MDMA-gestützte Therapie

 

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ZUSAMMENFASSUNG

Neben den klassischen Psychedelika, z. B. Psilocybin, werden wieder vermehrt andere Substanzen wie 3,4-Methylendioxy-N-methylamphetamin (MDMA) erforscht. Das Entaktogen („innerlich berührend“) ist in den USA nur noch wenige Schritte von einer möglichen Zulassung zur Behandlung der posttraumatischen Belastungsstörung entfernt. Dieser Artikel soll einen Überblick über die Wirkung, den Einsatz im therapeutischen Setting sowie den Forschungsstand geben. Hierbei sollen insbesondere Sicherheitsaspekte der MDMA-gestützten Therapie beleuchtet werden. Zuletzt folgt ein Ausblick auf eine mögliche Zulassung und damit einhergehende offene Fragen, wie beispielsweise die Umsetzung in der klinischen Praxis. Auch die Notwendigkeit weiterer Studien wird diskutiert.

ABSTRACT

In addition to classic psychedelics such as Psilocybin, further substances such as 3,4-Methylendioxy-N-methylamphetamine (MDMA) are also increasingly being researched. The so-called entactogen (“to produce a touching within”) is currently close to being approved by the US American Food and Drug Administration for the treatment of post-traumatic stress disorder. This article aims to provide an overview of its effects, its use in therapeutic settings and the current state of clinical research. In particular, safety aspects of MDMA-assisted therapy are highlighted. Finally, an outlook on the imminent approval and related open questions, such as the implementation in clinical practice will follow. The need for further studies is also being discussed.

Publication History

Article published online:
14 May 2024

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