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Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung — Neurobiologie

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Neurobiologie psychischer Störungen

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Literatur

  • Anand KJ, Scalzo FM (2000) Can adverse neonatal experiences alter brain development and subsequent behavior? Biol Neonate 77: 69–82

    Article  CAS  PubMed  Google Scholar 

  • Arnsten AF (1998) The biology of being frazzled. Science 280: 1711–1772

    Article  CAS  PubMed  Google Scholar 

  • Arnsten AF (2001) Modulation of prefrontal cortical-striatal circuits: relevance to therapeutic treatments for Tourette syndrome and attention-deficit hyperactivity disorder. Adv Neurol 85: 333–341

    CAS  PubMed  Google Scholar 

  • Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121: 65–94

    Article  CAS  PubMed  Google Scholar 

  • Barry RJ, Clarke AR, Johnstone SJ (2003a) A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clin Neurophysiol 114: 171–183

    Article  PubMed  Google Scholar 

  • Barry RJ, Johnstone SJ, Clarke AR (2003b) A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials. Clin Neurophysiol 114: 184–198

    Article  PubMed  Google Scholar 

  • Biederman J, Milberger S, Faraone SV et al (1995) Impact of adversity on functioning and comorbidity in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 34: 1495–1503

    Article  CAS  PubMed  Google Scholar 

  • Brandeis D, Banaschewski T, Baving L et al (2002) Multicenter P300 brain mapping of impaired attention to cues in hyperkinetic children. J Am Acad Child Adolesc Psychiatry 41: 990–998

    Article  PubMed  Google Scholar 

  • Bush G, Frazier JA, Rauch SL et al (1999) Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry 45: 1542–1552

    Article  CAS  PubMed  Google Scholar 

  • Buznikov GA, Shmukler YuB, Lauder JM (1999) Changes in the physiological roles of neurotransmitters during individual development. Neurosci Behav Physiol 29: 11–21

    Article  CAS  PubMed  Google Scholar 

  • Casey BJ, Castellanos FX, Giedd JN et al (1997) Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36: 374–383

    Article  CAS  PubMed  Google Scholar 

  • Castellanos FX (1997) Toward a pathophysiology of attention-deficit/hyperactivity disorder. Clin Pediatr 36: 381–393

    Article  CAS  Google Scholar 

  • Castellanos FX (2002) Proceed, with caution: SPECT cerebral blood flow studies of children and adolescents with attention deficit hyperactivity disorder. J Nucl Med 43: 1630–1633

    PubMed  Google Scholar 

  • Castellanos FX, Tannock R (2002) Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nature Neurosci 3: 617–628

    Article  CAS  Google Scholar 

  • Castellanos FX, Giedd JN, Marsh WL et al (1996) Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry 53: 607–616

    Article  CAS  PubMed  Google Scholar 

  • Castellanos FX, Giedd JN, Berquin PC et al (2001) Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 58: 289–295

    Article  CAS  PubMed  Google Scholar 

  • Cheon KA, Ryu YH, Kim YK, Namkoong K, Kim CH, Lee JD (2003) Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. Eur J Nucl Med Mol Imaging 30: 306–311

    Article  CAS  PubMed  Google Scholar 

  • Clarke AS, Hedeker DR, Ebert MH, Schmidt DE, McKinney WT, Kraemer GW (1996) Rearing experience and biogenic amine activity in infant rhesus monkeys. Biol Psychiatry 40: 338–352

    Article  CAS  PubMed  Google Scholar 

  • Clarke AR, Barry RJ, McCarthy R, Selikowitz M (2001) EEG-defined subtypes of children with attention-deficit/hyperactivity disorder. Clin Neurophysiol 112: 2098–2105

    Article  CAS  PubMed  Google Scholar 

  • Cook EH Jr, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL (1995) Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 56: 993–998

    PubMed Central  CAS  PubMed  Google Scholar 

  • Crabbe JC, Phillips TJ (2003) Mother nature meets mother nature. Nature Neurosci 6: 440–442

    Article  CAS  PubMed  Google Scholar 

  • Crespi F, Wright IK, Möbius C (1992) Isolation rearing of rats alters release of 5-hydroxytryptamine and dopamine in the frontal cortex: an in vivo electrochemical study. Exp Brain Res 88: 495–501

    Article  CAS  PubMed  Google Scholar 

  • Crosbie J, Schachar R (2001) Deficient inhibition as a marker for familial ADHD. Am J Psychiatry 158: 1884–1890

    Article  CAS  PubMed  Google Scholar 

  • Dammasch IE, Wagner GP, Wolff JR (1986) Self-stabilization of neuronal networks. Biol Cybern 54: 211–222

    Article  CAS  PubMed  Google Scholar 

  • Dawirs RR, Teuchert-Noodt G, Kacza J (1992) Naturally occurring degrading events in axon terminals of the dentate gyrus and stratum lucidum in the spiny mouse (Acomys cahirinus) during maturation, adulthood and aging. Dev Neurosci 14: 210–220

    Article  CAS  PubMed  Google Scholar 

  • Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ (1999) Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 354: 2132–2133

    Article  CAS  PubMed  Google Scholar 

  • Ernst M, Liebenauer LL, King AC, Fitzgerald GA, Cohen RM, Zametkin AJ (1994) Reduced brain metabolism in hyperactive girls. J Am Acad Child Adolesc Psychiatry 33: 858–868

    Article  CAS  PubMed  Google Scholar 

  • Ernst M, Zametkin AJ, Matochik JA, Jons PH, Cohen RM (1998) DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study. J Neurosci 18: 5901–5907

    CAS  PubMed  Google Scholar 

  • Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Jons PH, Cohen RM (1999) High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder. Am J Psychiatry 156: 1209–1215

    CAS  PubMed  Google Scholar 

  • Faraone SV (2003) Report from the 4th International Meeting of the Attention Deficit Hyperactivity Disorder Molecular Genetics Network. Am J Med Genet 121B: 55–59

    Article  PubMed  Google Scholar 

  • Faraone SV, Doyle AE (2000) Genetic influences on attention deficit hyperactivity disorder. Curr Psychiatry Rep 2: 143–146

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Biederman J, Weiffenbach B et al (1999) Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder. Am J Psychiatry 156: 768–770

    CAS  PubMed  Google Scholar 

  • Filipek PA, Semrud-Clikeman M, Steingard RJ, Renshaw PF, Kennedy DN, Biederman J (1997) Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity disorder with normal controls. Neurology 48: 589–601

    Article  CAS  PubMed  Google Scholar 

  • Fisher SE, Francks C, McCracken JT et al (2002) A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 70: 1183–1196

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fox NA, Rubin KH, Calkins SD et al (1995) Frontal activation asymmetry and social competence at four years of age. Child Dev 66: 1770–1784

    Article  CAS  PubMed  Google Scholar 

  • Francis DD, Szegda K, Campbell G, Martin WD, Insel TR (2003) Epigenetic sources of behavioral differences in mice. Nature Neurosci 6: 445–446

    CAS  PubMed  Google Scholar 

  • Fulford AJ, Marsden CA (1997) Effect of isolation-rearing on noradrenaline release in rat hypothalamus and hippocampus in vitro. Brain Res 748: 93–99

    Article  CAS  PubMed  Google Scholar 

  • Fuster JM (1989) The prefrontal cortex: anatomy, physiology and neuropsychology of the frontal lobe, 2nd edn. Raven, New York

    Google Scholar 

  • Garris PA, Ciolkowski EL, Pastore P, Wightman RM (1994) Efflux of dopamine from the synpatic cleft in the nucleus accumbens of the rat brain. J Neurosci 14: 6084–6093

    CAS  PubMed  Google Scholar 

  • Gaspar P, Berger B, Febvret A, Vigny A, Henry JP (1989) Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamnie-ß-hydroxylase. J Comp Neurol 279: 249–271

    Article  CAS  PubMed  Google Scholar 

  • Gentsch C, Lichtsteiner M, Feer H (1981) Locomotor activity, defecation score and corticosterone levels during an open-field exposure. A comparison among individually and group-housed rats and genetically selected rat lines. Physiol Behav 27: 183–186

    Article  CAS  PubMed  Google Scholar 

  • Goldman-Rakic PS, Brown RM (1982) Post-natal development of monoamine content and synthesis in the cerebral cortex of Rhesus monkey. Dev Brain Res 4: 339–349

    Article  CAS  Google Scholar 

  • Hall FS (1998) Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Crit Rev Neurobiol 12: 129–162

    Article  CAS  PubMed  Google Scholar 

  • Hall FS, Wilkinson LS, Humby T, Inglis W, Kendall DA, Marsden CA, Robbins TW (1998) Isolation rearing in rats: pre-and postsynaptic changes in striatal dopaminergic systems. Pharmacol Biochem Behav 59: 859–872

    Article  CAS  PubMed  Google Scholar 

  • Halperin JM, Newcorn JH, Koda VH, Pick L, McKay KE, Knott P (1997) Noradrenergic mechanisms in ADHD children with and without reading disabilities: a replication and extension. J Am Acad Child Adolesc Psychiatry 36: 1688–1697

    Article  CAS  PubMed  Google Scholar 

  • Haydon PG, McCobb DP, Kater SB (1984) Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons. Science 226: 561–564

    Article  CAS  PubMed  Google Scholar 

  • Heinrich H, Nelson K, Moll GH, Rothenberger A (1998) GöFI — Ein Neurofeedback-System für die Kinder-und Jugendpsychiatrie. Biomed Tech 43: 67–71

    Article  Google Scholar 

  • Heinrich H, Dickhaus H, Rothenberger A, Heinrich V, Moll GH (1999) Single-sweep analysis of evoked potentials by wavelet networks — methodological basis and clinical application. IEEE Trans Biomed Eng 46: 867–879

    Article  CAS  PubMed  Google Scholar 

  • Heinrich H, Moll GH, Dickhaus H, Kolev V, Yordanova J, Rothenberger A (2001) Time-on-task analysis using wavelet networks in an event-related potential study on attention-deficit hyperactivity disorder. Clin Neurophysiol 112: 1280–1287

    Article  CAS  PubMed  Google Scholar 

  • Heinrich H, Gevensleben H, Freisleder FJ, Moll GH, Rothenberger A (2004) Training of slow cortical potentials in ADHD children: evidence for positive behavioral and neurophysiological effects. Biol Psychiatry 55: 772–775

    Article  PubMed  Google Scholar 

  • Herskovits EH, Megalooikonomou V, Davatzikos C, Chen A, Bryan RN, Gerring JP (1999) Is the spatial distribution of brain lesions associated with closed-head injury predictive of subsequent development of attention-deficit/hyperactivity disorder? Analysis with brain-image database. Radiology 213: 389–394

    Article  CAS  PubMed  Google Scholar 

  • Hüher G (1998) Stress and the adaptive self-organization of neuronal connectivity during early childhood. Int J Dev Neurosci 16: 297–306

    Article  Google Scholar 

  • Ivry R (1997) Cerebellar timing systems. Int Rev Neurobiol 41: 555–573

    Article  CAS  PubMed  Google Scholar 

  • Jones GH, Marsden CA, Robbins TW (1991) Behavioural rigidity and rule-learning deficits following social isolation in rats: neurochemical correlates. Behav Brain Res 43: 35–50

    Article  CAS  PubMed  Google Scholar 

  • Jonkman LM, Kemner C, Verbaten MN et al (1997) Effects of methylphenidate on event-related potentials and performance of attention-deficit hyperactivity disorder children in auditory and visual selective attention tasks. Biol Psychiatry 41: 690–702

    Article  CAS  PubMed  Google Scholar 

  • Joseph R (1999) Environmental influences on neural plasticity, the limbic system, emotional development and attachment: a Review. Child Psychiatry Hum Dev 29: 189–208

    Article  CAS  PubMed  Google Scholar 

  • Kates WR, Frederikse M, Mostofsky SH et al (2002) MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome. Psychiatry Res 116: 63–81

    Article  PubMed  Google Scholar 

  • Kaya GC, Pekcanlar A, Bekis R, Ada E, Miral S, Emiroglu N, Durak H (2002) Technetium-99m HMPAO brain SPECT in children with attention deficit hyperactivity disorder. Ann Nucl Med 16: 527–531

    Article  PubMed  Google Scholar 

  • Kim BN, Lee JS, Shin MS, Cho SC, Lee DS (2002) Regional cerebral perfusion abnormalities in attention deficit/hyperactivity disorder. Statistical parametric mapping analysis. Eur Arch Psychiatry Clin Neurosci 252: 219–225

    Article  PubMed  Google Scholar 

  • Kotchoubey B, Strehl U, Holzapfel S, Schneider D, Blankenhorn V, Birbaumer N (1999) Control of cortical excitability in epilepsy. Adv Neurol 81: 281–290

    CAS  PubMed  Google Scholar 

  • Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K (2000) Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett 285: 107–110

    Article  CAS  PubMed  Google Scholar 

  • Kreppner JM, O’Connor TG, Rutter M (2001) Can inattention/overactivity be an institutional deprivation syndrome? J Abnorm Child Psychol 29: 513–528

    Article  CAS  PubMed  Google Scholar 

  • Lauder JM (1988) Neurotransmitters as morphogens. Prog Brain Res 73: 365–387

    Article  CAS  PubMed  Google Scholar 

  • Lazzaro I, Gordon E, Li W et al (1999) Simultaneous EEG and EDA measures in adolescent attention deficit hyperactivity disorder. Int J Psychophysiol 34: 123–134

    Article  CAS  PubMed  Google Scholar 

  • Lehmann K, Teuchert-Noodt G, Dawirs RR (2002) Postnatal rearing conditions influence ontogeny of adult dopamine transporter (DAT) immunoreactivity of the striatum in gerbils. J Neural Transm 109: 1129–1137

    Article  CAS  PubMed  Google Scholar 

  • Levy F, Hay DA, McStephen M, Wood C, Waldman I (1997) Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study. J Am Acad Child Adolesc Psychiatry 36: 737–744

    Article  CAS  PubMed  Google Scholar 

  • Lewis DA, Sesack SR, Levey AI, Rosenberg DR (1998) Dopamine axons in primate pre-frontal cortex: specificity of distribution, synaptic targets and development. Adv Pharmacol 42: 703–706

    Article  CAS  PubMed  Google Scholar 

  • Linden M, Habib T, Radojevic V (1996) A controlled study of EEG biofeedback effects on cognitive and behavioral measures with attention-deficit disorder and learning disabled children. Biofeedback Self Regul 21: 35–49

    Article  CAS  PubMed  Google Scholar 

  • Liu D, Diorio J, Tannenbaum B et al (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277: 1659–1662

    Article  CAS  PubMed  Google Scholar 

  • Ljungberg T, Apicella P, Schultz W (1992) Responses of monkey dopamine neurons during learning of behavioral reactions. J Neurophysiol 67: 154–163

    Google Scholar 

  • Lou HC, Henriksen L, Bruhn P (1984) Focal cerebral hypoperfusion in children with dysphasia and/or attention deficit disorder. Arch Neurol 41: 825–829

    Article  CAS  PubMed  Google Scholar 

  • Lubar JF, Swartwood MO, Swartwood JN, O’Donnell PH (1995) Evaluation of the effectiveness of EEG neurofeedback training for ADHD in a clinical setting as measured by changes in T.O.V. a. scores, behavioral ratings, and WISC-R performance. Biofeedback Self Regul 20: 83–99

    Article  CAS  PubMed  Google Scholar 

  • Madras BK, Miller GM, Fischman AJ (2002) The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res 130: 57–63

    Article  CAS  PubMed  Google Scholar 

  • Masterman DL, Cummings JL (1997) Frontal-subcortical circuits: the anatomic basis of executive, social and motivated behaviours. J Psychopharmacol 11: 107–114

    Article  CAS  PubMed  Google Scholar 

  • Mataro M, Garcia-Sanchez C, Junque C, Estevez-Gonzalez A, Pujol J (1997) Magnetic resonance imaging measurement of the caudate nucleus in adolescents with attention-deficit hyperactivity disorder and its relationship with neuropsychological and behavioral measures. Arch Neurol 54: 963–968

    Article  CAS  PubMed  Google Scholar 

  • Matsukawa M, Ogawa M, Nakadate K, Maeshima T, Ichitani Y, Kawai N, Okado N (1997) Serotonin and acetylcholine are crucial to maintain hippocampal synapses and memory acquisition in rats. Neurosci Lett 230: 13–16

    Article  CAS  PubMed  Google Scholar 

  • Mattson MP, Kater SB (1989) Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture. Brain Res 478: 337–348

    Article  CAS  PubMed  Google Scholar 

  • Mattson MP, Dou P, Kater SB (1988) Outgrowth regulating actions of glutamate in isolated hippocampal pyramidal neurons. J Neurosci 8: 2087–2100

    CAS  PubMed  Google Scholar 

  • Max JE, Fox PT, Lancaster JL et al (2002) Putamen lesions and the development of attention-deficit/hyperactivity symptomatology. J Am Acad Child Adolesc Psychiatry 41: 563–571

    Article  PubMed  Google Scholar 

  • Melchitzky DS, Lewis DA (2000) Tyrosine hydroxylase-and dopamine transporter-immunoreactive axons in the primate cerebellum. Evidence for a lobular-and laminar-specific dopamine innervation. Neuropsychopharmacology 22: 466–472

    Article  CAS  PubMed  Google Scholar 

  • Mellins CA, Gatz M, Baker L (1996) Children’s methods of coping with stress: a twin study of genetic and environmental influences. J Child Psychol Psychiatry 37: 721–730

    Article  CAS  PubMed  Google Scholar 

  • Mick E, Biederman J, Faraone SV, Sayer J, Kleinman S (2002) Case-control study of attention-deficit hyperactivity disorder and maternal smoking, alcohol use, and drug use during pregnancy. J Am Acad Child Adolesc Psychiatry 41: 378–385

    Article  PubMed  Google Scholar 

  • Moll GH, Heinrich H, Trott GE, Wirth S, Rothenberger A (2000) Deficient intracortical inhibition in drug-naive children with attention-defi— cit hyperactivity disorder is enhanced by methylphenidate. Neurosci Lett 284: 121–125

    Article  CAS  PubMed  Google Scholar 

  • Moll GH, Heinrich H, Trott GE, Wirth S, Bock N, Rothenberger A (2001) Children with comorbid attention-deficit hyperactivity disorder and tic disorder: evidence for additive inhibitory deficits within the motor system. Ann Neurol 49: 393–396

    Article  CAS  PubMed  Google Scholar 

  • Monastra VJ, Lubar JF, Linden M (2001) The development of a quantitative electroencephalographic scanning process for attention deficit-hyperactivity disorder: reliability and validity studies. Neuropsychology 15: 136–144

    Article  CAS  PubMed  Google Scholar 

  • Morgensen J (1991) Inflluences of rearing conditions on functional properties of the rat’s prefrontal system. Behav Brain Res 5: 375–386

    Article  Google Scholar 

  • Morgan MJ, Einon DF, Nocholas D (1975) The effects of isolation rearing on behavioural inhibition in the rat. Q J Exp Psychol 27: 615–634

    Article  Google Scholar 

  • Neddens J, Brandenburg K, Teuchert-Noodt G, Dawirs RR (2001) Differential environment alters ontogeny of dopamine innervation of the orbital prefrontal cortex in gerbils. J Neurosci Res 63: 209–213

    Article  CAS  PubMed  Google Scholar 

  • Nieoullon A (2002) Dopamine and the regulation of cognition and attention. Prog Neurobiol 67: 53–83

    Article  CAS  PubMed  Google Scholar 

  • Park GAS, Pappas BA, Murtha SM, Ally A (1992) Enriched enviromnment primes forebrain choline acetyltransferase activity to respond to learning experience. Neurosci Lett 143: 259–262

    Article  CAS  PubMed  Google Scholar 

  • Pendleton RG, Rasheed A, Roychowdhury R, Hillman R (1998) A new role for catecholamines: ontogenesis. Trends Physiol Sci 19: 248–251

    Article  CAS  Google Scholar 

  • Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathology. J Child Psychol Psychiatry 37: 51–87

    Article  CAS  PubMed  Google Scholar 

  • Peters DA (1984) Prenatal stress: effect on development of rat brain adrenergic receptors. Pharmacol Biochem Behav 21: 417–422

    Article  CAS  PubMed  Google Scholar 

  • Peters DA (1986) Prenatal stress: effect on development of rat brain serotonergic neurons. Pharmacol Biochem Behav 24: 1377–1382

    Article  CAS  PubMed  Google Scholar 

  • Plomin R, Pedersen NL, Lichtenstein P, McClearn GE (1994) Variability and stability in cognitive abilities are largely genetic later in life. Behav Genet 1994 24: 207–215

    Article  CAS  PubMed  Google Scholar 

  • Restani P, Corsini E, Galimberti R, Galli CL (1990) Post-natal ontogenesis of dopaminergic and serotoninergic system in rat caudate nucleus. Pharmacol Res 22: 343–350

    Article  CAS  PubMed  Google Scholar 

  • Robbins TW (1996) Dissociating executive functions of the prefrontal cortex. Philos Trans R Soc London Ser 351: 1463–1471

    Article  CAS  Google Scholar 

  • Rockstroh B, Elbert T, Lutzenberger W, Birbaumer N (1990) Biofeedback: Evaluation and therapy in children with attentional dysfunctions. In: Rothenberger A (ed) Brain and behavior in child psychiatry. Springer, Berlin Heidelberg New York, pp 345–357

    Chapter  Google Scholar 

  • Rosenzweig MR, Bennet EL (1996) Psychobiology of plasticity: effects of training and experience on brain and behavior. Behav Brain Res 78: 57–65

    Article  CAS  PubMed  Google Scholar 

  • Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SC, Simmons A, Bullmore ET (1999) Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am J Psychiatry 156: 891–896

    Article  CAS  PubMed  Google Scholar 

  • Rutter M, Silberg J (2002) Gene-environment interplay in relation to emotional and behavioral disturbance. Annu Rev Psychol 53: 463–490

    Article  PubMed  Google Scholar 

  • Sawaguchi T (2001) The effects of dopamine and its antagonists on directional delay-period activity of prefrontal neurons in monkeys during an oculomotor delayed-response task. Neurosci Res 41: 115–128

    Article  CAS  PubMed  Google Scholar 

  • Scahill L, Schwab-Stone M, Merikangas KR, Leckman JF, Zhang H, Kasl S (1999) Psychosocial and clinical correlates of ADHD in a community sample of school-age children. J Am Acad Child Adolesc Psychiatry 38: 976–984

    Article  CAS  PubMed  Google Scholar 

  • Schweitzer JB, Faber TL, Grafton ST, Tune LE, Hoffman JM, Kilts CD (2000) Alterations in the functional anatomy of working memory in adult attention deficit hyperactivity disorder. Am J Psychiatry 157: 278–280

    Article  CAS  PubMed  Google Scholar 

  • Seeman P, Madras BK (1998) Anti-hyperactivity medication: methylphenidate and amphetamine. Mol Psychiatry 3: 386–396

    Article  CAS  PubMed  Google Scholar 

  • Sergeant J (2000) The cognitive-energetic model: an empirical approach to attention-deficit hyperactivity disorder. Neurosci Biobehav Rev 24: 7–12

    Article  CAS  PubMed  Google Scholar 

  • Sieg KG, Gaffney GR, Preston DF, Hellings JA (1995) SPECT brain imaging abnormalities in attention deficit hyperactivity disorder. Clin Nucl Med 20: 55–60

    Article  CAS  PubMed  Google Scholar 

  • Smeets WJ, Marin O, Gonzalez A (2000) Evolution of the basal ganglia: new perspectives through a comparative approach. J Anat 196: 501–517

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Smith Y, Kieval JZ (2000) Anatomy of the dopamine system in the basal ganglia. Trends Neurosci 23 (Suppl): 28–33

    Article  Google Scholar 

  • Smith KM, Daly M, Fischer M, Yiannoutsos CT, Bauer L, Barkley R, Navia BA (2003) Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: Genetic analysis of the Milwaukee longitudinal study. Am J Med Genet 119B: 77–85

    Article  PubMed  Google Scholar 

  • Solanto MV (1998) Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 94: 127–152

    Article  CAS  PubMed  Google Scholar 

  • Solanto MV, Abikoff H, Sonuga-Barke E et al (2001) The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multimodal treatment study of AD/HD. J Abnorm Child Psychol 29: 215–228

    Article  CAS  PubMed  Google Scholar 

  • Stuss DT, Eskes GH, Foster JK (1994) Experimental neuropsychological studies of frontal lobe functions. Handbook Neuropsychol 9: 149–185

    Google Scholar 

  • Swanson JM, Flodman P, Kennedy J et al (2000) Dopamine genes and ADHD. Neurosci Biobehav Rev 24: 21–25

    Article  CAS  PubMed  Google Scholar 

  • Todd RD (1992) Neural development is regulated by classical neurotransmitters: dopamine D2 receptor stimulation enhances neurite outgrowth. Biol Psychiatry 31: 794–807

    Article  CAS  PubMed  Google Scholar 

  • van Dyck CH, Seibyl JP, Malison RT et al (1995) Age-related decline in striatal dopamine transporter binding with iodine-123-ß-CITSPECT. J Nucl Med 37: 1911–1912

    Google Scholar 

  • van Dyck CH, Quinlan DM, Cretella LM et al (2002) Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder. Am J Psychiatry 159: 309–312

    Article  PubMed  Google Scholar 

  • Vaughn JE (1989) Review: Fine structure of synaptogenesis in the vertebrate central nervous system. Synapse 3: 255–285

    Article  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al (1998) Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 155: 1325–1331

    Article  CAS  PubMed  Google Scholar 

  • Waldrep DA (2002) Two cases of ADHD following GABHS infection: a PANDAS subgroup? J Am Acad Child Adolesc Psychiatry 41: 1273–1274

    Article  PubMed  Google Scholar 

  • Wakshlak A, Weinstock M (1990) Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress. Physiol Behav 48: 289–292

    Article  CAS  PubMed  Google Scholar 

  • Walters JR, Ruskin DN, Allers KA, Bergstrom DA (2000) Pre-and postsynaptic aspects of dopamine-mediated transmittion. Trends Neurosci 23: 41–47

    Article  Google Scholar 

  • Winterfeld KT, Teuchert-Noodt G, Dawirs RR (1998) Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus). J Neurosci Res 52: 201–209

    Article  CAS  PubMed  Google Scholar 

  • Wolff JR, Wagner GP (1983) Self-organization in synaptogenesis: interaction between the formation of excitatory and inhibitory synapses. In: Basar E, Flohr H, Haken H et al. (eds) Synergetics of the brain. Springer, Berlin Heidelberg New York, pp 50–59

    Chapter  Google Scholar 

  • Yeo RA, Hill DE, Campbell RA et al (2003) Proton magnetic resonance spectroscopy investigation of the right frontal lobe in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 42: 303–310

    Article  PubMed  Google Scholar 

  • Yordanova J, Dumais-Huber C, Rothenberger A, Woerner W (1997) Frontocortical activity in children with comorbidity of tic disorder and attention-deficit hyperactivity disorder. Biol Psychiatry 41: 585–594

    Article  CAS  PubMed  Google Scholar 

  • Zametkin AJ, Nordahl TE, Gross M et al (1990) Cerebral glucose metabolism in adults with hyperactivity of childhood onset. N Engl J Med 323: 1361–1366

    Article  CAS  PubMed  Google Scholar 

  • Zametkin AJ, Liebenauer LL, Fitzgerald GA et al (1993) Brain metabolism in teenagers with attention-deficit hyperactivity disorder. Arch Gen Psychiatry 50: 333–340

    Article  CAS  PubMed  Google Scholar 

  • Zametkin AJ, Ernst M, Silver R (1998) Laboratory and diagnostic testing in child and adolescent psychiatry: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 37: 464–472

    Article  CAS  PubMed  Google Scholar 

  • Zhang LX, Levine S, Dent G et al (2002) Maternal deprivation increases cell death in the infant rat brain. Dev Brain Res 133: 1–11

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Kinder- und Jugendpsychiatrie am Universitätsklinikum Erlangen, Schwabachanlage 6 und 10, 91054, Erlangen

    Gunther H. Moll (Prof. Dr. med.)

  2. Psychiatrische Klinik, Universität Göttingen, von-Siebold-Straße 5, 37075, Göttingen

    Gerald Hüther (Prof. Dr. Dr. med.)

Authors
  1. Gunther H. Moll
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  2. Gerald Hüther
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Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Hans Förstl

  2. Abteilung für Klinische Psychologie und Entwicklungspsychologie, Universität Tübingen, Christophstraße 2, 72072, Tübingen, Germany

    Martin Hautzinger

  3. Institut für Hirnforschung, Universität Bremen, Postfach 33 04 40, 28334, Bremen, Germany

    Gerhard Roth

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© 2006 Springer Medizin Verlag Heidelberg

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Moll, G.H., Hüther, G. (2006). Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung — Neurobiologie. In: Förstl, H., Hautzinger, M., Roth, G. (eds) Neurobiologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30887-3_17

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  • DOI: https://doi.org/10.1007/3-540-30887-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25694-6

  • Online ISBN: 978-3-540-30887-4

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