Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

23.02.2018 | Original contributions | Ausgabe 2/2019

Zeitschrift für Gerontologie und Geriatrie 2/2019

Prevention of ovariectomy-induced osteoporosis in rats

Comparative study of zoledronic acid, parathyroid hormone (1-34) and strontium ranelate

Zeitschrift:
Zeitschrift für Gerontologie und Geriatrie > Ausgabe 2/2019
Autoren:
Zhou-Shan Tao, Wan-Shu Zhou, Xing-Jing Wu, Xin Zhang, Lin Wang, Jia-Bing Xie, Zhu-Jun Xu, Guo-Zheng Ding, Min Yang
Wichtige Hinweise
Zhou-Shan Tao and Wan-Shu Zhou contributed equally to this work and share the correspondence and first author.

Abstract

Recently, the use of the pharmacological agents strontium ranelate (SR), parathyroid hormone (1-34, PTH) and zoledronic acid (ZA) has come to prominence for the treatment of osteoporosis due to their ability to prevent bone loss in osteoporotic patients. Although much emphasis has been placed on using pharmacological agents for the prevention of disease, much less attention has been placed on which one is more effective. There is still no direct comparative study on these three drugs. The aim of the present study was to investigate the effect of SR, PTH, ZA on preventing ovariectomy-induced osteoporosis in rats. After bilateral ovariectomy the rats randomly received vehicle, SR (500 mg/kg body weight/day, orally), PTH (20 μg/kg/day, subcutaneously) or a single injection of ZA (0.1 mg/kg, i.v.) until death at 12 weeks. The distal femurs were harvested for evaluation of bone metabolism. The rats treated with ZA demonstrated the highest levels of new bone formation as assessed by microcomputed tomography (CT), biomechanical strength, histological analysis and bone metabolism. Furthermore, PTH and SR showed a stronger effect on improving trabecular bone mass at 12 weeks. The results from the present study demonstrate that systemic administration of PTH, SR and ZA could prevent bone loss, while a single dose of ZA has a better effect on preventing ovariectomy-induced osteoporosis than either PTH or SR.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:

Zeitschrift für Gerontologie und Geriatrie

Print-Titel

• Themenbezogene Hefte behandeln Fragen der Gerontologie, der Biologie und Grundlagenforschung des Alterns und der geriatrischen Forschung

• Erweitert mit Beiträgen zu Therapie, Psychologie und Soziologie sowie der praktischen Altenpflege.  

• Hot topics von Experten knapp, aussagekräftig und provokativ kommentiert

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 2/2019

Zeitschrift für Gerontologie und Geriatrie 2/2019 Zur Ausgabe

Journal Club

Journal Club