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Endosc Int Open 2014; 02(01): E21-E27
DOI: 10.1055/s-0034-1365222
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Duodenal-jejunal bypass liner implantation provokes rapid weight loss and improved glycemic control, accompanied by elevated fasting ghrelin levels

Parweez Koehestanie
2   Department of General Surgery, Rijnstate, Arnhem, The Netherlands
,
Kemal Dogan
2   Department of General Surgery, Rijnstate, Arnhem, The Netherlands
,
Frits Berends
2   Department of General Surgery, Rijnstate, Arnhem, The Netherlands
,
Ignace Janssen
2   Department of General Surgery, Rijnstate, Arnhem, The Netherlands
,
Peter Wahab
3   Department of Gastroenterology, Rijnstate, Arnhem, The Netherlands
,
Marcel Groenen
3   Department of Gastroenterology, Rijnstate, Arnhem, The Netherlands
,
Michael Müller
1   Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
,
Nicole de Wit
1   Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
› Author Affiliations
Further Information

Publication History

received 20 August 2013

accepted after revision 08 January 2014

Publication Date:
07 March 2014 (online)

Also available at
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Background and study aims: Endoscopic implantation of a duodenal-jejunal bypass liner (DJBL) is a novel bariatric technique to induce weight loss and remission of type 2 diabetes mellitus. Placement of the DJBL mimics the bypass component of the Roux-en-Y gastric bypass (RYGB) procedure. In this observational study, we evaluated improvement of glycemic control and weight loss in the course of the treatment (0 – 24 weeks after DJBL implantation) and analyzed accompanying gut hormone responses.

Patients and methods: 12 obese individuals with type 2 diabetes were selected for DJBL implantation. Body weight, fat mass, and fasting plasma levels of glucose, insulin, C-peptide, and glycated hemoglobin (HbA1c), were analyzed at 0, 1, 4 and 24 weeks post-implant. Fasting ghrelin, gastric inhibitory peptide (GIP), and glucagon-like peptide (GLP-1) were determined at 0, 1 and 4 weeks post-implant.

Results: Besides significant weight loss, fat mass, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index were also significantly decreased after DJBL implantation and a 42 % reduction was found in diabetes medication (P < 0.05). The fasting GLP-1 response in the first 4 weeks post-implant was significantly correlated with the fasting insulin and HOMA-IR response. Fasting ghrelin was found to be significantly elevated, in contrast to the decrease in ghrelin that is found after RYGB surgery.

Conclusions: DJBL implantation provoked significant weight loss, a decrease in fat mass, and an early remission of type 2 diabetes, comparable to results seen after RYGB surgery. Gut hormone analyses revealed a potential role of fasting GLP-1 in early remission of type 2 diabetes. Interestingly, the DJBL-induced elevation of ghrelin contradicts the suggested role of reduced ghrelin levels after RYGB in improvement of glycemic control.

 

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