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Literatur

  • Abbruzzese M, Ferri S, Scarone S (1997) The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: A double dissociation experimental finding. Neuropsychologia 35: 907–912

    Article  CAS  PubMed  Google Scholar 

  • Abramowitz JS (1997) Effectiveness of psychological and pharmacological treatments for obsessive-compulsive disorder: a quantitative review. J Consult Clin Psychol 65(1): 44–52

    Article  CAS  PubMed  Google Scholar 

  • Adams BL, Warneke LB, McEwan AJ, Fraser BA (1993) Single-photon emission computerized tomography in obsessive compulsive disorder: a preliminary study. J Psychiatry Neurosci 18(3): 109–112

    PubMed Central  CAS  PubMed  Google Scholar 

  • Adler CM, McDonough-Ryan P, Sax KW, Holland SK, Arndt S, Strakowski SM (2000) fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. J Psychiatr Res 34(4–5): 317–324

    Article  CAS  PubMed  Google Scholar 

  • Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, »prefrontal« and limbic functions. Prog Brain Res 85: 119–146

    Article  CAS  PubMed  Google Scholar 

  • Allen AJ, Leonard HL, Swedo SE (1995) Case study: a new infection-triggered, autoimmune subtype of pediatric OCD and Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry 34: 307–311

    Article  CAS  PubMed  Google Scholar 

  • Alsobrook JP 2nd, Pauls DL (1997) The genetics of Tourette syndrome. Neurol Clin 15(2): 381–393

    Article  PubMed  Google Scholar 

  • Alptekin K, Degirmenci B, Kivircik B et al (2001) Tc-99mHMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression. Psychiatry Res 107(1): 51–56

    Article  CAS  PubMed  Google Scholar 

  • Austin LS, Lydiard RB, Ballenger JC et al (1991) Dopamine blocking activity of clomipramine in patients with obsessive-compulsive disorder. Biol Psychiatry 30: 225–232

    Article  CAS  PubMed  Google Scholar 

  • Aylward EH, Schwartz J, Machlin S, Pearlson G (1991) Bicaudate ratio as a measure of caudate volume on MR images. Am J Neuroradiol 12(6): 1217–1222

    CAS  PubMed  Google Scholar 

  • Aylward EH, Harris GJ, Hoehn-Saric R, Barta PE, Machlin SR, Pearlson GD (1996) Normal caudate nucleus in obsessive-compulsive disorder assessed by quantitative neuroimaging. Arch Gen Psychiatry 53(7): 577–584

    Article  CAS  PubMed  Google Scholar 

  • Bartha R, Stein MB, Williamson PC et al (1998) A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects. Am J Psychiatry 155(11): 1584–1591

    Article  CAS  PubMed  Google Scholar 

  • Baumgarten HG, Grozdanovic Z (1998) Role of serotonin in obsessive-compulsive disorder. Br J Psychiatry 173(Suppl 35): 13–20

    Google Scholar 

  • Baxter LR Jr (1992) Neuroimaging studies of obsessive compulsive disorder. Psychiatr Clin N Am 15(4): 871–884

    Google Scholar 

  • Baxter LR Jr, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE (1987) Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 44(3): 211–218

    Article  PubMed  Google Scholar 

  • Baxter LR Jr, Schwartz JM, Mazziotta JC et al (1988) Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. Am J Psychiatry 145(12): 1560–1563

    Article  PubMed  Google Scholar 

  • Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7–15

    Article  CAS  PubMed  Google Scholar 

  • Behar D, Rapoport JL, Berg CJ et al (1984) Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder. Am J Psychiatry 141(3): 363–369

    Article  CAS  PubMed  Google Scholar 

  • Benazon NR, Moore GJ, Rosenberg DR (2003) Neurochemical analyses in pediatric obsessive-compulsive disorder in patients treated with cognitive-behavioral therapy. J Am Acad Child Adolesc Psychiatry 42(11): 1279–1285

    Article  PubMed  Google Scholar 

  • Benkelfat C, Nordahl TE, Semple WE, King AC, Murphy DL, Cohen RM (1990) Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine. Arch Gen Psychiatry 47(9): 840–848

    Article  CAS  PubMed  Google Scholar 

  • Blier P, de Montigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15: 220–226

    Article  CAS  PubMed  Google Scholar 

  • Breiter HC, Filipek PA, Kennedy DN et al (1994) Retrocallosal white matter abnormalities in patients with obsessive-compulsive disorder. Arch Gen Psychiatry 51(8): 663–664

    Article  CAS  PubMed  Google Scholar 

  • Breiter HC, Rauch SL, Kwong KK et al (1996) Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Arch Gen Psychiatry 53(7): 595–606

    Article  CAS  PubMed  Google Scholar 

  • Brody AL, Saxena S, Schwartz JM et al (1998) FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res 84(1): 1–6

    Article  CAS  PubMed  Google Scholar 

  • Broocks A, Pigott TA, Hill JL et al (1998) Acute intravenous administration of ondansetron and m-CPP, alone and in combination, in patients with obsessive-compulsive disorder (OCD): behavioral and biological results. Psychiatry Res 79: 11–20

    Article  CAS  PubMed  Google Scholar 

  • Büchel C, Dolan RJ (2000) Classical fear conditioning in functional neuroimaging. Curr Opin Neurobiol 10(2): 219–223

    Article  PubMed  Google Scholar 

  • Busatto GF, Zamignani DR, Buchpiguel CA et al (2000) A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive-compulsive disorder using single-photon emission computed tomography (SPECT). Psychiatry Res 99(1): 15–27

    Article  CAS  PubMed  Google Scholar 

  • Carey G, Gottesmann I (1981) Twin and family studies of anxiety, phobic and obsessive-compulsive disorders. In: Klein DF, Rabbin JG (eds) Anxiety: New research and changing concepts. Raven, New York

    Google Scholar 

  • Carter CS, Botvinick MM, Cohen JD (1999) The contribution of the anterior cingulate cortex to executive processes in cognition. Rev Neurosci 10(1): 49–57

    CAS  PubMed  Google Scholar 

  • Cavallaro R, Cavedini P, Mistretta P et al (2003) Basal-cortical circuits in schizophrenia and obsessive-compulsive disorder: a controlled, double dissociation study. Biol Psychiatry 54: 437–443

    Article  PubMed  Google Scholar 

  • Cavedini P, Riboldi G, D’Annucci A, Belotti P, Cisima M, Bellodi L (2002) Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia 40: 205–211

    Article  CAS  PubMed  Google Scholar 

  • Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004) Cognitive inflexibility after prefrontal serotonin depletion. Science 304: 878–880

    Article  CAS  PubMed  Google Scholar 

  • Clayton AH (1995) Antidepressant-induced tardive dyskinesia: review and case report. Psychopharmacol Bull 31: 259–264

    CAS  PubMed  Google Scholar 

  • Cottraux J, Gerard D, Cinotti L et al (1996) A controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals. Psychiatry Res 60(2–3): 101–112

    Article  CAS  PubMed  Google Scholar 

  • Crespo-Facorro B, Cabranes JA, Lopez-Ibor Alcocer MI et al (1999) Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder. A SPECT study. Eur Arch Psychiatry Clin Neurosci 249(3): 156–161

    Article  CAS  PubMed  Google Scholar 

  • Deckersbach T, Savage CR, Curran T et al (2002) A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorder. Am J Psychiatry 159(10): 1780–1782

    Article  PubMed  Google Scholar 

  • Ebert D, Speck O, Konig A, Berger M, Hennig J, Hohagen F (1997) 1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum. Psychiatry Res 74(3): 173–176

    Article  CAS  PubMed  Google Scholar 

  • Edmonstone Y, Austin MP, Prentice N et al (1994) Uptake of 99mTc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls. Acta Psychiatr Scand 90(4): 298–303

    Article  CAS  PubMed  Google Scholar 

  • El Mansari M, Bouchard C, Blier P (1995) Alteration of serotonin release in the guinea pig orbitofrontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology 13(2): 117–127

    Article  PubMed  Google Scholar 

  • Evans DW, Lewis MD, Iobst E (2004) The role of the orbitofrontal cortex in normally developing compulsive-like behaviours and obsessive-compulsive disorder. Brain Cogn 55: 220–234

    Article  PubMed  Google Scholar 

  • Fitzgerald KD, Moore GJ, Paulson LA, Stewart CM, Rosenberg DR (2000) Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder. Biol Psychiatry 47(3): 174–182

    Article  CAS  PubMed  Google Scholar 

  • Giedd JN, Rapoport JL, Leonard HL, Richter D, Swedo SE (1996) Case study: acute basal ganglia enlargement and obsessive-compulsive symptoms in an adolescent boy. J Am Acad Child Adolesc Psychiatry 35(7): 913–915

    Article  CAS  PubMed  Google Scholar 

  • Giedd JN, Rapoport JL, Garvey MA, Perlmutter S, Swedo SE (2000) MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection. Am J Psychiatry 157(2): 281–283

    Article  CAS  PubMed  Google Scholar 

  • Gilbert, AR, Moore GJ, Keshavan MS et al (2000) Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine. Arch Gen Psychiatry 57(5): 449–456

    Article  CAS  PubMed  Google Scholar 

  • Goodman WK, Price LH, Rasmussen SA et al (1989) The Yale-Brown Obsessive-Compulsive Scale I: Development, use, and realibility. Arch Gen Psychiatry 46: 1006–1011

    Article  CAS  PubMed  Google Scholar 

  • Grachev ID, Breiter HC, Rauch SL et al (1998) Structural abnormalities of frontal neocortex in obsessive-compulsive disorder. Arch Gen Psychiatry 55(2): 181–182

    Article  CAS  PubMed  Google Scholar 

  • Graybiel AM (1995) Building action repertoires: memory and learning functions of th basal ganglia. Curr Opin Neurobiol 5: 733–741

    Article  CAS  PubMed  Google Scholar 

  • Greist JH, Jefferson JW (1998) Pharmacotherapy of obsessive-compulsive disorder. Br J Psychiatry 173(Suppl 35): 64–70

    Google Scholar 

  • Gross-Isseroff R, Kindler S, Kotler M (1994) Pharmacologic challenges. In: Berend B, Hollander E, Marazziti D, Zohar J (eds) Current insights in obsessive-compulsive disorder. Wiley, Chichester

    Google Scholar 

  • Hanna GL, Veenstra-VanderWeele J, Cox NJ et al (2002) Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet 114(5): 541–552

    Article  PubMed  Google Scholar 

  • Hendler T, Goshen E, Tzila Zwas S, Sasson Y, Gal G, Zohar J (2003) Brain reactivity to specific symptom provocation indicates prospective therapeutic outcome in OCD. Psychiatry Res 124(2): 87–103

    Article  PubMed  Google Scholar 

  • Hoehn-Saric R, Pearlson GD, Harris GJ, Machlin SR, Camargo EE (1991) Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients. Am J Psychiatry 148(9): 1243–1245

    Article  CAS  PubMed  Google Scholar 

  • Hoehn-Saric R, Schlaepfer TE, Greenberg BD, McLeod DR, Pearlson GD, Wong SH (2001) Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Res 108(2): 89–100

    Article  CAS  PubMed  Google Scholar 

  • Hohagen F, Winkelmann G, Rasche-Ruchle H et al (1998) Combination of behaviour therapy with fluvoxamine in comparison with behaviour therapy and placebo. Results of a multicentre study. Br J Psychiatry Suppl(35): 71–88

    Google Scholar 

  • Hollander E (1999) Managing aggressive behavior in patients with obsessive-compulsive disorder and borderline personality disorder. J Clin Psychiatry 60(Suppl 15): 38–44

    PubMed  Google Scholar 

  • Hollander E, Wong CM (1995) Obsessive-compulsive spectrum disorders. J Clin Psychiatry 56: 3–6

    PubMed  Google Scholar 

  • Hollander E, DeCaria CM, Nitescu A et al (1992) Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Arch Gen Psychiatry 49(1): 21–28

    Article  CAS  PubMed  Google Scholar 

  • Insel TR, Donnelly EF, Lalakea ML, Alterman IS, Murphy DL (1983) Neurological and neuropsychological studies of patients with obsessive-compulsive disorder. Biol Psychiatry 18(7): 741–751

    CAS  PubMed  Google Scholar 

  • Jenike MA, Breiter HC, Baer L et al (1996) Cerebral structural abnormalities in obsessive-compulsive disorder. A quantitative morphometric magnetic resonance imaging study. Arch Gen Psychiatry 53(7): 625–632

    Article  CAS  PubMed  Google Scholar 

  • Jonnal AH, Gardner CO, Prescott CA, Kendler KS (2000) Obsessive and compulsive symptoms in a general population sample of female twins. Am J Med Genet 96(6): 791–796

    Article  CAS  PubMed  Google Scholar 

  • Kellner CH, Jolley RR, Holgate RC, Austin L, Lydiard RB, Laraia M, Ballenger JC (1991) Brain MRI in obsessive-compulsive disorder. Psychiatry Res 36(1): 45–49

    Article  CAS  PubMed  Google Scholar 

  • Kim JJ, Lee MC, Kim J et al (2001) Grey matter abnormalities in obsessive-compulsive disorder: statistical parametric mapping of segmented magnetic resonance images. Br J Psychiatry 179: 330–334

    Article  CAS  PubMed  Google Scholar 

  • Kim JJ, Youn T, Lee JM, Kim IY, Kim SI, Kwon JS (2003) Morphometric abnormality of the insula in schizophrenia: a comparison with obsessive-compulsive disorder and normal control using MRI. Schizophr Res 60(2–3): 191–198

    Article  PubMed  Google Scholar 

  • Kobak KA, Greist JH, Jefferson JW, Katzelnick DJ, Henk HJ (1998) Behavioral versus pharmacological treatments of obsessive compulsive disorder: a meta-analysis. Psychopharmacology 136(3): 205–216

    Article  CAS  PubMed  Google Scholar 

  • Kordon A, Kahl KG, Broocks A, Voderholzer U, Rasche-Rauchle H, Hohagen F (2005) Clinical outcome in patients with obsessive-compulsive disorder after discontinuation of SRI treatment: results from a two-year follow-up. Eur Arch Psychiatry Clin Neurosci 255(1):48–50

    Article  PubMed  Google Scholar 

  • Kurlan R (1994) Hypothesis II: Tourette’s syndrom is part of a clinical spectrum that includes normal brain development. Arch Neurol 51: 1145–1150

    Article  CAS  PubMed  Google Scholar 

  • Kwon JS, Shin YW, Kim CW et al (2003) Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex. J Neurol Neurosurg Psychiatry 74(7): 962–964

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lacerda AL, Dalgalarrondo P, Caetano D, Camargo EE, Etchebehere EC, Soares JC (2003) Elevated thalamic and prefrontal regional cerebral blood flow in obsessive-compulsive disorder: a SPECT study. Psychiatry Res 123(2): 125–134

    Article  PubMed  Google Scholar 

  • Leonard HL, Lenane MC, Swedo MC et al (1992) Tics and Tourette’s disorder: a 2-to 7-year-follow-up of 54 obsessive-compulsive children. Am J Psychiatry 149: 1244–1251

    Article  CAS  PubMed  Google Scholar 

  • Leplow B, Murphy R, Nutzinger D-O (2002) Specificity of conditional associative-learning in obsessive compulsive disorder. J Exp Clin Neuropsychol 24: 792–805

    Article  Google Scholar 

  • Lucey JV, Costa DC, Blanes T et al (1995) Regional cerebral blood flow in obsessive-compulsive disordered patients at rest. Differential correlates with obsessive-compulsive and anxious-avoidant dimensions. Br J Psychiatry 167(5): 629–634

    Article  CAS  PubMed  Google Scholar 

  • Lucey JV, Costa DC, Adshead G et al (1997a) Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). Br J Psychiatry 171: 346–350

    Article  CAS  PubMed  Google Scholar 

  • Lucey JV, Burness CE, Costa DC et al (1997b) Wisconsin Card Sorting Task (WCST) errors and cerebral blood flow in obsessive-compulsive disorder (OCD). Br J Med Psychol 70 (Pt 4): 403–411

    Article  PubMed  Google Scholar 

  • Luxenberg JS, Swedo SE, Flament MF, Friedland RP, Rapoport J, Rapoport SI (1988) Neuroanatomical abnormalities in obsessive-compulsive disorder detected with quantitative X-ray computed tomography. Am J Psychiatry 145(9): 1089–1093

    Article  CAS  PubMed  Google Scholar 

  • Machlin SR, Harris GJ, Pearlson GD, Hoehn-Saric R, Jeffery P, Camargo EE (1991) Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study. Am J Psychiatry 148(9): 1240–1242

    Article  CAS  PubMed  Google Scholar 

  • Malison RT, McDougle CJ, van Dyck CH et al (1995) I-123-β-CIT SPECT imaging of striatal dopamine transporter binding in Tourette’s disorder. Am J Psychiatry 152: 1359–1361

    Article  CAS  PubMed  Google Scholar 

  • Mallet L, Mesnage V, Houeto JL et al (2002) Compulsions, Parkinson’s disease, and stimulation. Lancet 360(9342): 1302–1304

    Article  PubMed  Google Scholar 

  • Martinot JL, Allilaire JF, Mazoyer BM et al (1990) Obsessive-compulsive disorder: a clinical, neuropsychological and positron emission tomography study. Acta Psychiatr Scand 82(3): 233–242

    Article  CAS  PubMed  Google Scholar 

  • Mataix-Cols D, Cullen S, Lange K et al (2003) Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers. Biol Psychiatry 53(6): 482–493

    Article  PubMed  Google Scholar 

  • McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH (1994) Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry 51: 302–308

    Article  CAS  PubMed  Google Scholar 

  • McDougle CJ, Epperson CN, Pelton GH, Wasylink S, Price LH (2000) A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 57: 794–801

    Article  CAS  PubMed  Google Scholar 

  • McGrath MJ, Campbell KM, Veldman MB, Burton FH (1999) Anxiety in a transgenic mouse model of cortical-limbic neuro-potentiated compulsive behavior. Behav Pharmacol 10: 435–443

    Article  CAS  PubMed  Google Scholar 

  • Mindus P, Nyman H (1991) Normalization of personality characteristics in patients with incapacitating anxiety disorders after capsulotomy. Acta Psychiatr Scand 83(4): 283–291

    Article  CAS  PubMed  Google Scholar 

  • Murphy TK, Goodmann WK, Fugde MW et al (1997) B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessivecompulsive disorder and Tourette’s syndrome? Am J Psychiatry 154: 402–407

    Article  CAS  PubMed  Google Scholar 

  • Murphy R, Nutzinger D-O, Paul T, Leplow B (2004) Conditional-associative learning in eating disorders: A comparison with OCD. J Exp Clin Neuropsychol 26: 190–199

    Article  CAS  Google Scholar 

  • Nakatani E, Nakgawa A, Ohara Y et al (2003) Effects of behavior therapy on regional cerebral blood flow in obsessive-compulsive disorder. Psychiatry Res 124(2): 113–120

    Article  PubMed  Google Scholar 

  • Nestadt G, Samuels J, Riddle M et al (2000) A family study of obsessivecompulsive disorder. Arch Gen Psychiatry 57(4): 358–363

    Article  CAS  PubMed  Google Scholar 

  • Nordahl TE, Benkelfat C, Semple WE, Gross M, King AC, Cohen RM (1989) Cerebral glucose metabolic rates in obsessive compulsive disorder. Neuropsychopharmacology 2(1): 23–28

    Article  CAS  PubMed  Google Scholar 

  • Ohara K, Isoda H, Suzuki Y, Takehara Y, Ochiai M, Takeda H, Igarashi Y (1999) Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Psychiatry Res 92(2–3): 83–91

    Article  CAS  PubMed  Google Scholar 

  • Pato MT, Zohar-Kadouch R, Zohar J, Murphy DL (1991) Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder. Am J Psychiatry 145: 1521–1525

    Google Scholar 

  • Pauls DL, Alsobrook JP 2nd, Goodman W, Rasmussen S, Leckman JF (1995) A family study of obsessive-compulsive disorder. Am J Psychiatry 152(1): 76–84

    Article  CAS  PubMed  Google Scholar 

  • Perani D, Colombo C, Bressi S et al (1995) [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment. Br J Psychiatry 166(2): 244–250

    Article  CAS  PubMed  Google Scholar 

  • Peterson BS, Leckman JF, Tucker D et al (2000) Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit/hyperactivity disorders. Arch Gen Psychiatry 57(4): 364–372

    Article  CAS  PubMed  Google Scholar 

  • Phillips ML, Marks IM, Senior C et al (2000) A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust. Psychol Med 30(5): 1037–1050

    Article  CAS  PubMed  Google Scholar 

  • Piccinelli M, Pini S, Bellantuono C, Wilkinson G (1995) Efficacy of drug treatment in obsessive-compulsive disorder. A meta-analytic review. Br J Psychiatry 166(4): 424–443

    Article  CAS  PubMed  Google Scholar 

  • Pogarell O, Hamann C, Popperl G et al (2003) Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder. Biol Psychiatry 54(12): 1406–1413

    Article  CAS  PubMed  Google Scholar 

  • Pujol J, Torres L, Deus J et al (1999) Functional magnetic resonance imaging study of frontal lobe activation during word generation in obsessive-compulsive disorder. Biol Psychiatry 45(7): 891–897

    Article  CAS  PubMed  Google Scholar 

  • Pujol J, Soriano-Mas C, Alonso P, Cardoner N, Menchon J, Deus J, Vallejo J (2004) Mapping structure brain alterations in obsessive compulsive disorder. Arch Gen Psychiatry 61: 720–730

    Article  PubMed  Google Scholar 

  • Purcell R, Maruff P, Kyrios M, Pantelis C (1998a) Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry 55(5): 415–423

    Article  CAS  PubMed  Google Scholar 

  • Purcell R, Maruff P, Kyrios M, Pantelis C (1998b) Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biol Psychiatry 43(5): 348–357

    Article  CAS  PubMed  Google Scholar 

  • Radomsky AS, Rachman S (1999) Memory bias in obsessive-compulsive disorder (OCD). Behav Res Ther 37: 605–618

    Article  CAS  PubMed  Google Scholar 

  • Rasmussen SA, Tsuang MT (1984) The epidemiology of obsessive compulsive disorder. J Clin Psychiatry 45(11): 450–457

    CAS  PubMed  Google Scholar 

  • Rauch SL, Jenike MA, Alpert NM et al (1994) Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 51(1): 62–70

    Article  CAS  PubMed  Google Scholar 

  • Rauch SL, Savage CR, Alpert NM et al (1997) Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning. J Neuropsychiatry Clin Neurosci 9(4): 568–573

    Article  CAS  PubMed  Google Scholar 

  • Rauch SL, Dougherty D, Shin LM (1998) Neural correlates of factor-analyzed OCD symptom dimensions: A PET study. CNS Spectrums 3: 37–43

    Google Scholar 

  • Rauch SL, Kim H, Makris N et al (2000a) Volume reduction in the caudate nucleus following stereotactic placement of lesions in the anterior cingulate cortex in humans: a morphometric magnetic resonance imaging study. J Neurosurg 93(6): 1019–1025

    Article  CAS  PubMed  Google Scholar 

  • Rauch SL, Whalen PJ, Curran T et al (2000b) Probing striato-thalamic function in OCD and Tourette syndrome using neuroimaging methods. Adv Neurol 85: 207–224

    Google Scholar 

  • Rauch SL, Whalen PJ, Curran T et al (2001) Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods. Adv Neurol 85: 207–224

    CAS  PubMed  Google Scholar 

  • Rauch SL, Shin LM, Dougherty DD, Alpert NM, Fischman AJ, Jenike MA (2002) Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study. Neuropsychopharmacology 27(5): 782–791

    Article  CAS  PubMed  Google Scholar 

  • Rettew DC, Swedo SE, Leonard HL et al (1992) Obsessions and compulsions across time in 79 children and adolescents with OCD. J Am Acad Child Adolesc Psychiatry 31: 1050–1056

    Article  CAS  PubMed  Google Scholar 

  • Robinson D, Wu H, Munne RA et al (1995) Reduced caudate nucleus volume in obsessive-compulsive disorder. Arch Gen Psychiatry 52(5): 393–398

    Article  CAS  PubMed  Google Scholar 

  • Rogers RD, Blackshaw AJ, Middleton HC et al (1999) Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis opf impulsive behaviour. Psychopharmacology 146: 482–491

    Article  CAS  PubMed  Google Scholar 

  • Rogers RD, Tunbridge EM, Bhagwagar Z, Drevets WC, Sahakian BJ, Carter CS (2003) Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology 28: 153–162

    Article  CAS  PubMed  Google Scholar 

  • Rolls ET (2004) The functions of the orbitofrontal cortex. Brain Cogn 55: 11–29

    Article  PubMed  Google Scholar 

  • Rose M, Haider H, Weiller C, Büchel C (2002) The role of medial temporal lobe structures in implicit learning: an event-related FMRI study. Neuron 36(6): 1221–1231

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg DR, Keshavan MS (1998) A. E. Bennett Research Award. Toward a neurodevelopmental model of of obsessive-compulsive disorder. Biol Psychiatry 43(9): 623–640

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg DR, Keshavan MS, O’Hearn KM et al (1997) Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder. Arch Gen Psychiatry 54(9): 824–830

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ (2000) Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 39(9): 1096–1103

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg DR, Amponsah A, Sullivan A, MacMillan S, Moore GJ (2001) Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging. J Child Neurol 16(9): 636–641

    Article  CAS  PubMed  Google Scholar 

  • Rubin RT, Villanueva-Meyer J, Ananth J, Trajmar PG, Mena I (1992) Regional xenon 133 cerebral blood flow and cerebral technetium 99mHMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects. Determination by high-resolution single-photon emission computed tomography. Arch Gen Psychiatry 49(9): 695–702

    Article  CAS  PubMed  Google Scholar 

  • Rubin RT, Ananth J, Villanueva-Meyer J, Trajmar PG, Mena I (1995) Regional 133xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment. Biol Psychiatry 38(7): 429–437

    Article  CAS  PubMed  Google Scholar 

  • Russell A, Cortese B, Lorch E et al (2003) Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 13(Suppl 1): S31–38

    Article  PubMed  Google Scholar 

  • Salovskis P, Shafran R, Rachman S, Freeston MH (1999) Multiple pathways to inflated responsibility beliefs in obsessional problems: possible origins and implications for therapy and research. Behav Res Ther 37(11): 1055–1072

    Article  Google Scholar 

  • Sawle GV, Hymas NF, Lees AJ, Frackowiak RS (1991) Obsessional slowness. Functional studies with positron emission tomography. Brain 114 (Pt 5): 2191–202

    Article  PubMed  Google Scholar 

  • Saxena S, Brody AL, Schwartz JM, Baxter LR (1998) Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl(35): 26–37

    Google Scholar 

  • Saxena S, Brody AL, Maidment KM et al (1999) Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology 21(6): 683–693

    Article  CAS  PubMed  Google Scholar 

  • Saxena S, Brody AL, Ho ML et al (2001) Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently. Biol Psychiatry 50(3): 159–170

    Article  CAS  PubMed  Google Scholar 

  • Saxena S, Brody AL, Ho ML et al (2002) Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry 59(3): 250–261

    Article  CAS  PubMed  Google Scholar 

  • Saxena S, Brody AL, Ho ML, Zohrabi N, Maidment KM, Baxter LR Jr (2003) Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am J Psychiatry 160(3): 522–532

    Article  PubMed  Google Scholar 

  • Scarone S, Colombo C, Livian S et al (1992) Increased right caudate nucleus size in obsessive-compulsive disorder: detection with magnetic resonance imaging. Psychiatry Res 45(2): 115–121

    Article  CAS  PubMed  Google Scholar 

  • Schwartz JM (1998) Neuroanatomical aspects of cognitive-behavioural therapy response in obsessive-compulsive disorder. An evolving perspective on brain and behaviour. Br J Psychiatry Suppl 35: 38–44

    PubMed  Google Scholar 

  • Schwartz JM, Stoessel PW, Baxter LR Jr, Martin KM, Phelps ME (1996) Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Arch Gen Psychiatry 53(2): 109–113

    Article  CAS  PubMed  Google Scholar 

  • Shapira NA, Liu Y, He AG et al (2003) Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry 54(7): 751–756

    Article  PubMed  Google Scholar 

  • Sieg J, Leplow B, Hand I (1999) Neuropsychologische Veränderungen bei Zwangspatienten vor und nach einer stationären Verhaltenstherapie. Ztsch Verhaltensther 9: 7–14

    Article  Google Scholar 

  • Simpson HB, Lombardo I, Slifstein M et al (2003) Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biol Psychiatry 54(12): 1414–1421

    Article  CAS  PubMed  Google Scholar 

  • Stein DJ, Hollander E, Chan S, DeCaria CM, Hilal S, Liebowitz MR, Klein DF (1993) Computed tomography and neurological soft signs in obsessive-compulsive disorder. Psychiatry Res 50(3): 143–150

    Article  CAS  PubMed  Google Scholar 

  • Stein DJ, Spadaccini E, Hollander E (1995) Meta-analysis of pharmacotherapy trials for obsessive-compulsive disorder. Int Clin Psychopharmacol 10: 11–18

    Article  CAS  PubMed  Google Scholar 

  • Stein DJ, Coetzer R, Lee M, Davids B, Bouwer C (1997) Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. Psychiatry Res 74(3): 177–182

    Article  CAS  PubMed  Google Scholar 

  • Stein DJ, Van Heerden B, Wessels CJ, Van Kradenburg J, Warwick J, Wasserman HJ (1999) Single photon emission computed tomography of the brain with Tc-99mHMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. Prog Neuropsychopharmacol Biol Psychiatry 23(6): 1079–1099

    Article  CAS  PubMed  Google Scholar 

  • Steketee G, Frost R, Bhar S et al (2003) Psychometric validation of the Obsessive Beliefs Questionnaire and the Interpretation of Intrusions Inventory: Part I. Behav Res Ther 41(8): 863–878

    Article  Google Scholar 

  • Swedo SE, Rapaport JL, Cheslow DL et al (1989a) High prevalence of obsessive compulsive symptoms in patients with Syndenham’s chorea. Am J Psychiatry 146: 246–249

    Article  CAS  PubMed  Google Scholar 

  • Swedo SE, Schapiro MB, Grady CL et al (1989b) Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry 46(6): 518–523

    Article  CAS  PubMed  Google Scholar 

  • Swedo SE, Pietrini P, Leonard HL et al (1992) Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy. Arch Gen Psychiatry 49(9): 690–694

    Article  CAS  PubMed  Google Scholar 

  • Swedo SE, Leonard HL, Mittelmann BB et al (1997) Identification of children with pediatric autoimmune neuropsychiatric disorders associated with strepptococcal infections by a marker associated with rheumatic fever. Am J Psychiatry 154: 110–112

    Article  CAS  PubMed  Google Scholar 

  • Swedo SE, Leonard HL, Garvey M et al (1998) Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical descriptions of the first 50 cases. Am J Psychiatry 155: 264–271

    CAS  PubMed  Google Scholar 

  • Szeszko PR, Robinson D, Alvir JM et al (1999) Orbital frontal and amygdale volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatry 56(10): 913–919

    Article  CAS  PubMed  Google Scholar 

  • Ursu S, Stenger VA, Shear MK, Jones MR, Carter CS (2003) Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychol Sci 14(4): 347–353

    Article  PubMed  Google Scholar 

  • van der Wee NJ, Ramsey NF, Jansma JM et al (2003) Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. Neuroimage 20(4): 2271–2280

    Article  PubMed  Google Scholar 

  • van Oppen P, Hoekstra RJ, Emmelkamp PM (1995) The structure of obsessive-compulsive symptoms. Behav Res Ther 33(1): 15–23

    Article  PubMed  Google Scholar 

  • Wolf SS, Jones DW, Knable MB et al (1996) Tourette syndrome: prediction of phenotypic variation in monzygotic twins by caudate nucleus D2 receptor binding. Science 273: 1225–1227

    Article  CAS  PubMed  Google Scholar 

  • Young SN, Leyton M (2002) The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol Biochem Behav 71: 857–865

    Article  CAS  PubMed  Google Scholar 

  • Zald DH, Kim SW (1996) Anatomy and function of the orbital frontal cortex, II: Function and relevance to obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 8: 249–261

    Article  CAS  PubMed  Google Scholar 

  • Zaworka W, Hand I, Jauering G, Lunenschlosz K (1983) HZI. Hamburger Zwangsinventar. Manual. Beltz Test, Weinheim

    Google Scholar 

  • Zohar J, Insel TR, Zohar-Kadouch RC, Hill JL, Murphy DL (1988) Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment. Arch Gen Psychiatry 45(2): 167–172

    Article  CAS  PubMed  Google Scholar 

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Kordon, A., Leplow, B., Hohagen, F. (2006). Zwangsstörungen. In: Förstl, H., Hautzinger, M., Roth, G. (eds) Neurobiologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30887-3_13

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