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Anästhesiol Intensivmed Notfallmed Schmerzther 2003; 38(10): 651-675
DOI: 10.1055/s-2003-42511
Fort- und Weiterbildung
© Georg Thieme Verlag Stuttgart · New York

Medikamentöse Therapie bei der kardiopulmonalen Reanimation

Drug Therapy During CPRC.  A.  Schmittinger1 , V.  Wenzel1 , H.  Herff1 , K.-H.  Stadlbauer1 , A.  C.  Krismer1 , W.  G.  Voelckel1 , H.-U.  Strohmenger1 , K.  H.  Lindner1
  • 1Univ.-Klinik für Anaesthesie und Allgemeine Intensivmedizin, Leopold-Franzens-Universität, Innsbruck, Österreich
Further Information

Publication History

Publication Date:
25 September 2003 (online)

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Weiterbildungsziele

In diesem Beitrag sollen folgende Weiterbildungsziele vermittelt werden:

  • Umsetzung der „neuen” CPR-Richtlinien vom August 2000 für die gängigsten Medikamente

  • Gewichtung der unterschiedlichen, präklinisch verfügbaren Applikationsmethoden von Medikamenten

  • Die Vasopressoren Adrenalin und Vasopressin sowie deren Anwendungsmodalitäten

  • Einsatz von Antiarrhythmika und derzeitige Wertigkeit

  • Einsatz von Natrium-Bikarbonat und präklinische Blindpufferung

  • Präklinische Thrombolyse: aktuelle Forderungen

Literatur

  • 1 Anonym. Todesursachenstatistik des Jahres 2001. Statistisches Bundesamt 2003
    Google Scholar
  • 2 Kroesen G, Baubin M. [Austrian emergency medicine in an international comparison].  Wien Klin Wochenschr. 1994;  106 634-639
    PubMedGoogle Scholar
  • 3 Murphy P, Taigman M. Oops! EMS mistakes - they’re inevitable, stressful, painful and oh-so educational. This guide helps you classify them and avoid sweating the small stuff.  J Emerg Med Serv JEMS. 1998;  23 37-42
    PubMedGoogle Scholar
  • 4 Cline D M, Welch K J, Cline L S. Physician compliance with advanced cardiac life support guidelines.  Ann Emerg Med. 1995;  25 52-57
    PubMedGoogle Scholar
  • 5 Slany J, Karnik R. [Complications of routine intensive care interventions].  Wien Klin Wochenschr. 1994;  106 1-7
    PubMedGoogle Scholar
  • 6 Plaisance P, Lurie K G, Vicaut E, Adnet F, Petit J L, Epain D, Ecollan P, Gruat R, Cavagna P, Biens J, Payen D. A comparison of standard cardiopulmonary resuscitation and active compression-decompression resuscitation for out-of-hospital cardiac arrest. French Active Compression-Decompression Cardiopulmonary Resuscitation Study Group.  N Engl J Med. 1999;  341 569-575
    CrossrefPubMedGoogle Scholar
  • 7 Madl C. [Prognosis for cardiopulmonary resuscitation].  Wien Klin Wochenschr. 1998;  110 699-700
    PubMedGoogle Scholar
  • 8 Paradis N A, Martin G B, Rivers E P, Goetting M G, Appleton T J, Feingold M, Nowak R M. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation.  JAMA. 1990;  263 1106-1113
    CrossrefPubMedGoogle Scholar
  • 9 Anonym. Standards for cardiopulmonary resuscitation (CPR) and emergency cardiac care (ECC).  JAMA. 1974;  227 (Suppl) 833-868
    PubMedGoogle Scholar
  • 10 Anonym. Standards and guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiac care (ECC).  JAMA. 1980;  244 453-509
    CrossrefPubMedGoogle Scholar
  • 11 Anonym. Standards and guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiac Care (ECC). National Academy of Sciences - National Research Council.  JAMA. 1986;  255 2905-2989
    CrossrefPubMedGoogle Scholar
  • 12 Anonym. Guidelines for cardiopulmonary resuscitation and emergency cardiac care. Emergency Cardiac Care Committee and Subcommittees, American Heart Association.  JAMA. 1992;  268 2212-2302
    PubMedGoogle Scholar
  • 13 Anonym. Guidelines for advanced life support. A statement by the Advanced Life Support Working Party of the European Resuscitation Council, 1992.  Resuscitation. 1992;  24 111-121
    CrossrefPubMedGoogle Scholar
  • 14 Anonym. Guidelines for the advanced management of the airway and ventilation during resuscitation. A statement by the Airway and Ventilation Management of the Working Group of the European Resuscitation Council.  Resuscitation. 1996;  31 201-230
    CrossrefPubMedGoogle Scholar
  • 15 Bossaert L, Handley A, Marsden A, Arntz R, Chamberlain D, Ekstrom L, Evans T, Monsieurs K, Robertson C, Steen P. European Resuscitation Council guidelines for the use of automated external defibrillators by EMS providers and first responders: A statement from the Early Defibrillation Task Force, with contributions from the Working Groups on Basic and Advanced Life Support, and approved by the Executive Committee.  Resuscitation. 1998;  37 91-94
    CrossrefPubMedGoogle Scholar
  • 16 Anonym. Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 6: advanced cardiovascular life support: 7D: the tachycardia algorithms. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation.  Circulation. 2000;  102 I158-I165
    PubMedGoogle Scholar
  • 17 Anonym. International Guidelines 2000 for CPR and ECC. A consensus on science. European Resuscitation Council.  Resuscitation. 2000;  46 1-447
    CrossrefPubMedGoogle Scholar
  • 18 Gaddis G M, Dolister M, Gaddis M L. Mock drug delivery to the proximal aorta during cardiopulmonary resuscitation: central vs peripheral intravenous infusion with varying flush vol-umes.  Acad Emerg Med. 1995;  2 1027-1033
    PubMedGoogle Scholar
  • 19 Gehani A A. Femoral vein cannulation during resuscitation: potential advantages.  Resuscitation. 1999;  42 251
    CrossrefPubMedGoogle Scholar
  • 20 Lindemann R. Endotracheal administration of epinephrine during cardiopulmonary resuscitation.  Am J Dis Child. 1982;  136 753-754
    PubMedGoogle Scholar
  • 21 Hähnel J, Lindner K H. Endobronchial administration of emergency drugs.  Resuscitation. 1989;  17 261-272
    CrossrefPubMedGoogle Scholar
  • 22 Krafft P, Frass M. [The difficult airway].  Wien Klin Wochenschr. 2000;  112 260-270
    PubMedGoogle Scholar
  • 23 Crespo S G, Schoffstall J M, Fuhs L R, Spivey W H. Comparison of two doses of endotracheal epinephrine in a cardiac arrest model.  Ann Emerg Med. 1991;  20 230-234
    CrossrefPubMedGoogle Scholar
  • 24 Hörnchen U, Schüttler J, Stoeckel H. [Pharmacokinetics and dynamics of endogenously released and therapeutically administered adrenaline in resuscitation. A comparative animal experimental study].  Anaesthesist. 1988;  37 615-619
    PubMedGoogle Scholar
  • 25 Schüttler J, Hörnchen U, Stoeckel H. [Endobronchial administration of adrenaline in cardiopulmonary resuscitation: pharmacokinetic and dynamic studies in the dog].  Langen-becks Arch Chir. 1987;  370 119-127
    PubMedGoogle Scholar
  • 26 Ralston S H, Tacker W A, Showen L, Carter A. Endotracheal versus intravenous epinephrine during electromechanical dissociation with CPR in dogs.  Ann Emerg Med. 1985;  14 1044-1048
    CrossrefPubMedGoogle Scholar
  • 27 Wenzel V, Prengel A W, Lindner K H. A strategy to improve endobronchial drug administration.  Anesth Analg. 2000;  91 255-256
    PubMedGoogle Scholar
  • 28 Hörnchen U, Schüttler J, Stoeckel H, Eichelkraut W, Hahn N. Endobronchial instillation of epinephrine during cardiopulmonary resuscitation.  Crit Care Med. 1987;  15 1037-1039
    PubMedGoogle Scholar
  • 29 Schüttler J, Bartsch A, Ebeling B J, Hörnchen U, Kulka P, Suhling B, Stoeckel H. [Endobronchial administration of adrenaline in preclinical cardiopulmonary resuscitation].  Anasth Intensivther Notfallmed. 1987;  22 63-68
    PubMedGoogle Scholar
  • 30 Naganobu K, Hasebe Y, Uchiyama Y, Hagio M. A comparison of distilled water and normal saline as diluents for endobronchial administration of epinephrine in the dog.  Anesth Analg. 2000;  91 317-321
    PubMedGoogle Scholar
  • 31 Roberts J R, Greenburg M I, Knaub M. Comparison of the pharmacological effects of epinephrine administered by the intravenous and endotracheal routes.  Jacep. 1978;  7 260-264
    PubMedGoogle Scholar
  • 32 Anonym. The 1998 European Resuscitation Council guidelines for adult advanced life support. Advanced Life Support Working Group of the European Resuscitation Council.  BMJ. 1998;  316 1863-1869
    PubMedGoogle Scholar
  • 33 Robertson C, Steen P, Adgey J, Bossaert L, Carli P, Chamberlain D, Dick W, Ekstrom L, Hapnes S A, Holmberg S, Juchems R, Kette F, Koster R, Latorre F J de, Lindner K, Perales N. The 1998 European Resuscitation Council guidelines for adult advanced life support: A statement from the Working Group on Advanced Life Support, and approved by the executive committee.  Resuscitation. 1998;  37 81-90
    CrossrefPubMedGoogle Scholar
  • 34 Wenzel V, Lindner K H. Employing vasopressin during cardiopulmonary resuscitation and vasodilatory shock as a lifesaving vasopressor.  Cardiovasc Res. 2001;  51 529-541
    CrossrefPubMedGoogle Scholar
  • 35 Kruse J A, Vyskocil J J, Haupt M T. Intraosseous infusions: a flexible option for the adult or child with delayed, difficult, or impossible conventional vascular access.  Crit Care Med. 1994;  22 728-729
    CrossrefPubMedGoogle Scholar
  • 36 Tocantins L M, O’Neill J F, Jones H W. Infusion of blood and other fluids via the bone marrow.  J Am Med Assoc. 1941;  117 1229-1234
    PubMedGoogle Scholar
  • 37 Fiser D H. Intraosseous infusion.  N Engl J Med. 1990;  322 1579-1581
    CrossrefPubMedGoogle Scholar
  • 38 Orlowski J P, Porembka D T, Gallagher J M, Lockrem J D, VanLente F. Comparison study of intraosseous, central intravenous, and peripheral intravenous infusions of emergency drugs.  Am J Dis Child. 1990;  144 112-117
    PubMedGoogle Scholar
  • 39 Fiallos M, Kissoon N, Abdelmoneim T, Johnson L, Murphy S, Lu L, Masood S, Idris A. Fat embolism with the use of intraosseous infusion during cardiopulmonary resuscitation.  Am J Med Sci. 1997;  314 73-79
    CrossrefPubMedGoogle Scholar
  • 40 Orlowski J P, Julius C J, Petras R E, Porembka D T, Gallagher J M. The safety of intraosseous infusions: risks of fat and bone marrow emboli to the lungs.  Ann Emerg Med. 1989;  18 1062-1067
    CrossrefPubMedGoogle Scholar
  • 41 Plewa M C, King R W, Fenn-Buderer N, Gretzinger K, Renuart D, Cruz R. Hematologic safety of intraosseous blood transfusion in a swine model of pediatric hemorrhagic hypovolemia.  Acad Emerg Med. 1995;  2 799-809
    PubMedGoogle Scholar
  • 42 Moller J C, Tegtmeyer F K, Schaible T F, Sussmane J B. [Intraosseous puncture as vascular access in pediatric emergency and intensive care medicine].  Anaesthesiol Reanim. 1996;  21 103-107
    PubMedGoogle Scholar
  • 43 Wenzel V, Lindner K H, Augenstein S, Voelckel W, Strohmenger H U, Prengel A W, Steinbach G. Intraosseous vasopressin improves coronary perfusion pressure rapidly during cardiopulmonary resuscitation in pigs.  Crit Care Med. 1999;  27 1565-1569
    CrossrefPubMedGoogle Scholar
  • 44 Sawyer R W, Bodai B I, Blaisdell F W, McCourt M M. The current status of intraosseous infusion.  J Am Coll Surg. 1994;  179 353-360
    PubMedGoogle Scholar
  • 45 Paradis N A, Wenzel V, Southall J. Pressor drugs in the treatment of cardiac arrest.  Cardiol Clin. 2002;  20 61-78
    PubMedGoogle Scholar
  • 46 Gottlieb R. Über die Wirkung der Nebennierenextrakte auf Herz und Blutdruck.  Arch Exp Path Pharm. 1897;  38 99-112
    PubMedGoogle Scholar
  • 47 Crile G D, Dolley H. An experimental research into resuscitation of dogs killed by anaesthetics and asphyxia.  J Exp Med. 1906;  8 713-725
    CrossrefPubMedGoogle Scholar
  • 48 Paradis N A, Koscove E M. Epinephrine in cardiac arrest: a critical review.  Ann Emerg Med. 1990;  19 1288-1301
    PubMedGoogle Scholar
  • 49 Ditchey R V. The choice of vasopressor agents in cardiopulmonary resuscitation.  Curr Opin Crit Care. 1996;  2 170-175
    PubMedGoogle Scholar
  • 50 Ditchey R V, Lindenfeld J. Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs.  Circulation. 1988;  78 382-389
    PubMedGoogle Scholar
  • 51 Niemann J T, Haynes K S, Garner D, Rennie C J, Jagels G, Stormo O. Postcounter-shock pulseless rhythms: response to CPR, artificial cardiac pacing, and adrenergic agonists.  Ann Emerg Med. 1986;  15 112-120
    PubMedGoogle Scholar
  • 52 Tang W, Weil M H, Sun S, Noc M, Yang L, Gazmuri R J. Epinephrine increases the severity of postresuscitation myocardial dysfunction.  Circulation. 1995;  92 3089-3093
    PubMedGoogle Scholar
  • 53 Tovar O H, Jones J L. Epinephrine facilitates cardiac fibrillation by shortening action potential refractoriness.  J Mol Cell Cardiol. 1997;  29 1447-1455
    CrossrefPubMedGoogle Scholar
  • 54 Tang W, Weil M H, Gazmuri R J, Sun S, Duggal C, Bisera J. Pulmonary ventilation/perfusion defects induced by epinephrine during cardiopulmonary resuscitation.  Circulation. 1991;  84 2101-2107
    PubMedGoogle Scholar
  • 55 Woodhouse S P, Cox S, Boyd P, Case C, Weber M. High dose and standard dose adrenaline do not alter survival, compared with placebo, in cardiac arrest.  Resuscitation. 1995;  30 243-249
    CrossrefPubMedGoogle Scholar
  • 56 Pearson J W. The role of epinephrine in cardiac resuscitation.  Anesth Analg. 1963;  42 599-606
    PubMedGoogle Scholar
  • 57 Redding J S, Pearson J W. Evaluation of drugs for cardiac resuscitation.  Anesth Analg. 1963;  24 203-207
    PubMedGoogle Scholar
  • 58 Kosnik J W, Jackson R E, Keats S, Tworek R M, Freeman S B. Dose-related response of centrally administered epinephrine on the change in aortic diastolic pressure during closed-chest massage in dogs.  Ann Emerg Med. 1985;  14 204-208
    PubMedGoogle Scholar
  • 59 Brown C G, Werman H A, Davis E A, Hamlin R, Hobson J, Ashton J A. Comparative effect of graded doses of epinephrine on regional brain blood flow during CPR in a swine model.  Ann Emerg Med. 1986;  15 1138-1144
    PubMedGoogle Scholar
  • 60 Brown C G, Werman H A, Davis E A, Hobson J, Hamlin R L. The effects of graded doses of epinephrine on regional myocardial blood flow during cardiopulmonary resuscitation in swine.  Circulation. 1987;  75 491-497
    PubMedGoogle Scholar
  • 61 Dean J M, Koehler R C, Schleien C L, Atchison D, Gervais H, Berkowitz I, Traystman R J. Improved blood flow during prolonged cardiopulmonary resuscitation with 30 % duty cycle in infant pigs.  Circulation. 1991;  84 896-904
    PubMedGoogle Scholar
  • 62 Gonzalez E R, Ornato J P, Garnett A R, Levine R L, Young D S, Racht E M. Dose-dependent vasopressor response to epinephrine during CPR in human beings.  Ann Emerg Med. 1989;  18 920-926
    PubMedGoogle Scholar
  • 63 Lindner K H, Ahnefeld F W, Bowdler I M. The effect of epinephrine on hemodynamics, acid-base status and potassium during spontaneous circulation and cardiopulmonary resuscitation.  Resuscitation. 1988;  16 251-261
    CrossrefPubMedGoogle Scholar
  • 64 Lindner K H, Ahnefeld F W, Bowdler I M. Comparison of epinephrine and dopamine during cardiopulmonary resuscitation.  Intensive Care Med. 1989;  15 432-438
    PubMedGoogle Scholar
  • 65 Paradis N A, Martin G B, Rosenberg J, Rivers E P, Goetting M G, Appleton T J, Feingold M, Cryer P E, Wortsman J, Nowak R M. The effect of standard- and high-dose epinephrine on coronary perfusion pressure during prolonged cardiopulmonary resuscitation.  JAMA. 1991;  265 1139-1144
    CrossrefPubMedGoogle Scholar
  • 66 Stiell I G, Hebert P C, Weitzman B N, Wells G A, Raman S, Stark R M, Higginson L A, Ahuja J, Dickinson G E. High-dose epinephrine in adult cardiac arrest.  N Engl J Med. 1992;  327 1045-1050
    PubMedGoogle Scholar
  • 67 Callaham M, Madsen C D, Barton C W, Saunders C E, Pointer J. A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest.  JAMA. 1992;  268 2667-2672
    CrossrefPubMedGoogle Scholar
  • 68 Brown C G, Martin D R, Pepe P E, Stueven H, Cummins R O, Gonzalez E. A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. The Multicenter High-Dose Epinephrine Study Group.  N Engl J Med. 1992;  327 1051-1055
    PubMedGoogle Scholar
  • 69 Behringer W, Kittler H, Sterz F, Domanovits H, Schoerkhuber W, Holzer M, Mullner M, Laggner A N. Cumulative epinephrine dose during cardiopulmonary resuscitation and neurologic outcome.  Ann Intern Med. 1998;  129 450-456
    PubMedGoogle Scholar
  • 70 Prengel A W, Lindner K H, Ensinger H, Grunert A. Plasma catecholamine concentrations after successful resuscitation in patients.  Crit Care Med. 1992;  20 609-614
    PubMedGoogle Scholar
  • 71 Lindner K H, Strohmenger H U, Prengel A W, Ensinger H, Goertz A, Weichel T. Hemodynamic and metabolic effects of epinephrine during cardiopulmonary resuscitation in a pig model.  Crit Care Med. 1992;  20 1020-1026
    PubMedGoogle Scholar
  • 72 Schultz C H, Rivers E P, Feldkamp C S, Goad E G, Smithline H A, Martin G B, Fath J J, Wortsman J, Nowak R M. A characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrest.  Crit Care Med. 1993;  21 1339-1347
    PubMedGoogle Scholar
  • 73 Lindner K H, Strohmenger H U, Ensinger H, Hetzel W D, Ahnefeld F W, Georgieff M. Stress hormone response during and after cardiopulmonary resuscitation.  Anesthesiology. 1992;  77 662-668
    PubMedGoogle Scholar
  • 74 Lindner K H, Haak T, Keller A, Bothner U, Lurie K G. Release of endogenous vasopressors during and after cardiopulmonary resuscitation.  Heart. 1996;  75 145-150
    PubMedGoogle Scholar
  • 75 Lindner K H, Prengel A W, Pfenninger E G, Lindner I M, Strohmenger H U, Georgieff M, Lurie K G. Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs.  Circulation. 1995;  91 215-221
    PubMedGoogle Scholar
  • 76 Achleitner U, Wenzel V, Strohmenger H U, Krismer A C, Lurie K G, Lindner K H, Amann A. The effects of repeated doses of vasopressin or epinephrine on ventricular fibrillation in a porcine model of prolonged cardiopulmonary resuscitation.  Anesth Analg. 2000;  90 1067-1075
    PubMedGoogle Scholar
  • 77 Amann A, Rheinberger K, Achleitner U, Krismer A C, Lingnau W, Lindner K H, Wenzel V. The prediction of defibrillation outcome using a new combination of mean frequency and amplitude in porcine models of cardiac arrest.  Anesth Analg. 2002;  95 716-722
    PubMedGoogle Scholar
  • 78 Prengel A W, Lindner K H. Cerebral oxygenation during cardiopulmonary resuscitation with epinephrine and vasopressin in pigs.  Stroke. 1996;  27 1241-1248
    PubMedGoogle Scholar
  • 79 Wenzel V, Lindner K H, Prengel A W, Maier C, Voelckel W, Lurie K G, Strohmenger H U. Vasopressin improves vital organ blood flow after prolonged cardiac arrest with postcounter-shock pulseless electrical activity in pigs.  Crit Care Med. 1999;  27 486-492
    PubMedGoogle Scholar
  • 80 Wenzel V, Linder K H, Augenstein S, Prengel A W, Strohmenger H U. Vasopressin combined with epinephrine decreases cerebral perfusion compared with vasopressin alone during cardiopulmonary resuscitation in pigs.  Stroke. 1998;  29 1462-1468
    PubMedGoogle Scholar
  • 81 Lolait S J, O’Carroll A M, Brownstein M J. Molecular biology of vasopressin receptors.  Ann N Y Acad Sci. 1995;  771 273-292
    PubMedGoogle Scholar
  • 82 Voelckel W G, Lindner K H, Wenzel V, Bonatti J, Hangler H, Frimmel C, Kunszberg E, Lingnau W. Effects of vasopressin and epinephrine on splanchnic blood flow and renal function during and after cardiopulmonary resuscitation in pigs.  Crit Care Med. 2000;  28 1083-1088
    PubMedGoogle Scholar
  • 83 Wenzel V, Lindner K H, Baubin M A, Voelckel W G. Vasopressin decreases endogenous catecholamine plasma concentrations during cardiopulmonary resuscitation in pigs.  Crit Care Med. 2000;  28 1096-1100
    PubMedGoogle Scholar
  • 84 Voelckel W G, Lindner K H, Wenzel V, Bonatti J O, Krismer A C, Miller E A, Lurie K G. Effect of small-dose dopamine on mesenteric blood flow and renal function in a pig model of cardio-pulmonary resuscitation with vasopressin.  Anesth Analg. 1999;  89 1430-1436
    PubMedGoogle Scholar
  • 85 Wenzel V, Lindner K H, Prengel A W, Lurie K G, Strohmenger H U. Endobronchial vasopressin improves survival during cardiopulmonary resuscitation in pigs.  Anesthesiology. 1997;  86 1375-1381
    PubMedGoogle Scholar
  • 86 Wenzel V, Lindner K H, Krismer A C, Miller E A, Voelckel W G, Lingnau W. Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs.  Circulation. 1999;  99 1379-1384
    PubMedGoogle Scholar
  • 87 Wenzel V, Lindner K H, Krismer A C, Voelckel W G, Schocke M F, Hund W, Witkiewicz M, Miller E A, Klima G, Wissel J, Lingnau W, Aichner F T. Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs.  J Am Coll Cardiol. 2000;  35 527-533
    PubMedGoogle Scholar
  • 88 Lindner K H, Prengel A W, Brinkmann A, Strohmenger H U, Lindner I M. Vasopressin administration in refractory cardiac arrest.  Ann Intern Med. 1996;  124 1061-1064
    PubMedGoogle Scholar
  • 89 Lindner K H, Dirks B, Strohmenger H U, Prengel A W, Lindner I M, Lurie K G. Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation.  Lancet. 1997;  349 535-537
    CrossrefPubMedGoogle Scholar
  • 90 Morris D C, Dereczyk B E, Grzybowski M, Martin G B, Rivers E P, Wortsman J. Vasopressin can improve coronary perfusion pressure during human cardiopulmonary resuscitation.  Acad Emerg Med. 1997;  4 878-883
    CrossrefPubMedGoogle Scholar
  • 91 Stiell I G, Hebert P C, Wells G A, Vandemheen K L, Tang A S, Higginson L A, Dreyer J F, Clement C, Battram E, Watpool I, Mason S, Klassen T. Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial.  Lancet. 2001;  358 105-109
    CrossrefPubMedGoogle Scholar
  • 92 Mayr V D, Wenzel V, Voelckel W G, Krismer A C, Mueller T, Lurie K G, Lindner K H. Developing a vasopressor combination in a pig model of adult asphyxial cardiac arrest.  Circulation. 2001;  104 1651-1656
    PubMedGoogle Scholar
  • 93 Krismer A C, Wenzel V, Lindner K H. Vasopressin oder Adrenalin bei der Therapie des präklinischen Herzkreislaufstillstandes: Studienprotokoll einer vergleichenden, multizentrischen, europäischen, blockrandomisierten Doppelblind-Studie unter der Schirmherrschaft des European Resuscitation Council.  Notfall Rettungsmed. 1999;  2 478-485
    CrossrefPubMedGoogle Scholar
  • 94 Wenzel V, Krismer A C, Arntz R, Sitter H, Stadlbauer K H, Lindner K H. A comparison of vasopressin vs. epinephrine during out-of-hospital cardiopulmonary resuscitation: results of a prospective, multicenter, randomized, controlled clinical trial. 2003 (eingereicht zur Publikation)
    Google Scholar
  • 95 DeBehnke D J, Swart G L, Spreng D, Aufderheide T P. Standard and higher doses of atropine in a canine model of pulseless electrical activity.  Acad Emerg Med. 1995 Dez;  2 1034-1041
    PubMedGoogle Scholar
  • 96 Coon G A, Clinton J E, Ruiz E. Use of atropine for brady-asystolic prehospital cardiac arrest.  Ann Emerg Med. 1981;  10 462-467
    PubMedGoogle Scholar
  • 97 Iseri L T, Humphrey S B, Siner E J. Prehospital brady-asystolic cardiac arrest.  Ann Intern Med. 1978;  88 741-745
    PubMedGoogle Scholar
  • 98 Zander R. Säure-Basen-Haushalt. In: Kochs E, Krier C, Bruzello W, Adams HA (eds) Anästhesiologie. Stuttgart, New York; Thieme 2001: 117 ff
    Google Scholar
  • 99 Guerci A D, Chandra N, Johnson E, Rayburn B, Wurmb E, Tsitlik J, Halperin H R, Siu C, Weisfeldt M L. Failure of sodium bicarbonate to improve resuscitation from ventricular fibrillation in dogs.  Circulation. 1986;  74 IV75-IV79
    PubMedGoogle Scholar
  • 100 Kette F, Weil M H, Planta M von, Gazmuri R J, Rackow E C. Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation.  Circulation. 1990;  81 1660-1666
    PubMedGoogle Scholar
  • 101 Dybvik T, Strand T, Steen P A. Buffer therapy during out-of-hospital cardiopulmonary resuscitation.  Resuscitation. 1995;  29 89-95
    CrossrefPubMedGoogle Scholar
  • 102 Hine L K, Laird N, Hewitt P, Chalmers T C. Meta-analytic evidence against prophylactic use of lidocaine in acute myocardial infarction.  Arch Intern Med. 1989;  149 2694-2698
    CrossrefPubMedGoogle Scholar
  • 103 Herlitz J, Ekstrom L, Wennerblom B, Axelsson A, Bang A, Lindkvist J, Persson N G, Holmberg S. Lidocaine in out-of-hospital ventricular fibrillation. Does it improve survival?.  Resuscitation. 1997;  33 199-205
    CrossrefPubMedGoogle Scholar
  • 104 Walraven C Van, Stiell I G, Wells G A, Hebert P C, Vandenheem K. group tOs . Do advanced cardiac life support drugs increase resuscitation rates from in-hospital cardiac arrest?.  Ann Emerg Med. 1998;  32 544-553
    PubMedGoogle Scholar
  • 105 Kudenchuk P J, Cobb L A, Copass M K, Cummins R O, Doherty A M, Fahrenbruch C E, Hallstrom A P, Murray W A, Olsufka M, Walsh T. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation.  N Engl J Med. 1999;  341 871-878
    Google Scholar
  • 106 Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation.  N Engl J Med. 2002;  346 884-890
    Google Scholar
  • 107 Scheinman M M, Levine J H, Cannom D S, Friehling T, Kopelman H A, Chilson D A, Platia E V, Wilber D J, Kowey P R. Dose-ranging study of intravenous amiodarone in patients with life-threat-ening ventricular tachyarrhythmias. The Intravenous Amiodarone Multicenter Investigators Group.  Circulation. 1995;  92 3264-3272
    PubMedGoogle Scholar
  • 108 Silfvast T. Cause of death in unsuccessful prehospital resuscitation.  J Intern Med. 1991;  229 331-335
    PubMedGoogle Scholar
  • 109 Bottiger B W, Martin E. Thrombolytic therapy during cardiopulmonary resuscitation and the role of coagulation activation after cardiac arrest.  Curr Opin Crit Care. 2001;  7 176-183
    CrossrefPubMedGoogle Scholar
  • 110 Bottiger B W, Bode C, Kern S, Gries A, Gust R, Glatzer R, Bauer H, Motsch J, Martin E. Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial.  Lancet. 2001;  357 1583-1585
    CrossrefPubMedGoogle Scholar
  • 111 Lederer W, Lichtenberger C, Pechlaner C, Kroesen G, Baubin M. Recombinant tissue plasminogen activator during cardiopulmonary resuscitation in 108 patients with out-of-hospital cardiac arrest.  Resuscitation. 2001;  50 71-76
    CrossrefPubMedGoogle Scholar
  • 112 Kern K B. Thrombolytic therapy during cardiopulmonary resuscitation.  Lancet. 2001;  357 1549-1550
    CrossrefPubMedGoogle Scholar
  • 113 Neumann F, Schenck B, Schleusener H, Schweikert H U. Endokrinpharmakologie. In: Forth W, Henschler D (eds) Allgemeine und spezielle Pharmakologie und Toxikologie. München, Jena; Urban & Fischer 1996: 581-637
    Google Scholar
  • 114 Schmitz J E. Säure-Basen-Status. In: Burchardi H, Larsen R, Schuster HP, Suter PM (eds) Intensivmedizin. Berlin, Heidelberg, New York; Springer 2001: 935-943
    Google Scholar

Dr. Christian A. Schmittinger

Univ.-Klinik für Anaesthesie und Allgemeine Intensivmedizin, Leopold-Franzens-Universität Innsbruck

Anichstraße 35

A-6020 Innsbruck

Österreich

Email: christian.schmittinger@uibk.ac.at

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