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Erschienen in: Zeitschrift für Gerontologie und Geriatrie 5/2019

01.07.2019 | Themenschwerpunkt

Should vitamin D administration for fracture prevention be continued?

A discussion of recent meta-analysis findings

verfasst von: Prof. Dr. Dr. Heike A. Bischoff-Ferrari

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 5/2019

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Abstract

In consideration and critical review of four recent meta-analyses on vitamin D and fracture prevention, vitamin D supplementation with or without calcium is supported among older adults age 65 years and older at risk of vitamin D deficiency and fractures if given in daily or equivalent weekly or monthly doses of 800 to 1000 IU and with good adherence. Vitamin D supplementation might not be effective in primary prevention among adults age 50 years and older without vitamin D deficiency and osteoporosis; however, clinical trials on primary prevention are limited. Notably, large annual bolus administration of vitamin D is detrimental with regard to falls and fractures among older adults at risk of fractures and should not be continued in clinical care. Larger monthly doses of 100,000 IU need further evaluation with respect to efficacy and safety.
Literatur
1.
Zurück zum Zitat Zhao JG et al (2017) Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and meta-analysis. JAMA 318(24):2466–2482 CrossRefPubMedPubMedCentral Zhao JG et al (2017) Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and meta-analysis. JAMA 318(24):2466–2482 CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Force USPST et al (2018) Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US preventive services task force recommendation statement. JAMA 319(15):1592–1599 CrossRef Force USPST et al (2018) Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US preventive services task force recommendation statement. JAMA 319(15):1592–1599 CrossRef
3.
Zurück zum Zitat Weaver CM et al (2016) Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int 27(1):367–376 CrossRefPubMed Weaver CM et al (2016) Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int 27(1):367–376 CrossRefPubMed
4.
Zurück zum Zitat Bolland MJ, Grey A, Avenell A (2018) Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis. Lancet Diabetes Endocrinol 6(11):847–858 CrossRefPubMed Bolland MJ, Grey A, Avenell A (2018) Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis. Lancet Diabetes Endocrinol 6(11):847–858 CrossRefPubMed
5.
Zurück zum Zitat Sanders KM et al (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303(18):1815–1822 CrossRefPubMed Sanders KM et al (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303(18):1815–1822 CrossRefPubMed
6.
Zurück zum Zitat Smith H et al (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatol 46(12):1852–1857 CrossRef Smith H et al (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatol 46(12):1852–1857 CrossRef
7.
Zurück zum Zitat Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC (2018) Issues of trial selection and subgroup considerations in the recent meta-analysis of Zhao and colleagues on fracture reduction by calcium and vitamin D supplementation in community-dwelling older adults. Osteoporos Int 29(9):2151–2152 CrossRefPubMed Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC (2018) Issues of trial selection and subgroup considerations in the recent meta-analysis of Zhao and colleagues on fracture reduction by calcium and vitamin D supplementation in community-dwelling older adults. Osteoporos Int 29(9):2151–2152 CrossRefPubMed
8.
Zurück zum Zitat Bischoff-Ferrari HA et al (2008) Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial. Am J Clin Nutr 87(6):1945–1951 CrossRefPubMed Bischoff-Ferrari HA et al (2008) Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial. Am J Clin Nutr 87(6):1945–1951 CrossRefPubMed
9.
Zurück zum Zitat Bischoff-Ferrari HA et al (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169(6):551–561 CrossRefPubMed Bischoff-Ferrari HA et al (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169(6):551–561 CrossRefPubMed
10.
Zurück zum Zitat Bischoff-Ferrari HA et al (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367(1):40–49 CrossRefPubMed Bischoff-Ferrari HA et al (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367(1):40–49 CrossRefPubMed
11.
Zurück zum Zitat Grant AM et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365(9471):1621–1628 CrossRefPubMed Grant AM et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365(9471):1621–1628 CrossRefPubMed
12.
Zurück zum Zitat Bischoff-Ferrari HA et al (2010) Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med 170(9):813–820 CrossRefPubMed Bischoff-Ferrari HA et al (2010) Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med 170(9):813–820 CrossRefPubMed
13.
Zurück zum Zitat Bischoff-Ferrari HA, Bhasin S, Manson JE (2018) Preventing fractures and falls: a limited role for calcium and vitamin D supplements? JAMA 319(15):1552–1553 CrossRefPubMed Bischoff-Ferrari HA, Bhasin S, Manson JE (2018) Preventing fractures and falls: a limited role for calcium and vitamin D supplements? JAMA 319(15):1552–1553 CrossRefPubMed
14.
Zurück zum Zitat Trivedi DP, Doll R, Khaw KT (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326(7387):469 CrossRefPubMedPubMedCentral Trivedi DP, Doll R, Khaw KT (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326(7387):469 CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Khaw KT et al (2017) Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol 5(6):438–447 CrossRefPubMed Khaw KT et al (2017) Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol 5(6):438–447 CrossRefPubMed
16.
Zurück zum Zitat Bischoff-Ferrari HA et al (2019) Vitamin D supplementation and musculoskeletal health. Lancet Diabetes Endocrinol 7(2):85 CrossRefPubMed Bischoff-Ferrari HA et al (2019) Vitamin D supplementation and musculoskeletal health. Lancet Diabetes Endocrinol 7(2):85 CrossRefPubMed
17.
19.
Zurück zum Zitat Dawson-Hughes B et al (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21(7):1151–1154 CrossRefPubMed Dawson-Hughes B et al (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21(7):1151–1154 CrossRefPubMed
20.
Zurück zum Zitat Holick MF et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930 CrossRefPubMed Holick MF et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930 CrossRefPubMed
22.
Zurück zum Zitat Melton LJ 3rd, Crowson CS, O’Fallon WM (1999) Fracture incidence in Olmsted County, Minnesota: comparison of urban with rural rates and changes in urban rates over time. Osteoporos Int 9(1):29–37 CrossRefPubMed Melton LJ 3rd, Crowson CS, O’Fallon WM (1999) Fracture incidence in Olmsted County, Minnesota: comparison of urban with rural rates and changes in urban rates over time. Osteoporos Int 9(1):29–37 CrossRefPubMed
Metadaten
Titel
Should vitamin D administration for fracture prevention be continued?
A discussion of recent meta-analysis findings
verfasst von
Prof. Dr. Dr. Heike A. Bischoff-Ferrari
Publikationsdatum
01.07.2019
Verlag
Springer Medizin
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 5/2019
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-019-01573-9

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