Aktuelle Ernährungsmedizin 2016; 41(01): 36-39
DOI: 10.1055/s-0041-111333
Viewpoint
© Georg Thieme Verlag KG Stuttgart · New York

Die Rolle früher parenteraler Ernährung bei Tumorpatienten

The Role of Early Parenteral Nutrition in Patients with Cancer
R. Simanek
3. Medizinische Abteilung, Hanusch-Krankenhaus, Wien, Österreich
› Author Affiliations
Further Information

Publication History

Publication Date:
22 February 2016 (online)

Zusammenfassung

Malnutrition und Kachexie sind häufige Ursachen für ungewollten Gewichtsverlust und können zu Sarkopenie führen, welche ihrerseits für funktionelle Einschränkungen bei onkologischen Patienten verantwortlich ist. Mit zunehmendem Verständnis der pathophysiologischen Grundlagen dieser Krankheitsbilder richtet sich das Augenmerk zunehmend auf frühzeitigen Einsatz von Ernährungsinterventionen. Auch funktionelle Störungen des Gastrointestinaltrakts müssen erkannt werden und sind bei der Wahl der Ernährungsunterstützung zu berücksichtigen. Gerade bei intermittierend hohem Kalorienbedarf ist bei bestehendem venösen Portsystem die Indikation zur parenteralen Ernährung bei malnutrierten Patienten und Patienten in frühen Kachexiephasen großzügig zu stellen.

Abstract

Malnutrition and cachexia are common in patients with malignancy, leading to weight loss and functional impairment due to sarcopenia. The growing understanding of the underlying patho-physiological mechanisms longs for early nutritional interventions. By choosing the route of nutritional support functional gastrointestinal impairments also have to be considered. Especially in short-term periods of increased calorie-need parenteral nutrition should be offered to malnourished patients and patients suffering from early stages of cachexia with a venous port system present.

 
  • Literatur

  • 1 von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: facts and numbers. Journal of cachexia, sarcopenia and muscle 2010; 1: 1-5
  • 2 Fearon K, Strasser F, Anker SD et al. Definition and classification of cancer cachexia: an international consensus. The lancet oncology 2011; 12: 489-495
  • 3 Cederholm T, Bosaeus I, Barazzoni R et al. Diagnostic criteria for malnutrition – An ESPEN Consensus Statement. Clinical nutrition (Edinburgh, Scotland) 2015; 34: 335-340
  • 4 Bauer JM, Volkert D, Wirth R et al. [Diagnosing malnutrition in the elderly]. Deutsche medizinische Wochenschrift (1946) 2006; 131: 223-227
  • 5 Tsoli M, Robertson G. Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem. Trends in endocrinology and metabolism: TEM 2013; 24: 174-183
  • 6 Bozzetti F. The oncologist as coordinator of the nutritional approach. Nutrition (Burbank, Los Angeles County, Calif 2015; 31: 619-620
  • 7 Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and ageing 2010; 39: 412-423
  • 8 Johns N, Tan BH, MacMillan M et al. Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies. Journal of genetics 2014; 93: 893-916
  • 9 Schindler K, Pernicka E, Laviano A et al. How nutritional risk is assessed and managed in European hospitals: a survey of 21,007 patients findings from the 2007–2008 cross-sectional nutritionDay survey. Clinical nutrition (Edinburgh, Scotland) 2010; 29: 552-559
  • 10 Martin L, Senesse P, Gioulbasanis I et al. Diagnostic criteria for the classification of cancer-associated weight loss. Journal of Clinical Oncology 2015; 33: 90-99
  • 11 Bozzetti F, Santarpia L, Pironi L et al. The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a multi-centre observational study with prospective follow-up of 414 patients. Ann Oncol 2014; 25: 487-493
  • 12 Lenk K, Schuler G, Adams V. Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training. Journal of cachexia, sarcopenia and muscle 2010; 1: 9-21
  • 13 Moertel CG, Schutt AJ, Reitemeier RJ et al. Corticosteroid therapy of preterminal gastrointestinal cancer. Cancer 1974; 33: 1607-1609
  • 14 Ruiz Garcia V, Lopez-Briz E, Carbonell Sanchis R et al. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane database of systematic reviews (Online) 2013; 3 CD004310
  • 15 Garcia JM, Boccia RV, Graham CD et al. Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. The lancet oncology 2015; 16: 108-116
  • 16 Pironi L, Arends J, Baxter J et al. ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. Clinical nutrition (Edinburgh, Scotland) 2015; 34: 171-180
  • 17 Bozzetti F, Arends J, Lundholm K et al. ESPEN Guidelines on Parenteral Nutrition: non-surgical oncology. Clinical nutrition (Edinburgh, Scotland) 2009; 28: 445-454
  • 18 Baldwin C, Spiro A, Ahern R et al. Oral nutritional interventions in malnourished patients with cancer: a systematic review and meta-analysis. Journal of the National Cancer Institute 2012; 104: 371-385
  • 19 Balstad TR, Solheim TS, Strasser F et al. Dietary treatment of weight loss in patients with advanced cancer and cachexia: a systematic literature review. Critical reviews in oncology/hematology 2014; 91: 210-221
  • 20 Lundholm K, Daneryd P, Bosaeus I et al. Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: effects on survival, metabolism, and function. Cancer 2004; 100: 1967-1977
  • 21 Pelzer U, Arnold D, Govercin M et al. Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study. BMC cancer 2010; 10: 86
  • 22 Koretz RL, Lipman TO, Klein S. AGA technical review on parenteral nutrition. Gastroenterology 2001; 121: 970-1001
  • 23 Scolapio JS, Picco MF, Tarrosa VB. Enteral versus parenteral nutrition: the patient’s preference. Jpen 2002; 26: 248-250