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Zeitschrift für Gerontologie und Geriatrie

Erschienen in:

29.12.2022 | Reviews

What role do extracellular vesicles play in developing physical frailty and sarcopenia?

A systematic review

verfasst von: Ling-xiao Wang, M.D., Xia Zhang, M.D., Li-juan Guan, M.D., Yang Pen, M.D.

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 8/2023

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Abstract

Background

Frailty and sarcopenia are typical geriatric conditions with a complex pathophysiology. Extracellular vesicles (EVs) are key regulators of age-related diseases, but the mechanisms underlying physical frailty, sarcopenia, and EVs are not well understood.

Methods

A systematic literature review was conducted to examine the evidence supporting an association between EVs and physical frailty and/or sarcopenia by searching the electronic databases, including the Cochrane Library, PubMed, and Embase, from January 2000 to January 2021.

Results

A total of 216 cross-sectional studies were retrieved, and after the removal of 43 duplicate records, the title and abstract of 167 articles were screened, identifying 6 relevant articles for full-text review. Of the studies five met the inclusion criteria, and heterogeneity among studies was high. There is controversy regarding whether frailty and/or sarcopenia are related to circulating EV levels; however, the cargo of EVs has been associated with frailty and sarcopenia in various ways, such as microRNAs, mitochondrial-derived vesicles (MDVs), and protein cargoes.

Conclusion

Recent studies, although limited, depicted that EVs could be one of the underlying mechanisms of frailty and/or sarcopenia. There is a possibility that physical frailty and sarcopenia may have specific EV concentrations and cargo profiles; however, further research is required to fully understand the mechanisms and identify potential biomarkers and early preventative strategies for physical frailty and sarcopenia.

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Titel: What role do extracellular vesicles play in developing physical frailty and sarcopenia?
A systematic review
verfasst von: Ling-xiao Wang, M.D.
Xia Zhang, M.D.
Li-juan Guan, M.D.
Yang Pen, M.D.
Publikationsdatum: 29.12.2022
Verlag: Springer Medizin
Erschienen in: Zeitschrift für Gerontologie und Geriatrie / Ausgabe 8/2023
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI: https://doi.org/10.1007/s00391-022-02150-3

Springerpflege

Abstract

Background

Methods

Results

Conclusion

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