Regular Research ArticlesComparison of Different Clinical Diagnostic Criteria for Depression in Alzheimer Disease
Section snippets
Subjects
The sample included subjects referred from the primary care centers to the UVaMiD memory clinic as a result of progressive cognitive decline. Clinical diagnosis of AD was made according to the standard UVaMiD memory clinic protocol, which includes the medical history through an interview with the patient and with the caregiver; a general medical, psychiatric, and neurologic examination; and a set of complementary tests: basic hematologic and biochemical analysis and brain computed axial
RESULTS
The sample consisted of 491 patients, of whom 70.9% were women and 40.1% were <75 years (mean age: 75.2 years, standard deviation [SD]: 6.6, range: 52–89 years). The mean number of years of education was 5.9 (SD: 3.7, range: 0–21 years). A total of 27.7% of the patients scored between 30 and 20 points on the MMSE, 66.6% between 19 and 11 points, and 5.3% scored 10 or less, and the mean score was 17.1 points (SD: 4.1, range: 6–27). The mean score on the CAMCOG was 55.6 points (SD: 13.4, range:
DISCUSSION
This study examined the prevalence rate of depression according to five different conceptualizations in a large clinical sample of patients with AD. The objective was to obtain estimations of prevalence based on five conceptualizations of depression in an increasing order of diagnostic rigidity. The prevalence rates for the four clinical diagnostic criteria ranged from 4.9% for the ICD-10 to 27.4% for the PDC-dAD. The prevalence rate according the screening question of the NPI depression
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2017, Critical Care ClinicsCitation Excerpt :Pharmacotherapy is often best initiated based on the presence of other symptoms (eg, neuroleptics for agitation, selective serotonin reuptake inhibitors for obsessions, mood stabilizers for mania) (see agents in Table 1).72 Depression is commonly comorbid with dementia, with prevalence ranging from 5% to 44% in AD depending on definition and often presents with associated features of agitation, anxiety, anhedonia, apathy, and irritability (see Table 1).73 Treating depression, irritability, and anxiety in dementia is often more challenging than treating depression alone.