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Literatur
Bouchard C, Perusse L (1993) Genetic aspects of obesity. Ann N Y Acad Sci 699: 26–35
Branson R, Potoczna N, Kral JG, Lentes KU, Hoehe MR, Horber FF (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348: 1096–1103
Chagnon YC, Rankinen T, Snyder EE, Weisnagel SJ, Perusse L, Bouchard C (2003) The human obesity gene map: the 2002 update. Obes Res 11: 313–367
Dempfle A, Hinney A, Heinzel-Gutenbrunner M, Raab M, Geller F, Gudermann T, Schäfer H, Hebebrand J (2004) Large quantitative effect of melanocortin-4 receptor gene mutations on BMI. JMG (im Druck)
Fabsitz RR, Carmelli D, Hewitt JK (1992) Evidence for independent genetic influences on obesity in middle age. Int J Obes Relat Metab Disord 16: 657–666
Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O’Rahilly S (2000) Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106: 271–279
Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O’Rahilly S (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348: 1085–1095
Geller F, Reichwald K, Dempfle A, Illig T, Vollmert C, Herpertz S, Siffert W, Platzer M, Hess C, Gudermann T, Biebermann H, Wichmann HE, Schafer H, Hinney A, Hebebrand J (2004) Melanocortin-4 receptor gene variant i103 is negatively associated with obesity. Am J Hum Genet 74:572–581
Hebebrand J, Hinney A, Roth H, Ziegler A (1998) Genetische Aspekte der Adipositas. In: Wechsler JG (Hrsg) Adipositas/Ursachen und Therapie. Ex Libris Roche-Blackwell, Berlin Wien, S. 105–117
Hebebrand J, Hinney A, Oeffner F (2001a) Molekulare Grundlagen der Adipositas. In: Ganten D, Ruckpaul K (Hrsg) Molekularmedizinische Grundlagen von Endokrinopathien. Springer, Berlin Heidelberg New York Tokio, S. 387–426
Hebebrand J, Sommerlad C, Geller F, Gorg T, Hinney A (2001b) The genetics of obesity: practical implications. Int J Obes Relat Metab Disord 25: S10–18
Hebebrand J, Friedel S, Schauble N, Geller F, Hinney A (2003) Perspectives: molecular genetic research in human obesity. Obes Rev 4: 139–146
Hebebrand J, Geller F, Dempfle A, Heinzel-Gutenbrunner M, Raab M, Gerber G, Wermter AK, Horro FF, Blundell J, Schäfer H, Remschmidt H, Herpertz S, Hinney A (2004) Bingeeating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Mol Psychiatry 23: (Epub ahead of print)
Hewitt JK (1997) The genetics of obesity: what have genetic studies told us about the environment. Behav Genet 27: 353–358
Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter A-K, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schäfer H, Gudermann T, Hebebrand J (2003) Melanocortin-4 Receptor Gene: Case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab 88: 4258–4267
Kries R von, Koletzko B, Sauerwald T, Mutius E von, Barnert D, Grunert V, von Voss H (1999) Breast feeding and obesity: cross sectional study. BMJ 319:147–150
Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19: 155–157
Maes HH, Neale MC, Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27: 325–351
Magnusson PK, Rasmussen F (2002) Familial resemblance of body mass index and familial risk of high and low body mass index. A study of young men in Sweden. Int J Obes Relat Metab Disord 26: 1225–1231
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O’Rahilly S (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903–908
Neel JV, Weder AB, Julius S (1998) Type II diabetes, essential hypertension, and obesity as »syndromes of impaired genetic homeostasis«: the »thrifty genotype« hypothesis enters the 21st century. Perspect Biol Med 42: 44–74
Pietilainen KH, Kaprio J, Rissanen A, Winter T, Rimpela A, Viken RJ, Rose RJ (1999) Distribution and heritability of BMI in Finnish adolescents aged 16y and 17y: a study of 4884 twins and 2509 singletons. Int J Obes Relat Metab Disord 23: 107–115
Stunkard AJ, Sorensen TI, Hanis C, Teasdale TW, Chakraborty R, Schull WJ, Schulsinger F (1986) An adoption study of human obesity. N Engl J Med 314: 193–198
Stunkard AJ, Harris JR, Pedersen NL, McClearn GE (1990) The body mass index of twins who have been reared apart. N Engl J Med 222: 1483–1487
Maes HH, Neale MC, Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27: 325–351
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Hebebrand, J., Wermter, AK., Hinney, A. (2005). Genetik und Gen-Umwelt-Interaktionen. In: Wabitsch, M., Kiess, W., Hebebrand, J., Zwiauer, K. (eds) Adipositas bei Kindern und Jugendlichen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26775-1_3
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DOI: https://doi.org/10.1007/3-540-26775-1_3
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