PiD - Psychotherapie im Dialog 2014; 15(02): 74-77
DOI: 10.1055/s-0034-1376937
Aus der Praxis
© Georg Thieme Verlag KG Stuttgart · New York

Neurobiologie des Zwangs

Erkenntnisse und Bedeutung für die Psychotherapie
Anne Katrin Külz
Further Information

Publication History

Publication Date:
18 June 2014 (online)

Die neurobiologische Basis von Zwangsstörungen gilt mittlerweile als gut abgesichert, auch wenn noch nicht alle beteiligten ­Faktoren ­bekannt sind. Im Rahmen der Psychotherapie können neuro­biologische Aspekte des Zwangs wertvoll sein, um Betroffenen die Entstehung und Aufrechterhaltung ihrer aufdringlichen Gedanken und belastenden Rituale zu vermitteln.

 
  • Literatur

  • 1 Baxter LR, Schwartz JM, Bergmann KS et al. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry 1992; 49: 681-689
  • 2 De Koning PP, Figee M, van den Munckhof P et al. Current status of deep Brain stimulation for obsessive-compulsive disorder: a clinical review of different targets. Curr Psychiatry Rep 2011; 13: 274-282
  • 3 Figee M, Luigjes J, Smolders R et al. Deep brain stimulation restores fronto-striatal network activity in obsessive-compulsive disorder. Nat Neurosci 2013; 16: 386-387
  • 4 Figee M, deKoning P, Klaassen S et al. Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder. Biol Psychiatry 2014; 75: 647-652
  • 5 Freyer T, Klöppel S, Tüscher O et al. Fronto-striatal activation in patients with obsessive-compulsive disorder before and after cognitive behavioral therapy. Psychol Med 2011; 41: 207-216
  • 6 Van Grootheest DS, Cath DC, Beekman AT, Boomsma DI. Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet 2005; 8: 450-458
  • 7 Jaafari N, de la Cruz LF, Grau M et al. Neurological soft signs in obsessive-compulsive disorder: two empirical studies and meta-analysis. Psychol Med 2013; 43: 1069-1079
  • 8 Külz AK, Riemann D, Halsband U et al. Neuropsychological impairment in obsessive-compulsive disorder – improvement over the course of cognitive behavioral treatment. J Clin Exp Neuropsychol 2006; 28: 1273-1287
  • 9 Külz AK, Meinzer S, Kopasz M, Voderholzer U. Effects of tryptophan depletion on cognitive functioning, obsessive-compulsive symptoms and mood in obsessive-compulsive disorder: preliminary results. Neuropsychobiol 2007; 56: 127-131
  • 10 Külz AK, Rose N. Achtsamkeitsbasierte kognitive Therapie bei Zwangsstörungen: Eine Adaptation des Originalkonzepts. Psychother Psych Med 2014; 64: 35-40
  • 11 Millet B, Dondaine T, Reymann JM et al. Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. PLoS One 2013; 8: e53241 DOI: 10.1371/journal. pone.0053241.
  • 12 Moritz S, Kloss M, Jacobson D et al. Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder. Behav Res Ther 2005; 43: 811-819
  • 13 O’Neill and Schwartz JM. The role of volition in OCD therapy: Neurocognitive, neuroimaging and neuroplastic aspects. Clin Neuropsychiatry 2004; 1: 13-31
  • 14 Pauls DP. The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci 2010; 12: 149-163
  • 15 Sesia T, Bizup B, Grace AA. Evaluation of animal models of obsessive-compulsive disorder: correlation with phasic dopamine neuron activity. Int J Neuropsychopharmacol 2013; 16: 1295-1307
  • 16 Shin NY, Lee TY, Kim E, Kwon JS. Cognitive functioning in obsessive-compulsive disorder: a meta-analysis. Psychol Med 2013; 149: 83-87
  • 17 Snider L, Lougee L, Slattery M et al. Antibiotic prophylaxis with Azithromycinor Penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry 2005; 57: 788-792
  • 18 Voderholzer U, Schwartz C, Freyer T et al. Cognitive functioning in medication-free obsessive-compulsive patients treated with cognitive-behavioural therapy. J Obsess Compuls Rel Disord 2013; 2: 241-248
  • 19 Welch JM, Lu J, Rodriguiz RM et al. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 2007; 448: 894-900
  • 20 Wu K, Hanna GL, Rosenberg DR, Arnold PD. The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacol Biochem Behav 2012; 100: 726-735
  • 21 Zurowski B, Kordon A, Weber-Fahr W et al. Relevance of orbitofrontal neurochemistry for the outcome of cognitive-behavioural therapy in patients with obsessive-compulsive disorder. Europ Arch Psychiatry Clin Neurosci 2012; 262: 617-624