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2015 | OriginalPaper | Buchkapitel

68. Medikamentöse Therapie der Adipositas

verfasst von : Marcus May, Jens Jordan

Erschienen in: Handbuch Essstörungen und Adipositas

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Durch Ernährungsinterventionen und körperliches Training allein können viele übergewichtige und adipöse Patienten keine anhaltende Gewichtsreduktion erreichen. Zur unterstützenden Therapie bei dieser Indikation sind nur wenige effektive Medikamente erhältlich. Derzeit ist in Deutschland nur der intestinale Lipaseinhibitor Orlistat für eine Langzeitbehandlung der Adipositas zugelassen. In diesem Kapitel werden Wirkmechanismus und klinische Daten des Wirkstoffs dargestellt. Darüber hinaus werden Antiadiposita, die für die USA kürzlich zugelassen wurden, sowie mögliche zukünftige Wirkstoffe beleuchtet. Auch Medikamente mit Gewichtsreduktion als Nebenwirkung finden Erwähnung.
Literatur
Zurück zum Zitat Allison DB, Gadde KM, Garvey WT et al (2012) Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring) 20:330–342CrossRef Allison DB, Gadde KM, Garvey WT et al (2012) Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring) 20:330–342CrossRef
Zurück zum Zitat Astrup A, Rossner S, Van Gaal L et al (2009) Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374:1606–1616CrossRefPubMed Astrup A, Rossner S, Van Gaal L et al (2009) Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374:1606–1616CrossRefPubMed
Zurück zum Zitat Bolinder J, Ljunggren O, Kullberg J et al (2012) Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 97:1020–1031CrossRefPubMed Bolinder J, Ljunggren O, Kullberg J et al (2012) Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 97:1020–1031CrossRefPubMed
Zurück zum Zitat DeFronzo RA, Ratner RE, Han J et al (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2. Diabetes Care 28:1092–1100CrossRefPubMed DeFronzo RA, Ratner RE, Han J et al (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2. Diabetes Care 28:1092–1100CrossRefPubMed
Zurück zum Zitat Fidler MC, Sanchez M, Raether B et al (2011) A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab 96:3067–3077CrossRefPubMed Fidler MC, Sanchez M, Raether B et al (2011) A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab 96:3067–3077CrossRefPubMed
Zurück zum Zitat Gadde KM, Allison DB, Ryan DH et al (2011) Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet 377:1341–1352CrossRefPubMed Gadde KM, Allison DB, Ryan DH et al (2011) Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet 377:1341–1352CrossRefPubMed
Zurück zum Zitat Garvey WT, Ryan DH, Look M et al (2012) Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr 95:297–308PubMedCentralCrossRefPubMed Garvey WT, Ryan DH, Look M et al (2012) Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr 95:297–308PubMedCentralCrossRefPubMed
Zurück zum Zitat Greenway FL, Fujioka K, Plodkowski RA et al (2010) Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 376:595–605CrossRefPubMed Greenway FL, Fujioka K, Plodkowski RA et al (2010) Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 376:595–605CrossRefPubMed
Zurück zum Zitat Hutton B, Fergusson D (2004) Changes in body weight and serum lipid profile in obese patients treated with orlistat in addition to a hypocaloric diet: a systematic review of randomized clinical trials. Am J Clin Nutr 80:1461–1468PubMed Hutton B, Fergusson D (2004) Changes in body weight and serum lipid profile in obese patients treated with orlistat in addition to a hypocaloric diet: a systematic review of randomized clinical trials. Am J Clin Nutr 80:1461–1468PubMed
Zurück zum Zitat Rosenstock J, Klaff LJ, Schwartz S et al (2010) Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 33:1173–1175PubMedCentralCrossRefPubMed Rosenstock J, Klaff LJ, Schwartz S et al (2010) Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 33:1173–1175PubMedCentralCrossRefPubMed
Zurück zum Zitat Rossner S, Sjostrom L, Noack R et al (2000) Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. European Orlistat Obesity Study Group. Obes Res 8:49–61CrossRefPubMed Rossner S, Sjostrom L, Noack R et al (2000) Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. European Orlistat Obesity Study Group. Obes Res 8:49–61CrossRefPubMed
Zurück zum Zitat Smith SR, Weissman NJ, Anderson CM et al (2010) Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med 363:245–256CrossRefPubMed Smith SR, Weissman NJ, Anderson CM et al (2010) Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med 363:245–256CrossRefPubMed
Zurück zum Zitat Wadden TA, Berkowitz RI, Womble LG et al (2005) Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med 353:2111–2120CrossRefPubMed Wadden TA, Berkowitz RI, Womble LG et al (2005) Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med 353:2111–2120CrossRefPubMed
Metadaten
Titel
Medikamentöse Therapie der Adipositas
verfasst von
Marcus May
Jens Jordan
Copyright-Jahr
2015
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-54573-3_68