Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Reviews
Left Ventricular Stiffening as Therapeutic Target for Heart Failure With Preserved Ejection Fraction
Yasushi SakataTomohito OhtaniYasuharu TakedaKazuhiro YamamotoToshiaki Mano
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2013 Volume 77 Issue 4 Pages 886-892

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Abstract

The high prevalence of patients with heart failure (HF) with preserved ejection fraction (HFpEF) has highlighted the pivotal role of diastolic function in the development of HF. Abnormalities of diastolic function induce elevated left ventricular (LV) end-diastolic pressure, which leads to pulmonary edema and the symptoms of HF because the LV, left atrium and the pulmonary veins form 1 chamber while the mitral valve is opening. Thus, LV diastolic dysfunction results in the development of HF, in particular, HFpEF. LV stiffness mainly contributes to the transition to HFpEF, but noninvasive assessment and the therapeutic strategy for LV stiffness have not been fully established. This review will focus on the contribution of LV passive stiffness to the development of HFpEF and on the evaluation and treatment of LV stiffening based on insights gained from a hypertensive HFpEF animal model we have developed.  (Circ J 2013; 77: 886–892)

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© 2013 THE JAPANESE CIRCULATION SOCIETY
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