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Genetik psychiatrischer Störugen

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Psychiatrie und Psychotherapie

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Literatur

  • Amadeo S, Abbar M, Fourcade ML et al. (1993) D2 dopamine receptor gene and alcoholism. J Psychiatry Res 27:173–179

    CAS  Google Scholar 

  • Angst J (1966) Zur Ätiologie und Nosologie endogener depressiver Psychosen. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Antonarakis SE, Blouin JL, Pulver AE et al. (1995) Schizophrenia susceptibility and chromosome 6p24–22. Nat Genet 11:235–236

    Article  CAS  PubMed  Google Scholar 

  • Antonarakis SE, Blouin JL, Curran M et al. (1996) Linkage and sibpair analysis reveal a potential schizophrenia susceptibility gene on chromosome 13q32. Psychiatr Genet 6:136

    Google Scholar 

  • Arinami T, Gao M, Hamaguchi H, Toru M (1997) A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6:577–582

    Article  CAS  PubMed  Google Scholar 

  • Armstrong M, Daly AK, Cholerton S, Bateman DN, Idle JP (1992) Mutant debrisoquine hydroxylation genes in Parkinson’s disease. Lancet 339:1017–1018

    Article  CAS  PubMed  Google Scholar 

  • Arolt V, Lencer R, Nolte A et al. (1996) Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 67:564–579

    Article  CAS  PubMed  Google Scholar 

  • Baron M (1976) Albinism and schizophreniform psychosis: a pedigree study. Am J Psychiatry 133:1070–1073

    CAS  PubMed  Google Scholar 

  • Baron M (1996) Further reflections on linkage results in schizophrenia. Am J Med Genet 67:430–432

    CAS  PubMed  Google Scholar 

  • Bassett AS, Honer WG (1994) Evidence for anticipation in schizophrenia. Am J Hum Genet 54:864–870

    CAS  PubMed  Google Scholar 

  • Beckmann H, Franzek E, Stöber G (1996) Genetic heterogeneity in catatonic schizophrenia: a family genetic study. Am J Med Genet 67:289–300

    Article  CAS  PubMed  Google Scholar 

  • Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN (1994) Mood-lowering effect of tryptophan depletion. Arch Gen Psychiatry 51:687–697

    CAS  PubMed  Google Scholar 

  • Bergem ALM, Engedal K, Kringlen E (1997) The role of heredity in late-onset Alzheimer disease and vascular dementia — a twin study. Arch Gen Psychiatry 54:264–270

    CAS  PubMed  Google Scholar 

  • Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JI, Gershon ES (1994) Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 91:5918–5921

    CAS  PubMed  Google Scholar 

  • Bertelsen A, Harvald B, Hauge M (1977) A Danish twin study of manic-depressive disorders. Br J Psychiatry 130:330–351

    CAS  PubMed  Google Scholar 

  • Biederman J, Rosenbaum JF, Bolduc EA, Faraone SV, Hirshfeld DR (1991) A high risk study of young children of parents with panic disorder and agoraphobia with and without comorbid major depression. Psychiatry Res 37:333–348

    Article  CAS  PubMed  Google Scholar 

  • Bierut LJ, Heath AC, Bucholz KK et al. (1999) Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women? Arch Gen Psychiatry 56:557–563

    CAS  PubMed  Google Scholar 

  • Black DW, Noyes R, Goldstein RB, Blum N (1992) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 49:362–368

    CAS  PubMed  Google Scholar 

  • Blackwood DH, He L, Morris SW et al. (1996) A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12:427–430

    Article  CAS  PubMed  Google Scholar 

  • Blouin JL, Dombroski BA, Nath SK et al. (1998) Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20:70–73

    CAS  PubMed  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ et al. (1990) Allelic association of human dopamine D2 receptor gene in alcoholics. JAMA 263:2055–2060

    CAS  PubMed  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ et al. (1991) Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol 8:409–416

    Article  CAS  PubMed  Google Scholar 

  • Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett AS (1999) Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 65:1096–1103

    CAS  PubMed  Google Scholar 

  • Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS (2000) Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21–q22. Science 288:678–682

    Article  CAS  PubMed  Google Scholar 

  • Cadoret RJ, O’Gorman TW, Troughton E (1985) Alcoholism and antisocial personality: interrelationships, genetic and environmental factors. Arch Gen Psychiatry 42:161–167

    CAS  PubMed  Google Scholar 

  • Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA (1995) Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 52:42–52

    CAS  PubMed  Google Scholar 

  • Cannon TD, Zorrilla LE, Shtasel D et al. (1994) Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry 51:651–661

    CAS  PubMed  Google Scholar 

  • Cannon TD, Kaprio J, Lönnqvist J, Huttunen M, Koskenvuo M (1998) The genetic epidemiology of schizophrenia in a Finnish twin cohort. Arch Gen Psychiatry 55:67–74

    CAS  PubMed  Google Scholar 

  • Cao Q, Martinez M, Zhang J et al. (1997) Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. Genomics 43:1–8

    Article  CAS  PubMed  Google Scholar 

  • Cardno AG, Marshall EJ, Coid B et al. (1999) Heritability estimates for psychotic dis-orders: the Maudsley twin psychosis series. Arch Gen Psychiatry 56:162–168

    CAS  PubMed  Google Scholar 

  • Chen WJ, Loh EW, Hsu Y-PP, Cheng ATA (1997) Alcohol dehydrogenase und aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines. Biol Psychiatry 41:703–709

    CAS  PubMed  Google Scholar 

  • Cichon S, Schmidt-Wolf G, Schumacher J et al. (2001a) A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26. Mol Psychiatry 6:342–349

    Article  CAS  PubMed  Google Scholar 

  • Cichon S, Schumacher J, Müller DJ et al. (2001b) A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 10:2933–2944

    Article  CAS  PubMed  Google Scholar 

  • Cloninger CR (1987) Neurogenetic adaptive mechanism in alcoholism. Science 236:412–420

    Google Scholar 

  • Cloninger CR, Bohmann M, Sigvardsson S (1981) Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch Gen Psychiatry 38:861–868

    CAS  PubMed  Google Scholar 

  • Coon H, Hoff M, Holik J et al. (1996) Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression. Biol Psychiatry 39:689–696

    Article  CAS  PubMed  Google Scholar 

  • Cornblatt BA, Keilp JG (1994) Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20:31–46

    CAS  PubMed  Google Scholar 

  • Coryell W, Zimmerman M (1988) The heritability of schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 45:323–327

    CAS  PubMed  Google Scholar 

  • Crabb DW, Edenberg HJ, Thomasson R, Li T-K (1995) Genetic factors that reduce the risk for developing alcoholism in animals and humans. In: Begleiter H, Kissin B (eds) The genetics of alcoholism. Oxford University Press, New York, pp 202–220

    Google Scholar 

  • Craddock N, McGuffin P, Owen M (1994) Darier’s disease cosegregating with affective disorder. Br J Psychiatry 165:272

    CAS  PubMed  Google Scholar 

  • Craddock N, Jones I (2001) Candidate gene studies of bipolar disorder. Ann Med 33:248–256

    PubMed  Google Scholar 

  • Craddock N, Khodel V, Van Eerdewegh P, Reich T (1995) Mathematical limits of multilocus models. The genetic transmission of bipolar disorder. Am J Hum Genet 57:690–702

    CAS  PubMed  Google Scholar 

  • Curtis L, Blouin JL, Radhakrishna U et al. (1999) No evidence for linkage between schizophrenia and markers at chromosome 15q13–14. Am J Med Genet 88:109–112

    CAS  PubMed  Google Scholar 

  • Davidson J, Smith R, Kudler H (1989) Familial psychiatric illness in chronic posttraumatic stress disorder. Compr Psychiatry 30:339–345

    CAS  PubMed  Google Scholar 

  • Dawson E, Parfitt E, Roberts Q et al. (1995) Linkage studies of bipolar disorder in the region of the Darier’s disease gene on chromosome 12q23–24.1. Am J Med Genet 60:94–102

    CAS  PubMed  Google Scholar 

  • De Bruyn A, Souery D, Mendelbaum K, Mendlewicz J, Van Broeckhoven C (1996) Linkage analysis of families with bipolar illness and chromosome 18 markers. Biol Psychiatry 39:679–688

    Google Scholar 

  • Degn B, Lundorf MD, Wang A, Vang M, Mors O, Kruse TA, Ewald H (2001) Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands. Mol Psychiatry 6:450–455

    Article  CAS  PubMed  Google Scholar 

  • Deitrich RA, Baker RC (1995) Genetic influences on alcohol metabolism and sensitivity to alcohol in animals. In: Begleiter H, Kissin B (eds) The genetics of alcoholism. Oxford University Press, New York, pp 139–164

    Google Scholar 

  • DeLisi LE, Shaw SH, Crow TJ et al. (2002) A genome-wide scan for linkage to chromo-somal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 159:803–812

    Article  PubMed  Google Scholar 

  • Detera-Wadleigh SD, Badner JA, Goldin LR et al. (1996) Affectedsib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder on 21q. Am J Hum Genet 58:1279–1285

    CAS  PubMed  Google Scholar 

  • Detera-Wadleigh SD, Badner JA, Berrettini WH et al. (1999) A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96:5604–5609

    Article  CAS  PubMed  Google Scholar 

  • Egeland JA, Gerhard D, Pauls DL et al. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325:783–787

    Article  CAS  PubMed  Google Scholar 

  • Ewald H, Mors O, Koed K, Eiberg H, Kruse TA (1997) Susceptibility loci for bipolar affective disorder on chromosome 18? A review and a study of Danish families. Psychiatr Genet 7:1–12

    CAS  PubMed  Google Scholar 

  • Ewald H, Degn B, Mors O, Kruse TA (1998) Significant linkage between bipolar affective disorder and chromosome 12q24. Psychiatr Genet 8:131–140

    CAS  PubMed  Google Scholar 

  • Ewald H, Flint TJ, Jorgensen TH et al. (2002) Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands. Am J Med Genet 114:196–204

    PubMed  Google Scholar 

  • Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT (1995) Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol 104:286–304

    CAS  PubMed  Google Scholar 

  • Faraone SV, Matise T, Svrakic D et al. (1998) Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet. 81:290–295

    CAS  PubMed  Google Scholar 

  • Farmer AE, McGuffin P, Gottesman II (1987) Twin concordance for DSM-III schizophrenia: scrutinising the validity of the definition. Arch Gen Psychiatry 44:634–641

    CAS  PubMed  Google Scholar 

  • Farrer LA, Sherbatich T, Keryanov SA et al. (2000) Association between angiotensin-converting enzyme and Alzheimer disease. Arch Neurol 57:210–214

    CAS  PubMed  Google Scholar 

  • Fidani L, Rooke K, Chartier-Harlin M-C et al. (1992) Screening for mutations in the open reading frame and promoter of the ß-amyloid-precursor protein gene in familial Alzheimer’s disease: identification of a further family with APP717 Val→Ilc. Hum Mol Genet 1:165–168

    CAS  PubMed  Google Scholar 

  • Foroud T, Edenberg HJ, Goate A et al. (2000) Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24:933–945

    CAS  PubMed  Google Scholar 

  • Franke P, Maier W, Hardt J, Hain C, Cornblatt BA (1994) Attentional abilities and measures of schizotypy: their variation and co-variation in schizophrenic patients, their siblings, and normal control subjects. Psychiatry Res 54:259–272

    Article  CAS  PubMed  Google Scholar 

  • Franzek E, Beckmann H (1996) Die genetische Heterogenität der Schizophrenie. Ergebnisse einer systematischen Zwillingsstudie. Nervenarzt 67:583–594

    CAS  PubMed  Google Scholar 

  • Freedman R, Coon H, Myles-Worsley M et al. (1997) Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA. 94:587–592

    Article  CAS  PubMed  Google Scholar 

  • Freimer NB, Reus VI, Escamilla MA et al. (1996) Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22–q23. Nat Genet 12:436–441

    Article  CAS  PubMed  Google Scholar 

  • Friedman D, Cornblatt BA, Vaughan H, Erlenmeyer-Kimling L (1988) Auditory event-related potentials in children at risk for schizophrenia: The complete initial sample. Psychiatry Res 26:203–221

    Article  CAS  PubMed  Google Scholar 

  • Fyer AJ, Mannuzza S, Gallops MS, Martin LY, Aaronson C, Gorman JM, Liebowiz MR, Klein DF (1990) Familial transmission of simple phobias and fears. Arch Gen Psychiatry 47:252–256

    CAS  PubMed  Google Scholar 

  • Fyer AJ, Mannuzza S, Chapman TF, Martin LY, Klein DF (1995) Specificity in familial aggregation of phobic disorders. Arch Gen Psychiatry 52:564–573

    CAS  PubMed  Google Scholar 

  • Gejman PV, Sanders AR, Badner JA, Cao Q, Zhang J (2001) Linkage analysis of schizophrenia to chromosome 15. Am J Med Genet 105:789–793

    Article  CAS  PubMed  Google Scholar 

  • Gershon ES, DeLisi LE, Hamovit J et al. (1988) A controlled family study of chronic psychoses. Schizophrenia and schizoaffective psychoses. Arch Gen Psychiatry 45:328–336

    CAS  PubMed  Google Scholar 

  • Gershon ES, Badner JA, Detera-Wadleigh SD, Ferraro TN, Berrettini WH (1996) Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees. Am J Med Genet 67:202–207

    Article  CAS  PubMed  Google Scholar 

  • Gill M, Vallada H, Collier D et al. (1996) A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet 67:40–45

    Article  CAS  PubMed  Google Scholar 

  • Gilligan SB, Reich T, Cloninger CR (1987) Etiologic heterogeneity in alcoholism. Genet Epidemiol 4:395–414

    Article  CAS  PubMed  Google Scholar 

  • Goldman D, Brown GL, Albaugh B et al. (1993) DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Alcohol Clin Exp Res 17:199–204

    CAS  PubMed  Google Scholar 

  • Goldstein RB, Weissman MM, Adams PB et al. (1994) Psychiatric disorders in relatives of probands with panic disorders and/or major depression. Arch Gen Psychiatry 51:383–394

    CAS  PubMed  Google Scholar 

  • Goldstein RB, Wickramaratne PJ, Horwarth E, Weissman MM (1997) Familial aggregation and phenomenology of ‚Early’-Onset (at or before age 20 years) panic disorders. Arch Gen Psychiatry 54:271–278

    CAS  PubMed  Google Scholar 

  • Gottesman II, Bertelsen A (1989) Confirming unexpressed genotypes for schizophrenia. Arch Gen Psychiatry 46:867–872

    CAS  PubMed  Google Scholar 

  • Green MF, Nuechterlein KH, Breitmeier B (1997) Backward masking performance in unaffected siblings of schizophrenic patients. Arch Gen Psychiatry 54:465–472

    CAS  PubMed  Google Scholar 

  • Greenberg DA (1993) Linkage analysis of „necessary“ disease loci versus „susceptibility“ loci. Am J Hum Genet 52:135–143

    CAS  PubMed  Google Scholar 

  • Grigoroiu-Serbanescu M, Wickramaratne PJ, Hodge A, Milea S, Mihailescu R (1997) Genetic anticipation and imprinting in bipolar I illness. Br J Psychiatry 170:162–166

    CAS  PubMed  Google Scholar 

  • Gurling H, Smyth C, Kalsi G et al. (1995) Linkage findings in bipolar disorder (letter). Nat Genet 10:8–9

    Article  CAS  PubMed  Google Scholar 

  • Hain C, Maier W, Hoechst-Janneck S, Franke P (1995) Subclinical thought disorder in first-degree relatives of schizophrenic patients. Results from a matched-pairs study with the Thought Disorder Index. Acta Psychiatr Scand 92:305–309

    CAS  PubMed  Google Scholar 

  • Heath AC, Meyer J, Eaves LJ, Martin NG (1991a) The inheritance of alcohol consumption patterns in a general population twin sample: I. multidimensional scaling of quantity/frequency data. J Stud Alcohol 52:345–351

    CAS  PubMed  Google Scholar 

  • Heath AC, Meyer J, Jardine R, Martin NG (1991b) The inheritance of alcohol consumption patterns in a general population twin sample: II. determinants of consumption frequency and quantity consumed. J Stud Alcohol 52:425–433

    CAS  PubMed  Google Scholar 

  • Hettema JM, Prescott CA, Kendler KS (2001) A population-based twin study of generalized anxiety disorder in men and women. J Nerv Ment Dis 189:413–420

    CAS  PubMed  Google Scholar 

  • Higuchi S, Muramatsu T, Shigemori K, Saito M, Kono H, Dufour MC, Harford T (1992) The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. J Stud Alcohol 53:170–175

    CAS  PubMed  Google Scholar 

  • Holmans P, Craddock N (1997) Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis. Am J Hum Genet 60:657–666

    CAS  PubMed  Google Scholar 

  • Holzman PS, Kringlen E, Matthysse S et al. (1988) A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Arch Gen Psychiatry 45:641–647

    CAS  PubMed  Google Scholar 

  • Horwarth E, Wolk SI, Goldstein RB et al. (1995) Is the comorbidity between social phobia and panic disorder due to familial co-transmission or other factors? Arch Gen Psychiatry 52:574–582

    Google Scholar 

  • Huntington’s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72:971–983

    Google Scholar 

  • Jacobsen NJ, Franks EK, Owen MJ, Craddock NJ (1999) Mutational analysis of phospholipase A2A: a positional candidate susceptibility gene for bipolar disorder. Mol Psychiatry 4:274–279

    Article  CAS  PubMed  Google Scholar 

  • Jonsson EG, Nothen MM, Neidt H et al. (1999) Association between a promoter poly-morphism in the dopamine D2 receptor gene and schizophrenia. Schizophr Res 40:31–36

    Article  CAS  PubMed  Google Scholar 

  • Jorde LB (1995) Linkage disequilibrium as a gene-mapping tool. Am J Hum Genet 56:11–14

    CAS  PubMed  Google Scholar 

  • Jorgensen TH, Borglum AD, Mors O et al. (2002) Search for common haplotypes on chromosome 22q in patients with schizophrenia or bipolar disorder from the Faroe Islands. Am J Med Genet 114:245–252

    Article  CAS  PubMed  Google Scholar 

  • Kaprio J, Viken R, Koskenvuo M, Romanov K, Rose RJ (1992) Consistency and change in patterns of social drinking: a 6-year follow-up of the Finnish twin cohort. Alcohol Clin Exp Res 16:234–240

    CAS  PubMed  Google Scholar 

  • Kaufmann CA, Suarez B, Malaspina D et al. (1998) NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am J Med Genet 81:282–289

    Article  CAS  PubMed  Google Scholar 

  • Kaye JA (1997) Oldest-old healthy brain function. Arch Neurol 54:1217–1221

    CAS  PubMed  Google Scholar 

  • Keefe RSE, Silverman JM, Mohs RC et al. (1997) Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry 54:169–176

    CAS  PubMed  Google Scholar 

  • Kelsoe JR. Ginns EI, Egeland JA et al. (1989) Reevaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342:238–243

    Article  CAS  PubMed  Google Scholar 

  • Kelsoe JR, Spence MA, Loetscher E et al. (2001) A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98:585–590

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS (1993) Twin studies of psychiatric illness: current status and future directions. Arch Gen Psychiatry 50:905–915

    CAS  PubMed  Google Scholar 

  • Kendler KS, Diehl SR (1993) The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull 19:261–285

    CAS  PubMed  Google Scholar 

  • Kendler KS, Prescott CA (1999) A population-based twin study of lifetime major depression in men and women. Arch Gen Psychiatry 56:39–44

    CAS  PubMed  Google Scholar 

  • Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1992a) A population-based twin study of major depression im women. The impact of varying definitions of illness. Arch Gen Psychiatry 49:257–266

    CAS  PubMed  Google Scholar 

  • Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1992b) Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Arch Gen Psychiatry 49:716–722

    CAS  PubMed  Google Scholar 

  • Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1992c) The genetic epidemiology of phobias in women. The interrelationship of agoraphobia, social phobia, situational phobia and simple phobia. Arch Gen Psychiatry 49:273–281

    CAS  PubMed  Google Scholar 

  • Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ (1992d) A population-based twin study of alcoholism in women. JAMA 268:1877–1882

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS, McGuire M, Gruenberg AM, O’Hare A, Spellman M, Walsh D (1993a) The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 50:527–540

    CAS  PubMed  Google Scholar 

  • Kendler KS, McGuire M, Gruenberg AM, O’Hare A, Spellman M, Walsh D (1993b) The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch Gen Psychiatry 50:952–960

    CAS  PubMed  Google Scholar 

  • Kendler KS, Kessler RC, Neale MC, Heath AC, Eaves LJ (1993c) The prediction of major depression in women: toward an integrated etiologic model. Am J Psychiatry 150:1139–1148

    CAS  PubMed  Google Scholar 

  • Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1993d) Panic disorder in women: a population-based twin study. Psychol Med 23:397–406

    CAS  PubMed  Google Scholar 

  • Kendler KS, Pedersen NL, Johnson L, Neale MC, Mathë AA (1993e) A pilot Swedish twin study of affective illness including hospital-and population-ascertained subsamples. Arch Gen Psychiatry 50:699–706

    CAS  PubMed  Google Scholar 

  • Kendler KS, Gruenberg AM, Kinney DK (1994) Independent diagnoses of adoptees and relatives as defined by DSM-III in the provincial and national samples of the Danish adoption study of schizophrenia. Arch Gen Psychiatry 51:456–468

    CAS  PubMed  Google Scholar 

  • Kendler KS, McGuire M, Gruenberg AM, Walsh D (1995) Schizotypal symptoms and signs in the Roscommon Family Study. Their factor structure and familial relationship with psychotic and affective disorders. Arch Gen Psychiatry 52:296–303

    CAS  PubMed  Google Scholar 

  • Kendler KS, Karkowski-Shuman L, Walsh D (1996a) Age at onset in schizophrenia and risk of illness in relatives. Br J Psychiatry 169:213–218

    CAS  PubMed  Google Scholar 

  • Kendler KS, Mac Lean CJ, O’Neill FA et al. (1996b) Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenia families. Am J Psychiatry 153:1534–1540

    CAS  PubMed  Google Scholar 

  • Kendler KS, Myers J, Prescott CA, Neale MC (2001) The genetic epidemiology of irrational fears and phobias in men. Arch Gen Psychiatry 58:257–265

    CAS  PubMed  Google Scholar 

  • Kety SS (1983) Mental illness in the biological and adoptive relatives of schizophrenic adoptees, findings relevant to genetic and environmental factors in etiology. Am J Psychiatry 140:720–727

    CAS  PubMed  Google Scholar 

  • Khoury MJ, Beaty TH, Cohen BH (1993) Fundamentals of genetic epidemiology. Monographs in epidemiology and biostatistics, vol 19. Oxford University Press, New York

    Google Scholar 

  • Kinney DK, Holzman PS, Jacobsen B et al. (1997) Thought disorder in schizophrenic and control adoptees and their relatives. Arch Gen Psychiatry 54:475–479

    CAS  PubMed  Google Scholar 

  • Klein DN, Lewinsohn PM, Seeley JR, Rohde P (2001) A family study of major depressive disorder in a community sample of adolescents. Arch Gen Psychiatry 58:13–20

    CAS  PubMed  Google Scholar 

  • Kosobud AE, Crabbe JC (1995) Genetic influences on the development of physical dependence and withdrawal in animals. In: Begleiter H, Kissin B (eds) The genetics of alcoholism. Oxford University Press, New York, pp 221–256

    Google Scholar 

  • Kremen WS, Goldstein JM, Seidman LJ, Toomey R, Lyons MJ, Tsuang MT, Faraone SV (1997) Sex differences in neuropsychological function in non-psychotic relatives of schizophrenic probands. Psychiatry Res 66:131–144

    Article  CAS  PubMed  Google Scholar 

  • Kringlen E (1976) Twins — still our best method. Schizophr Bull 2:429–433

    CAS  PubMed  Google Scholar 

  • Kunugi H, Vallada HP, Sham PC et al. (1997) Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatr Genet 7:97–101

    CAS  PubMed  Google Scholar 

  • Lander ES, Schork N (1994) Genetic dissection of complex traits. Science 265:2037–2048

    CAS  PubMed  Google Scholar 

  • Lauer CJ, Schreiber W, Holsboer F, Krieg JC (1995) In quest of identifying vulnerability markers for psychiatric disorders by allnight polysomnography. Arch Gen Psychiatry 52:145–153

    CAS  PubMed  Google Scholar 

  • Lawford BR, Young R, Rowell JA et al. (1997) Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls. Biol Psychiatry 41:386–393

    Article  CAS  PubMed  Google Scholar 

  • Leonard S, Gault J, Moore T et al. (1998) Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative. Am J Med Genet 81:308–312

    Article  CAS  PubMed  Google Scholar 

  • Levinson DF, Holmans P, Straub RE et al. (2000) Multicenter linkage study of schizo-phre-nia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. Am J Hum Genet 67:652–663

    Article  CAS  PubMed  Google Scholar 

  • Levinson DF, Holmans PA, Laurent C et al. (2002) No major schizophrenia locus de-tected on chromosome 1q in a large multicenter sample. Science 296:739–741

    Article  CAS  PubMed  Google Scholar 

  • Li T, Arranz M, Aitchison KJ et al. (1998) Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia. Schizophr Res 32:87–92

    CAS  PubMed  Google Scholar 

  • Lieb R, Wittchen HU, Hofler M et al. (2000) Parental psychopathology, parenting styles, and the risk of social phobia in offspring: a prospective-longitudinal community study. Arch Gen Psychiatry 57:859–866

    CAS  PubMed  Google Scholar 

  • Lindsay EA, Morris MA, Gos A et al. (1995) Schizophrenia and chromosomal deletions within 22q11.2. Am J Hum Genet 56:1502–1503

    CAS  PubMed  Google Scholar 

  • Liu CM, Hwu HG, Lin MW et al. (2001) Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13—14 in Taiwanese families. Am J Med Genet 105:658–661

    CAS  PubMed  Google Scholar 

  • Liu H, Heath SC, Sobin C et al. (2002) Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci USA 99:3717–3722

    CAS  PubMed  Google Scholar 

  • Long JC, Knowler WC, Hanson RL et al. (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216–221

    Article  CAS  PubMed  Google Scholar 

  • Lu R-B, Ko H-C, Chang F-M et al. (1996) No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. Biol Psychiatry 39:419–429

    CAS  PubMed  Google Scholar 

  • Lumeng L, Murphy JM, McBride WJ, Li T-K (1995) Genetic influences on alcohol preference in animals. In: Begleiter H, Kissin B (eds) The genetics of alcoholism. Oxford University Press, New York, pp 165–201

    Google Scholar 

  • Luthar SS, Anton SF, Merikangas KR, Rounsaville BJ (1992) Vulnerability to substance abuse and psychopathology among siblings of opioid abusers. J Nerv Ment Dis 180:153–161

    CAS  PubMed  Google Scholar 

  • Lyons MJ, Eisen SA, Goldberg J et al. (1998) A registry-based twin study of depression in men. Arch Gen Psychiatry 55:468–472

    CAS  PubMed  Google Scholar 

  • Maier W (1995) Mechanismen der familiären Übertragung von Alkoholabhängigkeit und Alkoholabusus. Z Klin Psychol 24:147–158

    Google Scholar 

  • Maier W, Lichtermann D (1993) Die familiäre Häufung affektiver Erkrankungen. Eine Übersicht über neuere familiengenetische Arbeiten. Nervenheilk 12:34–40

    Google Scholar 

  • Maier W, Philipp M (1993) Reliabilität und Validität der Subtypisierung und Schweregradmessung depressiver Syndrome. Springer, Berlin Heidelberg New York Tokyo (Monographien aus dem Gesamtgebiete der Psychiatrie, Bd 72)

    Google Scholar 

  • Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O, Levinson DF (1993a) Continuity and discontinuity of affective disorders and schizophrenia. Arch Gen Psychiatry 50:871–883

    CAS  PubMed  Google Scholar 

  • Maier W, Minges J, Lichtermann D (1993b) Alcoholism and panic disorder: co-occurrence and co-transmission in families. Eur Arch Psychiatry Clin Neurosci 243:205–211

    CAS  PubMed  Google Scholar 

  • Maier W, Lichtermann D, Minges, Oehrlein A, Franke P (1993c). A controlled family study in panic disorder. J Psychiatr Res 27(Suppl 1):79–87

    PubMed  Google Scholar 

  • Maier W, Lichtermann D, Minges J, Heun R (1994a) Personality disorders among the relatives of schizophrenia patients. Schizophr Bull 20:481–493

    CAS  PubMed  Google Scholar 

  • Maier W, Lichtermann D, Minges J (1994b) The relationship between alcoholism and unipolar depression — a controlled family study. J Psychiatr Res 28:303–317

    Article  CAS  PubMed  Google Scholar 

  • Mannuzza S, Scneier FR, Chapman TF, Liebowitz MR, Klein DF, Fyer AJ (1995) Generalized social phobia: reliability and validity. Arch Gen Psychiatry 52:230–237

    CAS  PubMed  Google Scholar 

  • Martinez M, Goldin LR, Cao Q et al. (1999) Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q. Am J Med Genet 88:337–343

    Article  CAS  PubMed  Google Scholar 

  • McGue M, Gottesman II (1991) The genetic epidemiology of schizophrenia and the design of linkage studies. Eur Arch Psychiatry Clin Neurosci 240:174–181

    Article  CAS  PubMed  Google Scholar 

  • McGue M, Pickens RW, Sviskis DS (1992) Sex and age effects on the inheritance of alcohol problems: a twin study. J Abnorm Psychol 101:3–17

    Article  CAS  PubMed  Google Scholar 

  • McGuffin P, Farmer AE, Gottesman II, Murray RM, Reveley AM (1984) Twin concordance for operationally defined schizophrenia. Arch Gen Psychiatry 41:541–545

    CAS  PubMed  Google Scholar 

  • McGuffin P, Farmer AE, Gottesman II (1987) Is there really a split in schizophrenia? The genetic evidence. Br J Psychiatry 150:581–592

    CAS  PubMed  Google Scholar 

  • McGuffin P, Katz R, Rutherford J (1991) Nature, nurture and depression: a twin study. Psychol Med 21:329–335

    CAS  PubMed  Google Scholar 

  • McGuffin P, Katz R, Watkins S, Rutherford J (1996) A hospitalbased twin register of the heritability of DSM-IV unipolar depression. Arch Gen Psychiatry 53:129–136

    CAS  PubMed  Google Scholar 

  • McInnes LA, Escamilla MA, Service SK et al. (1996) A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees. Proc Natl Acad Sci USA 93:13060–13065

    Article  CAS  PubMed  Google Scholar 

  • McInnis MG, McMahon FJ, Chase GA, et al. (1993) Anticipation in bipolar affective disorder. Am J Hum Genet 53:385–390

    CAS  PubMed  Google Scholar 

  • McMahon FJ, Stine OC, Myers DA et al. (1995) Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet 56:1277–1286

    CAS  PubMed  Google Scholar 

  • Melo JA, Shendure J, Pociask K, Silver LM (1996) Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nat Genet 13:147–153

    Article  CAS  PubMed  Google Scholar 

  • Mendlewicz J, Papadimitriou GN, Wilmotte J (1993) Family study of panic disorder: comparison with generalized anxiety disorder, major depression and normal subjects. Psychiatr Genet 3:73–78

    Google Scholar 

  • Merikangas K (1990) The genetic epidemiology of alcoholism. Psychol Med 20:11–22

    CAS  PubMed  Google Scholar 

  • Merikangas KR, Leckman JF, Prusoff BA, Pauls DL, Weissmann MM (1985) Familial transmission of depression and alcoholism. Arch Gen Psychiatry 42:367–372

    CAS  PubMed  Google Scholar 

  • Merikangas KR, Risch NJ, Weissman MM (1994) Comorbidity and co-transmission of alcoholism, anxiety and depression. Psychol Med 24:69–80

    CAS  PubMed  Google Scholar 

  • Moises HW, Yang L, Kristbjarnarson H et al. (1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 11:321–324

    Article  CAS  PubMed  Google Scholar 

  • Morissette J, Villeneuve A, Bordeleau L et al. (1999) Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23–q24. Am J Med Genet 88:567–587

    Article  CAS  PubMed  Google Scholar 

  • Mujaheed M, Corbex M, Lichtenberg P, Levinson DF, Deleuze JF, Mallet J, Ebstein RP (2000) Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a Palestinian Arab population. Am J Med Genet 96:836–838

    Article  CAS  PubMed  Google Scholar 

  • Myers A, Holmans P, Marshall H et al. (2000) Susceptibility locus for Alzheimer’s disease on chromosome 10. Science 290:2304–2305

    Article  CAS  PubMed  Google Scholar 

  • Neves-Pereira M, Bassett AS, Honer WG, Lang D, King NA, Kennedy JL (1998) No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families. Am J Med Genet 81:361–363

    Article  CAS  PubMed  Google Scholar 

  • Nöthen MM, Propping P, Fimmers R (1993) Association versus linkage studies in psychosis genetics. J Med Genet 30:634–637

    PubMed  Google Scholar 

  • Nöthen MM, Cichon S, Craddock N et al. (1996) Linkage studies of bipolar disorder to chromosome 18 markers. Biol Psychiatry 39:615

    Google Scholar 

  • Noyes R, Crowe RR, Harris EL, Hamra BJ, McChesney CM, Chaudhry DR (1986) Relationship between panic disorder and agoraphobia. Arch Gen Psychiatry 43:227–232

    PubMed  Google Scholar 

  • Noyes R, Clarkson C, Crowe RR, Yates WR, McChesney CM (1987) A family study of generalized anxiety disorder. Am J Psychiatry 144:1019–1024

    PubMed  Google Scholar 

  • Nurnberger JI, Blehar MC, Kaufmann CA et al. (1994) Diagnostic interview for genetic studies. Arch Gen Psychiatry 51:849–859

    PubMed  Google Scholar 

  • O’Donovan MC, Guy C, Craddock N et al.(1996) Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychol Med 26:1145–1153

    CAS  PubMed  Google Scholar 

  • Ohara K, Nagai M, Tani K, Nakamura Y, Ino A, Ohara K (1998) Functional polymorphism of-141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry Res 81:117–123

    CAS  PubMed  Google Scholar 

  • Onstad S, Skre I, Torgersen S, Kringlen E (1991) Twin concordance for DSM-III-R schizophrenia. Acta Psychiatr Scand 83:395–402

    CAS  PubMed  Google Scholar 

  • Park S, Holzman PS, Goldman-Rakic S (1995) Spatial working memory deficits in the relatives of schizop hrenic patients. Arch Gen Psychiatry 52:821–828

    CAS  PubMed  Google Scholar 

  • Parnas J, Cannon TD, Jacobsen B, Schulsinger H, Schulsinger F, Mednick SA (1993) Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers. Arch Gen Psychiatry 50:707–714

    CAS  PubMed  Google Scholar 

  • Pauls DL, Alsobrook JP 2nd, Goodman W, Rasmussen S, Leckman JF (1995) A family study of obsessive-compulsive disorder. Am J Psychiatry 152:76–84

    CAS  PubMed  Google Scholar 

  • Paunio T, Ekelund J, Varilo T et al. (2001) Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 10:3037–3048

    Article  CAS  PubMed  Google Scholar 

  • Penrose LS (1948) The problem of anticipation in pedigrees of dystrophia myotonica. Ann Eugenics 14:125–132

    Google Scholar 

  • Pickens RW, Sviskis DS, McGue M, Lykken DT, Heston LL, Clayton PJ (1991) Heterogeneity in the inheritance of alcoholism: a study of male and female twins. Arch Gen Psychiatry 48:19–28

    CAS  PubMed  Google Scholar 

  • Preisig M, Bellivier F, Fenton BT et al. (2000) Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study. Am J Psychiatry 157:948–955

    Article  CAS  PubMed  Google Scholar 

  • Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a populationbased sample of male twins. Am J Psychiatry 156:34–40

    CAS  PubMed  Google Scholar 

  • Propping P (1983) Genetic disorders presenting as „schizophrenia“. Karl Bonhoeffer’s view of the psychosis in the light of medical genetics. Hum Genet 65:1–10

    Article  CAS  PubMed  Google Scholar 

  • Propping P (1989) Psychiatrische Genetik. Befunde und Konzepte. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Pulver AE, Karayiorgou M, Wolyniec PS et al. (1994a) Sequential strategy to identify a susceptibility gene for schizophrenia: a report of potential linkage on chromosome 22q12–q13: Part 1. Am J Med Genet 54:36–43

    CAS  PubMed  Google Scholar 

  • Pulver AE, Karayiorgou M, Lasseter VK et al. (1994b) Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12–q13.1: Part 2. Am J Med Genet 54:44–50

    CAS  PubMed  Google Scholar 

  • Pulver AE, Nestadt G, Goldberg R et al. (1994c) Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 182:476–478

    CAS  PubMed  Google Scholar 

  • Pulver AE, Lasseter VK, Kasch L et al. (1995) Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60:252–260

    Article  CAS  PubMed  Google Scholar 

  • Rice J, Reich T, Andreasen NC et al. (1987) The familial transmission of bipolar illness. Arch Gen Psychiatry 44:441–447

    CAS  PubMed  Google Scholar 

  • Reich T, Edenberg HJ, Goate A et al. (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207–215

    Article  CAS  PubMed  Google Scholar 

  • Riley BP, Makoff A, Mogudi-Carter M, Jenkins T, Williamson R, Collier D, Murray R (2000) Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families. Am J Med Genet 96:196–201

    Article  CAS  PubMed  Google Scholar 

  • Risch N (1990) Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46:222–228

    CAS  PubMed  Google Scholar 

  • Risch N, Botstein D (1996) A manic depressive history. Nat Genet 12:351–353

    Article  CAS  PubMed  Google Scholar 

  • Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516–1517

    CAS  PubMed  Google Scholar 

  • Risch NJ (2000) Searching for genetic determinants in the new millennium. Nature 405:847–856

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg DR, Sweeney, JA, Squires-Wheeler E, Keshavan MS, Cornblatt BA, Erlenmeyer-Kimling L (1997) Eye-tracking dysfunction in offspring from the New York high-risk project: diagnostic specificity and the role of attention. Psychiatry Res 66:121–130

    Article  CAS  PubMed  Google Scholar 

  • Rousseau F, Heitz D, Tarleton J et al. (1994) A multicenter study on genotype-phenotype correlations in the fragile X syndrome, using direct diagnosis with probe StB 12.3: the first 2,253 cases. Am J Hum Genet 55:225–237

    CAS  PubMed  Google Scholar 

  • Scherrer JF, True WR, Xian H et al. (2000) Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic. J Affect Disord 57:25–35

    Article  CAS  PubMed  Google Scholar 

  • Schuckit MA (1984 a) Differences in plasma cortisol after ethanol in relatives of alcoholics and controls. J Clin Psychiatry 144:854–859

    Google Scholar 

  • Schuckit MA (1984b) Prospective markers for alcoholism. In: Goodwin DW, Van Dusen KT, Mednick SA (eds) Longitudinal research in alcoholism. Kluwer-Nijhoff, Boston, pp 147–163

    Google Scholar 

  • Schuckit MA (1985) Ethanol-induced changes in body sway in men at high alcoholism risk. Arch Gen Psychiatry 42:375–379

    CAS  PubMed  Google Scholar 

  • Schuckit MA, Gold E, Risch SC (1987) Plasma cortisol levels following ethanol in sons of alcoholics and controls. Arch Gen Psychiatry 44:942–945

    CAS  PubMed  Google Scholar 

  • Schwab SG, Lerer B, Albus M et al. (1995a) Potential linkage for schizophrenia on chromosome 22q12–q13: a replication study. Am J Med Genet 60:436–443

    Article  CAS  PubMed  Google Scholar 

  • Schwab SG, Albus M, Hallmayer J et al. (1995b) Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 11:325–327

    Article  CAS  PubMed  Google Scholar 

  • Schwab SG, Eckstein GN, Hallmayer J et al. (1997) Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Mol Psychiatry 2:156–160

    Article  CAS  PubMed  Google Scholar 

  • Schwab SG, Hallmayer J, Albus M et al. (1998) Further evidence for a susceptibility locus on chromosome 10p14–p11 in 72 families with schizophrenia by nonparametric linkage analysis. Am J Med Genet 81:302–307

    Article  CAS  PubMed  Google Scholar 

  • Sherrington R, Brynjolfsson J, Petursson H et al. (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336:164–167

    Article  CAS  PubMed  Google Scholar 

  • Silberg J, Rutter M, Neale M, Eaves L (2001) Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br J Psychiatry 179:116–121

    Article  CAS  PubMed  Google Scholar 

  • Sillaber I, Rammes G, Zimmermann S et al. (2002) Enhanced and Delayed Stress-Induced Alcohol Drinking in Mice Lacking Functional CRH1 Receptors. Science 296:931–933

    Article  CAS  PubMed  Google Scholar 

  • Smith CAD, Gough AC, Leigh PN et al. (1992) Debrisoquine hydroxylase polymorphism and susceptibility to Parkinson’s disease. Lancet 339:1375–1377

    CAS  PubMed  Google Scholar 

  • Sobell JL, Heston LL, Sommer SS (1992) Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics 12:1–6

    Article  CAS  PubMed  Google Scholar 

  • Stefansson H, Sigurdsson E, Steinthorsdottir V et al. (2002) Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71:(im Druck)

    Google Scholar 

  • Stein MB, Chartier MJ, Hazen AL et al. (1998) A direct-interview family study of generalized social phobia. Am J Psychiatry 155:90–97

    CAS  PubMed  Google Scholar 

  • Stine OC, Xu J, Koskela R et al. (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 57:1384–1394

    CAS  PubMed  Google Scholar 

  • Straub RE, Lehner T, Luo Y et al. (1994) A possible vulnerability locus for bipolar disorder on chromosome 21q22.3. Nat Genet 8:291–296

    Article  CAS  PubMed  Google Scholar 

  • Straub RE, MacLean CJ, O’Neill FO et al. (1995) A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity. Nat Genet 11:287–293

    Article  CAS  PubMed  Google Scholar 

  • Straub RE, MacLean CJ, O–Neill FO, Walsh D, Kendler KS (1997) Support for a schizophrenia vulnerability locus in region 5q21–q31 in Irish pedigrees. Mol Psychiatry 2:148–155

    Article  CAS  PubMed  Google Scholar 

  • Straub RE, MacLean CJ, Martin RB et al. (1998) A schizophrenia locus may be located in region 10p15–p11. Am J Med Genet 81:296–301

    Article  CAS  PubMed  Google Scholar 

  • Tallerico T, Ulpian C, Liu IS (1999) Dopamine D2 receptor promoter polymorphism: no association with schizophrenia. Psychiatry Res 85:215–219

    Article  CAS  PubMed  Google Scholar 

  • Tarter RE, Hegedus AM, Goldstein G, Shelly C, Alterman A (1984) Adolescent sons of alcoholics: neurophysiological and personality characteristics. Alcohol Clin Exp Res 8:216–222

    CAS  PubMed  Google Scholar 

  • Torgersen S (1986) Genetic factors in moderately severe and mild affective disorders. Arch Gen Psychiatry 43:222–226

    CAS  PubMed  Google Scholar 

  • True WR, Rice J, Eisen SA, Heath AC, Goldberg J, Lyons MJ, Nowak J (1993) A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch Gen Psychiatry 50:257–264

    CAS  PubMed  Google Scholar 

  • Tsuang DW, Skol AD, Faraone SV et al. (2001) Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample. Am J Med Genet 105:662–668

    CAS  PubMed  Google Scholar 

  • Vallada H, Craddock N, Vasques L et al. (1996) Linkage studies in bipolar affective disorder with markers on chromosome 21. J Affect Disord 41:217–221

    Article  CAS  PubMed  Google Scholar 

  • Van Broeckhoven C (1995) Presenilins and Alzheimer disease. Nat Genet 11:230–232

    Article  PubMed  Google Scholar 

  • Van Os J, Marcelis M, Sham P, Jones P, Gilvarry K, Murray R (1997) Psychopathological syndromes and familial morbid risk of psychosis. Br J Psychiatry 170:241–246

    PubMed  Google Scholar 

  • Verkerk AJMH, Pieretti M, Sutcliffe JS et al. (1991) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65:905–914

    Article  CAS  PubMed  Google Scholar 

  • Wang S, Sun CE, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR (1995) Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 10:41–46

    PubMed  Google Scholar 

  • Weissman MM, Wickramaratne P, Adams PB et al. (1993) The relationship between panic disorder and major depression. A new family study. Arch Gen Psychiatry 50:767–780

    CAS  PubMed  Google Scholar 

  • Weissman MM, Warner V, Wickramaratne P, Moreau D, Olfson M (1997) Offspring of depressed parents. 10 years later. Arch Gen Psychiatry 54:932–940

    CAS  PubMed  Google Scholar 

  • Wildenauer DB, Schwab SG, Eckstein G et al. (1995) Searching for susceptibility genes in schizophrenia by affected sib pair analysis: evidence for loci in 22q, 5q, 6p. Am J Hum Genet 57(Suppl):176

    Google Scholar 

  • Wildenauer DB, Hallmayer J, Schwab SG et al. (1996) Searching for susceptibility genes in schizophrenia by genetic linkage analysis. Cold Spring Harbor Symposia on Quantitative Biology, vol LXI. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 845–850

    Google Scholar 

  • Williams J, Spurlock G, McGuffin P et al. (1996) Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet 347:1294–1296

    CAS  PubMed  Google Scholar 

  • Williams J, Spurlock G, Holmans P et al. (1998) A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 3:141–149

    CAS  PubMed  Google Scholar 

  • Winokur G, Coryell W (1991) Familial alcoholism in primary unipolar major depressive disorder. Am J Psychiatry 148:184–188

    CAS  PubMed  Google Scholar 

  • Winokur G, Cadoret RJ, Dorzab J, Baker M (1971) Depressive disease: a genetic study. Arch Gen Psychiatry 24:135–144

    CAS  PubMed  Google Scholar 

  • Winokur G, Coryell W, Keller M, Endicott J, Leon A (1995) A family study of manic-depressive (bipolar I) disease. Arch Gen Psychiatry 52:367–383

    CAS  PubMed  Google Scholar 

  • Xu J, Pato MT, Torre CD et al. (2001) Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families. Am J Med Genet 105:669–674

    CAS  PubMed  Google Scholar 

  • Zahn TP, Nurnberger JI, Berrettini WH (1989) Electrodermal activity in young adults at genetic risk for affective disorder. Arch Gen Psychiatry 46:1120–1124

    CAS  PubMed  Google Scholar 

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  1. W. Maier
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  3. M. Rietschel
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  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Ludwig-Maximilians-Universität München, Nußbaumstraße 7, 80336, München

    Hans-Jürgen Möller  & Hans-Peter Kapfhammer  & 

  2. Bezirksklinikum Gabersee, Fachkrankenhaus für Psychiatrie Psychotherapie und Neurologie, Gabersee 7, 83512, Wasserburg a. Inn

    Gerd Laux

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Maier, W., Schwab, S., Rietschel, M. (2003). Genetik psychiatrischer Störugen. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie und Psychotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27386-7_4

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