Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Zeitschrift für Gerontologie und Geriatrie 7/2017

18.07.2017 | Themenschwerpunkt

Sleep in older adults and in subjects with dementia

verfasst von: PD Dr. Helmut Frohnhofen, Jeanina Schlitzer, Nikolaus Netzer

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 7/2017

Einloggen, um Zugang zu erhalten

Abstract

The neuronal structures for the regulation of sleep and wakefulness are located in the brain. This complex network is vulnerable to numerous factors, most importantly neurodegenerative diseases and drugs. The macrostructure and microstructure of sleep change with age. These changes are more pronounced in subjects with dementia. Sleep disorders in subjects with dementia may be independent of dementia or caused by dementia. Furthermore, epidemiological studies reveal that sleep disorders per se may induce dementia by reduction of cerebral clearance of beta-amyloids. The population attributable risk (PAR) of sleep disturbances to the incidence of dementia is estimated to be about 15%; therefore, management of sleep disturbances in older adults and subjects with dementia gives the opportunity of an impact on incidence and course of dementia. Sleep history should be taken from each individual and obvious sleep disturbances, especially sleep apnea, should be managed according to current guidelines. Future studies that concern the incidence and the management of dementia must take into account sleep and sleep disturbances.
Literatur
1.
Zurück zum Zitat Ancoli-Israel S, Klauber MR, Butters N, Parker L, Kripke DF (1991) Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc 39:258–263 CrossRef Ancoli-Israel S, Klauber MR, Butters N, Parker L, Kripke DF (1991) Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc 39:258–263 CrossRef
2.
Zurück zum Zitat Ancoli-Israel S, Palmer BW, Cooke JR et al (2008) Cognitive effects of treating obstructive sleep apnea in Alzheimer’s disease: a randomized controlled study. J Am Geriatr Soc 56:2076–2081 CrossRef Ancoli-Israel S, Palmer BW, Cooke JR et al (2008) Cognitive effects of treating obstructive sleep apnea in Alzheimer’s disease: a randomized controlled study. J Am Geriatr Soc 56:2076–2081 CrossRef
3.
Zurück zum Zitat Aston-Jones G, Chen S, Zhu Y, Oshinsky ML (2001) A neural circuit for circadian regulation of arousal. Nat Neurosci 4:732–738 CrossRef Aston-Jones G, Chen S, Zhu Y, Oshinsky ML (2001) A neural circuit for circadian regulation of arousal. Nat Neurosci 4:732–738 CrossRef
4.
Zurück zum Zitat Aurora RN, Zak RS, Maganti RK et al (2010) Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 6:85–95 PubMedPubMedCentral Aurora RN, Zak RS, Maganti RK et al (2010) Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 6:85–95 PubMedPubMedCentral
5.
Zurück zum Zitat Bliwise DL (1993) Sleep in normal aging and dementia. Sleep 16:40–81 CrossRef Bliwise DL (1993) Sleep in normal aging and dementia. Sleep 16:40–81 CrossRef
6.
Zurück zum Zitat Bliwise DL (2004) Sleep disorders in Alzheimer’s disease and other dementias. Clin Cornerstone 6(1 Suppl A):S16–S28 CrossRef Bliwise DL (2004) Sleep disorders in Alzheimer’s disease and other dementias. Clin Cornerstone 6(1 Suppl A):S16–S28 CrossRef
7.
Zurück zum Zitat Bliwise DL, Tinklenberg J, Yesavage JA et al (1989) REM latency in Alzheimer’s disease. Biol Psychiatry 25:320–328 CrossRef Bliwise DL, Tinklenberg J, Yesavage JA et al (1989) REM latency in Alzheimer’s disease. Biol Psychiatry 25:320–328 CrossRef
8.
Zurück zum Zitat Bliwise DL, Hughes M, McMahon PM, Kutner N (1995) Observed sleep/wakefulness and severity of dementia in an Alzheimer’s disease special care unit. J Gerontol A Biol Sci Med Sci 50:6 Bliwise DL, Hughes M, McMahon PM, Kutner N (1995) Observed sleep/wakefulness and severity of dementia in an Alzheimer’s disease special care unit. J Gerontol A Biol Sci Med Sci 50:6
9.
Zurück zum Zitat Bliwise DL, Watts RL, Watts N, Rye DB, Irbe D, Hughes M (1995) Disruptive nocturnal behavior in Parkinson’s disease and Alzheimer’s disease. J Geriatr Psychiatry Neurol 8:107–110 CrossRef Bliwise DL, Watts RL, Watts N, Rye DB, Irbe D, Hughes M (1995) Disruptive nocturnal behavior in Parkinson’s disease and Alzheimer’s disease. J Geriatr Psychiatry Neurol 8:107–110 CrossRef
10.
Zurück zum Zitat Bliwise DL, Mercaldo ND, Avidan AY, Boeve BF, Greer SA, Kukull WA (2011) Sleep disturbance in dementia with Lewy bodies and Alzheimer’s disease: a multicenter analysis. Dement Geriatr Cogn Disord 31:239–246 CrossRef Bliwise DL, Mercaldo ND, Avidan AY, Boeve BF, Greer SA, Kukull WA (2011) Sleep disturbance in dementia with Lewy bodies and Alzheimer’s disease: a multicenter analysis. Dement Geriatr Cogn Disord 31:239–246 CrossRef
11.
Zurück zum Zitat Bloom HG, Ahmed I, Alessi CA et al (2009) Evidence-based recommendations for the assessment and management of sleep disorders in older persons. J Am Geriatr Soc 57:761–789 CrossRef Bloom HG, Ahmed I, Alessi CA et al (2009) Evidence-based recommendations for the assessment and management of sleep disorders in older persons. J Am Geriatr Soc 57:761–789 CrossRef
12.
Zurück zum Zitat Boddy F, Rowan EN, Lett D, O’Brien JT, McKeith IG, Burn DJ (2007) Subjectively reported sleep quality and excessive daytime somnolence in Parkinson’s disease with and without dementia, dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry 22:529–535 CrossRef Boddy F, Rowan EN, Lett D, O’Brien JT, McKeith IG, Burn DJ (2007) Subjectively reported sleep quality and excessive daytime somnolence in Parkinson’s disease with and without dementia, dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry 22:529–535 CrossRef
13.
Zurück zum Zitat Bombois S, Derambure P, Pasquier F, Monaca C (2010) Sleep disorders in aging and dementia. J Nutr Health Aging 14:212–217 CrossRef Bombois S, Derambure P, Pasquier F, Monaca C (2010) Sleep disorders in aging and dementia. J Nutr Health Aging 14:212–217 CrossRef
14.
Zurück zum Zitat Bonanni E, Maestri M, Tognoni G et al (2005) Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment. J Sleep Res 14:311–317 CrossRef Bonanni E, Maestri M, Tognoni G et al (2005) Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment. J Sleep Res 14:311–317 CrossRef
15.
Zurück zum Zitat Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259 CrossRef Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259 CrossRef
16.
Zurück zum Zitat Brock MA (1991) Chronobiology and aging. J Am Geriatr Soc 39:74–91 CrossRef Brock MA (1991) Chronobiology and aging. J Am Geriatr Soc 39:74–91 CrossRef
18.
Zurück zum Zitat de Bruijn RFAG, Bos MJ, Portegies MLP et al (2015) The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam study. BMC Med 13:132 CrossRef de Bruijn RFAG, Bos MJ, Portegies MLP et al (2015) The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam study. BMC Med 13:132 CrossRef
19.
Zurück zum Zitat Conte F, Arzilli C, Errico BM, Giganti F, Iovino D, Ficca G (2014) Sleep measures expressing ‘functional uncertainty’ in elderlies’ sleep. Gerontology 60:448–457 CrossRef Conte F, Arzilli C, Errico BM, Giganti F, Iovino D, Ficca G (2014) Sleep measures expressing ‘functional uncertainty’ in elderlies’ sleep. Gerontology 60:448–457 CrossRef
20.
Zurück zum Zitat Cooke JR, Ancoli-Israel S (2011) Normal and abnormal sleep in the elderly. Handb Clin Neurol 98:653–665 CrossRef Cooke JR, Ancoli-Israel S (2011) Normal and abnormal sleep in the elderly. Handb Clin Neurol 98:653–665 CrossRef
21.
Zurück zum Zitat Drummond SP, Brown GG, Gillin JC, Stricker JL, Wong EC, Buxton RB (2000) Altered brain response to verbal learning following sleep deprivation. Nature 403:655–657 CrossRef Drummond SP, Brown GG, Gillin JC, Stricker JL, Wong EC, Buxton RB (2000) Altered brain response to verbal learning following sleep deprivation. Nature 403:655–657 CrossRef
22.
Zurück zum Zitat Feinberg I, Koresko RL, Heller N (1967) EEG sleep patterns as a function of normal and pathological aging in man. J Psychiatr Res 5:107–144 CrossRef Feinberg I, Koresko RL, Heller N (1967) EEG sleep patterns as a function of normal and pathological aging in man. J Psychiatr Res 5:107–144 CrossRef
23.
Zurück zum Zitat Frohnhofen H, Roffe C (2012) Intermittent nocturnal hypoxemia in individuals with dementia: prevalence and relationship with functional status. J Am Geriatr Soc 60:1997–1999 CrossRef Frohnhofen H, Roffe C (2012) Intermittent nocturnal hypoxemia in individuals with dementia: prevalence and relationship with functional status. J Am Geriatr Soc 60:1997–1999 CrossRef
24.
Zurück zum Zitat Frohnhofen H, Schlitzer J (2015) CME Zertifizierte Fortbildung. Schlaf und Schlafstörungen beim alten Menschen ; Teil 3: Restless-legs-Syndrom. Z Gerontol Geriatr 48:379–387 CrossRef Frohnhofen H, Schlitzer J (2015) CME Zertifizierte Fortbildung. Schlaf und Schlafstörungen beim alten Menschen ; Teil 3: Restless-legs-Syndrom. Z Gerontol Geriatr 48:379–387 CrossRef
25.
Zurück zum Zitat Garland K, Beer E, Eppingstall B, O’Connor DW (2007) A comparison of two treatments of agitated behavior in nursing home residents with dementia: simulated family presence and preferred music. Am J Geriatr Psychiatry 15:514–521 CrossRef Garland K, Beer E, Eppingstall B, O’Connor DW (2007) A comparison of two treatments of agitated behavior in nursing home residents with dementia: simulated family presence and preferred music. Am J Geriatr Psychiatry 15:514–521 CrossRef
27.
Zurück zum Zitat Guarnieri B, Adorni F, Musicco M et al (2012) Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord 33:50–58 CrossRef Guarnieri B, Adorni F, Musicco M et al (2012) Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord 33:50–58 CrossRef
28.
Zurück zum Zitat Harper DG, Stopa EG, McKee AC et al (2001) Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry 58:353–360 CrossRef Harper DG, Stopa EG, McKee AC et al (2001) Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry 58:353–360 CrossRef
29.
Zurück zum Zitat Harper DG, Stopa EG, McKee AC, Satlin A, Fish D, Volicer L (2004) Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease. Neurobiol Aging 25:771–781 CrossRef Harper DG, Stopa EG, McKee AC, Satlin A, Fish D, Volicer L (2004) Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease. Neurobiol Aging 25:771–781 CrossRef
30.
Zurück zum Zitat Hofman MA (1997) Lifespan changes in the human hypothalamus. Exp Gerontol 32:559–575 CrossRef Hofman MA (1997) Lifespan changes in the human hypothalamus. Exp Gerontol 32:559–575 CrossRef
31.
Zurück zum Zitat Hofman MA, Swaab DF (1995) Influence of aging on the seasonal rhythm of the vasopressin-expressing neurons in the human suprachiasmatic nucleus. Neurobiol Aging 16:965–971 CrossRef Hofman MA, Swaab DF (1995) Influence of aging on the seasonal rhythm of the vasopressin-expressing neurons in the human suprachiasmatic nucleus. Neurobiol Aging 16:965–971 CrossRef
32.
Zurück zum Zitat Hofman MA, Swaab DF (2006) Living by the clock: the circadian pacemaker in older people. Ageing Res Rev 5:33–51 CrossRef Hofman MA, Swaab DF (2006) Living by the clock: the circadian pacemaker in older people. Ageing Res Rev 5:33–51 CrossRef
33.
Zurück zum Zitat Huang Y, Potter R, Sigurdson W et al (2012) Effects of age and amyloid deposition on Abeta dynamics in the human central nervous system. Arch Neurol 69:51–58 CrossRef Huang Y, Potter R, Sigurdson W et al (2012) Effects of age and amyloid deposition on Abeta dynamics in the human central nervous system. Arch Neurol 69:51–58 CrossRef
35.
Zurück zum Zitat Ju Y‑ES, McLeland JS, Toedebusch CD et al (2013) Sleep quality and preclinical Alzheimer disease. JAMA Neurol 70:587–593 CrossRef Ju Y‑ES, McLeland JS, Toedebusch CD et al (2013) Sleep quality and preclinical Alzheimer disease. JAMA Neurol 70:587–593 CrossRef
36.
Zurück zum Zitat Kang J‑E, Lim MM, Bateman RJ et al (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326:1005–1007 CrossRef Kang J‑E, Lim MM, Bateman RJ et al (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326:1005–1007 CrossRef
37.
Zurück zum Zitat Lin PW, Chan W, Ng BF, Lam LC (2007) Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry 22(5):405–410. doi: 10.​1002/​gps.​1688 CrossRefPubMed Lin PW, Chan W, Ng BF, Lam LC (2007) Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry 22(5):405–410. doi: 10.​1002/​gps.​1688 CrossRefPubMed
38.
Zurück zum Zitat Lu J, Greco MA, Shiromani P, Saper CB (2000) Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep. J Neurosci 20:3830–3842 CrossRef Lu J, Greco MA, Shiromani P, Saper CB (2000) Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep. J Neurosci 20:3830–3842 CrossRef
39.
Zurück zum Zitat van Maanen A, Meijer AM, van der Heijden KB, Oort FJ (2016) The effects of light therapy on sleep problems: a systematic review and meta-analysis. Sleep Med Rev 29:52–62 CrossRef van Maanen A, Meijer AM, van der Heijden KB, Oort FJ (2016) The effects of light therapy on sleep problems: a systematic review and meta-analysis. Sleep Med Rev 29:52–62 CrossRef
41.
Zurück zum Zitat McCurry SM, LaFazia DM, Pike KC, Logsdon RG, Teri L (2012) Development and evaluation of a sleep education program for older adults with dementia living in adult family homes. Am J Geriatr Psychiatry 20:494–504 CrossRef McCurry SM, LaFazia DM, Pike KC, Logsdon RG, Teri L (2012) Development and evaluation of a sleep education program for older adults with dementia living in adult family homes. Am J Geriatr Psychiatry 20:494–504 CrossRef
42.
Zurück zum Zitat Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N (2013) Poor sleep quality impairs cognitive performance in older adults. J Sleep Res 22:535–541 CrossRef Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N (2013) Poor sleep quality impairs cognitive performance in older adults. J Sleep Res 22:535–541 CrossRef
43.
Zurück zum Zitat McCurry SM, Pike KC, Vitiello MV, Logsdon RG, Larson EB, Teri L (2011) Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer’s disease: results of a randomized, controlled trial. J Am Geriatr Soc 59:1393–1402 CrossRef McCurry SM, Pike KC, Vitiello MV, Logsdon RG, Larson EB, Teri L (2011) Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer’s disease: results of a randomized, controlled trial. J Am Geriatr Soc 59:1393–1402 CrossRef
44.
Zurück zum Zitat Monk TH (1991) Sleep and circadian rhythms. Exp Gerontol 26:233–243 CrossRef Monk TH (1991) Sleep and circadian rhythms. Exp Gerontol 26:233–243 CrossRef
45.
Zurück zum Zitat Moran M, Walsh C, Lynch A, Coen RF, Coakley D, Lawlor BA (2004) Syndromes of behavioural and psychological symptoms in mild Alzheimer’s disease. Int J Geriatr Psychiatry 19:359–364 CrossRef Moran M, Walsh C, Lynch A, Coen RF, Coakley D, Lawlor BA (2004) Syndromes of behavioural and psychological symptoms in mild Alzheimer’s disease. Int J Geriatr Psychiatry 19:359–364 CrossRef
46.
Zurück zum Zitat Moran M, Lynch CA, Walsh C, Coen R, Coakley D, Lawlor BA (2005) Sleep disturbance in mild to moderate Alzheimer’s disease. Sleep Med 6:347–352 CrossRef Moran M, Lynch CA, Walsh C, Coen R, Coakley D, Lawlor BA (2005) Sleep disturbance in mild to moderate Alzheimer’s disease. Sleep Med 6:347–352 CrossRef
47.
Zurück zum Zitat Netzer NCC, Ancoli-Israel SC-C, Bliwise DL et al (2016) Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly. The consensus of the International Geriatric Sleep Medicine Task Force. Eur Respir J 48:992–1018 CrossRef Netzer NCC, Ancoli-Israel SC-C, Bliwise DL et al (2016) Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly. The consensus of the International Geriatric Sleep Medicine Task Force. Eur Respir J 48:992–1018 CrossRef
48.
Zurück zum Zitat Ohayon MM (2004) Interactions between sleep normative data and sociocultural characteristics in the elderly. J Psychosom Res 56:479–486 CrossRef Ohayon MM (2004) Interactions between sleep normative data and sociocultural characteristics in the elderly. J Psychosom Res 56:479–486 CrossRef
49.
Zurück zum Zitat Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27:1255–1273 CrossRef Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27:1255–1273 CrossRef
50.
Zurück zum Zitat Ooms S, Ju Y‑E (2016) Treatment of sleep disorders in dementia. Curr Treat Options Neurol 18:40 CrossRef Ooms S, Ju Y‑E (2016) Treatment of sleep disorders in dementia. Curr Treat Options Neurol 18:40 CrossRef
51.
Zurück zum Zitat Peyron C, Tighe DK, van den Pol AN et al (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996–10015 CrossRef Peyron C, Tighe DK, van den Pol AN et al (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996–10015 CrossRef
52.
Zurück zum Zitat Pittendrigh CS, Daan S (1974) Circadian oscillations in rodents: a systematic increase of their frequency with age. Science 186:548–550 CrossRef Pittendrigh CS, Daan S (1974) Circadian oscillations in rodents: a systematic increase of their frequency with age. Science 186:548–550 CrossRef
53.
Zurück zum Zitat Pollak CP, Perlick D (1991) Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol 4:204–210 PubMed Pollak CP, Perlick D (1991) Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol 4:204–210 PubMed
54.
Zurück zum Zitat Polzella DJ (1975) Effects of sleep deprivation on short-term recognition memory. J Exp Psychol Hum Learn 104:194–200 CrossRef Polzella DJ (1975) Effects of sleep deprivation on short-term recognition memory. J Exp Psychol Hum Learn 104:194–200 CrossRef
55.
Zurück zum Zitat Ralph MR, Hurd MW (1995) Circadian pacemakers in vertebrates. Ciba Found Symp 183:67–81 (discussion 81–87) PubMed Ralph MR, Hurd MW (1995) Circadian pacemakers in vertebrates. Ciba Found Symp 183:67–81 (discussion 81–87) PubMed
56.
Zurück zum Zitat Ralph MR, Hurd MW (1996) Pacemaker interactions in the mammalian circadian system. Braz J Med Biol Res 29:77–85 PubMed Ralph MR, Hurd MW (1996) Pacemaker interactions in the mammalian circadian system. Braz J Med Biol Res 29:77–85 PubMed
57.
Zurück zum Zitat Rechtschaffen A (ed) (2002) Ein Manual der standardisierten Terminologie, Techniken und Auswertung der Schlafstadien beim Menschen. ecomed, Landsberg Rechtschaffen A (ed) (2002) Ein Manual der standardisierten Terminologie, Techniken und Auswertung der Schlafstadien beim Menschen. ecomed, Landsberg
58.
Zurück zum Zitat Reynolds CF, Kupfer DJ, Taska LS et al (1985) EEG sleep in elderly depressed, demented, and healthy subjects. Biol Psychiatry 20:431–442 CrossRef Reynolds CF, Kupfer DJ, Taska LS et al (1985) EEG sleep in elderly depressed, demented, and healthy subjects. Biol Psychiatry 20:431–442 CrossRef
59.
Zurück zum Zitat Roepke SK, Ancoli-Israel S (2010) Sleep disorders in the elderly. Indian J Med Res 131:302–310 PubMed Roepke SK, Ancoli-Israel S (2010) Sleep disorders in the elderly. Indian J Med Res 131:302–310 PubMed
60.
Zurück zum Zitat Rogers NL, Dorrian J, Dinges DF (2003) Sleep, waking and neurobehavioural performance. Front Biosci 8:67 CrossRef Rogers NL, Dorrian J, Dinges DF (2003) Sleep, waking and neurobehavioural performance. Front Biosci 8:67 CrossRef
61.
Zurück zum Zitat Saper CB (2013) The central circadian timing system. Curr Opin Neurobiol 23:747–751 CrossRef Saper CB (2013) The central circadian timing system. Curr Opin Neurobiol 23:747–751 CrossRef
62.
Zurück zum Zitat Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257–1263 CrossRef Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257–1263 CrossRef
63.
Zurück zum Zitat Schlitzer J, Heubaum S, Frohnhofen H (2014) CME Zertifizierte Fortbildung. Schlaf und Schlafstörungen beim alten Menschen ; Teil 2: Therapie. Z Gerontol Geriatr 47:611–620 CrossRef Schlitzer J, Heubaum S, Frohnhofen H (2014) CME Zertifizierte Fortbildung. Schlaf und Schlafstörungen beim alten Menschen ; Teil 2: Therapie. Z Gerontol Geriatr 47:611–620 CrossRef
64.
Zurück zum Zitat Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ventrolateral preoptic neurons during sleep. Science 271:216–219 CrossRef Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ventrolateral preoptic neurons during sleep. Science 271:216–219 CrossRef
65.
Zurück zum Zitat Sloan EP, Flint AJ, Reinish L, Shapiro CM (1996) Circadian rhythms and psychiatric disorders in the elderly. J Geriatr Psychiatry Neurol 9:164–170 CrossRef Sloan EP, Flint AJ, Reinish L, Shapiro CM (1996) Circadian rhythms and psychiatric disorders in the elderly. J Geriatr Psychiatry Neurol 9:164–170 CrossRef
66.
Zurück zum Zitat Stickgold R (2005) Sleep-dependent memory consolidation. Nature 437:1272–1278 CrossRef Stickgold R (2005) Sleep-dependent memory consolidation. Nature 437:1272–1278 CrossRef
67.
Zurück zum Zitat Sung H, Lee W, Li T, Watson R (2012) A group music intervention using percussion instruments with familiar music to reduce anxiety and agitation of institutionalized older adults with dementia. Int J Geriatr Psychiatry 27:621–627 CrossRef Sung H, Lee W, Li T, Watson R (2012) A group music intervention using percussion instruments with familiar music to reduce anxiety and agitation of institutionalized older adults with dementia. Int J Geriatr Psychiatry 27:621–627 CrossRef
68.
Zurück zum Zitat Terao A, Apte-Deshpande A, Morairty S, Freund YR, Kilduff TS (2002) Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 332:190–194 CrossRef Terao A, Apte-Deshpande A, Morairty S, Freund YR, Kilduff TS (2002) Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 332:190–194 CrossRef
69.
Zurück zum Zitat Van Dongen HPA, Maislin G, Mullington JM, Dinges DF (2003) The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26:117–126 CrossRef Van Dongen HPA, Maislin G, Mullington JM, Dinges DF (2003) The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26:117–126 CrossRef
70.
Zurück zum Zitat Volicer L, Harper DG, Manning BC, Goldstein R, Satlin A (2001) Sundowning and circadian rhythms in Alzheimer’s disease. Am J Psychiatry 158:704–711 CrossRef Volicer L, Harper DG, Manning BC, Goldstein R, Satlin A (2001) Sundowning and circadian rhythms in Alzheimer’s disease. Am J Psychiatry 158:704–711 CrossRef
71.
Zurück zum Zitat Walker MP, Stickgold R (2006) Sleep, memory, and plasticity. Annu Rev Psychol 57:139–166 CrossRef Walker MP, Stickgold R (2006) Sleep, memory, and plasticity. Annu Rev Psychol 57:139–166 CrossRef
72.
Zurück zum Zitat Wang JL, Lim AS, Chiang W‑Y et al (2015) Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Ann Neurol 78:317–322 CrossRef Wang JL, Lim AS, Chiang W‑Y et al (2015) Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Ann Neurol 78:317–322 CrossRef
73.
Zurück zum Zitat Williams HL, Gieseking CF, Lubin A (1966) Some effects of sleep loss on memory. Percept Mot Skills 23:1287–1293 CrossRef Williams HL, Gieseking CF, Lubin A (1966) Some effects of sleep loss on memory. Percept Mot Skills 23:1287–1293 CrossRef
74.
Zurück zum Zitat Woods DL, Dimond M (2002) The effect of therapeutic touch on agitated behavior and cortisol in persons with Alzheimer’s disease. Biol Res Nurs 4:104–114 CrossRef Woods DL, Dimond M (2002) The effect of therapeutic touch on agitated behavior and cortisol in persons with Alzheimer’s disease. Biol Res Nurs 4:104–114 CrossRef
75.
Zurück zum Zitat Xie L, Kang H, Xu Q et al (2013) Sleep drives metabolite clearance from the adult brain. Science 342:373–377 CrossRef Xie L, Kang H, Xu Q et al (2013) Sleep drives metabolite clearance from the adult brain. Science 342:373–377 CrossRef
76.
Zurück zum Zitat Yaffe K, Laffan AM, Harrison SL et al (2011) Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306:613–619 PubMedPubMedCentral Yaffe K, Laffan AM, Harrison SL et al (2011) Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306:613–619 PubMedPubMedCentral
77.
Zurück zum Zitat Zee PC, Rosenberg RS, Turek FW (1992) Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity. Am J Physiol 263:103 Zee PC, Rosenberg RS, Turek FW (1992) Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity. Am J Physiol 263:103
78.
Zurück zum Zitat Zhang JH, Sampogna S, Morales FR, Chase MH (2002) Age-related changes in hypocretin (orexin) immunoreactivity in the cat brainstem. Brain Res 930:206–211 CrossRef Zhang JH, Sampogna S, Morales FR, Chase MH (2002) Age-related changes in hypocretin (orexin) immunoreactivity in the cat brainstem. Brain Res 930:206–211 CrossRef
79.
Zurück zum Zitat Zhdanova IV, Masuda K, Quasarano-Kourkoulis C, Rosene DL, Killiany RJ, Wang S (2011) Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. J Biol Rhythms 26:149–159 CrossRef Zhdanova IV, Masuda K, Quasarano-Kourkoulis C, Rosene DL, Killiany RJ, Wang S (2011) Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. J Biol Rhythms 26:149–159 CrossRef
Metadaten
Titel
Sleep in older adults and in subjects with dementia
verfasst von
PD Dr. Helmut Frohnhofen
Jeanina Schlitzer
Nikolaus Netzer
Publikationsdatum
18.07.2017
Verlag
Springer Medizin
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 7/2017
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-017-1289-0

Weitere Artikel der Ausgabe 7/2017

Zeitschrift für Gerontologie und Geriatrie 7/2017 Zur Ausgabe

Mitteilungen der ÖGGG

Mitteilungen der ÖGGG

Mitteilungen des BV Geriatrie

Mitteilungen des BV Geriatrie

Mitteilungen der DGGG

Bericht des Sekretärs

Journal Club

Journal Club