google Scholar 

  • Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmüller B (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20: 379–382

    Article  CAS  PubMed  Google Scholar 

  • Kirkpatrick B, Buchanan RW, Ross DE, Carpenter WT Jr (2001) A separate disease within the syndrome of schizophrenia. Arch Gen Psychiatry 58: 165–171

    Article  CAS  PubMed  Google Scholar 

  • Klosterkötter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58: 158–164

    Article  PubMed  Google Scholar 

  • Knable MB, Kleinman JE, Weinberger DR (1998) Neurobiology of schizophrenia: genetic studies. The American Psychiatric Press textbook of psychopharmacology 2nd edn. pp 589–599

    Google Scholar 

  • Konick LC, Friedman L (2001) Meta-analysis of thalamic size in schizophrenia. Biol Psychiatry 49: 28–38

    Article  CAS  PubMed  Google Scholar 

  • Konradi C, Heckers S (2001) Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia. Biol Psychiatry 50: 729–749

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Konradi C, Heckers S (2003) Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Therapeutics 97: 153–179

    Article  CAS  Google Scholar 

  • Kopala LC, Good KP, Torrey EF, Honer WG (1998) Olfactory function in monozygotic twins discordant for schizophrenia. Am J Psychiatry 155: 134–146

    Article  CAS  PubMed  Google Scholar 

  • Kopala LC, Good KP, Morrison K, Bassett AS, Alda M, Honer WG (2001) Impaired olfactory identification in relatives of patients with familial schizophrenia. Am J Psychiatry 158: 1286–1290

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kovács I (2000) Human development of perceptual organization. Vision Res 40: 1301–1310

    Article  PubMed  Google Scholar 

  • Kraepelin E (1904) Psychiatrie. Ein Lehrbuch für Studierende und Ärzte, 7. Aufl. Barth, Leipzig

    Google Scholar 

  • Lane A, Colgan K, Moynihan F, Burke T, Waddington JL, Larkin C, O’Callaghan E (1996) Schizophrenia and neurological soft signs: gender differences in clinical correlates and antecedent factors. Psychiatry Res 64:105–114

    Article  CAS  PubMed  Google Scholar 

  • Lane A, Kinsella A, Murphy P et al (1997) The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Psychol Med 27: 1155–1164

    Article  CAS  PubMed  Google Scholar 

  • Laruelle M, Abi-Dargham A, van Dyck CH et al (1996) Single-photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 93: 9235–9240

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Laruelle M, Abi-Dargham A, Gil R, Kegeles L, Innis R (1999) Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol Psychiatry 46: 56–72

    Article  CAS  PubMed  Google Scholar 

  • Lawrie SM, Abukmeil SS (1998) Brain abnormality in schizophrenia. Br J Psychiatry 173: 110–120

    Article  Google Scholar 

  • Lawrie SM, Whalley HC, Job DE, Johnstone EC (2003) Structural and functional abnormalities of the amygdala in schizophrenia. Ann NY Acad Sci 985: 445–460

    Article  PubMed  Google Scholar 

  • Lencer R, Malchow CP, Krecker K et al (1999) Smooth pursuit performance in families with multiple occurrence of schizophrenia and nonpsychotic families. Biol Psychiatry 45: 694–703

    Article  CAS  PubMed  Google Scholar 

  • Lenzenweger MF (1998) Schizotypy and schizotypic psychopathology: mapping an alternative expression of schizophrenia liability. In: Lenzenweger MF, Dworkin RH (eds) Origins and developement of schizophrenia: Advances in experimental psychopathology. American Psychological Asssociation, Washington DC, pp 93–121

    Chapter  Google Scholar 

  • Lenzenweger MF (2000) Two-point discrimination thresholds and schizotypy: illuminating a somatosensory dysfunction. Schizophr Res 42: 111–124

    Article  CAS  PubMed  Google Scholar 

  • Levinson DF, Holmans P, Straub RE et al (2000) Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. Am J Hum Genet 67: 652–663

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lewis CM, Kapur S, Jones C et al (1999) Serotonin 5-HT2 receptors in schizoprhenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects. Am J Psychiatry 156: 72–78

    Article  CAS  PubMed  Google Scholar 

  • Lewis CM, Levinson DF, Wise LH et al (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, Part II: Schizophrenia. Am J Hum Genet 73: 34–48

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Liddle P (1987) The symptoms of chronic schizophrenia. A reexamination of the positive-negative dichotomy. Br J Psychiatry 151: 147–151

    Article  Google Scholar 

  • Lidow MS, Williams GV, Goldman-Rakic PS (1998) The cerebral cortex a case for a common site of action of antipsychotics. Trends Pharmacol Sci 19: 136–140

    Article  CAS  PubMed  Google Scholar 

  • Lieb K, Denz E, Hess R, Schüttler R, Kornhuber HH, Schreiber H (1996) Preattentive information processing as measured by backward masking and texton detection tasks in adolescents at high genetic risk for schizophrenia. Schizophr Res 21: 171–182

    Article  CAS  PubMed  Google Scholar 

  • Lieberman JA (1999) Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol Psychiatry 46: 729–739

    Article  CAS  PubMed  Google Scholar 

  • Lieberman JA, Sheitman BB, Kinon BJ (1997) Neurochemical sensitization in the pathophysiology of schizophrenia: Deficits and dysfunction in neuronal regulation and plasticity. Neuropsychopharmacology 17: 205–229

    Article  CAS  PubMed  Google Scholar 

  • Lindenmayer JP, Bernstein-Hyman R, Grochowski S (1994) Five-factor model of schizophrenia. Initial validation. J Nerv Ment Dis 182: 631–638

    Article  CAS  PubMed  Google Scholar 

  • Lohr JB, Flynn K (1993) Minor physical anomalies in schizophrenia and mood disorders. Schizophr Bull 19: 551–556

    Article  CAS  PubMed  Google Scholar 

  • Madsen AL, Vorstrup S, Rubin P, Larsen JK, Hemmingsen R (1999) Neurological abnormalities in schizophrenic patients: a prospective follow-up study 5 years after first admission. Acta Psychiatr Scand 100: 119–125

    Article  CAS  PubMed  Google Scholar 

  • Maier W, Lichtermann D, Rietschel M, Held T, Falkai P, Wagner M, Schwab S (1999) Genetik schizophrener Störungen — Neuere Konzepte und Befunde. Nervenarzt 70: 955–969

    Article  CAS  PubMed  Google Scholar 

  • Maier W, Zobel A, Rietschel M (2003) Genetics of schizophrenia and affective disorders. Pharmacopsychiatry 36: 195–202

    Article  Google Scholar 

  • Malaspina D, Coleman E (2003) Olfaction and social drive in schizophrenia. Arch Gen Psychiatry 60: 578–584

    Article  PubMed  Google Scholar 

  • Malaspina D, Coleman E, Goetz RR et al (2002) Odor identification, eye tracking and deficit syndrome schizophrenia. Biol Psychiatry 51: 809–815

    Article  PubMed Central  PubMed  Google Scholar 

  • Marder SR, Davis JM, Chouinard G (1997) The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials. J Clin Psychiatry 58: 538–546

    Article  CAS  PubMed  Google Scholar 

  • Marenco S, Weinberger DR (2000) The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 12: 501–527

    Article  CAS  PubMed  Google Scholar 

  • Marx CE, Lieberman JA (1998) Psychoneuroendocrinology of schizophrenia. Psychoneuroendocrinology 21: 413–434

    CAS  Google Scholar 

  • Matthysse S, Holzmann PS, Gusella JF et al (2004) Linkage of eye movement dysfunction to chromosome 6p in schizophrenia: additional evidence. Am J Med Genet B Neuropsychiatr Genet 128: 30–36

    Article  Google Scholar 

  • Maynard TM, Sikich L, Lieberman JA, LaMantia AS (2001) Neural development, cell-cell signaling, and the »two-hit« hypothesis of schizophrenia. Schizophr Bull 27: 457–476

    Article  CAS  PubMed  Google Scholar 

  • McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, Shenton ME (1999) MRI anatomy of schizophrenia. Biol Psychiatry 1: 1099–1119

    Article  Google Scholar 

  • McGorry PD, Edwards J, Mihalopoulos C, Harrigan SM, Jackson HJ (1996) EPPIC: an evolving system of early detection and optimal management. Schizophr Bull 22: 305–326

    Article  CAS  PubMed  Google Scholar 

  • McGue M, Gottesman II (1991) The genetic epidemiology of schizophrenia and the design of linkage studies. Eur Arch Psychiatry Clin Neurosci 240: 174–181

    Article  CAS  PubMed  Google Scholar 

  • McKay CM, Headlam DM, Copolov DL (2000) Central auditory processing in patients with auditory hallucinations. Am J Psychiatry 157: 759–766

    Article  CAS  PubMed  Google Scholar 

  • McNeil TF, Cantor-Graae E, Ismail B (2000) Obstetric complications and congenital malformation in schizophrenia. Brain Res Brain Res Rev 31: 166–178

    Article  CAS  PubMed  Google Scholar 

  • Meisenzahl EM, Frodl T, Zetzsche T et al (2000) Adhesio interthalamica in male patients with schizophrenia. Am J Psychiatry 157: 823–825

    Article  CAS  PubMed  Google Scholar 

  • Meissner B, Purmann S, Schurmann M et al (1999) hSKCa3: a candidate gene for schizophrenia? Psychiatr Genet 9: 91–96

    Article  CAS  PubMed  Google Scholar 

  • Meltzer HY, Park S, Kessler R (1999) Cognition, schizophrenia and the atypical antipsychotic drugs. Proc Natl Acad Sci USA 96: 13 591–13 593

    Article  CAS  Google Scholar 

  • Mirnics K, Middleton FA, Lewis DA, Levitt P (2001a) Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 24: 479–486

    Article  CAS  PubMed  Google Scholar 

  • Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P (2001b) Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 6: 293–301

    Article  CAS  PubMed  Google Scholar 

  • Mitelman SA, Shihabuddin L, Brickman AM, Hazlett EA, Buchsbaum MS (2003) MRI assessment of gray and white matter distribution in Brodmann’s areas of the cortex in patients with schizophrenia with good and poor outcomes. Am J Psychiatry 160: 2154–2168

    Article  PubMed  Google Scholar 

  • Miyoshi K, Honda A, Baba K et al (2003) Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry 8: 685–694

    Article  CAS  PubMed  Google Scholar 

  • Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL (1999) Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21: 325–340

    Article  CAS  PubMed  Google Scholar 

  • Mohr F, Hubmann W, Albus M et al (2003) Neurological soft signs and neuropsychological performance in patients with first episode schizophrenia. Psychiatry Res 121: 21–30

    Article  PubMed  Google Scholar 

  • Moises HW, Yang L, Kristbjarnarson H et al (1995) An international two-stage genomewide search for schizophrenia susceptibility genes. Nature Genet 11: 321–324

    Article  CAS  PubMed  Google Scholar 

  • Moises HW, Zoega T, Gottesman II (2002) The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia. BMC Psychiatry 2: 8

    Article  PubMed Central  PubMed  Google Scholar 

  • Moore H, West AR, Grace AA (1999) The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia. Biol Psychiatry 46: 40–55

    Article  CAS  PubMed  Google Scholar 

  • Morris DW, Rodgers A, McGhee KA et al (2004) Confirming RGS4 as a susceptibility gene for schizophrenia. Am J Med Genet 125B: 50–53

    Article  PubMed  Google Scholar 

  • Mosher LR, Pollin W, Stabenau JR (1971) Identical twins discordant for schizophrenia. Arch Gen Psychiatry 24: 422–430

    Article  CAS  PubMed  Google Scholar 

  • Müller N, Riedel M, Gruber R, Ackenheil M, Schwarz MJ (2000) The immune system and schizophrenia. An integrative view. Ann NY Acad Sci 917: 456–467

    Article  PubMed  Google Scholar 

  • Mundt C, Lang H (1987) Die Psychopathologie der Schizophrenie. In: Kisker KP, Lauter H, Meyer JE, Müller C, Strömgren E (Hrsg) Psychiatrie der Gegenwart 3. Aufl. Springer, Berlin Heidelberg New York, S 39–70

    Google Scholar 

  • Munk-Jörgensen P, Ewald H (2001) Epidemiology in neurobiological research: exemplified by the influenza-schizophrenia theory. Br J Psychiatry 178: S30–S32

    Article  Google Scholar 

  • Myles-Worsley M, Coon H, McDowell J et al (1999) Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet 88: 544–550

    Article  CAS  PubMed  Google Scholar 

  • Nelson MD, Saykin AJ, Flashman LA, Riordan HJ (1998) Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging. Arch Gen Psychiatry 55: 433–440

    Article  CAS  PubMed  Google Scholar 

  • Ngan ET, Yatham LN, Ruth TJ, Liddle PF (2000) Decreased serotonin 2A receptor densities in neuroleptic-naive patients with schizophrenia: a PET study using [(18)F]setoperone. Am J Psychiatry 157: 1016–1018

    Article  CAS  PubMed  Google Scholar 

  • Niculescu AB 3rd, Kelsoe JR (2001) Convergent functional genomics: application to bipolar disorder. Ann Med 33: 263–271

    Article  CAS  PubMed  Google Scholar 

  • Niethammer R, Weisbrod M, Schiesser S et al (2000) Genetic influence on laterality in schizophrenia? A twin study of neurological soft signs. Am J Psychiatry 157: 272–274

    Article  CAS  PubMed  Google Scholar 

  • Niznikiewicz MA, Kubicki M, Shenton ME (2003) Recent structural and functional imaging findings in schizophrenia. Curr Opin Psychiatry 16: 123–147

    Article  Google Scholar 

  • Norra C, Waberski TD, Kawohl W et al (2004) High-frequency somatosensory thalamocortical oscillations and psychopathology in schizophrenia. Neuropsychobiology 49: 71–80

    Article  PubMed  Google Scholar 

  • O’Driscoll GA, Benkelfat C, Florencio PS, Wolff AL, Joober R, Lal S, Evans AC (1999) Neural correlates of eye tracking deficits in first-degree relatives of schizophrenic patients: a positron emission tomography study. Arch Gen Psychiatry 56: 1127–1134

    Article  PubMed  Google Scholar 

  • Okubo Y, Suhara T, Suzuki K, Kobayashi K et al (2000) Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography. Life Sci 66: 2455–2464

    Article  CAS  PubMed  Google Scholar 

  • Okubo Y, Saijo T, Oda K (2001) A review of MRI studies of progressive brain changes in schizophrenia. J Med Dent Sci 48: 61–67

    CAS  PubMed  Google Scholar 

  • Pantelis C, Velakoulis D, McGorry PD et al (2003) Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361: 281–288

    Article  PubMed  Google Scholar 

  • Paunio T, Ekelund J, Varilo T et al (2001) Genomewide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 10: 3037–3048

    Article  CAS  PubMed  Google Scholar 

  • Pearce BD (2001) Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms. Mol Psychiatry 6: 634–646

    Article  CAS  PubMed  Google Scholar 

  • Pearlson GD, Marsh L (1999) Structural brain imaging in schizophrenia: A selective review. Biol Psychiatry 46: 627–649

    Article  CAS  PubMed  Google Scholar 

  • Peled A, Pressman A, Geva AB, Modai I (2003) Somatosensory evoked potentials during a rubber-hand illusion in schizophrenia. Schizophr Res 64: 157–163

    Article  PubMed  Google Scholar 

  • Pickar D, Breier A, Hsiao JK, Doran AR, Wolkowitz OM, Pato CN, Konicki PE (1990) Cererbrospinal fluid and plasma monoamine metabolites and their relation to psychosis. Implications for regional brain dysfunction in schizophrenia. Arch Gen Psychiatry 47: 641–648

    Article  CAS  PubMed  Google Scholar 

  • Pierri JN, Chaudry AS, Woo T-UW, Lewis DA (1999) Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenia subjects. Am J Psychiatry 156: 1709–1719

    CAS  PubMed  Google Scholar 

  • Pilowsky LS, Costa DC, Ell PJ et al (1992) Clozapine, single-photon emission tomography and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet 340: 199–202

    Article  CAS  PubMed  Google Scholar 

  • Pollmacher T, Hinze-Selch D (1998) Factors confounding studies of circulating soluble interleukin-2 receptor levels in schizophrenia. Schizophr Res 33: 123–124

    Article  CAS  PubMed  Google Scholar 

  • Pilowsky LS, Costa DC, Ell PJ et al (1993) Antipsychotic medication, D2 dopamine receptor blockade and clinical response — a 1231 IBZM SPET (single photon emission tomography) study. Psychol Med 23: 791–799

    Article  CAS  PubMed  Google Scholar 

  • Prasad S, Semwal P, Deshpande S, Bhatia T, Nimgaonkar VL, Thelma BK (2002) Molecular genetics of schizophrenia: past, present and future. J Biosci 27: 35–52

    Article  CAS  PubMed  Google Scholar 

  • Pulver AE, Lasseter VK, Kasch L et al (1995) Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60: 252–260

    Article  CAS  PubMed  Google Scholar 

  • Pulver AE, Mulle J, Nestadt G et al (2000) Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry 5: 650–653

    Article  CAS  PubMed  Google Scholar 

  • Raemaekers M, Jansma JM, Cahn W et al (2002) Neuronal substrate of the saccadic inhibition deficit in schizophrenia investigated with 3-dimensional event-related functional magnetic resonance imaging. Arch Gen Psychiatry 59: 313–320

    Article  PubMed  Google Scholar 

  • Rajkowska G, Miguel-Hidalgo JJ, Makkos Z, Meltzer H, Overholser J, Stockmeier C (2002) Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophrenia. Schizophr Res 57: 127–138

    Article  PubMed  Google Scholar 

  • Rao ML, Kölsch H (2003) Effects of estrogen on brain development and neuroprotection — implications for negative symptoms in schizophrenia. Psychoneuroendocrinology 28: 83–96

    Article  CAS  PubMed  Google Scholar 

  • Raz S, Raz N (1990) Structural brain abnormalities in the major psychoses: a quantitative review of the evidence from computerized imaging. Psychol Bull 108(1): 93–108

    Article  CAS  PubMed  Google Scholar 

  • Reite M, Teale P, Rojas DC, Benkers TL, Carlson J (2003) Anomalous somatosensory cortical localization in schizophrenia. Am J Psychiatry 160: 2148–2153

    Article  PubMed  Google Scholar 

  • Riedel M, Kronig H, Schwarz MJ et al (2002) No association between the G308A polymorphism of the tumor necrosis factor-± gene and schizophrenia. Eur Arch Psychiatry Clin Neurosci 252: 232–234

    Article  PubMed  Google Scholar 

  • Ross DE, Thaker GK, Holcomb HH, Cascella NG, Medoff DR, Tamminga CA (1995) Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res 58: 53–67

    Article  CAS  PubMed  Google Scholar 

  • Rossi A, De Cataldo S, Di Michele V, Manna V, Ceccoli S, Stratta P, Casacchia M (1990) Neurological soft signs in schizophrenia. Br J Psychiatry 157: 735–739

    Article  CAS  PubMed  Google Scholar 

  • Rothermundt M, Arolt V, Weitzsch C, Eckhoff D, Kirchner H (1996) Production of cytokines in acute schizophrenic psychosis. Biol Psychiatry 40: 1294–1297

    Article  CAS  PubMed  Google Scholar 

  • Rothermundt M, Arolt V, Weitzsch C, Eckhoff D, Kirchner H (1998) Immunological dysfunction in schizophrenia: a systematic approach. Neuropsychobiology 37: 186–193

    Article  CAS  PubMed  Google Scholar 

  • Rothermundt M, Arolt V, Leadbeater J, Peters M, Rudolf S, Kirchner H (2000) Cytokine production in unmedicated and treated schizophrenic patients. NeuroReport 11: 3385–3388

    Article  CAS  PubMed  Google Scholar 

  • Rothermundt M, Arolt V, Bayer TA (2001) Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 15: 319–339

    Article  CAS  PubMed  Google Scholar 

  • Rothermundt M, Peters M, Prehn JHM, Arolt V (2003a) S100B in brain damage and neurodegeneration. Microsc Res Tech 60: 614–632

    Article  CAS  PubMed  Google Scholar 

  • Rothermundt M, Ponath G, Arolt V (2003b) S100B in schizophrenic psychosis. Int Rev Neurobiol 59: 445–470

    Article  Google Scholar 

  • Rund BR, Melle I, Friis S et al (2004) Neurocognitive dysfunction in first-episode psychosis: correlates with symptoms, premorbid adjustment and duration of untreated psychosis. Am J Psychiatry 161: 466–472

    Article  PubMed  Google Scholar 

  • Rupp CI (2003) Dysfunctions in olfactory processing in schizophrenia. Curr Opin Psychiatry 16: 181–185

    Article  Google Scholar 

  • Rybakowski JK, Borkowska A, Czerski PM, Hauser J (2001) Dopamine D3 receptor (DRD3) gene polymorphism is associated with the intensity of eye movement disturbances in schizophrenic patients and healthy subjects. Mol Psychiatry 6: 718–724

    Article  CAS  PubMed  Google Scholar 

  • Rybakowski JK, Borkowska A, Czerski PM, Hauser J (2002) Eye movement disturbances in schizophrenia and a polymorphism of catechol-O-methyltransferase gene. Psychiatry Res 113: 49–57

    Article  CAS  PubMed  Google Scholar 

  • Saijo T, Abe T, Someya Y et al (2001) Ten year progressive ventricular enlargement in schizophrenia: an MRI morphometrical study. Psychiatry Clin Neurosci 55: 41–47

    Article  CAS  PubMed  Google Scholar 

  • Schechter I, Butler PD, Silipo G, Zemon V, Javitt DC (2003) Magnocellular and parvocellular contributions to backward masking dysfunctionin schizophrenia. Schizophr Res 64: 91–101

    Article  PubMed  Google Scholar 

  • Scherk H, Vogeley K, Falkai P (2003) Die Bedeutung von Interneuronen bei affektiven und schizophrenen Erkrankungen. Fortschr Neurol Psychiatr 1: 27–32

    Google Scholar 

  • Schmitt A, Weber-Fahr W, Jatzko A, Tost H, Henn FA, Braus DF (2001) Aktueller Überblick ber strukturelle Magnetresonanztomographie bei Schizophrenie. Fortschr Neurol Psychiatr 69: 105–115

    Article  CAS  PubMed  Google Scholar 

  • Schröder J (1997) Subsyndrome der chronischen Schizophrenie. Untersuchungen mit bildgebenden Verfahren zur Heterogenitt schizophrener Psychosen (Monographien aus dem Gesamtgebiete der Psychiatrie Bd 85). Springer, Heidelberg Berlin New York

    Google Scholar 

  • Schröder J, Essig M, Baudendistel K et al (1999) Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: A study with functional magnetic resonance imaging. Neuroimage 9: 81–87

    Article  PubMed  Google Scholar 

  • Schröder J, Niethammer R, Geider FJ, Reitz C, Binkert M, Jauss M, Sauer H (1991) Neurological soft signs in schizophrenia. Schizophr Res 6: 25–30

    Article  PubMed  Google Scholar 

  • Schumacher J, Jamra RA, Freudenberg J et al (2004) Examination of G72 and D-amino acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9: 203–207

    Article  CAS  PubMed  Google Scholar 

  • Schwab SG, Albus M, Hallmayer J et al (1995) Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genet 11: 325–327

    Article  CAS  PubMed  Google Scholar 

  • Schwab SG, Hallmayer J, Albus M et al (2000) A genomewide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosomes 10p and 6. Mol Psychiatry 5: 638–649

    Article  CAS  PubMed  Google Scholar 

  • Schwab SG, Knapp M, Mondabon S et al (2003) Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 72: 185–190

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Schwarcz R, Rassoulpour A, Wu HQ et al (2001) Increased cortical kynureninate content in schizophrenia. Biol Psychiatry 50: 521–530

    Article  CAS  PubMed  Google Scholar 

  • Schwarz MJ, Chiang S, Muller N, Ackenheil M (2001) T-helper-1 and Thelper-2 responses in psychiatric disorders. Brain Behav Immun 4: 340–370

    Article  CAS  Google Scholar 

  • Selemon LD, Goldman-Rakic PS (1999) The reduced neuropil hypothesis: A circuit based model of schizophrenia. Biol Psychiatry 45: 17–25

    Article  CAS  PubMed  Google Scholar 

  • Selemon LD, Rajkowska G (2003) Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder. Curr Mol Med 3: 427–436

    Article  CAS  PubMed  Google Scholar 

  • Shagass C, Straumanis JJ Jr, Roemer RA, Amadeo M (1977) Evoked potentials of schizophrenics in several sensory modalities. Biol Psychiatry 12: 221–235

    CAS  PubMed  Google Scholar 

  • Shapleske J, Rossell SL, Woodruff PW, David AS (1999) The planum temporale: a systematic, quantitative review of its structural, functional and clinical significance. Brain Res Brain Res Rev 29: 26–49

    Article  CAS  PubMed  Google Scholar 

  • Shaw SH, Kelly M, Smith AB et al (1998) A genomewide search for chizophrenia susceptibility genes. Am J Med Genet 81: 364–376

    Article  CAS  PubMed  Google Scholar 

  • Shenton ME, Dickey CC, Frumin M, McCarley RW (2001). A review of MRI findings in schizophrenia. Schizophr Res 49: 1–52

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Shenton ME, Gerig G, McCarley RW, Szekely G, Kikinis R (2002) Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data. Psychiatry Res 115: 15–35

    Article  PubMed Central  PubMed  Google Scholar 

  • Shergill SS, Brammer MJ, Williams SC, Murray RM, McGuire PK (2000) Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Arch Gen Psychiatry 57: 1033–1038

    Article  CAS  PubMed  Google Scholar 

  • Shibre T, Kebede D, Alem A et al (2002) Neurological soft signs (NSS) in 200 treatment-naive cases with schizophrenia: a community-based study in a rural setting. Nord J Psychiatry 56: 425–431

    Article  CAS  PubMed  Google Scholar 

  • Silbersweig D, Stern E (1996) Functional neuroimaging of hallucinations in schizophrenia: toward an integration of bottom-up and top-down approaches. Mol Psychiatry 1: 367–375

    CAS  PubMed  Google Scholar 

  • Silbersweig DA, Stern E, Frith C et al (1995) A functional neuroanatomy of hallucinations in schizophrenia. Nature 378: 176–179

    Article  CAS  PubMed  Google Scholar 

  • Sillitoe RV, Benson MA, Blake DJ, Hawkes R (2003) Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy. J Neurosci 23: 6576–6585

    CAS  PubMed  Google Scholar 

  • Silverman JM, Greenberg DA, Altstiel LD et al (1996) Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree. Am J Med Genet 67: 162–171

    Article  CAS  PubMed  Google Scholar 

  • Silverstein SM, Knight RA, Schwarzkopf SB, West LL, Osborn LM, Kamin D (1996a) Stimulus configuration and context effects in perceptual organization in schizophrenia. J Abnorm Psychol 105: 410–420

    Article  CAS  PubMed  Google Scholar 

  • Silverstein SM, Matteson S, Knight RA (1996b) Reduced top-down influence in auditory perceptual organization in schizophrenia. J Abnorm Psychol 105: 663–667

    Article  CAS  PubMed  Google Scholar 

  • Silverstein SM, Kovács I, Corry R, Valone C (2000) Perceptual organization, the disorganization syndrome, and context processing in chronic schizophrenia. Schizophr Res 43: 11–20

    Article  CAS  PubMed  Google Scholar 

  • Snyder PJ, Bogerts B, Wu H, Bilder RM, Deoras KS, Lieberman JA (1998) Absence of the adhesio interthalamica as a marker of early developmental neuropathology in schizophrenia: an MRI and post mortem histologic study. J Neuroimaging 8: 159–163

    CAS  PubMed  Google Scholar 

  • Stefansson H, Sigurdsson E, Steinthorsdottir V et al (2002). Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71: 877–892

    Article  PubMed Central  PubMed  Google Scholar 

  • Stefansson H, Sarginson J, Kong A et al (2003) Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 72: 83–87

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Stein L, Wise CD (1971) Possible etiology of schizophrenia: progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science 171: 1032–1036

    Article  CAS  PubMed  Google Scholar 

  • Stephenson CME, Bigliani V, Jones HM et al (2000) Striatal and extrastriatal d2/D3 receptor occupancy by quetiapine in vivo [123 1] epidepride single photon emission tomography (SPET) study. Br J Psychiatry 177: 408–415

    Article  CAS  PubMed  Google Scholar 

  • Strange PG (2001) Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects. Pharmacol Rev: 53: 119–133

    CAS  PubMed  Google Scholar 

  • Straub RE, MacLean CJ, O’Neill FA et al (1995) A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genet 11: 287–293

    Article  CAS  PubMed  Google Scholar 

  • Straub RE, MacLean CJ, O’Neill FA, Walsh D, Kendler KS (1997) Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry 2: 148–155

    Article  CAS  PubMed  Google Scholar 

  • Straub RE, Jiang Y, MacLean CJ et al (2002) Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 71: 337–348

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Suslow T, Arolt V (1998) Backward masking in schizophrenia: time course of visual processing deficits during task performance. Schizophr Res 33: 79–86

    Article  CAS  PubMed  Google Scholar 

  • Sweeney JA, Luna B, Srinivasagam NM, Keshavan MS, Schooler NR, Haas GL, Carl JR (1998) Eye tracking abnormalities in schizophrenia: evidence for dysfunction in the frontal eye fields. Biol Psychiatry 44: 698–708

    Article  CAS  PubMed  Google Scholar 

  • Thompson PM, Vidal C, Giedd JN et al (2001) Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc Natl Acad Sci USA 98: 11650–11655

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Tienari P, Wynne LC, Sorri A et al (2004) Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees. Br J Psychiatry 184: 216–222

    Article  PubMed  Google Scholar 

  • Torrey EF, Miller J, Rawlings N, Yolken RH (1997) Seasonality of birth in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 28: 1–38

    Article  CAS  PubMed  Google Scholar 

  • Tregellas JR, Tanabe JL, Miller DE, Ross RG, Olincy A, Freedman R (2004) Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an FMRI study. Am J Psychiatry 161: 315–321

    Article  PubMed  Google Scholar 

  • Trichard C., Paillere-Martinot ML, Attar-Levy D, Blin J, Feline A, Martinot JL (1998) No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET. Schizophr Res 31: 13–17

    Article  CAS  PubMed  Google Scholar 

  • Tsai G, Coyle JT (2002) Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 42: 165–179

    Article  CAS  PubMed  Google Scholar 

  • Tsai G, Yang P, Li-Chen C, Lange N, Coyle JT (1998) D-Serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 44: 1081–1089

    Article  CAS  PubMed  Google Scholar 

  • Ujike H, Takehisa Y, Takaki M et al (2001) NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. Neurosci Lett 301: 41–44

    Article  CAS  PubMed  Google Scholar 

  • van Kammen DP, Peters J, Yao J, van Kammen WB, Neylan T, Shaw D, Linnoila M (1990) Norepinephrine in acute exacerbations of chronic schizophrenia. Negative symptoms revisited. Arch Gen Psychiatry 47: 161–168

    Article  PubMed  Google Scholar 

  • Venkatasubramanian G, Latha V, Gangadhar BN, Janakiramaiah N, Subbakrishna DK, Jayakumar PN, Keshavan MS (2003) Neurological soft signs in never-treated schizophrenia. Acta Psychiatr Scand 108: 144–146

    Article  CAS  PubMed  Google Scholar 

  • Verhoeff NP, Meyer JH, Kecojevic A et al (2000) A voxed-by-voxed analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT (2A) receptor changes in schizophrenia. Psychiatry Res 99: 123–135

    Article  CAS  PubMed  Google Scholar 

  • Vogeley K, Schneider-Axmann T, Pfeiffer U et al (2000) Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study. Am J Psychiatry 157: 34–39

    Article  CAS  PubMed  Google Scholar 

  • Walker E, Lewine RJ (1990) Prediction of adult-onset schizophrenia from childhood home movies of the patients. Am J Psychiatry 147: 1052–1056

    Article  CAS  PubMed  Google Scholar 

  • Walker MA, Highley JR, Esiri MM, MacDonald B, Roberts HC, Evans SP, Crow TJ (2002) Estimated neuronal populations and volumes of the hippocampus and its subfields in schizophrenia. Am J Psychiatry 159: 821–828

    Article  PubMed  Google Scholar 

  • Wei J, Hemmings GP (2000) The NOTCH4 locus is associated with susceptibility to schizophrenia. Nature Genet 25: 376–377

    Article  CAS  PubMed  Google Scholar 

  • Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660–669

    Article  CAS  PubMed  Google Scholar 

  • Weinberger DR, Laruelle M (2001) Neurochemical and neuropharmacological imaging in schizophrenia. In: Davis KL, Charney DS, Coyle JT, Nemeroff C (eds) Neuropharmacology — The fifth generation of progress. Lippincott, Williams & Wilkins, Philadelphia

    Google Scholar 

  • Weinberger DR, McClure RK (2002) Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain? Arch Gen Psychiatry 59: 553–558

    Article  PubMed  Google Scholar 

  • Whitty P, Clarke M, Browne S et al (2003) Prospective evaluation of neurological soft signs in first-episode schizophrenia in relation to psychopathology: state versus trait phenomena. Psychol Med 33: 1479–1484

    Article  CAS  PubMed  Google Scholar 

  • Wiedl KH, Wienobst J, Schottke HH, Green MF, Nuechterlein KH (2001) Attentional characteristics of schizophrenia patients differing in learning proficiency on the Wisconsin Card Sorting Test. Schizophr Bull 27: 687–695

    Article  CAS  PubMed  Google Scholar 

  • Wilke I, Arolt V, Rothermundt M, Weitzsch C, Hornberg M, Kirchner H (1996) Investigations of cytokine production in whole blood cultures of paranoid and residual schizophrenic patients. Eur Arch Psychiatry Clin Neurosci 246: 279–284

    Article  CAS  PubMed  Google Scholar 

  • Williams J, Spurlock G, Holmans P et al (1998) A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 3: 141–149

    Article  CAS  PubMed  Google Scholar 

  • Williams NM, Preece A, Spurlock G et al (2004) Support for RGS4 as a susceptibility gene for schizophrenia. Biol Psychiatry 55: 192–195

    Article  CAS  PubMed  Google Scholar 

  • Woodruff PW, McManus IC, David AS (1995) Meta-analysis of corpus callosum size in schizophrenia. J Neurol Neurosurg Psychiatry 58: 457–461

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Woods BT (1998) Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry 155: 1661–1670

    Article  CAS  PubMed  Google Scholar 

  • Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET (2000) Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157: 16–25

    Article  CAS  PubMed  Google Scholar 

  • Xiberas X, Martinot JL, Mallet L et al (2001) Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia. Br J Psychiatry 179: 503–508

    Article  CAS  PubMed  Google Scholar 

  • Zobel A, Maier W (2004) Endophänotypen — ein neues Konzept zur biologischen Charakterisierung psychischer Störungen. Nervenarzt 75: 205–214

    Article  CAS  PubMed  Google Scholar 

  • Zuckerman L, Rehavi M, Nachman R, Weiner I (2003) Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the off spring: a novel neurodevelopmental model of schizophrenia. Neuropsychopharmacology 28: 1778–1789

    Article  CAS  PubMed  Google Scholar 

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Arolt, V., Ohrmann, P., Rothermundt, M. (2006). Schizophrenie und verwandte Störungen — Neurobiologie. In: Förstl, H., Hautzinger, M., Roth, G. (eds) Neurobiologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30887-3_7

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