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Zeitschrift für Gerontologie und Geriatrie

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17.04.2018 | Reviews

Prevalence of vitamin D insufficiency and evidence for disease prevention in the older population

verfasst von: Julia Kühn, Paula Trotz, Prof. Dr. Gabriele I. Stangl

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 5/2018

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Abstract

The prevalence of vitamin D insufficiency, usually assessed by the analysis of circulating 25-hydroxyvitamin D (25[OH])D), is very high in the aging German population. An important factor that reduces endogenous vitamin D synthesis in older persons is physical inactivity or care-dependency that limits the time spent outside. Additionally, it has been suggested that the age-dependent decline in the glomerular filtration rate is associated with a reduced production of bioactive calcitriol. As this phenomenon is not detectable by the assessment of 25(OH)D, it is necessary to analyze the level of parathyroid hormone as a marker of calcitriol function. Because 25(OH)D levels are highly correlated with an active and healthy life style, data from epidemiological studies are not necessarily suitable to elucidate the role of vitamin D in disease prevention. Recently published meta-analyses of randomized controlled trials (RCTs) showed moderate effects of vitamin D supplementation on fracture risk and found that vitamin D was more effective when administered in combination with calcium. The role of vitamin D in the prevention of falls and frailty remains unclear. Much evidence has demonstrated the beneficial effects of vitamin D on respiratory tract infections and asthma, which are very relevant health issues in the older population. To conclude, vitamin D, particularly combined with calcium, has moderately beneficial effects on the skeletal system and is useful for the prevention of respiratory tract infections.

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Titel: Prevalence of vitamin D insufficiency and evidence for disease prevention in the older population
verfasst von: Julia Kühn
Paula Trotz
Prof. Dr. Gabriele I. Stangl
Publikationsdatum: 17.04.2018
Verlag: Springer Medizin
Erschienen in: Zeitschrift für Gerontologie und Geriatrie / Ausgabe 5/2018
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI: https://doi.org/10.1007/s00391-018-1390-z

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