Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.01.2016 | Übersichten | Ausgabe 1/2016

Zeitschrift für Gerontologie und Geriatrie 1/2016

Paraoxonase (PON1) polymorphisms Q192R and L55M are not associated with human longevity

A meta-analysis

Zeitschrift:
Zeitschrift für Gerontologie und Geriatrie > Ausgabe 1/2016
Autoren:
Gan-Zhong Wei, Mei-Yan Zhu, Fang Wang, Yue-Guang Zhao, Shan-Shan Li, Tong-Yang Liu, Ying Luo, Dr. Wen-Ru Tang

Abstract

Background

Genetic mutations in the paraoxonase 1 (PON1) encoding gene have been considered to affect mortality and of these the functional promoter region polymorphisms Q192R and L55M are among the most widely studied.

Objective

The aim of this study was to determine whether the Q192R and L55M polymorphisms of PON1 can increase susceptibility to longevity. A meta-analysis was performed to obtain a comprehensive estimation of the association between Q192R and L55M and longevity in long-lived individuals (LLIs) aged 80 years or more.

Material and methods

A search was carried out in the PubMed database (from January 2001 to May 2014) to obtain data on the role of PON1 polymorphisms in longevity and a pooled odds ratio (OR) with a 95 % confidence interval (CI) was used to assess the associations.

Results

The meta-analysis was based on 9 studies of PON1 Q192R and 5 studies of PON1 L55M that covered a total of 5086 LLIs and 4494 controls. Overall, significantly increased risks were not observed for either Q192R or L55M. The results of the statistical calculations were as follows: R vs. Q (additive model): OR = 1.080, 95 % CI = 0.989–1.179, p = 0.088 and RR + RQ vs. QQ (dominant model): OR = 1.099, 95 % CI = 0.975–1.240, p = 0.124; M vs. L (additive model): OR = 0.946, 95 % CI = 0.862–1.039, p = 0.245 and MM + ML vs. LL (dominant model): OR = 0.951, 95 % CI = 0.836–1.081, p = 0.442 for Q192R and L55M, respectively. The results did not change with an age cut-off among the LLIs of ≥ 93 years.

Conclusion

No evidence that the Q192R and L55M polymorphisms of PON1 impacted on the probability of reaching extreme ages was found although this cannot be completely ruled out; however, the possibility of population-specific effects due to the influence of and interaction between different genes or environmental factors could not be ruled out.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:

Zeitschrift für Gerontologie und Geriatrie

Print-Titel

• Themenbezogene Hefte behandeln Fragen der Gerontologie, der Biologie und Grundlagenforschung des Alterns und der geriatrischen Forschung

• Erweitert mit Beiträgen zu Therapie, Psychologie und Soziologie sowie der praktischen Altenpflege.  

• Hot topics von Experten knapp, aussagekräftig und provokativ kommentiert

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2016

Zeitschrift für Gerontologie und Geriatrie 1/2016 Zur Ausgabe

Beiträge zum Themenschwerpunkt

Ambivalenz, Alter und Agency

Mitteilungen der DGGG

Mitteilungen der DGGG

Beiträge zum Themenschwerpunkt

Zeitliche Ambivalenzen des Alter(n)s