Infertility is a major physiological and psychological problem for women, and can also put strain on the husband-wife relationship. A number of approaches have been developed for the infertile woman with a fertile husband, such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and artificial insemination with the husband’s (or partner’s) sperm (AIH). Although the success rate with these approaches is good, some women remain refractorily infertile. Low incident levels of laser energy, known as low reactive-level laser therapy (LLLT), have been proved useful in a variety of clinical fields, including the enhancement of local blood flow rate and volume. The present study evaluated the adjunctive application of an 830 nm diode LLLT system (60 mW in continuous wave, 5 min/point, approx. 300 J/cm²) in combination with artificial reproductive technology (ART). Twenty-four patients (ages ranging from 30-48 yrs) received LLLT, among whom there were 8 pregnancies (33.3%) and 3 miscarriages (12.5%), with greater efficacy seen in the younger age groups. Of the 24, 19 underwent ICSI plus LLLT with 7 pregnancies (pregnancy rate of 36.8%). On the other hand, in twenty-one ICSI patients during the same period who did not receive LLLT, only 4 pregnancies occurred (pregnancy rate of 19%). However, the series is too small to state definitively that LLLT significantly contributed to improvement in the rate of pregnancy among refractorily infertile women, but based on our experience we feel that LLLT improved the blood supply to the ovum and womb, thereby increasing the pregnancy rate. Furthermore, LLLT is safe, painless, easy to deliver and well tolerated. We will certainly continue using LLLT in infertile women, and larger studies are planned for the future to confirm the interesting results of the present study.