Skip to main content
Erschienen in: Zeitschrift für Gerontologie und Geriatrie 2/2016

01.02.2016 | Originalien

Prevalence and definition of sarcopenia in community dwelling older people

Data from the Berlin aging study II (BASE-II)

verfasst von: Dr. D. Spira, Priv.-Doz. Dr. K. Norman, J. Nikolov, MSc., Priv.-Doz. Dr. I. Demuth, Univ.-Prof. Dr. E. Steinhagen-Thiessen, Dr. R. Eckardt

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten

Abstract

Background

Sarcopenia describes the age-associated loss of muscle mass, strength and function. The aim of this study was to compare the prevalence of sarcopenia in a cohort of community dwelling elderly people living in Berlin, Germany, according to the criteria proposed by current consensus statements and to study the respective impact on self-reported physical performance.

Material and methods

This study included 1405 participants from the Berlin aging study II (BASE-II). The appendicular skeletal muscle mass index (SMI) was assessed with dual energy X-ray absorptiometry (DXA), muscle strength was measured by hand grip strength and the timed up and go” test (TUG) was performed as a functional parameter to reflect mobility.

Results

The prevalence of sarcopenia was 24.3 % in terms of reduced SMI only and considerably lower for sarcopenia with reduced grip strength (4.1 %) and sarcopenia with limited mobility (2.4 %). Only 0.6 % of the participants fulfilled all three criteria. Of the subjects with a normal SMI, 8.6 % had reduced grip strength and 5.1 % had limited mobility, whereas 1.3 % subjects fulfilled both criteria. Participants with reduced strength or function reported severe difficulties in performing physical tasks significantly more often than participants with normal or reduced SMI alone (p <0.029–p <0.0001).

Conclusion

In BASE-II low skeletal muscle mass was much more frequent than reduced grip strength or poor function. Reduced strength and function were found to be associated with a greater impact on physical performance than reduced muscle mass. Low SMI does not seem to be a prerequisite for low strength or limitations in mobility.
Literatur
1.
Zurück zum Zitat Aagaard P, Suetta C, Caserotti P, Magnusson SP, Kjaer M (2010) Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure. Scand J Med Sci Sports 20(1):49–64CrossRefPubMed Aagaard P, Suetta C, Caserotti P, Magnusson SP, Kjaer M (2010) Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure. Scand J Med Sci Sports 20(1):49–64CrossRefPubMed
2.
Zurück zum Zitat Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR et al (1988) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755–763CrossRef Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR et al (1988) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755–763CrossRef
3.
Zurück zum Zitat Bertram L, Bockenhoff A, Demuth I, Duzel S, Eckardt R, Li SC et al (2014) Cohort profile: the Berlin aging study II (BASE-II). Int J Epidemiol 43:703–712CrossRefPubMed Bertram L, Bockenhoff A, Demuth I, Duzel S, Eckardt R, Li SC et al (2014) Cohort profile: the Berlin aging study II (BASE-II). Int J Epidemiol 43:703–712CrossRefPubMed
4.
Zurück zum Zitat Bijlsma AY, Meskers CG, Ling CH, Narici M, Kurrle SE, Cameron ID et al (2013) Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort. Age (Dordr) 35(3):871–881CrossRef Bijlsma AY, Meskers CG, Ling CH, Narici M, Kurrle SE, Cameron ID et al (2013) Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort. Age (Dordr) 35(3):871–881CrossRef
5.
Zurück zum Zitat Bohannon RW (2001) Dynamometer measurements of hand-grip strength predict multiple outcomes. Percept Mot Skills 93(2):323–328CrossRefPubMed Bohannon RW (2001) Dynamometer measurements of hand-grip strength predict multiple outcomes. Percept Mot Skills 93(2):323–328CrossRefPubMed
6.
Zurück zum Zitat Bohannon RW (2006) Grip strength predicts outcome. Age Ageing 35(3):320CrossRef Bohannon RW (2006) Grip strength predicts outcome. Age Ageing 35(3):320CrossRef
7.
Zurück zum Zitat Buford TW, Anton SD, Judge AR, Marzetti E, Wohlgemuth SE, Carter CS et al (2010) Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev 9(4):369–383PubMedCentralCrossRefPubMed Buford TW, Anton SD, Judge AR, Marzetti E, Wohlgemuth SE, Carter CS et al (2010) Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev 9(4):369–383PubMedCentralCrossRefPubMed
8.
Zurück zum Zitat Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European working group on Sarcopenia in older people. Age Ageing 39(4):412–423PubMedCentralCrossRef Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European working group on Sarcopenia in older people. Age Ageing 39(4):412–423PubMedCentralCrossRef
9.
Zurück zum Zitat Davis DH, Rockwood MR, Mitnitski AB, Rockwood K (2011) Impairments in mobility and balance in relation to frailty. Arch Gerontol Geriatr 53(1):79–83CrossRefPubMed Davis DH, Rockwood MR, Mitnitski AB, Rockwood K (2011) Impairments in mobility and balance in relation to frailty. Arch Gerontol Geriatr 53(1):79–83CrossRefPubMed
10.
Zurück zum Zitat De Buyser SL, Petrovic M, Taes YE, Toye KR, Kaufman JM, Goemaere S (2013) Physical function measurements predict mortality in ambulatory older men. Eur J Clin Invest 43(4):379–386CrossRefPubMed De Buyser SL, Petrovic M, Taes YE, Toye KR, Kaufman JM, Goemaere S (2013) Physical function measurements predict mortality in ambulatory older men. Eur J Clin Invest 43(4):379–386CrossRefPubMed
11.
Zurück zum Zitat Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P et al (2009) Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 90(6):1579–1585PubMedCentralCrossRefPubMed Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P et al (2009) Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 90(6):1579–1585PubMedCentralCrossRefPubMed
12.
Zurück zum Zitat Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12(4):249–256CrossRefPubMed Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12(4):249–256CrossRefPubMed
13.
Zurück zum Zitat Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56(3):M146–156CrossRefPubMed Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56(3):M146–156CrossRefPubMed
14.
Zurück zum Zitat Gale CR, Martyn CN, Cooper C, Sayer AA (2007) Grip strength, body composition, and mortality. Int J Epidemiol 36(1):228–235CrossRefPubMed Gale CR, Martyn CN, Cooper C, Sayer AA (2007) Grip strength, body composition, and mortality. Int J Epidemiol 36(1):228–235CrossRefPubMed
15.
Zurück zum Zitat Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R et al (2001) Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci 56(5):B209–217CrossRefPubMed Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R et al (2001) Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci 56(5):B209–217CrossRefPubMed
16.
Zurück zum Zitat Iannuzzi-Sucich M, Prestwood KM, Kenny AM (2002) Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 57(12):M772–777CrossRefPubMed Iannuzzi-Sucich M, Prestwood KM, Kenny AM (2002) Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 57(12):M772–777CrossRefPubMed
17.
Zurück zum Zitat Janssen I, Heymsfield SB, Ross R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50(5):889–896CrossRefPubMed Janssen I, Heymsfield SB, Ross R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50(5):889–896CrossRefPubMed
18.
Zurück zum Zitat Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di IA et al (2003) Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985) 95(5):1851–1860CrossRef Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di IA et al (2003) Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985) 95(5):1851–1860CrossRef
19.
Zurück zum Zitat Lee WJ, Liu LK, Peng LN, Lin MH, Chen LK (2013) Comparisons of sarcopenia defined by IWGS and EWGSOP criteria among older people: results from the I-Lan longitudinal aging study. J Am Med Dir Assoc 14(7):528.e1–7CrossRefPubMed Lee WJ, Liu LK, Peng LN, Lin MH, Chen LK (2013) Comparisons of sarcopenia defined by IWGS and EWGSOP criteria among older people: results from the I-Lan longitudinal aging study. J Am Med Dir Assoc 14(7):528.e1–7CrossRefPubMed
20.
Zurück zum Zitat Legrand D, Vaes B, Mathei C, Swine C, Degryse JM (2013) The prevalence of sarcopenia in very old individuals according to the European consensus definition: insights from the BELFRAIL study. Age Ageing 42:727–734CrossRefPubMed Legrand D, Vaes B, Mathei C, Swine C, Degryse JM (2013) The prevalence of sarcopenia in very old individuals according to the European consensus definition: insights from the BELFRAIL study. Age Ageing 42:727–734CrossRefPubMed
21.
Zurück zum Zitat Maden-Wilkinson TM, Degens HF, Jones DA FAU, McPhee JS (2013) Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles. J Musculoskelet Neuronal Interact 13:320–328PubMed Maden-Wilkinson TM, Degens HF, Jones DA FAU, McPhee JS (2013) Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles. J Musculoskelet Neuronal Interact 13:320–328PubMed
22.
Zurück zum Zitat Marzetti E, Leeuwenburgh C (2006) Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol 41(12):1234–1238CrossRefPubMed Marzetti E, Leeuwenburgh C (2006) Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol 41(12):1234–1238CrossRefPubMed
23.
Zurück zum Zitat Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S et al (2011) Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 12(6):403–409CrossRefPubMed Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S et al (2011) Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 12(6):403–409CrossRefPubMed
24.
Zurück zum Zitat Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB et al (2006) Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 61(1):72–77CrossRefPubMed Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB et al (2006) Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 61(1):72–77CrossRefPubMed
25.
Zurück zum Zitat Norman K, Stobaus N, Gonzalez MC, Schulzke JD, Pirlich M (2010) Hand grip strength: outcome predictor and marker of nutritional status. Clin Nutr 30(2):135–142CrossRefPubMed Norman K, Stobaus N, Gonzalez MC, Schulzke JD, Pirlich M (2010) Hand grip strength: outcome predictor and marker of nutritional status. Clin Nutr 30(2):135–142CrossRefPubMed
26.
Zurück zum Zitat Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC et al (2013) Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing 42(3):378–384PubMedCentralCrossRefPubMed Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC et al (2013) Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing 42(3):378–384PubMedCentralCrossRefPubMed
27.
Zurück zum Zitat Patil R, Uusi-Rasi K, Pasanen M, Kannus P, Karinkanta S, Sievanen H (2013) Sarcopenia and osteopenia among 70–80-year-old home-dwelling Finnish women: prevalence and association with functional performance. Osteoporos Int 24(3):787–796CrossRefPubMed Patil R, Uusi-Rasi K, Pasanen M, Kannus P, Karinkanta S, Sievanen H (2013) Sarcopenia and osteopenia among 70–80-year-old home-dwelling Finnish women: prevalence and association with functional performance. Osteoporos Int 24(3):787–796CrossRefPubMed
28.
Zurück zum Zitat Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39(2):142–148CrossRefPubMed Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39(2):142–148CrossRefPubMed
29.
Zurück zum Zitat Rantanen T, Avlund K, Suominen H, Schroll M, Frandin K, Pertti E (2002) Muscle strength as a predictor of onset of ADL dependence in people aged 75 years. Aging Clin Exp Res 14(3 Suppl):10–15PubMed Rantanen T, Avlund K, Suominen H, Schroll M, Frandin K, Pertti E (2002) Muscle strength as a predictor of onset of ADL dependence in people aged 75 years. Aging Clin Exp Res 14(3 Suppl):10–15PubMed
30.
Zurück zum Zitat Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127(5 Suppl):990–991 Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127(5 Suppl):990–991
31.
Zurück zum Zitat Roubenoff R, Hughes VA (2000) Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci 55(12):M716–724CrossRefPubMed Roubenoff R, Hughes VA (2000) Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci 55(12):M716–724CrossRefPubMed
32.
Zurück zum Zitat Sasaki H, Kasagi F, Yamada M, Fujita S (2007) Grip strength predicts cause-specific mortality in middle-aged and elderly persons. Am J Med 120(4):337–342CrossRefPubMed Sasaki H, Kasagi F, Yamada M, Fujita S (2007) Grip strength predicts cause-specific mortality in middle-aged and elderly persons. Am J Med 120(4):337–342CrossRefPubMed
33.
Zurück zum Zitat Viccaro LJ, Perera S, Studenski SA (2011) Is timed up and go better than gait speed in predicting health, function, and falls in older adults? J Am Geriatr Soc 59(5):887–892PubMedCentralCrossRefPubMed Viccaro LJ, Perera S, Studenski SA (2011) Is timed up and go better than gait speed in predicting health, function, and falls in older adults? J Am Geriatr Soc 59(5):887–892PubMedCentralCrossRefPubMed
34.
Zurück zum Zitat Volpato S, Bianchi L, Cherubini A, Landi F, Maggio M, Savino E et al (2014) Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm. J Gerontol A Biol Sci Med Sci 69:438–446PubMedCentralCrossRefPubMed Volpato S, Bianchi L, Cherubini A, Landi F, Maggio M, Savino E et al (2014) Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm. J Gerontol A Biol Sci Med Sci 69:438–446PubMedCentralCrossRefPubMed
35.
Zurück zum Zitat von Haehling S, Morley JE, Anker SD (2010) An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle 1(2):129–133CrossRef von Haehling S, Morley JE, Anker SD (2010) An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle 1(2):129–133CrossRef
36.
Zurück zum Zitat Wennie Huang WN, Perera S, VanSwearingen J, Studenski S (2010) Performance measures predict onset of activity of daily living difficulty in community-dwelling older adults. J Am Geriatr Soc 58(5):844–852CrossRefPubMed Wennie Huang WN, Perera S, VanSwearingen J, Studenski S (2010) Performance measures predict onset of activity of daily living difficulty in community-dwelling older adults. J Am Geriatr Soc 58(5):844–852CrossRefPubMed
Metadaten
Titel
Prevalence and definition of sarcopenia in community dwelling older people
Data from the Berlin aging study II (BASE-II)
verfasst von
Dr. D. Spira
Priv.-Doz. Dr. K. Norman
J. Nikolov, MSc.
Priv.-Doz. Dr. I. Demuth
Univ.-Prof. Dr. E. Steinhagen-Thiessen
Dr. R. Eckardt
Publikationsdatum
01.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 2/2016
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-015-0886-z

Weitere Artikel der Ausgabe 2/2016

Zeitschrift für Gerontologie und Geriatrie 2/2016 Zur Ausgabe

Mitteilungen der ÖGGG

Mitteilungen der ÖGGG

Journal Club

Journal Club

CME Zertifizierte Fortbildung

Wirbelsäulenfrakturen