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Z Geburtshilfe Neonatol 2024; 228(02): 156-160
DOI: 10.1055/a-2125-0973
Original Article

First-trimester neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI) as predictors of composite adverse outcomes in pregnant women with Familial Mediterranean fever

Refaettin Sahin 
1   Division of Perinatology, Department of Obstetric and Gynecology, Ankara Bilkent City Hospital, Cankaya, Turkey
,
Atakan Tanacan 
1   Division of Perinatology, Department of Obstetric and Gynecology, Ankara Bilkent City Hospital, Cankaya, Turkey
,
Hakki Serbetci
1   Division of Perinatology, Department of Obstetric and Gynecology, Ankara Bilkent City Hospital, Cankaya, Turkey
,
Busra Karagoz
2   Obstetrics and Gynecology, Ankara Bilkent City Hospital, Cankaya, Turkey
,
Zahid Agaoglu
1   Division of Perinatology, Department of Obstetric and Gynecology, Ankara Bilkent City Hospital, Cankaya, Turkey
,
Ozgur Kara
1   Division of Perinatology, Department of Obstetric and Gynecology, Ankara Bilkent City Hospital, Cankaya, Turkey
,
Dilek Sahin
3   Department of Obstetrics and Gynecology, Division of Perinatology, Ankara City Hospital, Cankaya, Turkey
4   Department of Obstetrics and Gynecology, Division of Perinatology, University of Health Sciences, Istanbul, Turkey
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Abstract

Objective To evaluate the utility of the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI) in the prediction of adverse pregnancy outcomes in pregnant women with Familial Mediterranean fever (FMF)

Material and methods This retrospective case-control study was conducted between 2019–2023. First-trimester NLR, SII (NLR X platelet count), and SIRI (NLR X monocyte count) values were compared between pregnant women with FMF (n=85) and without FMF (n=105). Thereafter, pregnant women with FMF were divided into two groups: 1) FMF with perinatal complications (n=30), and 2) FMF without perinatal complications (n=55). NLR, SII, and SIRI values were compared between the two subgroups. Finally, an ROC analysis was performed to determine optimal cut-off values for NLR, SII, and SIRI in the prediction of composite adverse pregnancy outcomes.

Results The FMF group had significantly higher first-trimester NLR, SII, and SIRI values compared to the controls. The FMF with perinatal complications group had significantly higher NLR, SII, and SIRI values than the FMF group without perinatal complications (p<0.05). Optimal cut-off values were 4.89 (80% sensitivity, 78.2% specificity), 1180.6 (76.7% sensitivity, 72.7% specificity), and 1.9 (83.3% sensitivity,72.7% specificity) for NLR, SII, and SIRI, respectively.

Conclusion SII, SIRI, and NLR may be used to predict adverse pregnancy outcomes in pregnant women with FMF.

Key words

Perinatal complications - SII - SIRI - NLR - familial mediterranean fever


Publication History

Received: 12 June 2023

Accepted: 28 June 2023

Article published online:
17 August 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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