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Planta Med 2002; 68(7): 647-649
DOI: 10.1055/s-2002-32903
Letter
© Georg Thieme Verlag Stuttgart · New York

ent-Trachyloban-3β-ol, a New Cytotoxic Diterpene from Croton zambesicus

S. Block1 , C. Stévigny1 , M.-C. De Pauw-Gillet2 , E. de Hoffmann3 , G. Llabrès4 , V. Adjakidjé5 , J. Quetin-Leclercq1
  • 1Laboratoire de Pharmacognosie, Unité d’Analyse Chimique et Physico-Chimique des Médicaments, Université Catholique de Louvain, UCL 72.30-CHAM, Bruxelles, Belgium
  • 2CRCE, Histologie-Cytologie Université de Liège, Liège, Belgium
  • 3Laboratoire de Spectrométrie de Masse, Université Catholique de Louvain, Louvain-la-Neuve, Belgium
  • 4Département de Physique Expérimentale, Université de Liège, Liège, Belgium
  • 5Département de Biologie Végétale, Faculté des Sciences et Techniques, Université Nationale du Bénin, Abomey-Calavy, Bénin
Further Information

Publication History

Received: October 22, 2001

Accepted: February 24, 2002

Publication Date:
22 July 2002 (online)

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Abstract

The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3β-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 μg/ml) . This is the first report on the cytotoxicity of a trachylobane diterpene.

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Sébastien Block

Laboratoire de pharmacognosie

Unité CHAM

UCL 72.30

Avenue E. Mounier 72

1200 Bruxelles

Belgium

Email: sebastien.block@cham.ucl.ac.be

Fax: +32 2 764.72.53

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