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Erschienen in: Zeitschrift für Gerontologie und Geriatrie 6/2015

01.08.2015 | Originalien

Parameters of bone health and fracture risk in older female fall victims: what do they tell us?

verfasst von: Heinrich W. Thaler, MD, Christian Oudshoorn, MD, Klaas A. Hartholt, MD, PhD, Assist. Prof. (em) Tischa J.M. van der Cammen, MD, PhD

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 6/2015

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Abstract

Introduction

A common and severe osteoporotic type fracture in older women is a hip fracture. It is not clear whether bone turnover parameters measured in blood can be a useful tool to predict fracture risk in older persons. The aim of the current study was to assess the association between serum vitamin D (25OHD) levels, parathyroid hormone (PTH), total osteocalcin, carboxy-terminal collagen crosslinks (CTX) and hip fractures in older fallers.

Material and methods

A single centre, prospective cohort study of bone parameters was carried out in 400 female patients aged > 70 years including 200 with a hip fracture and 200 without fractures, admitted after a fall between January 2005 and December 2007.

Results

Serum total osteocalcin levels were significantly lower in the fracture group compared to the non-fracture group (20.4 ng/ml vs 26.1 ng/ml, respectively, p = 0.01). This finding remained significant after exclusion of the patients on bisphosphonates (p = 0.003). There were no significant differences in 25OHD, PTH or CTX levels between the two groups.

Conclusion

In the current study there was an association between the presence of a hip fracture and lower total serum osteocalcin concentrations. This could be indicative of low bone turnover osteoporosis in these women. An association for other bone turnover markers was lacking.
Literatur
1.
Zurück zum Zitat Stalenhoef PA, Diederiks JP, Knottnerus JA, de Witte LP, Crebolder HF (2000) The construction of a patient record-based risk model for recurrent falls among elderly people living in the community. Fam Pract 17:490–496CrossRefPubMed Stalenhoef PA, Diederiks JP, Knottnerus JA, de Witte LP, Crebolder HF (2000) The construction of a patient record-based risk model for recurrent falls among elderly people living in the community. Fam Pract 17:490–496CrossRefPubMed
2.
Zurück zum Zitat Hartholt KA, van der Velde N, Looman CW, van Lieshout EM, Panneman MJ, van Beeck EF et al (2010) Trends in fall-related hospital admissions in older persons in the Netherlands. Arch Intern Med 170:905–911CrossRefPubMed Hartholt KA, van der Velde N, Looman CW, van Lieshout EM, Panneman MJ, van Beeck EF et al (2010) Trends in fall-related hospital admissions in older persons in the Netherlands. Arch Intern Med 170:905–911CrossRefPubMed
3.
Zurück zum Zitat Hartholt KA, van Beeck EF, Polinder S, van der Velde N, van Lieshout EM, Panneman MJ et al (2011) Societal consequences of falls in the older population: injuries, healthcare costs, and long-term reduced quality of life. J Trauma 71:748–753CrossRefPubMed Hartholt KA, van Beeck EF, Polinder S, van der Velde N, van Lieshout EM, Panneman MJ et al (2011) Societal consequences of falls in the older population: injuries, healthcare costs, and long-term reduced quality of life. J Trauma 71:748–753CrossRefPubMed
4.
Zurück zum Zitat Samelson EJ, Zhang Y, Kiel DP, Hannan MT, Felson DT (2002) Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study. Am J Public Health 92:858–862PubMedCentralCrossRefPubMed Samelson EJ, Zhang Y, Kiel DP, Hannan MT, Felson DT (2002) Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study. Am J Public Health 92:858–862PubMedCentralCrossRefPubMed
5.
Zurück zum Zitat Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 24:23–57PubMedCentralCrossRefPubMed Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 24:23–57PubMedCentralCrossRefPubMed
6.
7.
Zurück zum Zitat Gibson MJ, Andres RO, Isaacs B, Radebaugh T, Worm-Peterson J (1987) The prevention of falls in later life: a report of the Kellogg International Work Group on the prevention of falls by the elderly. Dan Med Bull 34:1–24 Gibson MJ, Andres RO, Isaacs B, Radebaugh T, Worm-Peterson J (1987) The prevention of falls in later life: a report of the Kellogg International Work Group on the prevention of falls by the elderly. Dan Med Bull 34:1–24
9.
Zurück zum Zitat Riis BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C (1996) Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 19:9–12CrossRefPubMed Riis BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C (1996) Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 19:9–12CrossRefPubMed
10.
Zurück zum Zitat Akesson K, Ljunghall S, Jonsson B, Sernbo I, Johnell O, Gärdsell P et al (1995) Assessment of biochemical markers of bone metabolism in relation to the occurrence of fracture: a retrospective and prospective population-based study of women. J Bone Miner Res 10:1823–1829CrossRefPubMed Akesson K, Ljunghall S, Jonsson B, Sernbo I, Johnell O, Gärdsell P et al (1995) Assessment of biochemical markers of bone metabolism in relation to the occurrence of fracture: a retrospective and prospective population-based study of women. J Bone Miner Res 10:1823–1829CrossRefPubMed
11.
Zurück zum Zitat Rodrigues AM, Caetano-Lopes J, Vale AC, Vidal B, Lopes A, Aleixo I et al (2012) Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures. Bone 51:981–989CrossRefPubMed Rodrigues AM, Caetano-Lopes J, Vale AC, Vidal B, Lopes A, Aleixo I et al (2012) Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures. Bone 51:981–989CrossRefPubMed
12.
Zurück zum Zitat Singer FR, Eyre DR (2008) Using biochemical markers of bone turnover in clinical practice. Cleve Clin J Med 75:739–750CrossRefPubMed Singer FR, Eyre DR (2008) Using biochemical markers of bone turnover in clinical practice. Cleve Clin J Med 75:739–750CrossRefPubMed
13.
Zurück zum Zitat Hlaing TT, Compston JE (2014) Biochemical markers of bone turnover—uses and limitations. Ann Clin Biochem 51:189–202CrossRefPubMed Hlaing TT, Compston JE (2014) Biochemical markers of bone turnover—uses and limitations. Ann Clin Biochem 51:189–202CrossRefPubMed
14.
Zurück zum Zitat Burr DB, Allen MR (2008) Low bone turnover and microdamage? How and where to assess it? J Bone Miner Res 23:1150–1151CrossRefPubMed Burr DB, Allen MR (2008) Low bone turnover and microdamage? How and where to assess it? J Bone Miner Res 23:1150–1151CrossRefPubMed
15.
Zurück zum Zitat Seriolo B, Paolino S, Casabella A, Botticella G, Seriolo C, Molfetta L (2013) Osteoporosis in the elderly. Aging Clin Exp Res 25:27–29CrossRef Seriolo B, Paolino S, Casabella A, Botticella G, Seriolo C, Molfetta L (2013) Osteoporosis in the elderly. Aging Clin Exp Res 25:27–29CrossRef
16.
Zurück zum Zitat Luukinen H, Käkönen SM, Pettersson K, Koski K, Laippala P, Lövgren T et al (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15:2473–2478CrossRefPubMed Luukinen H, Käkönen SM, Pettersson K, Koski K, Laippala P, Lövgren T et al (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15:2473–2478CrossRefPubMed
Metadaten
Titel
Parameters of bone health and fracture risk in older female fall victims: what do they tell us?
verfasst von
Heinrich W. Thaler, MD
Christian Oudshoorn, MD
Klaas A. Hartholt, MD, PhD
Assist. Prof. (em) Tischa J.M. van der Cammen, MD, PhD
Publikationsdatum
01.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 6/2015
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-014-0843-2

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