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Thromb Haemost 2005; 93(02): 236-241.
DOI: 10.1160/TH04-09-0570
Review Article
Schattauer GmbH

Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome

A systematic review and meta-analysis
Peer Wille-Jørgensen
1   Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark
,
Lars N. Jorgensen
1   Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark
,
Michael Crawford
2   Department of Anaesthesiology, Bispebjerg Hospital, University of Copenhagen, Denmark
› Author AffiliationsGrant support: This review was supported by an unrestricted grant of 3,000 EURO from Sanofi-Synthelabo. We thank Dr. J. A. Caprini who kindly provided supplementary original data for the review.
Further Information

Publication History

Received 07 September 2004

Accepted after resubmission 01 January 2004

Publication Date:
11 December 2017 (online)

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Summary

Perioperative antithrombotic clinical regimens have reduced the incidence of postoperative deep venous thrombosis (DVT). Long-term effects of asymptomatic postoperative DVT have been studied in a number of clinical trials and the present review describes the clinical significance of asymptomatic postoperative DVT regarding the possible development of postthrombotic syndrome (PTS).We performed a systematic review of reference databases focusing upon studies including patients suspected of having postoperative DVT and reporting subsequent cases of PTS at the end of a well-defined follow-up period. The included studies were stratified according to type of screening method and applied statistics. Over-all evaluation included metaanalyses based upon the Cochrane software package. The overall relative risk of developing PTS was 1.58 (95% confidence intervals: 1.24 – 2.02) in patients suffering from asymptomatic DVT as compared to patients without DVT ( p < 0.0005).In conclusion, asymptomatic postoperative DVT is associated with an increased risk of late development of PTS. The finding emphasizes that postoperative DVT, diagnosed by means of well-defined objective measures, remains the correct scientific endpoint in trials evaluating the efficacy of preoperative antithrombotic treatment regimens.

Keywords

Postthrombotic syndrome - deep vein thrombosis - surgery
 

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