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Thromb Haemost 2002; 87(05): 859-866
DOI: 10.1055/s-0037-1613097
Review Article
Schattauer GmbH

European Concerted Action on Anticoagulation

Comparison of Fresh Plasma and Whole Blood Multicentre ISI Calibrations of CoaguChek Mini and TAS PT-NC Whole Blood Prothrombin Time Point-of-Care Monitors
L. Poller   *
1   European Concerted Action on Anticoagulation Central Facility, School of Biological Sciences, The University of Manchester, Manchester
,
M. Keown
1   European Concerted Action on Anticoagulation Central Facility, School of Biological Sciences, The University of Manchester, Manchester
,
N. Chauhan
1   European Concerted Action on Anticoagulation Central Facility, School of Biological Sciences, The University of Manchester, Manchester
,
A.M.H.P. van den Besselaar   *
2   Haemostasis and Thrombosis Research Centre, Leiden University Medical Center, Leiden
,
A. Tripodi   *
3   A Bianchi Bonomi, Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Milan
,
C. Shiach   *
4   Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester
,
J. Jespersen   *
5   Department for Thrombosis Research, University of Southern Denmark and Department of Clinical Biochemistry, Ribe County Hospital, Esbjerg
,
J. Conard
6   Laboratoire Central D’Hématologie, Hôtel-Dieu de Paris, Paris
,
D. Dias
7   Service Immunotherapia, Hospital de S. Joao, 4760 Vila Nova de Famalicao, Porto
,
N. Egberg
8   Department of Clinical Chemistry, Karolinska Hospital, Stockholm
,
J.A. Iriarte
9   Instituto de Epidemiologia y prevencion de enfermedades cardiovasculares, Hospital Civil de Basurto, Bilbao
,
I. Kontopoulou-Griva
10   Anticoagulant Unit, Hippocration General Hospital, Athens
,
B. Otridge
11   Haematology Department, Mater Misericordiae Hospital, Dublin
› Author Affiliations
Further Information

Publication History

Received 12 October 2001

Accepted after resubmission 24 January 2002

Publication Date:
11 December 2017 (online)

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Summary

A procedure for using citrated fresh plasmas for International Sensitivity Index (ISI) calibration of two types of whole blood point-of-care test (POCT) prothrombin time (PT) monitor systems has been assessed in a multicentre study.

The CoaguChek Mini and TAS PT-NC systems gave higher ISI with whole blood samples than with fresh plasma calibrations. However, there was good agreement between whole blood and fresh plasma monitor system International Normalised Ratio (INR) and the reference INR of target samples.

Reliable INR can therefore be obtained with both whole blood and plasma samples on these two POCT systems based on their respective ISI. With the CoaguChek Mini system, the plasma calibration ISI can also be used to derive reliable INR with whole blood PT results. This was not possible with the TAS PT-NC system.

Keywords

Prothrombin time - International Normalised Ratio - plasma calibrations - Multicentre ISI - POCT monitors

* European Concerted Action on Anticoagulation Steering Group Members


 

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