Skip to main content
Erschienen in:
Buchtitelbild

2018 | OriginalPaper | Buchkapitel

1. Plazentaentwicklung mit histologischen Aspekten

verfasst von : Berthold Huppertz

Erschienen in: Die Plazenta

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Dieses Kapitel widmet sich der Entwicklung der grundlegenden Strukturen der humanen Plazenta. Die Entwicklung der Plazenta startet während des Blastozystenstadiums; hier differenziert der erste Zelltyp des Menschen, der Trophoblast. Innerhalb weniger Wochen formieren sich alle essentiellen Gewebe und Strukturen der Plazenta bis hin zu den verschiedenen Zottentypen. Während der Schwangerschaft werden diese Zottentypen sowie die darin liegende Plazentaschranke angepasst und verändert, um eine möglichst optimale Versorgung des Embryos/Feten zu gewährleisten. Die verschiedenen Zelltypen innerhalb der plazentaren Zotten, allen voran der villöse Trophoblast, prägen das Erscheinungsbild der Zottentypen. Die zweite Population des Trophoblasten, der extravillöse Trophoblast, invadiert in die Wand des Uterus und erreicht das innere Drittel des Myometriums. Während dieses Invasionsweges werden alle luminalen Strukturen des Uterus invadiert: Arterien, Venen, Drüsen und Lymphgefäße. Dieses Invasionsverhalten hat einen entscheidenden Einfluss auf die Durchblutung der Plazenta mit maternalem Blut.
Literatur
Zurück zum Zitat Baergen RN (2011) Manual of pathology of the human placenta, Bd 2. Springer, New YorkCrossRef Baergen RN (2011) Manual of pathology of the human placenta, Bd 2. Springer, New YorkCrossRef
Zurück zum Zitat Ball E, Bulmer JN, Ayis S, Lyall F, Robson SC (2006a) Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol 208:535–542CrossRef Ball E, Bulmer JN, Ayis S, Lyall F, Robson SC (2006a) Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol 208:535–542CrossRef
Zurück zum Zitat Ball E, Robson SC, Ayis S, Lyall F, Bulmer JN (2006b) Early embryonic demise: no evidence of abnormal spiral artery transformation or trophoblast invasion. J Pathol 208:528–534CrossRef Ball E, Robson SC, Ayis S, Lyall F, Bulmer JN (2006b) Early embryonic demise: no evidence of abnormal spiral artery transformation or trophoblast invasion. J Pathol 208:528–534CrossRef
Zurück zum Zitat Benirschke K, Kaufmann P, Baergen RN (2006) Pathology of the human placenta, Bd 5. Springer, New York Benirschke K, Kaufmann P, Baergen RN (2006) Pathology of the human placenta, Bd 5. Springer, New York
Zurück zum Zitat Burton GJ, Jauniaux E, Charnock-Jones DS (2007) Human early placental development: potential roles of the endometrial glands. Placenta 28:S64–69CrossRef Burton GJ, Jauniaux E, Charnock-Jones DS (2007) Human early placental development: potential roles of the endometrial glands. Placenta 28:S64–69CrossRef
Zurück zum Zitat Burton GJ, Jauniaux E, Watson AL (1999) Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. Am J Obstet Gynecol 181:718–724CrossRef Burton GJ, Jauniaux E, Watson AL (1999) Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. Am J Obstet Gynecol 181:718–724CrossRef
Zurück zum Zitat Burton GJ, Watson AL, Hempstock J, Skepper JN, Jauniaux E (2002) Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab 87:2954–2959CrossRef Burton GJ, Watson AL, Hempstock J, Skepper JN, Jauniaux E (2002) Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab 87:2954–2959CrossRef
Zurück zum Zitat Demir R, Kayisli UA, Seval Y, Celik-Ozenci C, Korgun ET, Demir-Weusten AY, Huppertz B (2004) Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis. Placenta 25:560–572CrossRef Demir R, Kayisli UA, Seval Y, Celik-Ozenci C, Korgun ET, Demir-Weusten AY, Huppertz B (2004) Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis. Placenta 25:560–572CrossRef
Zurück zum Zitat Eaton BM, Leach L, Firth JA (1993) Permeability of the fetal villous microvasculature in the isolated perfused term human placenta. J Physiol 463:141–155CrossRef Eaton BM, Leach L, Firth JA (1993) Permeability of the fetal villous microvasculature in the isolated perfused term human placenta. J Physiol 463:141–155CrossRef
Zurück zum Zitat Fernandez H, Al-Najjar F, Chauveaud-Lambling A, Frydman R, Gervaise A (2006) Fertility after treatment of Asherman’s syndrome stage 3 and 4. J Minim Invasive Gynecol 13:398–402CrossRef Fernandez H, Al-Najjar F, Chauveaud-Lambling A, Frydman R, Gervaise A (2006) Fertility after treatment of Asherman’s syndrome stage 3 and 4. J Minim Invasive Gynecol 13:398–402CrossRef
Zurück zum Zitat He N, Iperen L van, Jong D de, Szuhai K, Helmerhorst FM, Westerlaken LAJ van der, Sousa Chuva de, Lopes SM (2017) Human extravillous trophoblasts penetrate decidual veins and lymphatics before remodeling spiral arteries during early pregnancy. PloS One 12:e0169849CrossRef He N, Iperen L van, Jong D de, Szuhai K, Helmerhorst FM, Westerlaken LAJ van der, Sousa Chuva de, Lopes SM (2017) Human extravillous trophoblasts penetrate decidual veins and lymphatics before remodeling spiral arteries during early pregnancy. PloS One 12:e0169849CrossRef
Zurück zum Zitat Huppertz B, Gauster M, Orendi K, König J, Moser G (2009) Oxygen as modulator of trophoblast invasion. J Anat 215:14–20CrossRef Huppertz B, Gauster M, Orendi K, König J, Moser G (2009) Oxygen as modulator of trophoblast invasion. J Anat 215:14–20CrossRef
Zurück zum Zitat Huppertz B, Kertschanska S, Frank HG, Gaus G, Funayama H, Kaufmann P (1996) Extracellular matrix components of the placental extravillous trophoblast: immunocytochemistry and ultrastructural distribution. Histochem Cell Biol 106:291–301CrossRef Huppertz B, Kertschanska S, Frank HG, Gaus G, Funayama H, Kaufmann P (1996) Extracellular matrix components of the placental extravillous trophoblast: immunocytochemistry and ultrastructural distribution. Histochem Cell Biol 106:291–301CrossRef
Zurück zum Zitat Jauniaux E, Collins SL, Jurkovic D, Burton GJ (2016) Accreta placentation: a systematic review of prenatal ultrasound imaging and grading of villous invasiveness. Am J Obstet Gynecol 215:712–721CrossRef Jauniaux E, Collins SL, Jurkovic D, Burton GJ (2016) Accreta placentation: a systematic review of prenatal ultrasound imaging and grading of villous invasiveness. Am J Obstet Gynecol 215:712–721CrossRef
Zurück zum Zitat Jauniaux E, Gulbis B, Burton GJ (2003a) The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus–a review. Placenta 24:S86–93CrossRef Jauniaux E, Gulbis B, Burton GJ (2003a) The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus–a review. Placenta 24:S86–93CrossRef
Zurück zum Zitat Jauniaux E, Hempstock J, Greenwold N, Burton GJ (2003b) Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 162:115–125CrossRef Jauniaux E, Hempstock J, Greenwold N, Burton GJ (2003b) Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 162:115–125CrossRef
Zurück zum Zitat Jauniaux E, Jurkovic D, Campbell S, Kurjak A, Hustin J (1991) Investigation of placental circulations by color doppler ultrasonography. Am J Obstet Gynecol 164:486–488CrossRef Jauniaux E, Jurkovic D, Campbell S, Kurjak A, Hustin J (1991) Investigation of placental circulations by color doppler ultrasonography. Am J Obstet Gynecol 164:486–488CrossRef
Zurück zum Zitat Jauniaux E, Watson AL, Hempstock J, Bao YP, Skepper JN, Burton GJ (2000) Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol 157:2111–2122CrossRef Jauniaux E, Watson AL, Hempstock J, Bao YP, Skepper JN, Burton GJ (2000) Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol 157:2111–2122CrossRef
Zurück zum Zitat Kadyrov M, Schmitz C, Black S, Kaufmann P, Huppertz B (2003) Pre-eclampsia and maternal anaemia display reduced apoptosis and opposite invasive phenotypes of extravillous trophoblast. Placenta 24:540–548CrossRef Kadyrov M, Schmitz C, Black S, Kaufmann P, Huppertz B (2003) Pre-eclampsia and maternal anaemia display reduced apoptosis and opposite invasive phenotypes of extravillous trophoblast. Placenta 24:540–548CrossRef
Zurück zum Zitat Kaufmann P, Black S, Huppertz B (2003) Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod 69:1–7CrossRef Kaufmann P, Black S, Huppertz B (2003) Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod 69:1–7CrossRef
Zurück zum Zitat Kaufmann P, Huppertz B (2007) Tenney Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia. In: Lyall F, Befort M (Hrsg) Pre-eclampsia. Etiology and clinical practice. Cambridge University Press, Cambridge Kaufmann P, Huppertz B (2007) Tenney Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia. In: Lyall F, Befort M (Hrsg) Pre-eclampsia. Etiology and clinical practice. Cambridge University Press, Cambridge
Zurück zum Zitat Kaufmann P, Huppertz B, Frank HG (1996) The fibrinoids of the human placenta: origin, composition and functional relevance. Ann Anat 178:485–501CrossRef Kaufmann P, Huppertz B, Frank HG (1996) The fibrinoids of the human placenta: origin, composition and functional relevance. Ann Anat 178:485–501CrossRef
Zurück zum Zitat Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC (1996) Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol 175:1534–1542CrossRef Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC (1996) Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol 175:1534–1542CrossRef
Zurück zum Zitat Mayhew TM1, Leach L, McGee R, Ismail WW, Myklebust R, Lammiman MJ (1999) Proliferation, differentiation and apoptosis in villous trophoblast at 13−41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes). Placenta 20: 407–422CrossRef Mayhew TM1, Leach L, McGee R, Ismail WW, Myklebust R, Lammiman MJ (1999) Proliferation, differentiation and apoptosis in villous trophoblast at 13−41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes). Placenta 20: 407–422CrossRef
Zurück zum Zitat McMaster MT, Librach CL, Zhou Y, Lim KH, Janatpour MJ, DeMars R, Kovats S, Damsky C, Fisher SJ (1995) Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol Baltim 154:3771–3778 McMaster MT, Librach CL, Zhou Y, Lim KH, Janatpour MJ, DeMars R, Kovats S, Damsky C, Fisher SJ (1995) Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol Baltim 154:3771–3778
Zurück zum Zitat Moser G, Gauster M, Orendi K, Glasner A, Theuerkauf R, Huppertz B (2010) Endoglandular trophoblast, an alternative route of trophoblast invasion? Analysis with novel confrontation co-culture models. Hum Reprod 25:1127–1136CrossRef Moser G, Gauster M, Orendi K, Glasner A, Theuerkauf R, Huppertz B (2010) Endoglandular trophoblast, an alternative route of trophoblast invasion? Analysis with novel confrontation co-culture models. Hum Reprod 25:1127–1136CrossRef
Zurück zum Zitat Moser G, Huppertz B (2017) Implantation and extravillous trophoblast invasion: from rare archival specimens to modern biobanking. Placenta 56:19–26CrossRef Moser G, Huppertz B (2017) Implantation and extravillous trophoblast invasion: from rare archival specimens to modern biobanking. Placenta 56:19–26CrossRef
Zurück zum Zitat Moser G, Weiss G, Gauster M, Sundl M, Huppertz B (2015) Evidence from the very beginning: endoglandular trophoblasts penetrate and replace uterine glands in situ and in vitro. Hum Reprod 30:2747–2757CrossRef Moser G, Weiss G, Gauster M, Sundl M, Huppertz B (2015) Evidence from the very beginning: endoglandular trophoblasts penetrate and replace uterine glands in situ and in vitro. Hum Reprod 30:2747–2757CrossRef
Zurück zum Zitat Moser G, Weiss G, Sundl M, Gauster M, Siwetz M, Lang-Olip I, Huppertz B (2017) Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins. Histochem Cell Biol 147(3):353–366CrossRef Moser G, Weiss G, Sundl M, Gauster M, Siwetz M, Lang-Olip I, Huppertz B (2017) Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins. Histochem Cell Biol 147(3):353–366CrossRef
Zurück zum Zitat Roberts VH, Lo JO, Salati JA, Lewandowski KS, Lindner JR, Morgan TK, Frias AE (2016) Quantitative assessment of placental perfusion by contrast-enhanced ultrasound in macaques and human subjects. Am J Obstet Gynecol 214:369.e1–8CrossRef Roberts VH, Lo JO, Salati JA, Lewandowski KS, Lindner JR, Morgan TK, Frias AE (2016) Quantitative assessment of placental perfusion by contrast-enhanced ultrasound in macaques and human subjects. Am J Obstet Gynecol 214:369.e1–8CrossRef
Zurück zum Zitat Schaaps JP, Hustin J (1988) In vivo aspect of the maternal-trophoblastic border during the first trimester of gestation. Trophoblast Res 3:39–48 Schaaps JP, Hustin J (1988) In vivo aspect of the maternal-trophoblastic border during the first trimester of gestation. Trophoblast Res 3:39–48
Zurück zum Zitat Silver RM, Landon MB, Rouse DJ, Leveno KJ, Spong CY, Thom EA, Moawad AH, Caritis SN, Harper M, Wapner RJ, Sorokin Y, Miodovnik M, Carpenter M, Peaceman AM, O’Sullivan MJ, Sibai B, Langer O, Thorp JM, Ramin SM, Mercer BM, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (2006) Maternal morbidity associated with multiple repeat cesarean deliveries. Obstet Gynecol 107:1226–1232CrossRef Silver RM, Landon MB, Rouse DJ, Leveno KJ, Spong CY, Thom EA, Moawad AH, Caritis SN, Harper M, Wapner RJ, Sorokin Y, Miodovnik M, Carpenter M, Peaceman AM, O’Sullivan MJ, Sibai B, Langer O, Thorp JM, Ramin SM, Mercer BM, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (2006) Maternal morbidity associated with multiple repeat cesarean deliveries. Obstet Gynecol 107:1226–1232CrossRef
Zurück zum Zitat Simmons DG, Fortier AL, Cross JC (2007) Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Dev Biol 304:567–578CrossRef Simmons DG, Fortier AL, Cross JC (2007) Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Dev Biol 304:567–578CrossRef
Zurück zum Zitat Soothill PW, Nicolaides KH, Rodeck CH, Campbell S (1986) Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Ther 1:168–175CrossRef Soothill PW, Nicolaides KH, Rodeck CH, Campbell S (1986) Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Ther 1:168–175CrossRef
Zurück zum Zitat Tenney B, Parker F (1940) The placenta in toxaemia of pregnancy. Am J Obstet Gynecol 39:1000–1005CrossRef Tenney B, Parker F (1940) The placenta in toxaemia of pregnancy. Am J Obstet Gynecol 39:1000–1005CrossRef
Zurück zum Zitat Weiss G, Sundl M, Glasner A, Huppertz B, Moser G (2016) The trophoblast plug during early pregnancy: a deeper insight. Histochem Cell Biol 146:749–756CrossRef Weiss G, Sundl M, Glasner A, Huppertz B, Moser G (2016) The trophoblast plug during early pregnancy: a deeper insight. Histochem Cell Biol 146:749–756CrossRef
Zurück zum Zitat Windsperger K, Dekan S, Pils S, Golletz C, Kunihs V, Fiala C, Kristiansen G, Knöfler M, Pollheimer J (2017) Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions. Hum Reprod 32:1208–1217CrossRef Windsperger K, Dekan S, Pils S, Golletz C, Kunihs V, Fiala C, Kristiansen G, Knöfler M, Pollheimer J (2017) Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions. Hum Reprod 32:1208–1217CrossRef
Metadaten
Titel
Plazentaentwicklung mit histologischen Aspekten
verfasst von
Berthold Huppertz
Copyright-Jahr
2018
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-55622-1_1