Dtsch Med Wochenschr 2011; 136(48): 2458-2460
DOI: 10.1055/s-0031-1297266
Endokrinologie und Diabetologie | Commentary
Endokrinologie, Osteologie
© Georg Thieme Verlag KG Stuttgart · New York

Innovationen in der Therapie der Osteoporose

Innovations in the treatment of osteoporosisE. Tsourdi1 , L. C. Hofbauer1
  • 1Bereich Endokrinologie/Diabetes/Metabolische Knochenerkrankungen, Medizinische Klinik III, Universitätsklinikum der Technischen Universität Dresden
Further Information

Publication History

Publication Date:
22 November 2011 (online)

Literatur

  • 1 Balemans W, Ebeling M, Patel N. et al . Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).  Hum Mol Genet. 2001;  10 537-543
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  • 3 Bone H G, McClung M R, Roux C, Recker R R, Eisman J A, Verbruggen N, Hustad C M, DaSilva C, Santora A C, Ince B A. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density.  J Bone Miner Res. 2010;  25 937-947
  • 4 Brown J P, Prince R L, Deal C. et al . Comparison of the Effect of denosumab and alendronate on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial.  J Bone Miner Res. 2009;  24 153-161
  • 5 Cummings S R, San Martin J, McClung M R. et al . FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis.  N Engl J Med. 2009;  361 756-765
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  • 8 Heath D J, Chantry A D, Buckle C H, Coulton L, Shaughnessy J D Jr, Evans H R, Snowden J A, Stover D R, Vanderkerken K, Croucher P I. Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.  J Bone Miner Res. 2009;  24 425-436
  • 9 Hofbauer L C, Heufelder A E. Clinical review 114: hot topic. The role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases.  J Clin Endocrinol Metab. 2000;  85 2355-2363
  • 10 Kimura S, Nakagawa T, Matsuo Y, Ishida Y, Okamoto Y, Hayashi M. JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats.  Eur J Pharmacol. 2011; ;  Jul 28. [Epub ahead of print]
  • 11 Kramer I, Halleux C, Keller H, Pegurri M, Gooi J H, Weber P B, Feng J Q, Bonewald L F, Kneissel M. Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis.  Mol Cell Biol. 2010;  30 3071-3085
  • 12 Li X, Ominsky M S, Warmington K S. et al . Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis.  J Bone Miner Res. 2009;  24 578-588
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Prof. Dr. med. Lorenz C. Hofbauer

Bereich Endokrinologie/Diabetes/Knochenerkrankungen
Medizinische Klinik und Poliklinik III
Technische Universität Dresden

Fetscherstr. 74

01307 Dresden

Phone: 0351/458-3173

Fax: 0351/458-4309

Email: Lorenz.Hofbauer@uniklinikum-dresden.de

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