Skip to main content
Log in

Baroreflex activation as a novel therapeutic strategy for diastolic heart failure

  • Letter to the Editors
  • Published:
Clinical Research in Cardiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW (2009) 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 119:e391–e479

    Article  PubMed  Google Scholar 

  2. Massie BM, Carson PE, McMurray JJ, Komajda M, McKelvie R, Zile MR, Anderson S, Donovan M, Iverson E, Staiger C, Ptaszynska A (2008) Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med 359:2456–2467

    Article  CAS  PubMed  Google Scholar 

  3. Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J (2003) Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 362:777–781

    Article  CAS  PubMed  Google Scholar 

  4. Cleland JG, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J (2006) The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 27:2338–2345

    Article  CAS  PubMed  Google Scholar 

  5. Burns J, Sivananthan MU, Ball SG, Mackintosh AF, Mary DA, Greenwood JP (2007) Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension. Circulation 115:1999–2005

    Article  PubMed  Google Scholar 

  6. Kaye DM, Lambert GW, Lefkovits J, Morris M, Jennings G, Esler MD (1994) Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. J Am Coll Cardiol 23:570–578

    Article  CAS  PubMed  Google Scholar 

  7. Giannattasio C, Cattaneo BM, Seravalle G, Grassi G, Mancia G (1991) Left ventricular hypertrophy and the ‘cardiogenic reflex’ in man. J Hypertens Suppl 9:S43–S50

    Article  CAS  PubMed  Google Scholar 

  8. Palatini P, Benetos A, Julius S (2006) Impact of increased heart rate on clinical outcomes in hypertension: implications for antihypertensive drug therapy. Drugs 66:133–144

    Article  CAS  PubMed  Google Scholar 

  9. Eckberg DL, Fletcher GF, Braunwald E (1972) Mechanism of prolongation of the R-R interval with electrical stimulation of the carotid sinus nerves in man. Circ Res 30:131–138

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

CVRx Inc. provided financial support of the study and supported device implantation and programming.

Conflict of interest

M.C.B., N.M., and U.C.H. report no conflicts of interest. R.V. is an employee of CVRx Inc.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Uta C. Hoppe.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brandt, M.C., Madershahian, N., Velden, R. et al. Baroreflex activation as a novel therapeutic strategy for diastolic heart failure. Clin Res Cardiol 100, 249–251 (2011). https://doi.org/10.1007/s00392-010-0249-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00392-010-0249-0

Keywords

Navigation