Fusarium Meningoencephalitis in a Child with Acute Leukemia

D. P. Agamanolis; D. K. Kalwinsky; C. E. Krill Jr; Sarada Dasu; B. Halasa; Pamela G. Galloway

doi:10.1055/s-2008-1071428

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Neuropediatrics 1991; 22(2): 110-112
DOI: 10.1055/s-2008-1071428

Case report

Fusarium Meningoencephalitis in a Child with Acute Leukemia

D. P. Agamanolis¹ , D. K. Kalwinsky² , C. E. Krill Jr¹ , Sarada Dasu¹ , B. Halasa¹ , Pamela G. Galloway¹

¹Department of Pathology and Pediatrics (Hematology-Oncology), Children's Hospital Medical Center of Akron, Akron, Ohio, and Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
²St. Jude Children's Hospital, Division of Leukemia/Lymphoma, Memphis, Tennessee

Further Information

Publication History

Publication Date:
19 March 2008 (online)

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Abstract

A 15-year-old boy with acute lymphoblastic leukemia (ALL) developed disseminated fusarium infection with meningoencephalitis following a contaminated skin wound. With antifungal therapy, the cutaneous lesions cleared but central nervous system (CNS) infection persisted causing a fibrosing meningitis and a brain granuloma. Fusaria are soil saprophytes that are more commonly associated with superficial eye and skin lesions, but may also cause severe systemic infections with CNS involvement in immuno-compromised patients. The organism may be confused with Aspergillus in tissue sections, and can only be diagnosed by culture.

Key words

Fusarium - Fungal infections - Acute lymphoblastic leukemia - Opportunistic infections - Meningitis

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